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Protein

Mitochondrial 2-oxoglutarate/malate carrier protein

Gene

SLC25A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity).By similarity1 Publication

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.29.2.13 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxoglutarate/malate carrier protein
Short name:
OGCP
Alternative name(s):
Solute carrier family 25 member 11
Gene namesi
Name:SLC25A11
Synonyms:SLC20A4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108528.13
HGNCiHGNC:10981 SLC25A11
MIMi604165 gene
neXtProtiNX_Q02978

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 42Helical; Name=1Sequence analysisAdd BLAST19
Transmembranei83 – 101Helical; Name=2Sequence analysisAdd BLAST19
Transmembranei119 – 140Helical; Name=3Sequence analysisAdd BLAST22
Transmembranei183 – 202Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei222 – 240Helical; Name=5Sequence analysisAdd BLAST19
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8402
OpenTargetsiENSG00000108528
PharmGKBiPA35857

Polymorphism and mutation databases

BioMutaiSLC25A11
DMDMi20141580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000906252 – 314Mitochondrial 2-oxoglutarate/malate carrier proteinAdd BLAST313

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei6PhosphoserineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei73N6-acetyllysineCombined sources1
Modified residuei102PhosphotyrosineBy similarity1
Modified residuei256N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ02978
PaxDbiQ02978
PeptideAtlasiQ02978
PRIDEiQ02978
TopDownProteomicsiQ02978-1 [Q02978-1]

PTM databases

CarbonylDBiQ02978
iPTMnetiQ02978
PhosphoSitePlusiQ02978
SwissPalmiQ02978

Expressioni

Gene expression databases

BgeeiENSG00000108528
CleanExiHS_SLC25A11
ExpressionAtlasiQ02978 baseline and differential
GenevisibleiQ02978 HS

Organism-specific databases

HPAiHPA021167

Interactioni

Protein-protein interaction databases

BioGridi11399057 interactors.
IntActiQ02978 20 interactors.
MINTiQ02978
STRINGi9606.ENSP00000225665

Structurei

3D structure databases

ProteinModelPortaliQ02978
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 108Solcar 1Add BLAST86
Repeati117 – 208Solcar 2Add BLAST92
Repeati217 – 306Solcar 3Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0759 Eukaryota
ENOG410XQHU LUCA
GeneTreeiENSGT00760000119170
HOGENOMiHOG000165139
HOVERGENiHBG009528
InParanoidiQ02978
KOiK15104
OMAiGFTPYYF
OrthoDBiEOG091G0BQ7
PhylomeDBiQ02978
TreeFamiTF354262

Family and domain databases

Gene3Di1.50.40.101 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02978-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATASAGAG GIDGKPRTSP KSVKFLFGGL AGMGATVFVQ PLDLVKNRMQ
60 70 80 90 100
LSGEGAKTRE YKTSFHALTS ILKAEGLRGI YTGLSAGLLR QATYTTTRLG
110 120 130 140 150
IYTVLFERLT GADGTPPGFL LKAVIGMTAG ATGAFVGTPA EVALIRMTAD
160 170 180 190 200
GRLPADQRRG YKNVFNALIR ITREEGVLTL WRGCIPTMAR AVVVNAAQLA
210 220 230 240 250
SYSQSKQFLL DSGYFSDNIL CHFCASMISG LVTTAASMPV DIAKTRIQNM
260 270 280 290 300
RMIDGKPEYK NGLDVLFKVV RYEGFFSLWK GFTPYYARLG PHTVLTFIFL
310
EQMNKAYKRL FLSG
Length:314
Mass (Da):34,062
Last modified:January 23, 2007 - v3
Checksum:i9D61F817089FF5AA
GO
Isoform 2 (identifier: Q02978-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-82: Missing.

Note: Gene prediction based on EST data.
Show »
Length:263
Mass (Da):28,494
Checksum:iBB946818247A37F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12I → M in CAA46905 (PubMed:1457818).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04674532 – 82Missing in isoform 2. CuratedAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66114 Genomic DNA Translation: CAA46905.1
AF070548 mRNA Translation: AAC28637.1
AC004771 Genomic DNA No translation available.
BC006508 mRNA Translation: AAH06508.1
BC006519 mRNA Translation: AAH06519.1
BC016294 mRNA Translation: AAH16294.1
BC017170 mRNA Translation: AAH17170.1
CCDSiCCDS11059.1 [Q02978-1]
CCDS54069.1 [Q02978-2]
PIRiA56650
RefSeqiNP_003553.2, NM_003562.4 [Q02978-1]
UniGeneiHs.184877

Genome annotation databases

EnsembliENST00000225665; ENSP00000225665; ENSG00000108528 [Q02978-1]
ENST00000544061; ENSP00000440804; ENSG00000108528 [Q02978-2]
GeneIDi8402
KEGGihsa:8402
UCSCiuc021toe.2 human [Q02978-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiM2OM_HUMAN
AccessioniPrimary (citable) accession number: Q02978
Secondary accession number(s): F5GY65, O75537, Q969P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome