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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

SLC25A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

GO - Molecular functioni

  • oxoglutarate:malate antiporter activity Source: Reactome
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • gluconeogenesis Source: Reactome
  • glucose metabolic process Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108528-MONOMER.
ReactomeiR-HSA-70263. Gluconeogenesis.
R-HSA-70326. Glucose metabolism.

Protein family/group databases

TCDBi2.A.29.2.13. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
Name:SLC25A11
Synonyms:SLC20A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:10981. SLC25A11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 42Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei83 – 101Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 240Helical; Name=5Sequence analysisAdd BLAST19
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • mitochondrial inner membrane Source: Reactome
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108528.
PharmGKBiPA35857.

Polymorphism and mutation databases

BioMutaiSLC25A11.
DMDMi20141580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000906252 – 314Mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysineCombined sources1
Modified residuei102PhosphotyrosineBy similarity1
Modified residuei256N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ02978.
PaxDbiQ02978.
PeptideAtlasiQ02978.
PRIDEiQ02978.
TopDownProteomicsiQ02978-1. [Q02978-1]

PTM databases

iPTMnetiQ02978.
PhosphoSitePlusiQ02978.
SwissPalmiQ02978.

Expressioni

Gene expression databases

BgeeiENSG00000108528.
CleanExiHS_SLC25A11.
ExpressionAtlasiQ02978. baseline and differential.
GenevisibleiQ02978. HS.

Organism-specific databases

HPAiHPA021167.

Interactioni

Protein-protein interaction databases

BioGridi113990. 52 interactors.
IntActiQ02978. 18 interactors.
MINTiMINT-1161051.
STRINGi9606.ENSP00000225665.

Structurei

3D structure databases

ProteinModelPortaliQ02978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 108Solcar 1Add BLAST86
Repeati117 – 208Solcar 2Add BLAST92
Repeati217 – 306Solcar 3Add BLAST90

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ02978.
KOiK15104.
OMAiSDNIFCH.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ02978.
TreeFamiTF354262.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02978-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKAVIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALIR ITREEGVLTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIAKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,062
Last modified:January 23, 2007 - v3
Checksum:i9D61F817089FF5AA
GO
Isoform 2 (identifier: Q02978-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-82: Missing.

Note: Gene prediction based on EST data.
Show »
Length:263
Mass (Da):28,494
Checksum:iBB946818247A37F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12I → M in CAA46905 (PubMed:1457818).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04674532 – 82Missing in isoform 2. CuratedAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66114 Genomic DNA. Translation: CAA46905.1.
AF070548 mRNA. Translation: AAC28637.1.
AC004771 Genomic DNA. No translation available.
BC006508 mRNA. Translation: AAH06508.1.
BC006519 mRNA. Translation: AAH06519.1.
BC016294 mRNA. Translation: AAH16294.1.
BC017170 mRNA. Translation: AAH17170.1.
CCDSiCCDS11059.1. [Q02978-1]
CCDS54069.1. [Q02978-2]
PIRiA56650.
RefSeqiNP_003553.2. NM_003562.4. [Q02978-1]
UniGeneiHs.184877.

Genome annotation databases

EnsembliENST00000225665; ENSP00000225665; ENSG00000108528. [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528. [Q02978-2]
GeneIDi8402.
KEGGihsa:8402.
UCSCiuc021toe.2. human. [Q02978-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66114 Genomic DNA. Translation: CAA46905.1.
AF070548 mRNA. Translation: AAC28637.1.
AC004771 Genomic DNA. No translation available.
BC006508 mRNA. Translation: AAH06508.1.
BC006519 mRNA. Translation: AAH06519.1.
BC016294 mRNA. Translation: AAH16294.1.
BC017170 mRNA. Translation: AAH17170.1.
CCDSiCCDS11059.1. [Q02978-1]
CCDS54069.1. [Q02978-2]
PIRiA56650.
RefSeqiNP_003553.2. NM_003562.4. [Q02978-1]
UniGeneiHs.184877.

3D structure databases

ProteinModelPortaliQ02978.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113990. 52 interactors.
IntActiQ02978. 18 interactors.
MINTiMINT-1161051.
STRINGi9606.ENSP00000225665.

Protein family/group databases

TCDBi2.A.29.2.13. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ02978.
PhosphoSitePlusiQ02978.
SwissPalmiQ02978.

Polymorphism and mutation databases

BioMutaiSLC25A11.
DMDMi20141580.

Proteomic databases

EPDiQ02978.
PaxDbiQ02978.
PeptideAtlasiQ02978.
PRIDEiQ02978.
TopDownProteomicsiQ02978-1. [Q02978-1]

Protocols and materials databases

DNASUi8402.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225665; ENSP00000225665; ENSG00000108528. [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528. [Q02978-2]
GeneIDi8402.
KEGGihsa:8402.
UCSCiuc021toe.2. human. [Q02978-1]

Organism-specific databases

CTDi8402.
GeneCardsiSLC25A11.
HGNCiHGNC:10981. SLC25A11.
HPAiHPA021167.
MIMi604165. gene.
neXtProtiNX_Q02978.
OpenTargetsiENSG00000108528.
PharmGKBiPA35857.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0759. Eukaryota.
ENOG410XQHU. LUCA.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ02978.
KOiK15104.
OMAiSDNIFCH.
OrthoDBiEOG091G0BQ7.
PhylomeDBiQ02978.
TreeFamiTF354262.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000108528-MONOMER.
ReactomeiR-HSA-70263. Gluconeogenesis.
R-HSA-70326. Glucose metabolism.

Miscellaneous databases

ChiTaRSiSLC25A11. human.
GeneWikiiSLC25A11.
GenomeRNAii8402.
PROiQ02978.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108528.
CleanExiHS_SLC25A11.
ExpressionAtlasiQ02978. baseline and differential.
GenevisibleiQ02978. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM2OM_HUMAN
AccessioniPrimary (citable) accession number: Q02978
Secondary accession number(s): F5GY65, O75537, Q969P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.