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Protein

Zinc finger protein 354A

Gene

Znf354a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 210C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

  • kidney development Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • nucleolar fragmentation Source: RGD
  • response to folic acid Source: RGD
  • response to hypoxia Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354A
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 1
Renal transcription factor Kid-1
Transcription factor 17
Short name:
TCF-17
Gene namesi
Name:Znf354a
Synonyms:Kid1, Tcf17, Zfp354a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2967. Zfp354a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472401 – 576Zinc finger protein 354AAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ02975.
PRIDEiQ02975.

PTM databases

iPTMnetiQ02975.
PhosphoSitePlusiQ02975.

Expressioni

Tissue specificityi

Predominantly in the kidney.

Developmental stagei

Protein levels accumulate with age in postnatal renal development.

Gene expression databases

BgeeiENSRNOG00000003634.
ExpressionAtlasiQ02975. baseline and differential.
GenevisibleiQ02975. RN.

Interactioni

Protein-protein interaction databases

IntActiQ02975. 1 interactor.
STRINGi10116.ENSRNOP00000049437.

Structurei

3D structure databases

ProteinModelPortaliQ02975.
SMRiQ02975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 86KRABPROSITE-ProRule annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi170 – 189Nuclear localization signalAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 111Glu/Pro/Ser/Thr-richAdd BLAST16

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 210C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140896.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ02975.
KOiK09228.
OMAiHKNTELS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ02975.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di2.40.155.10. 1 hit.
3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR009017. GFP.
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q02975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEQREGAS QVSVTFEDVA VLFTRDEWKK LDLSQRSLYR EVMLENYSNL
60 70 80 90 100
ASMAGFLFTK PKVISLLQQG EDPWQVEKEG PRYFSLGLKC SHRTTKSTQT
110 120 130 140 150
QDSSFQELIV RKSKRTFAFE PLNMKSENLF IHEGKLEEKW DKNTLTVERS
160 170 180 190 200
HKNNEFSPKS HREKRSSECK KQISYLSNPP GITPDKRYKC SMCEKTFINT
210 220 230 240 250
SSLRKHEKNH SGEKLFKCKE CSKAFSQSSA LIQHQITHTG EKPYVCKECG
260 270 280 290 300
KAFTLSTSLY KHLRTHTVEK SYRCKECGKS FGQRSGLFIH QKIHARENPH
310 320 330 340 350
RYNPGRKASA SLSGCQRAHS RKKTYLCNEC GNTFKSSSSL RYHQRIHTGE
360 370 380 390 400
KPFRCSECGR AFSQSASLIQ HERIHTGEKP YRCGECGKGF TSISRLNRHR
410 420 430 440 450
IIHTGEKLYN CNECGKALSS HSTLIIHERI HTGEKPCKCK VCGKAFRQSS
460 470 480 490 500
ALIQHQRMHT GERPYKCNEC GKTFRCNSSL SNHQRIHTGE KPYQCIECGM
510 520 530 540 550
SFGQSSALIQ HRRIHTGEKP FKCNTCGKTF RQSSSRIAHQ RIHTGEKPYE
560 570
CNTCGKLFNY RSSLTNHYKI HVDEDP
Length:576
Mass (Da):66,253
Last modified:November 1, 1995 - v1
Checksum:i61C2C43156BDD63A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96548 mRNA. Translation: AAB07673.1.
S73488
, S73484, S73485, S73486 Genomic DNA. Translation: AAB31189.1.
PIRiA48157.
RefSeqiNP_434685.1. NM_052798.2.
XP_006246289.1. XM_006246227.3.
UniGeneiRn.11049.

Genome annotation databases

EnsembliENSRNOT00000045596; ENSRNOP00000049437; ENSRNOG00000003634.
GeneIDi24522.
KEGGirno:24522.
UCSCiRGD:2967. rat.

Similar proteinsi

Entry informationi

Entry nameiZ354A_RAT
AccessioniPrimary (citable) accession number: Q02975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families