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Protein

Proto-oncogene tyrosine-protein kinase Yrk

Gene

YRK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in signaling pathways.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei298ATPPROSITE-ProRule annotation1
Active sitei389Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi276 – 284ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase Yrk (EC:2.7.10.2)
Alternative name(s):
Yes-related kinase
p60-Yrk
Gene namesi
Name:YRK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000881882 – 536Proto-oncogene tyrosine-protein kinase YrkAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Lipidationi6S-palmitoyl cysteineBy similarity1
Modified residuei419Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei530PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ02977.

Expressioni

Tissue specificityi

There are elevated levels of this protein in neural and hematopoietic tissues.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ02977.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 142SH3PROSITE-ProRule annotationAdd BLAST62
Domaini148 – 245SH2PROSITE-ProRule annotationAdd BLAST98
Domaini270 – 523Protein kinasePROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOVERGENiHBG008761.
InParanoidiQ02977.
KOiK17511.
PhylomeDBiQ02977.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCVHCKEKI SGKGQGGSGT GTPAHPPSQY DPDPTQLSGA FTHIPDFNNF
60 70 80 90 100
HAAAVSPPVP FSGPGFYPCN TLQAHSSITG GGVTLFIALY DYEARTEDDL
110 120 130 140 150
SFQKGEKFHI INNTEGDWWE ARSLSSGATG YIPSNYVAPV DSIQAEEWYF
160 170 180 190 200
GKIGRKDAER QLLCHGNCRG TFLIRESETT KGAYSLSIRD WDEAKGDHVK
210 220 230 240 250
HYKIRKLDSG GYYITTRAQF DTIQQLVQHY IERAAGLCCR LAVPCPKGTP
260 270 280 290 300
KLADLSVKTK DVWEIPRESL QLLQKLGNGQ FGEVWMGTWN GTTKVAVKTL
310 320 330 340 350
KPGTMSPEAF LEEAQIMKRL RHDKLVQLYA VVSEEPIYIV TEFMSQGSLL
360 370 380 390 400
DFLKDGDGRY LKLPQLVDMA AQIAAGMAYI ERMNYIHRDL RAANILVGDN
410 420 430 440 450
LVCKIADFGL ARLIEDNEYT ARQGAKFPIK WTAPEAALFG KFTIKSDVWS
460 470 480 490 500
FGILLTELVT KGRVPYPGMN NREVLEQVER GYRMQCPGGC PPSLHDVMVQ
510 520 530
CWKREPEERP TFEYLQSFLE DYFTATEPQY QPGDNQ
Length:536
Mass (Da):60,002
Last modified:January 23, 2007 - v2
Checksum:i61BB5DEE000EE993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67786 mRNA. Translation: CAA47996.1.
PIRiS33569.
RefSeqiNP_001103257.1. NM_001109787.1.
UniGeneiGga.37861.

Genome annotation databases

EnsembliENSGALT00000063550; ENSGALP00000043829; ENSGALG00000032199.
GeneIDi777583.
KEGGigga:777583.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67786 mRNA. Translation: CAA47996.1.
PIRiS33569.
RefSeqiNP_001103257.1. NM_001109787.1.
UniGeneiGga.37861.

3D structure databases

ProteinModelPortaliQ02977.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ02977.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000063550; ENSGALP00000043829; ENSGALG00000032199.
GeneIDi777583.
KEGGigga:777583.

Organism-specific databases

CTDi337571.

Phylogenomic databases

GeneTreeiENSGT00760000118938.
HOVERGENiHBG008761.
InParanoidiQ02977.
KOiK17511.
PhylomeDBiQ02977.

Enzyme and pathway databases

BRENDAi2.7.10.2. 1306.

Miscellaneous databases

PROiQ02977.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR028459. FGR.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF224. PTHR24418:SF224. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYRK_CHICK
AccessioniPrimary (citable) accession number: Q02977
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.