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Q02978

- M2OM_HUMAN

UniProt

Q02978 - M2OM_HUMAN

Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

SLC25A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

    GO - Molecular functioni

    1. oxoglutarate:malate antiporter activity Source: Reactome
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. alpha-ketoglutarate transport Source: GOC
    2. carbohydrate metabolic process Source: Reactome
    3. gluconeogenesis Source: Reactome
    4. glucose metabolic process Source: Reactome
    5. small molecule metabolic process Source: Reactome
    6. transport Source: ProtInc

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_1520. Gluconeogenesis.

    Protein family/group databases

    TCDBi2.A.29.2.13. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial 2-oxoglutarate/malate carrier protein
    Short name:
    OGCP
    Alternative name(s):
    Solute carrier family 25 member 11
    Gene namesi
    Name:SLC25A11
    Synonyms:SLC20A4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:10981. SLC25A11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrion Source: UniProt
    4. nucleus Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35857.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed4 Publications
    Chaini2 – 314313Mitochondrial 2-oxoglutarate/malate carrier proteinPRO_0000090625Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine4 Publications
    Modified residuei57 – 571N6-succinyllysineBy similarity
    Modified residuei73 – 731N6-acetyllysine1 Publication
    Modified residuei102 – 1021PhosphotyrosineBy similarity
    Modified residuei256 – 2561N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ02978.
    PaxDbiQ02978.
    PeptideAtlasiQ02978.
    PRIDEiQ02978.

    PTM databases

    PhosphoSiteiQ02978.

    Expressioni

    Gene expression databases

    ArrayExpressiQ02978.
    BgeeiQ02978.
    CleanExiHS_SLC25A11.
    GenevestigatoriQ02978.

    Organism-specific databases

    HPAiHPA021167.

    Interactioni

    Protein-protein interaction databases

    BioGridi113990. 23 interactions.
    IntActiQ02978. 11 interactions.
    MINTiMINT-1161051.
    STRINGi9606.ENSP00000225665.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02978.
    SMRiQ02978. Positions 22-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4219Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10119Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei183 – 20220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei222 – 24019Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30020Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 10886Solcar 1Add
    BLAST
    Repeati117 – 20892Solcar 2Add
    BLAST
    Repeati217 – 30690Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300113.
    HOGENOMiHOG000165139.
    HOVERGENiHBG009528.
    InParanoidiQ02978.
    KOiK15104.
    OMAiFRISKHE.
    OrthoDBiEOG793B7Z.
    PhylomeDBiQ02978.
    TreeFamiTF354262.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02978-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ    50
    LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG 100
    IYTVLFERLT GADGTPPGFL LKAVIGMTAG ATGAFVGTPA EVALIRMTAD 150
    GRLPADQRRG YKNVFNALIR ITREEGVLTL WRGCIPTMAR AVVVNAAQLA 200
    SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIAKTRIQNM 250
    RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL 300
    EQMNKAYKRL FLSG 314
    Length:314
    Mass (Da):34,062
    Last modified:January 23, 2007 - v3
    Checksum:i9D61F817089FF5AA
    GO
    Isoform 2 (identifier: Q02978-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-82: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:263
    Mass (Da):28,494
    Checksum:iBB946818247A37F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121I → M in CAA46905. (PubMed:1457818)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 8251Missing in isoform 2. CuratedVSP_046745Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66114 Genomic DNA. Translation: CAA46905.1.
    AF070548 mRNA. Translation: AAC28637.1.
    AC004771 Genomic DNA. No translation available.
    BC006508 mRNA. Translation: AAH06508.1.
    BC006519 mRNA. Translation: AAH06519.1.
    BC016294 mRNA. Translation: AAH16294.1.
    BC017170 mRNA. Translation: AAH17170.1.
    CCDSiCCDS11059.1. [Q02978-1]
    CCDS54069.1. [Q02978-2]
    PIRiA56650.
    RefSeqiNP_003553.2. NM_003562.4. [Q02978-1]
    UniGeneiHs.184877.

    Genome annotation databases

    EnsembliENST00000225665; ENSP00000225665; ENSG00000108528. [Q02978-1]
    ENST00000544061; ENSP00000440804; ENSG00000108528. [Q02978-2]
    GeneIDi8402.
    KEGGihsa:8402.
    UCSCiuc002fzo.2. human. [Q02978-1]

    Polymorphism databases

    DMDMi20141580.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X66114 Genomic DNA. Translation: CAA46905.1 .
    AF070548 mRNA. Translation: AAC28637.1 .
    AC004771 Genomic DNA. No translation available.
    BC006508 mRNA. Translation: AAH06508.1 .
    BC006519 mRNA. Translation: AAH06519.1 .
    BC016294 mRNA. Translation: AAH16294.1 .
    BC017170 mRNA. Translation: AAH17170.1 .
    CCDSi CCDS11059.1. [Q02978-1 ]
    CCDS54069.1. [Q02978-2 ]
    PIRi A56650.
    RefSeqi NP_003553.2. NM_003562.4. [Q02978-1 ]
    UniGenei Hs.184877.

    3D structure databases

    ProteinModelPortali Q02978.
    SMRi Q02978. Positions 22-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113990. 23 interactions.
    IntActi Q02978. 11 interactions.
    MINTi MINT-1161051.
    STRINGi 9606.ENSP00000225665.

    Protein family/group databases

    TCDBi 2.A.29.2.13. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q02978.

    Polymorphism databases

    DMDMi 20141580.

    Proteomic databases

    MaxQBi Q02978.
    PaxDbi Q02978.
    PeptideAtlasi Q02978.
    PRIDEi Q02978.

    Protocols and materials databases

    DNASUi 8402.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225665 ; ENSP00000225665 ; ENSG00000108528 . [Q02978-1 ]
    ENST00000544061 ; ENSP00000440804 ; ENSG00000108528 . [Q02978-2 ]
    GeneIDi 8402.
    KEGGi hsa:8402.
    UCSCi uc002fzo.2. human. [Q02978-1 ]

    Organism-specific databases

    CTDi 8402.
    GeneCardsi GC17M004840.
    HGNCi HGNC:10981. SLC25A11.
    HPAi HPA021167.
    MIMi 604165. gene.
    neXtProti NX_Q02978.
    PharmGKBi PA35857.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300113.
    HOGENOMi HOG000165139.
    HOVERGENi HBG009528.
    InParanoidi Q02978.
    KOi K15104.
    OMAi FRISKHE.
    OrthoDBi EOG793B7Z.
    PhylomeDBi Q02978.
    TreeFami TF354262.

    Enzyme and pathway databases

    Reactomei REACT_1520. Gluconeogenesis.

    Miscellaneous databases

    ChiTaRSi SLC25A11. human.
    GeneWikii SLC25A11.
    GenomeRNAii 8402.
    NextBioi 31442.
    PROi Q02978.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02978.
    Bgeei Q02978.
    CleanExi HS_SLC25A11.
    Genevestigatori Q02978.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier."
      Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E.
      DNA Seq. 3:79-88(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Yu W., Gibbs R.A.
      Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle and Uterus.
    5. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiM2OM_HUMAN
    AccessioniPrimary (citable) accession number: Q02978
    Secondary accession number(s): F5GY65, O75537, Q969P7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3