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Q02A16

- NADK_SOLUE

UniProt

Q02A16 - NADK_SOLUE

Protein

NAD kinase

Gene

nadK

Organism
Solibacter usitatus (strain Ellin6076)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei155 – 1551NADUniRule annotation
    Binding sitei172 – 1721NADUniRule annotation
    Binding sitei174 – 1741NADUniRule annotation
    Binding sitei244 – 2441NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi70 – 712NADUniRule annotation
    Nucleotide bindingi144 – 1452NADUniRule annotation
    Nucleotide bindingi185 – 1906NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSUSI234267:GHSK-1127-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Acid_1116
    OrganismiSolibacter usitatus (strain Ellin6076)
    Taxonomic identifieri234267 [NCBI]
    Taxonomic lineageiBacteriaAcidobacteriaSolibacteresSolibacteralesSolibacteraceaeCandidatus Solibacter
    ProteomesiUP000000671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287NAD kinasePRO_1000192519Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi234267.Acid_1116.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02A16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q02A16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIIKTAGII SKPNSTAAEE IVPKLIEWLR RRGIAVRIDE QTSLYSGGVS    50
    GMPREEVPQS CDLVVVLGGD GTLLSAARAI GRREIPLFPV NLGGLGFLTA 100
    ISIEELYPEL ERALRGEHRI AKRKLMTTEV IRENNVIASF DALNDAVLTK 150
    SSIARMIDLD TYVDEQFVCA YKADGLIIAT PTGSTAYSLS AGGPIIFPSV 200
    PAICLTPICP HMLTNRPVLV PETSVIRVAS RGPDESVYLT IDGQVGTPIR 250
    EHDTVVCHSS HHSLLLIRPP RMMFFDVLRQ KLKWGER 287
    Length:287
    Mass (Da):31,420
    Last modified:November 14, 2006 - v1
    Checksum:iE92BF9BAC0580F3C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000473 Genomic DNA. Translation: ABJ82110.1.
    RefSeqiYP_822395.1. NC_008536.1.

    Genome annotation databases

    EnsemblBacteriaiABJ82110; ABJ82110; Acid_1116.
    GeneIDi4430731.
    KEGGisus:Acid_1116.
    PATRICi32004353. VBICanSol30224_1166.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000473 Genomic DNA. Translation: ABJ82110.1 .
    RefSeqi YP_822395.1. NC_008536.1.

    3D structure databases

    ProteinModelPortali Q02A16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 234267.Acid_1116.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ82110 ; ABJ82110 ; Acid_1116 .
    GeneIDi 4430731.
    KEGGi sus:Acid_1116.
    PATRICi 32004353. VBICanSol30224_1166.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SUSI234267:GHSK-1127-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ellin6076.

    Entry informationi

    Entry nameiNADK_SOLUE
    AccessioniPrimary (citable) accession number: Q02A16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3