Q02977 (YRK_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proto-oncogene tyrosine-protein kinase Yrk
EC=2.7.10.2

Alternative name(s):
Yes-related kinase
p60-Yrk

Gene names

Name:

YRK

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May participate in signaling pathways.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Tissue specificity	There are elevated levels of this protein in neural and hematopoietic tissues.
Post-translational modification	Phosphorylated.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Contains 1 protein kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.

Ontologies

Keywords
Disease	Proto-oncogene
Domain	SH2 domain SH3 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Lipoprotein Myristate Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 536	535	Proto-oncogene tyrosine-protein kinase Yrk		PRO_0000088188
Regions
	Domain	81 – 142	62	SH3
	Domain	148 – 245	98	SH2
	Domain	270 – 523	254	Protein kinase
	Nucleotide binding	276 – 284	9	ATP By similarity
Sites
	Active site	389	1	Proton acceptor By similarity
	Binding site	298	1	ATP By similarity
Amino acid modifications
	Modified residue	419	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	530	1	Phosphotyrosine By similarity
	Lipidation	2	1	N-myristoyl glycine By similarity
	Lipidation	3	1	S-palmitoyl cysteine By similarity
	Lipidation	6	1	S-palmitoyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02977 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 61BB5DEE000EE993	FASTA	536	60,002
	10 20 30 40 50 60 MGCVHCKEKI SGKGQGGSGT GTPAHPPSQY DPDPTQLSGA FTHIPDFNNF HAAAVSPPVP 70 80 90 100 110 120 FSGPGFYPCN TLQAHSSITG GGVTLFIALY DYEARTEDDL SFQKGEKFHI INNTEGDWWE 130 140 150 160 170 180 ARSLSSGATG YIPSNYVAPV DSIQAEEWYF GKIGRKDAER QLLCHGNCRG TFLIRESETT 190 200 210 220 230 240 KGAYSLSIRD WDEAKGDHVK HYKIRKLDSG GYYITTRAQF DTIQQLVQHY IERAAGLCCR 250 260 270 280 290 300 LAVPCPKGTP KLADLSVKTK DVWEIPRESL QLLQKLGNGQ FGEVWMGTWN GTTKVAVKTL 310 320 330 340 350 360 KPGTMSPEAF LEEAQIMKRL RHDKLVQLYA VVSEEPIYIV TEFMSQGSLL DFLKDGDGRY 370 380 390 400 410 420 LKLPQLVDMA AQIAAGMAYI ERMNYIHRDL RAANILVGDN LVCKIADFGL ARLIEDNEYT 430 440 450 460 470 480 ARQGAKFPIK WTAPEAALFG KFTIKSDVWS FGILLTELVT KGRVPYPGMN NREVLEQVER 490 500 510 520 530 GYRMQCPGGC PPSLHDVMVQ CWKREPEERP TFEYLQSFLE DYFTATEPQY QPGDNQ

References

[1]

"A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues." Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T. Oncogene 8:823-831(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: White leghorn. Tissue: Brain and Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67786 mRNA. Translation: CAA47996.1.
IPI	IPI00579970.
PIR	S33569.
RefSeq	NP_001103257.1. NM_001109787.1.
UniGene	Gga.37861.
3D structure databases
ProteinModelPortal	Q02977.
SMR	Q02977. Positions 83-535.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	777583.
KEGG	gga:777583.
Organism-specific databases
CTD	337571.
Phylogenomic databases
HOVERGEN	HBG008761.
Enzyme and pathway databases
BRENDA	2.7.10.2. 1306.
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20924203.

Entry information

Entry name

YRK_CHICK

Accession

Primary (citable) accession number: Q02977

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program