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Q02977

- YRK_CHICK

UniProt

Q02977 - YRK_CHICK

Protein

Proto-oncogene tyrosine-protein kinase Yrk

Gene

YRK

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    • Comment

    Functioni

    May participate in signaling pathways.

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei298 – 2981ATPPROSITE-ProRule annotation
    Active sitei389 – 3891Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi276 – 2849ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. innate immune response Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 1306.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proto-oncogene tyrosine-protein kinase Yrk (EC:2.7.10.2)
    Alternative name(s):
    Yes-related kinase
    p60-Yrk
    Gene namesi
    Name:YRK
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 536535Proto-oncogene tyrosine-protein kinase YrkPRO_0000088188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity
    Lipidationi6 – 61S-palmitoyl cysteineBy similarity
    Modified residuei419 – 4191Phosphotyrosine; by autocatalysisBy similarity
    Modified residuei530 – 5301PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated.

    Keywords - PTMi

    Lipoprotein, Myristate, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiQ02977.

    Expressioni

    Tissue specificityi

    There are elevated levels of this protein in neural and hematopoietic tissues.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02977.
    SMRiQ02977. Positions 83-535.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini81 – 14262SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini148 – 24598SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini270 – 523254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    HOVERGENiHBG008761.
    KOiK17511.
    PhylomeDBiQ02977.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR028459. FGR.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PANTHERiPTHR24418:SF224. PTHR24418:SF224. 1 hit.
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02977-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCVHCKEKI SGKGQGGSGT GTPAHPPSQY DPDPTQLSGA FTHIPDFNNF    50
    HAAAVSPPVP FSGPGFYPCN TLQAHSSITG GGVTLFIALY DYEARTEDDL 100
    SFQKGEKFHI INNTEGDWWE ARSLSSGATG YIPSNYVAPV DSIQAEEWYF 150
    GKIGRKDAER QLLCHGNCRG TFLIRESETT KGAYSLSIRD WDEAKGDHVK 200
    HYKIRKLDSG GYYITTRAQF DTIQQLVQHY IERAAGLCCR LAVPCPKGTP 250
    KLADLSVKTK DVWEIPRESL QLLQKLGNGQ FGEVWMGTWN GTTKVAVKTL 300
    KPGTMSPEAF LEEAQIMKRL RHDKLVQLYA VVSEEPIYIV TEFMSQGSLL 350
    DFLKDGDGRY LKLPQLVDMA AQIAAGMAYI ERMNYIHRDL RAANILVGDN 400
    LVCKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALFG KFTIKSDVWS 450
    FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMQCPGGC PPSLHDVMVQ 500
    CWKREPEERP TFEYLQSFLE DYFTATEPQY QPGDNQ 536
    Length:536
    Mass (Da):60,002
    Last modified:January 23, 2007 - v2
    Checksum:i61BB5DEE000EE993
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67786 mRNA. Translation: CAA47996.1.
    PIRiS33569.
    RefSeqiNP_001103257.1. NM_001109787.1.
    UniGeneiGga.37861.

    Genome annotation databases

    GeneIDi777583.
    KEGGigga:777583.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67786 mRNA. Translation: CAA47996.1 .
    PIRi S33569.
    RefSeqi NP_001103257.1. NM_001109787.1.
    UniGenei Gga.37861.

    3D structure databases

    ProteinModelPortali Q02977.
    SMRi Q02977. Positions 83-535.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q02977.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 777583.
    KEGGi gga:777583.

    Organism-specific databases

    CTDi 337571.

    Phylogenomic databases

    HOVERGENi HBG008761.
    KOi K17511.
    PhylomeDBi Q02977.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 1306.

    Miscellaneous databases

    NextBioi 20924203.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR028459. FGR.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    PANTHERi PTHR24418:SF224. PTHR24418:SF224. 1 hit.
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel Yes-related kinase, Yrk, is expressed at elevated levels in neural and hematopoietic tissues."
      Sudol M., Greulich H., Newman L., Sarkar A., Sukegawa J., Yamamoto T.
      Oncogene 8:823-831(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: White leghorn.
      Tissue: Brain and Kidney.

    Entry informationi

    Entry nameiYRK_CHICK
    AccessioniPrimary (citable) accession number: Q02977
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3