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Protein

Zinc finger protein 354A

Gene

Znf354a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 21023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

  • kidney development Source: RGD
  • negative regulation of transcription from RNA polymerase II promoter Source: RGD
  • nucleolar fragmentation Source: RGD
  • response to folic acid Source: RGD
  • response to hypoxia Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354A
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 1
Renal transcription factor Kid-1
Transcription factor 17
Short name:
TCF-17
Gene namesi
Name:Znf354a
Synonyms:Kid1, Tcf17, Zfp354a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2967. Zfp354a.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Zinc finger protein 354APRO_0000047240Add
BLAST

Proteomic databases

PaxDbiQ02975.
PRIDEiQ02975.

PTM databases

iPTMnetiQ02975.
PhosphoSiteiQ02975.

Expressioni

Tissue specificityi

Predominantly in the kidney.

Developmental stagei

Protein levels accumulate with age in postnatal renal development.

Gene expression databases

ExpressionAtlasiQ02975. baseline and differential.
GenevisibleiQ02975. RN.

Interactioni

Protein-protein interaction databases

IntActiQ02975. 1 interaction.
STRINGi10116.ENSRNOP00000049437.

Structurei

3D structure databases

ProteinModelPortaliQ02975.
SMRiQ02975. Positions 213-294, 322-543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8673KRABPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi170 – 18920Nuclear localization signalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi96 – 11116Glu/Pro/Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 21023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri521 – 54323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ02975.
KOiK09228.
OMAiHKNTELS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ02975.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR033345. ZNF354A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24377:SF146. PTHR24377:SF146. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEQREGAS QVSVTFEDVA VLFTRDEWKK LDLSQRSLYR EVMLENYSNL
60 70 80 90 100
ASMAGFLFTK PKVISLLQQG EDPWQVEKEG PRYFSLGLKC SHRTTKSTQT
110 120 130 140 150
QDSSFQELIV RKSKRTFAFE PLNMKSENLF IHEGKLEEKW DKNTLTVERS
160 170 180 190 200
HKNNEFSPKS HREKRSSECK KQISYLSNPP GITPDKRYKC SMCEKTFINT
210 220 230 240 250
SSLRKHEKNH SGEKLFKCKE CSKAFSQSSA LIQHQITHTG EKPYVCKECG
260 270 280 290 300
KAFTLSTSLY KHLRTHTVEK SYRCKECGKS FGQRSGLFIH QKIHARENPH
310 320 330 340 350
RYNPGRKASA SLSGCQRAHS RKKTYLCNEC GNTFKSSSSL RYHQRIHTGE
360 370 380 390 400
KPFRCSECGR AFSQSASLIQ HERIHTGEKP YRCGECGKGF TSISRLNRHR
410 420 430 440 450
IIHTGEKLYN CNECGKALSS HSTLIIHERI HTGEKPCKCK VCGKAFRQSS
460 470 480 490 500
ALIQHQRMHT GERPYKCNEC GKTFRCNSSL SNHQRIHTGE KPYQCIECGM
510 520 530 540 550
SFGQSSALIQ HRRIHTGEKP FKCNTCGKTF RQSSSRIAHQ RIHTGEKPYE
560 570
CNTCGKLFNY RSSLTNHYKI HVDEDP
Length:576
Mass (Da):66,253
Last modified:November 1, 1995 - v1
Checksum:i61C2C43156BDD63A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96548 mRNA. Translation: AAB07673.1.
S73488
, S73484, S73485, S73486 Genomic DNA. Translation: AAB31189.1.
PIRiA48157.
RefSeqiNP_434685.1. NM_052798.2.
XP_006246289.1. XM_006246227.2.
UniGeneiRn.11049.

Genome annotation databases

EnsembliENSRNOT00000045596; ENSRNOP00000049437; ENSRNOG00000003634.
GeneIDi24522.
KEGGirno:24522.
UCSCiRGD:2967. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96548 mRNA. Translation: AAB07673.1.
S73488
, S73484, S73485, S73486 Genomic DNA. Translation: AAB31189.1.
PIRiA48157.
RefSeqiNP_434685.1. NM_052798.2.
XP_006246289.1. XM_006246227.2.
UniGeneiRn.11049.

3D structure databases

ProteinModelPortaliQ02975.
SMRiQ02975. Positions 213-294, 322-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02975. 1 interaction.
STRINGi10116.ENSRNOP00000049437.

PTM databases

iPTMnetiQ02975.
PhosphoSiteiQ02975.

Proteomic databases

PaxDbiQ02975.
PRIDEiQ02975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045596; ENSRNOP00000049437; ENSRNOG00000003634.
GeneIDi24522.
KEGGirno:24522.
UCSCiRGD:2967. rat.

Organism-specific databases

CTDi21408.
RGDi2967. Zfp354a.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ02975.
KOiK09228.
OMAiHKNTELS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ02975.
TreeFamiTF341817.

Miscellaneous databases

NextBioi603569.
PROiQ02975.

Gene expression databases

ExpressionAtlasiQ02975. baseline and differential.
GenevisibleiQ02975. RN.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR033345. ZNF354A.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR24377:SF146. PTHR24377:SF146. 1 hit.
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury."
    Witzgall R., O'Leary E., Gessner R., Ouellette A.J., Bonventre J.V.
    Mol. Cell. Biol. 13:1933-1942(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1."
    Witzgall R., Volk R., Yeung R.S., Bonventre J.V.
    Genomics 20:203-209(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-110.
    Tissue: Liver.

Entry informationi

Entry nameiZ354A_RAT
AccessioniPrimary (citable) accession number: Q02975
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.