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Protein

Proto-oncogene tyrosine-protein kinase Yrk

Gene

YRK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in signaling pathways.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei298 – 2981ATPPROSITE-ProRule annotation
Active sitei389 – 3891Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2849ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. innate immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase Yrk (EC:2.7.10.2)
Alternative name(s):
Yes-related kinase
p60-Yrk
Gene namesi
Name:YRK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 536535Proto-oncogene tyrosine-protein kinase YrkPRO_0000088188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Lipidationi3 – 31S-palmitoyl cysteineBy similarity
Lipidationi6 – 61S-palmitoyl cysteineBy similarity
Modified residuei419 – 4191Phosphotyrosine; by autocatalysisBy similarity
Modified residuei530 – 5301PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ02977.

Expressioni

Tissue specificityi

There are elevated levels of this protein in neural and hematopoietic tissues.

Structurei

3D structure databases

ProteinModelPortaliQ02977.
SMRiQ02977. Positions 83-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 14262SH3PROSITE-ProRule annotationAdd
BLAST
Domaini148 – 24598SH2PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 523254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

HOVERGENiHBG008761.
InParanoidiQ02977.
KOiK17511.
PhylomeDBiQ02977.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVHCKEKI SGKGQGGSGT GTPAHPPSQY DPDPTQLSGA FTHIPDFNNF
60 70 80 90 100
HAAAVSPPVP FSGPGFYPCN TLQAHSSITG GGVTLFIALY DYEARTEDDL
110 120 130 140 150
SFQKGEKFHI INNTEGDWWE ARSLSSGATG YIPSNYVAPV DSIQAEEWYF
160 170 180 190 200
GKIGRKDAER QLLCHGNCRG TFLIRESETT KGAYSLSIRD WDEAKGDHVK
210 220 230 240 250
HYKIRKLDSG GYYITTRAQF DTIQQLVQHY IERAAGLCCR LAVPCPKGTP
260 270 280 290 300
KLADLSVKTK DVWEIPRESL QLLQKLGNGQ FGEVWMGTWN GTTKVAVKTL
310 320 330 340 350
KPGTMSPEAF LEEAQIMKRL RHDKLVQLYA VVSEEPIYIV TEFMSQGSLL
360 370 380 390 400
DFLKDGDGRY LKLPQLVDMA AQIAAGMAYI ERMNYIHRDL RAANILVGDN
410 420 430 440 450
LVCKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALFG KFTIKSDVWS
460 470 480 490 500
FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMQCPGGC PPSLHDVMVQ
510 520 530
CWKREPEERP TFEYLQSFLE DYFTATEPQY QPGDNQ
Length:536
Mass (Da):60,002
Last modified:January 22, 2007 - v2
Checksum:i61BB5DEE000EE993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67786 mRNA. Translation: CAA47996.1.
PIRiS33569.
RefSeqiNP_001103257.1. NM_001109787.1.
UniGeneiGga.37861.

Genome annotation databases

GeneIDi777583.
KEGGigga:777583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67786 mRNA. Translation: CAA47996.1.
PIRiS33569.
RefSeqiNP_001103257.1. NM_001109787.1.
UniGeneiGga.37861.

3D structure databases

ProteinModelPortaliQ02977.
SMRiQ02977. Positions 83-535.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ02977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi777583.
KEGGigga:777583.

Organism-specific databases

CTDi337571.

Phylogenomic databases

HOVERGENiHBG008761.
InParanoidiQ02977.
KOiK17511.
PhylomeDBiQ02977.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Miscellaneous databases

NextBioi20924203.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues."
    Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T.
    Oncogene 8:823-831(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiYRK_CHICK
AccessioniPrimary (citable) accession number: Q02977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: January 22, 2007
Last modified: February 3, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.