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Q02977 (YRK_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proto-oncogene tyrosine-protein kinase Yrk

EC=2.7.10.2
Alternative name(s):
Yes-related kinase
p60-Yrk
Gene names
Name:YRK
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May participate in signaling pathways.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Tissue specificity

There are elevated levels of this protein in neural and hematopoietic tissues.

Post-translational modification

Phosphorylated.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 536535Proto-oncogene tyrosine-protein kinase Yrk
PRO_0000088188

Regions

Domain81 – 14262SH3
Domain148 – 24598SH2
Domain270 – 523254Protein kinase
Nucleotide binding276 – 2849ATP By similarity

Sites

Active site3891Proton acceptor By similarity
Binding site2981ATP By similarity

Amino acid modifications

Modified residue4191Phosphotyrosine; by autocatalysis By similarity
Modified residue5301Phosphotyrosine By similarity
Lipidation21N-myristoyl glycine By similarity
Lipidation31S-palmitoyl cysteine By similarity
Lipidation61S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02977 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 61BB5DEE000EE993

FASTA53660,002
        10         20         30         40         50         60 
MGCVHCKEKI SGKGQGGSGT GTPAHPPSQY DPDPTQLSGA FTHIPDFNNF HAAAVSPPVP 

        70         80         90        100        110        120 
FSGPGFYPCN TLQAHSSITG GGVTLFIALY DYEARTEDDL SFQKGEKFHI INNTEGDWWE 

       130        140        150        160        170        180 
ARSLSSGATG YIPSNYVAPV DSIQAEEWYF GKIGRKDAER QLLCHGNCRG TFLIRESETT 

       190        200        210        220        230        240 
KGAYSLSIRD WDEAKGDHVK HYKIRKLDSG GYYITTRAQF DTIQQLVQHY IERAAGLCCR 

       250        260        270        280        290        300 
LAVPCPKGTP KLADLSVKTK DVWEIPRESL QLLQKLGNGQ FGEVWMGTWN GTTKVAVKTL 

       310        320        330        340        350        360 
KPGTMSPEAF LEEAQIMKRL RHDKLVQLYA VVSEEPIYIV TEFMSQGSLL DFLKDGDGRY 

       370        380        390        400        410        420 
LKLPQLVDMA AQIAAGMAYI ERMNYIHRDL RAANILVGDN LVCKIADFGL ARLIEDNEYT 

       430        440        450        460        470        480 
ARQGAKFPIK WTAPEAALFG KFTIKSDVWS FGILLTELVT KGRVPYPGMN NREVLEQVER 

       490        500        510        520        530 
GYRMQCPGGC PPSLHDVMVQ CWKREPEERP TFEYLQSFLE DYFTATEPQY QPGDNQ 

« Hide

References

[1]"A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues."
Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T.
Oncogene 8:823-831(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.
Tissue: Brain and Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X67786 mRNA. Translation: CAA47996.1.
PIRS33569.
RefSeqNP_001103257.1. NM_001109787.1.
UniGeneGga.37861.

3D structure databases

ProteinModelPortalQ02977.
SMRQ02977. Positions 83-535.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ02977.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID777583.
KEGGgga:777583.

Organism-specific databases

CTD337571.

Phylogenomic databases

HOVERGENHBG008761.
KOK17511.
PhylomeDBQ02977.

Enzyme and pathway databases

BRENDA2.7.10.2. 1306.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24418:SF224. PTHR24418:SF224. 1 hit.
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20924203.

Entry information

Entry nameYRK_CHICK
AccessionPrimary (citable) accession number: Q02977
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families