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Q02AZ6

- LPXB_SOLUE

UniProt

Q02AZ6 - LPXB_SOLUE

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, Acid_0771
Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-776-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Acid_0771
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
ProteomesiUP000000671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Lipid-A-disaccharide synthaseUniRule annotationPRO_1000049423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi234267.Acid_0771.

Structurei

3D structure databases

ProteinModelPortaliQ02AZ6.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02AZ6-1 [UniParc]FASTAAdd to Basket

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MPKILVSAGE ASGDLYASLV VQELRRIMPD AEFFGCTGPR LRAAGVRTIV    50
DSADLAVVGL IEVVAHIPRI YGEFRKLLRA AREERPLLAI LTDSPDFHLR 100
VARKLHRQEV PVVYLVAPQA WAWRRGRVRE MRRTIRRLLC IFPFEEEFFR 150
RYGVPATYIG HPLAGLVHPA LSREEFFKKH RLAAERPLVS VLPGSRRGEA 200
ARHIPALLDA VDRIYREQAV NVVLPASATT GVAFFQERMG NSPIRVIEGE 250
SWDAMAHSDL ALAASGTVTV EAALLGTPMV TFYKVTGVSW LAGKFLVDIP 300
FYSMVNLIAG RAVVPELMQS QMTGENLARE ALRLLQGGRD REEMKAGLAQ 350
VKEKLAGRTG APGRAALAIQ EILEGQVTHV S 381
Length:381
Mass (Da):42,109
Last modified:November 14, 2006 - v1
Checksum:i3C3E61C3F4128B47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ81770.1.
RefSeqiYP_822055.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ81770; ABJ81770; Acid_0771.
GeneIDi4431100.
KEGGisus:Acid_0771.
PATRICi32003627. VBICanSol30224_0809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000473 Genomic DNA. Translation: ABJ81770.1 .
RefSeqi YP_822055.1. NC_008536.1.

3D structure databases

ProteinModelPortali Q02AZ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 234267.Acid_0771.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ81770 ; ABJ81770 ; Acid_0771 .
GeneIDi 4431100.
KEGGi sus:Acid_0771.
PATRICi 32003627. VBICanSol30224_0809.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SUSI234267:GHSK-776-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ellin6076.

Entry informationi

Entry nameiLPXB_SOLUE
AccessioniPrimary (citable) accession number: Q02AZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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