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Protein

Histone deacetylase HOS3

Gene

HOS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei196By similarity1

GO - Molecular functioni

GO - Biological processi

  • histone deacetylation Source: SGD
  • positive regulation of transcription by RNA polymerase II Source: SGD
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34016-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase HOS3 (EC:3.5.1.98)
Gene namesi
Name:HOS3
Ordered Locus Names:YPL116W
ORF Names:LPH11W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL116W
SGDiS000006037 HOS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147271 – 697Histone deacetylase HOS3Add BLAST697

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei582PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02959
PaxDbiQ02959
PRIDEiQ02959

PTM databases

iPTMnetiQ02959

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi36065, 93 interactors
DIPiDIP-8047N
IntActiQ02959, 47 interactors
MINTiQ02959
STRINGi4932.YPL116W

Structurei

3D structure databases

ProteinModelPortaliQ02959
SMRiQ02959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 440Histone deacetylaseAdd BLAST401

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246666
InParanoidiQ02959
KOiK11484
OMAiNASTCIM
OrthoDBiEOG092C345D

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q02959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKHSDPLE RFYKQFQAFV QNNPNVISAA RAAAQIPESA KAVVVLSPYS
60 70 80 90 100
LQHVFPREWV TKSYRKTIVE RPERLLASSM GISAAITMYP SLFTLKSSHQ
110 120 130 140 150
RKGSLMAPHV LKVHGSSWPA ELIELCQMAD AKLLKGEIEV PDTWNSGDIY
160 170 180 190 200
LSSKTIKALQ GTIGAIETGV DSIFKGPSAE HISNRAFVAI RPPGHHCHYG
210 220 230 240 250
TPSGFCLLNN AHVAIEYAYD TYNVTHVVVL DFDLHHGDGT QDICWKRAGF
260 270 280 290 300
KPEEEPEDSS YDDFGKKFAE FPKVGYFSMH DINSFPTESG FATKENIKNA
310 320 330 340 350
STCIMNSHDL NIWNIHLSKW TTEEEFNVLY RTKYRTLFAK ADEFFRSAKL
360 370 380 390 400
EMNQQGRPFK GLVVISAGFD ASEFEQTSMQ RHSVNVPTSF YTTFTKDALK
410 420 430 440 450
LAQMHCHGKV LSLMEGGYSD KAICSGVFAH LIGLQNQDWV KEWGSEQVVK
460 470 480 490 500
EIVRGCKPAW KPYKTKRAKD VIRIWAEEVI RLGRAMIPEF DDIIFKDAVN
510 520 530 540 550
SAPSNSLLKA TVEPASTSTI AQRIIRSHRS NASPEKELHE NKPRSTEKQE
560 570 580 590 600
QREIRSDTKV KQLSSNNRAA ETQIPFLQQE FSSEDEDEEY VYDEELNKTF
610 620 630 640 650
NRTVEDITID DISRHLETLE IEKKGDEDSD HELKEKNWKN SHQRRLQGNG
660 670 680 690
MYKIPSNTKP HRIRQPQNAN TPTYDDSDIS MISHVSRKHT TRSGGRW
Length:697
Mass (Da):79,200
Last modified:November 1, 1996 - v1
Checksum:iF2B5D09E87B097E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43503 Genomic DNA Translation: AAB68246.1
BK006949 Genomic DNA Translation: DAA11318.1
PIRiS62006
RefSeqiNP_015209.1, NM_001183930.1

Genome annotation databases

EnsemblFungiiYPL116W; YPL116W; YPL116W
GeneIDi855987
KEGGisce:YPL116W

Similar proteinsi

Entry informationi

Entry nameiHOS3_YEAST
AccessioniPrimary (citable) accession number: Q02959
Secondary accession number(s): D6W3Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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