Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q02978 (M2OM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein

Short name=OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene names
Name:SLC25A11
Synonyms:SLC20A4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q02978-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q02978-2)

The sequence of this isoform differs from the canonical sequence as follows:
     32-82: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 314313Mitochondrial 2-oxoglutarate/malate carrier protein
PRO_0000090625

Regions

Transmembrane24 – 4219Helical; Name=1; Potential
Transmembrane83 – 10119Helical; Name=2; Potential
Transmembrane119 – 14022Helical; Name=3; Potential
Transmembrane183 – 20220Helical; Name=4; Potential
Transmembrane222 – 24019Helical; Name=5; Potential
Transmembrane281 – 30020Helical; Name=6; Potential
Repeat23 – 10886Solcar 1
Repeat117 – 20892Solcar 2
Repeat217 – 30690Solcar 3

Amino acid modifications

Modified residue21N-acetylalanine Ref.5 Ref.6 Ref.9 Ref.10
Modified residue571N6-succinyllysine By similarity
Modified residue731N6-acetyllysine Ref.7
Modified residue1021Phosphotyrosine By similarity
Modified residue2561N6-acetyllysine By similarity

Natural variations

Alternative sequence32 – 8251Missing in isoform 2.
VSP_046745

Experimental info

Sequence conflict121I → M in CAA46905. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 9D61F817089FF5AA

FASTA31434,062
        10         20         30         40         50         60 
MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ LSGEGAKTRE 

        70         80         90        100        110        120 
YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG IYTVLFERLT GADGTPPGFL 

       130        140        150        160        170        180 
LKAVIGMTAG ATGAFVGTPA EVALIRMTAD GRLPADQRRG YKNVFNALIR ITREEGVLTL 

       190        200        210        220        230        240 
WRGCIPTMAR AVVVNAAQLA SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV 

       250        260        270        280        290        300 
DIAKTRIQNM RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL 

       310 
EQMNKAYKRL FLSG 

« Hide

Isoform 2 [UniParc].

Checksum: BB946818247A37F1
Show »

FASTA26328,494

References

« Hide 'large scale' references
[1]"Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier."
Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E.
DNA Seq. 3:79-88(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Yu W., Gibbs R.A.
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle and Uterus.
[5]Bienvenut W.V.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X66114 Genomic DNA. Translation: CAA46905.1.
AF070548 mRNA. Translation: AAC28637.1.
AC004771 Genomic DNA. No translation available.
BC006508 mRNA. Translation: AAH06508.1.
BC006519 mRNA. Translation: AAH06519.1.
BC016294 mRNA. Translation: AAH16294.1.
BC017170 mRNA. Translation: AAH17170.1.
CCDSCCDS11059.1. [Q02978-1]
CCDS54069.1. [Q02978-2]
PIRA56650.
RefSeqNP_003553.2. NM_003562.4. [Q02978-1]
UniGeneHs.184877.

3D structure databases

ProteinModelPortalQ02978.
SMRQ02978. Positions 22-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113990. 27 interactions.
IntActQ02978. 10 interactions.
MINTMINT-1161051.
STRING9606.ENSP00000225665.

Protein family/group databases

TCDB2.A.29.2.13. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteQ02978.

Polymorphism databases

DMDM20141580.

Proteomic databases

MaxQBQ02978.
PaxDbQ02978.
PeptideAtlasQ02978.
PRIDEQ02978.

Protocols and materials databases

DNASU8402.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225665; ENSP00000225665; ENSG00000108528. [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528. [Q02978-2]
GeneID8402.
KEGGhsa:8402.
UCSCuc002fzo.2. human. [Q02978-1]

Organism-specific databases

CTD8402.
GeneCardsGC17M004840.
HGNCHGNC:10981. SLC25A11.
HPAHPA021167.
MIM604165. gene.
neXtProtNX_Q02978.
PharmGKBPA35857.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG300113.
HOGENOMHOG000165139.
HOVERGENHBG009528.
InParanoidQ02978.
KOK15104.
OMAFRISKHE.
OrthoDBEOG793B7Z.
PhylomeDBQ02978.
TreeFamTF354262.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_116125. Disease.

Gene expression databases

ArrayExpressQ02978.
BgeeQ02978.
CleanExHS_SLC25A11.
GenevestigatorQ02978.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC25A11. human.
GeneWikiSLC25A11.
GenomeRNAi8402.
NextBio31442.
PROQ02978.
SOURCESearch...

Entry information

Entry nameM2OM_HUMAN
AccessionPrimary (citable) accession number: Q02978
Secondary accession number(s): F5GY65, O75537, Q969P7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM