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Protein

Zinc finger protein 354A

Gene

Znf354a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 210C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • kidney development Source: RGD
  • negative regulation of transcription by RNA polymerase II Source: RGD
  • nucleolar fragmentation Source: RGD
  • response to folic acid Source: RGD
  • response to hypoxia Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 354A
Alternative name(s):
Kidney, ischemia, and developmentally-regulated protein 1
Renal transcription factor Kid-1
Transcription factor 17
Short name:
TCF-17
Gene namesi
Name:Znf354a
Synonyms:Kid1, Tcf17, Zfp354a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2967 Zfp354a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472401 – 576Zinc finger protein 354AAdd BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki159Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki242Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ02975
PRIDEiQ02975

PTM databases

iPTMnetiQ02975
PhosphoSitePlusiQ02975

Expressioni

Tissue specificityi

Predominantly in the kidney.

Developmental stagei

Protein levels accumulate with age in postnatal renal development.

Gene expression databases

BgeeiENSRNOG00000003634
ExpressionAtlasiQ02975 baseline and differential
GenevisibleiQ02975 RN

Interactioni

Protein-protein interaction databases

IntActiQ02975, 1 interactor
STRINGi10116.ENSRNOP00000049437

Structurei

3D structure databases

ProteinModelPortaliQ02975
SMRiQ02975
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 86KRABPROSITE-ProRule annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi170 – 189Nuclear localization signalAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 111Glu/Pro/Ser/Thr-richAdd BLAST16

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri188 – 210C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri216 – 238C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri244 – 266C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri272 – 294C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri521 – 543C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144148
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ02975
KOiK09228
OMAiHKNTELS
OrthoDBiEOG091G02KC
PhylomeDBiQ02975
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q02975-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPEQREGAS QVSVTFEDVA VLFTRDEWKK LDLSQRSLYR EVMLENYSNL
60 70 80 90 100
ASMAGFLFTK PKVISLLQQG EDPWQVEKEG PRYFSLGLKC SHRTTKSTQT
110 120 130 140 150
QDSSFQELIV RKSKRTFAFE PLNMKSENLF IHEGKLEEKW DKNTLTVERS
160 170 180 190 200
HKNNEFSPKS HREKRSSECK KQISYLSNPP GITPDKRYKC SMCEKTFINT
210 220 230 240 250
SSLRKHEKNH SGEKLFKCKE CSKAFSQSSA LIQHQITHTG EKPYVCKECG
260 270 280 290 300
KAFTLSTSLY KHLRTHTVEK SYRCKECGKS FGQRSGLFIH QKIHARENPH
310 320 330 340 350
RYNPGRKASA SLSGCQRAHS RKKTYLCNEC GNTFKSSSSL RYHQRIHTGE
360 370 380 390 400
KPFRCSECGR AFSQSASLIQ HERIHTGEKP YRCGECGKGF TSISRLNRHR
410 420 430 440 450
IIHTGEKLYN CNECGKALSS HSTLIIHERI HTGEKPCKCK VCGKAFRQSS
460 470 480 490 500
ALIQHQRMHT GERPYKCNEC GKTFRCNSSL SNHQRIHTGE KPYQCIECGM
510 520 530 540 550
SFGQSSALIQ HRRIHTGEKP FKCNTCGKTF RQSSSRIAHQ RIHTGEKPYE
560 570
CNTCGKLFNY RSSLTNHYKI HVDEDP
Length:576
Mass (Da):66,253
Last modified:November 1, 1995 - v1
Checksum:i61C2C43156BDD63A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96548 mRNA Translation: AAB07673.1
S73488
, S73484, S73485, S73486 Genomic DNA Translation: AAB31189.1
PIRiA48157
RefSeqiNP_434685.1, NM_052798.2
XP_006246289.1, XM_006246227.3
UniGeneiRn.11049

Genome annotation databases

EnsembliENSRNOT00000045596; ENSRNOP00000049437; ENSRNOG00000003634
GeneIDi24522
KEGGirno:24522
UCSCiRGD:2967 rat

Similar proteinsi

Entry informationi

Entry nameiZ354A_RAT
AccessioniPrimary (citable) accession number: Q02975
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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