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Protein

Macrophage migration inhibitory factor

Gene

MIF

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).By similarity

Catalytic activityi

Keto-phenylpyruvate = enol-phenylpyruvate.
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Proton acceptor; via imino nitrogenBy similarity1
Binding sitei33SubstrateBy similarity1
Binding sitei65Substrate; via amide nitrogenBy similarity1
Binding sitei98SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Isomerase
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-GGA-202733 Cell surface interactions at the vascular wall
R-GGA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage migration inhibitory factor (EC:5.3.2.1)
Short name:
MIF
Alternative name(s):
L-dopachrome isomerase
L-dopachrome tautomerase (EC:5.3.3.12)
Phenylpyruvate tautomerase
Gene namesi
Name:MIF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001580692 – 115Macrophage migration inhibitory factorAdd BLAST114

Proteomic databases

PaxDbiQ02960
PRIDEiQ02960

Expressioni

Gene expression databases

BgeeiENSGALG00000006326

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • MHC class II protein binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010214

Structurei

3D structure databases

ProteinModelPortaliQ02960
SMRiQ02960
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIF family.Curated

Phylogenomic databases

eggNOGiKOG1759 Eukaryota
ENOG41122MF LUCA
GeneTreeiENSGT00910000144267
HOGENOMiHOG000112325
HOVERGENiHBG003240
InParanoidiQ02960
KOiK07253
OMAiPDRIYIN
OrthoDBiEOG091G0ZNJ
PhylomeDBiQ02960
TreeFamiTF313853

Family and domain databases

Gene3Di3.30.429.10, 1 hit
InterProiView protein in InterPro
IPR001398 Macrophage_inhib_fac
IPR019829 Macrophage_inhib_fac_CS
IPR014347 Tautomerase/MIF_sf
PANTHERiPTHR11954 PTHR11954, 1 hit
PfamiView protein in Pfam
PF01187 MIF, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004816 Macrophage_inhib_fac, 1 hit
SUPFAMiSSF55331 SSF55331, 1 hit
PROSITEiView protein in PROSITE
PS01158 MIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMFTIHTNV CKDAVPDSLL GELTQQLAKA TGKPAQYIAV HIVPDQMMSF
60 70 80 90 100
GGSTDPCALC SLYSIGKIGG QQNKTYTKLL CDMIAKHLHV SADRVYINYF
110
DINAANVGWN GSTFA
Length:115
Mass (Da):12,484
Last modified:January 23, 2007 - v3
Checksum:iB85216F4E500B314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95776 mRNA Translation: AAA48939.1
PIRiC47274
RefSeqiNP_001292020.1, NM_001305091.1
XP_015157549.1, XM_015302063.1
UniGeneiGga.3585

Genome annotation databases

EnsembliENSGALT00000010228; ENSGALP00000010214; ENSGALG00000006326
GeneIDi100857237
107057091
KEGGigga:100857237
gga:107057091

Similar proteinsi

Entry informationi

Entry nameiMIF_CHICK
AccessioniPrimary (citable) accession number: Q02960
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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