Q02978 (M2OM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name=OGCP

Alternative name(s):
Solute carrier family 25 member 11

Gene names

Name:	SLC25A11
Synonyms:	SLC20A4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc mitochondrial inner membrane Traceable author statement. Source: Reactome
Molecular_function	oxoglutarate:malate antiporter activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 314	313	Mitochondrial 2-oxoglutarate/malate carrier protein		PRO_0000090625
Regions
	Transmembrane	24 – 42	19	Helical; Name=1; Potential
	Transmembrane	83 – 101	19	Helical; Name=2; Potential
	Transmembrane	119 – 140	22	Helical; Name=3; Potential
	Transmembrane	183 – 202	20	Helical; Name=4; Potential
	Transmembrane	222 – 240	19	Helical; Name=5; Potential
	Transmembrane	281 – 300	20	Helical; Name=6; Potential
	Repeat	23 – 108	86	Solcar 1
	Repeat	117 – 208	92	Solcar 2
	Repeat	217 – 306	90	Solcar 3
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.4
	Modified residue	73	1	N6-acetyllysine Ref.5
	Modified residue	102	1	Phosphotyrosine By similarity
	Modified residue	202	1	Phosphotyrosine By similarity
Experimental info
	Sequence conflict	12	1	I → M in CAA46905. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q02978 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 9D61F817089FF5AA	FASTA	314	34,062
	10 20 30 40 50 60 MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ LSGEGAKTRE 70 80 90 100 110 120 YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG IYTVLFERLT GADGTPPGFL 130 140 150 160 170 180 LKAVIGMTAG ATGAFVGTPA EVALIRMTAD GRLPADQRRG YKNVFNALIR ITREEGVLTL 190 200 210 220 230 240 WRGCIPTMAR AVVVNAAQLA SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV 250 260 270 280 290 300 DIAKTRIQNM RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL 310 EQMNKAYKRL FLSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier." Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E. DNA Seq. 3:79-88(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle and Uterus.
[4]	Bienvenut W.V. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[5]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-73, MASS SPECTROMETRY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X66114 Genomic DNA. Translation: CAA46905.1. AF070548 mRNA. Translation: AAC28637.1. BC006508 mRNA. Translation: AAH06508.1. BC006519 mRNA. Translation: AAH06519.1. BC016294 mRNA. Translation: AAH16294.1. BC017170 mRNA. Translation: AAH17170.1.
IPI	IPI00219729.
PIR	A56650.
RefSeq	NP_003553.2. NM_003562.4.
UniGene	Hs.184877.
3D structure databases
ProteinModelPortal	Q02978.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q02978. 7 interactions.
MINT	MINT-1161051.
STRING	9606.ENSP00000225665.
PTM databases
PhosphoSite	Q02978.
Polymorphism databases
DMDM	20141580.
Proteomic databases
PaxDb	Q02978.
PeptideAtlas	Q02978.
PRIDE	Q02978.
Protocols and materials databases
DNASU	8402.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000225665; ENSP00000225665; ENSG00000108528.
GeneID	8402.
KEGG	hsa:8402.
UCSC	uc002fzo.2. human.
Organism-specific databases
CTD	8402.
GeneCards	GC17M004840.
HGNC	HGNC:10981. SLC25A11.
HPA	HPA021167.
MIM	604165. gene.
neXtProt	NX_Q02978.
PharmGKB	PA35857.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300113.
HOGENOM	HOG000165139.
HOVERGEN	HBG009528.
InParanoid	Q02978.
KO	K15104.
OMA	KVIRYEG.
OrthoDB	EOG44BB2N.
PhylomeDB	Q02978.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q02978.
Bgee	Q02978.
CleanEx	HS_SLC25A11.
Genevestigator	Q02978.
GermOnline	ENSG00000108528. Homo sapiens.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC25A11. human.
GenomeRNAi	8402.
NextBio	31442.
SOURCE	Search...

Entry information

Entry name

M2OM_HUMAN

Accession

Primary (citable) accession number: Q02978
Secondary accession number(s): O75537, Q969P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 117 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.