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Protein

Proto-oncogene tyrosine-protein kinase Yrk

Gene

YRK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May participate in signaling pathways.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei298ATPPROSITE-ProRule annotation1
Active sitei389Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi276 – 284ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 1306

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase Yrk (EC:2.7.10.2)
Alternative name(s):
Yes-related kinase
p60-Yrk
Gene namesi
Name:YRK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000881882 – 536Proto-oncogene tyrosine-protein kinase YrkAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Lipidationi6S-palmitoyl cysteineBy similarity1
Modified residuei419Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei530PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ02977

Expressioni

Tissue specificityi

There are elevated levels of this protein in neural and hematopoietic tissues.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ02977
SMRiQ02977
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 142SH3PROSITE-ProRule annotationAdd BLAST62
Domaini148 – 245SH2PROSITE-ProRule annotationAdd BLAST98
Domaini270 – 523Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

GeneTreeiENSGT00760000118938
HOVERGENiHBG008761
InParanoidiQ02977
KOiK17511
PhylomeDBiQ02977

Family and domain databases

CDDicd12006 SH3_Fyn_Yrk, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035750 Fyn/Yrk_SH3
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF00017 SH2, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVHCKEKI SGKGQGGSGT GTPAHPPSQY DPDPTQLSGA FTHIPDFNNF
60 70 80 90 100
HAAAVSPPVP FSGPGFYPCN TLQAHSSITG GGVTLFIALY DYEARTEDDL
110 120 130 140 150
SFQKGEKFHI INNTEGDWWE ARSLSSGATG YIPSNYVAPV DSIQAEEWYF
160 170 180 190 200
GKIGRKDAER QLLCHGNCRG TFLIRESETT KGAYSLSIRD WDEAKGDHVK
210 220 230 240 250
HYKIRKLDSG GYYITTRAQF DTIQQLVQHY IERAAGLCCR LAVPCPKGTP
260 270 280 290 300
KLADLSVKTK DVWEIPRESL QLLQKLGNGQ FGEVWMGTWN GTTKVAVKTL
310 320 330 340 350
KPGTMSPEAF LEEAQIMKRL RHDKLVQLYA VVSEEPIYIV TEFMSQGSLL
360 370 380 390 400
DFLKDGDGRY LKLPQLVDMA AQIAAGMAYI ERMNYIHRDL RAANILVGDN
410 420 430 440 450
LVCKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALFG KFTIKSDVWS
460 470 480 490 500
FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMQCPGGC PPSLHDVMVQ
510 520 530
CWKREPEERP TFEYLQSFLE DYFTATEPQY QPGDNQ
Length:536
Mass (Da):60,002
Last modified:January 23, 2007 - v2
Checksum:i61BB5DEE000EE993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67786 mRNA Translation: CAA47996.1
PIRiS33569
RefSeqiNP_001103257.1, NM_001109787.1
UniGeneiGga.37861

Genome annotation databases

EnsembliENSGALT00000063550; ENSGALP00000043829; ENSGALG00000032199
GeneIDi777583
KEGGigga:777583

Similar proteinsi

Entry informationi

Entry nameiYRK_CHICK
AccessioniPrimary (citable) accession number: Q02977
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health