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Protein

Catalase-peroxidase

Gene

katG

Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei102 – 1021Transition state stabilizerUniRule annotation
Active sitei106 – 1061Proton acceptorUniRule annotation
Metal bindingi268 – 2681Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-1123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Acid_1112
OrganismiSolibacter usitatus (strain Ellin6076)
Taxonomic identifieri234267 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
Proteomesi
  • UP000000671 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Catalase-peroxidasePRO_0000354936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki105 ↔ 227Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-253)UniRule annotation
Cross-linki227 ↔ 253Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-105)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi234267.Acid_1112.

Structurei

3D structure databases

ProteinModelPortaliQ02A20.
SMRiQ02A20. Positions 29-732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02A20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQSNDAAV AGAPNDHGAA KCPVAHTAHG RRNRDWWPDA LDISTLHRNS
60 70 80 90 100
SLSDPMGSGF DYAMEFESLD LQAVIKDLHA LMTDSQDWWP ADFGHYGGLM
110 120 130 140 150
IRMAWHSAGT YRITDGRGGA GAGQQRFAPL NSWPDNANLD KARRLLWPVK
160 170 180 190 200
QKYGDKISWA DLMVLAGNVA LESMGFKTFG FAGGRSDVWE PEELYWGPEG
210 220 230 240 250
TWLGDERYSG ERQLSEPLGA VQMGLIYVNP EGPNGNPDPV AAAKDIRETF
260 270 280 290 300
FRMAMNDEET VALIAGGHTF GKTHGAGDPS LVGPDPESGA LEDQGLGWKS
310 320 330 340 350
KFGTGFGADA ITGGPEVTWS QTPTQWSNSF FKNLFENEWE LTNSPAGAKQ
360 370 380 390 400
WRAKNGQATI PDPFDKSKKR VPTMLTTDLS LRFDPAYEKI SRRFYENPDQ
410 420 430 440 450
FADAFARAWF KLTHRDMGPI ARYLGPLVPK ETLLWQDPIP PVDHPLIDEN
460 470 480 490 500
DASALKAKIL ASGLSTSDLV STAWASASTF RGSDKRGGAN GARIRLAPQK
510 520 530 540 550
DWEVNQPKQL AKVLEKLETI GKEFGKKVSL ADLIVLGGDA AIEKAAKDAG
560 570 580 590 600
VEVKIPFTPG RMDASQEQTD VASFAPLEPK ADGFRNYIGR KTQFLQPEEA
610 620 630 640 650
LVDRAQLLRL TGPEMTVLVG GLRVLGANTA GSKHGVFTAT PGVLTNDFFV
660 670 680 690 700
NLLDMRTHWQ PAGGEEGVYE GRDRKTNALK WTGTRVDLIF GSHSQLRAFA
710 720 730 740
EVYAWAGSKE KFVKDFAAAW NKVMNLDRYD VARTGETKKA AVV
Length:743
Mass (Da):81,479
Last modified:November 14, 2006 - v1
Checksum:i15497A51D56B3C8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA. Translation: ABJ82106.1.
RefSeqiWP_011682882.1. NC_008536.1.

Genome annotation databases

EnsemblBacteriaiABJ82106; ABJ82106; Acid_1112.
KEGGisus:Acid_1112.
PATRICi32004345. VBICanSol30224_1162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000473 Genomic DNA. Translation: ABJ82106.1.
RefSeqiWP_011682882.1. NC_008536.1.

3D structure databases

ProteinModelPortaliQ02A20.
SMRiQ02A20. Positions 29-732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi234267.Acid_1112.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ82106; ABJ82106; Acid_1112.
KEGGisus:Acid_1112.
PATRICi32004345. VBICanSol30224_1162.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciSUSI234267:GHSK-1123-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SOLUE
AccessioniPrimary (citable) accession number: Q02A20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.