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Q02978

- M2OM_HUMAN

UniProt

Q02978 - M2OM_HUMAN

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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

SLC25A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.

GO - Molecular functioni

  1. oxoglutarate:malate antiporter activity Source: Reactome
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. alpha-ketoglutarate transport Source: GOC
  2. carbohydrate metabolic process Source: Reactome
  3. gluconeogenesis Source: Reactome
  4. glucose metabolic process Source: Reactome
  5. small molecule metabolic process Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_1520. Gluconeogenesis.

Protein family/group databases

TCDBi2.A.29.2.13. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
Name:SLC25A11
Synonyms:SLC20A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:10981. SLC25A11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4219Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei83 – 10119Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei119 – 14022Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei183 – 20220Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei222 – 24019Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei281 – 30020Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrion Source: UniProt
  4. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35857.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed4 Publications
Chaini2 – 314313Mitochondrial 2-oxoglutarate/malate carrier proteinPRO_0000090625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine4 Publications
Modified residuei57 – 571N6-succinyllysineBy similarity
Modified residuei73 – 731N6-acetyllysine1 Publication
Modified residuei102 – 1021PhosphotyrosineBy similarity
Modified residuei256 – 2561N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ02978.
PaxDbiQ02978.
PeptideAtlasiQ02978.
PRIDEiQ02978.

PTM databases

PhosphoSiteiQ02978.

Expressioni

Gene expression databases

BgeeiQ02978.
CleanExiHS_SLC25A11.
ExpressionAtlasiQ02978. baseline and differential.
GenevestigatoriQ02978.

Organism-specific databases

HPAiHPA021167.

Interactioni

Protein-protein interaction databases

BioGridi113990. 37 interactions.
IntActiQ02978. 11 interactions.
MINTiMINT-1161051.
STRINGi9606.ENSP00000225665.

Structurei

3D structure databases

ProteinModelPortaliQ02978.
SMRiQ02978. Positions 22-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 10886Solcar 1Add
BLAST
Repeati117 – 20892Solcar 2Add
BLAST
Repeati217 – 30690Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300113.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165139.
HOVERGENiHBG009528.
InParanoidiQ02978.
KOiK15104.
OMAiFRISKHE.
OrthoDBiEOG793B7Z.
PhylomeDBiQ02978.
TreeFamiTF354262.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02978-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKAVIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALIR ITREEGVLTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIAKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,062
Last modified:January 23, 2007 - v3
Checksum:i9D61F817089FF5AA
GO
Isoform 2 (identifier: Q02978-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-82: Missing.

Note: Gene prediction based on EST data.

Show »
Length:263
Mass (Da):28,494
Checksum:iBB946818247A37F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121I → M in CAA46905. (PubMed:1457818)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 8251Missing in isoform 2. CuratedVSP_046745Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66114 Genomic DNA. Translation: CAA46905.1.
AF070548 mRNA. Translation: AAC28637.1.
AC004771 Genomic DNA. No translation available.
BC006508 mRNA. Translation: AAH06508.1.
BC006519 mRNA. Translation: AAH06519.1.
BC016294 mRNA. Translation: AAH16294.1.
BC017170 mRNA. Translation: AAH17170.1.
CCDSiCCDS11059.1. [Q02978-1]
CCDS54069.1. [Q02978-2]
PIRiA56650.
RefSeqiNP_003553.2. NM_003562.4. [Q02978-1]
UniGeneiHs.184877.

Genome annotation databases

EnsembliENST00000225665; ENSP00000225665; ENSG00000108528. [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528. [Q02978-2]
GeneIDi8402.
KEGGihsa:8402.
UCSCiuc002fzo.2. human. [Q02978-1]

Polymorphism databases

DMDMi20141580.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66114 Genomic DNA. Translation: CAA46905.1 .
AF070548 mRNA. Translation: AAC28637.1 .
AC004771 Genomic DNA. No translation available.
BC006508 mRNA. Translation: AAH06508.1 .
BC006519 mRNA. Translation: AAH06519.1 .
BC016294 mRNA. Translation: AAH16294.1 .
BC017170 mRNA. Translation: AAH17170.1 .
CCDSi CCDS11059.1. [Q02978-1 ]
CCDS54069.1. [Q02978-2 ]
PIRi A56650.
RefSeqi NP_003553.2. NM_003562.4. [Q02978-1 ]
UniGenei Hs.184877.

3D structure databases

ProteinModelPortali Q02978.
SMRi Q02978. Positions 22-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113990. 37 interactions.
IntActi Q02978. 11 interactions.
MINTi MINT-1161051.
STRINGi 9606.ENSP00000225665.

Protein family/group databases

TCDBi 2.A.29.2.13. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q02978.

Polymorphism databases

DMDMi 20141580.

Proteomic databases

MaxQBi Q02978.
PaxDbi Q02978.
PeptideAtlasi Q02978.
PRIDEi Q02978.

Protocols and materials databases

DNASUi 8402.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225665 ; ENSP00000225665 ; ENSG00000108528 . [Q02978-1 ]
ENST00000544061 ; ENSP00000440804 ; ENSG00000108528 . [Q02978-2 ]
GeneIDi 8402.
KEGGi hsa:8402.
UCSCi uc002fzo.2. human. [Q02978-1 ]

Organism-specific databases

CTDi 8402.
GeneCardsi GC17M004840.
HGNCi HGNC:10981. SLC25A11.
HPAi HPA021167.
MIMi 604165. gene.
neXtProti NX_Q02978.
PharmGKBi PA35857.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300113.
GeneTreei ENSGT00760000119170.
HOGENOMi HOG000165139.
HOVERGENi HBG009528.
InParanoidi Q02978.
KOi K15104.
OMAi FRISKHE.
OrthoDBi EOG793B7Z.
PhylomeDBi Q02978.
TreeFami TF354262.

Enzyme and pathway databases

Reactomei REACT_1520. Gluconeogenesis.

Miscellaneous databases

ChiTaRSi SLC25A11. human.
GeneWikii SLC25A11.
GenomeRNAii 8402.
NextBioi 31442.
PROi Q02978.
SOURCEi Search...

Gene expression databases

Bgeei Q02978.
CleanExi HS_SLC25A11.
ExpressionAtlasi Q02978. baseline and differential.
Genevestigatori Q02978.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier."
    Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E.
    DNA Seq. 3:79-88(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Yu W., Gibbs R.A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle and Uterus.
  5. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-73, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiM2OM_HUMAN
AccessioniPrimary (citable) accession number: Q02978
Secondary accession number(s): F5GY65, O75537, Q969P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3