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Q02AZ6 (LPXB_SOLUE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:Acid_0771
OrganismSolibacter usitatus (strain Ellin6076) [Complete proteome] [HAMAP]
Taxonomic identifier234267 [NCBI]
Taxonomic lineageBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_1000049423

Sequences

Sequence LengthMass (Da)Tools
Q02AZ6 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 3C3E61C3F4128B47

FASTA38142,109
        10         20         30         40         50         60 
MPKILVSAGE ASGDLYASLV VQELRRIMPD AEFFGCTGPR LRAAGVRTIV DSADLAVVGL 

        70         80         90        100        110        120 
IEVVAHIPRI YGEFRKLLRA AREERPLLAI LTDSPDFHLR VARKLHRQEV PVVYLVAPQA 

       130        140        150        160        170        180 
WAWRRGRVRE MRRTIRRLLC IFPFEEEFFR RYGVPATYIG HPLAGLVHPA LSREEFFKKH 

       190        200        210        220        230        240 
RLAAERPLVS VLPGSRRGEA ARHIPALLDA VDRIYREQAV NVVLPASATT GVAFFQERMG 

       250        260        270        280        290        300 
NSPIRVIEGE SWDAMAHSDL ALAASGTVTV EAALLGTPMV TFYKVTGVSW LAGKFLVDIP 

       310        320        330        340        350        360 
FYSMVNLIAG RAVVPELMQS QMTGENLARE ALRLLQGGRD REEMKAGLAQ VKEKLAGRTG 

       370        380 
APGRAALAIQ EILEGQVTHV S 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000473 Genomic DNA. Translation: ABJ81770.1.
RefSeqYP_822055.1. NC_008536.1.

3D structure databases

ProteinModelPortalQ02AZ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING234267.Acid_0771.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ81770; ABJ81770; Acid_0771.
GeneID4431100.
KEGGsus:Acid_0771.
PATRIC32003627. VBICanSol30224_0809.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018004.
KOK00748.
OMAYIAPQEW.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycSUSI234267:GHSK-776-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_SOLUE
AccessionPrimary (citable) accession number: Q02AZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways