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Q02959

- HOS3_YEAST

UniProt

Q02959 - HOS3_YEAST

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Protein

Histone deacetylase HOS3

Gene

HOS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei196 – 1961By similarity

GO - Molecular functioni

  1. histone deacetylase activity Source: SGD
  2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. histone deacetylation Source: SGD
  2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  3. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34016-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase HOS3 (EC:3.5.1.98)
Gene namesi
Name:HOS3
Ordered Locus Names:YPL116W
ORF Names:LPH11W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL116w.
SGDiS000006037. HOS3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 697697Histone deacetylase HOS3PRO_0000114727Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei582 – 5821Phosphoserine1 Publication
Modified residuei583 – 5831Phosphoserine1 Publication
Modified residuei613 – 6131Phosphoserine1 Publication
Modified residuei629 – 6291Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02959.
PaxDbiQ02959.
PeptideAtlasiQ02959.

Expressioni

Gene expression databases

GenevestigatoriQ02959.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi36065. 57 interactions.
DIPiDIP-8047N.
IntActiQ02959. 45 interactions.
MINTiMINT-2781063.
STRINGi4932.YPL116W.

Structurei

3D structure databases

ProteinModelPortaliQ02959.
SMRiQ02959. Positions 145-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 440401Histone deacetylaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000246666.
InParanoidiQ02959.
KOiK11484.
OMAiFAEFPKV.
OrthoDBiEOG75J0WK.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q02959-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKHSDPLE RFYKQFQAFV QNNPNVISAA RAAAQIPESA KAVVVLSPYS
60 70 80 90 100
LQHVFPREWV TKSYRKTIVE RPERLLASSM GISAAITMYP SLFTLKSSHQ
110 120 130 140 150
RKGSLMAPHV LKVHGSSWPA ELIELCQMAD AKLLKGEIEV PDTWNSGDIY
160 170 180 190 200
LSSKTIKALQ GTIGAIETGV DSIFKGPSAE HISNRAFVAI RPPGHHCHYG
210 220 230 240 250
TPSGFCLLNN AHVAIEYAYD TYNVTHVVVL DFDLHHGDGT QDICWKRAGF
260 270 280 290 300
KPEEEPEDSS YDDFGKKFAE FPKVGYFSMH DINSFPTESG FATKENIKNA
310 320 330 340 350
STCIMNSHDL NIWNIHLSKW TTEEEFNVLY RTKYRTLFAK ADEFFRSAKL
360 370 380 390 400
EMNQQGRPFK GLVVISAGFD ASEFEQTSMQ RHSVNVPTSF YTTFTKDALK
410 420 430 440 450
LAQMHCHGKV LSLMEGGYSD KAICSGVFAH LIGLQNQDWV KEWGSEQVVK
460 470 480 490 500
EIVRGCKPAW KPYKTKRAKD VIRIWAEEVI RLGRAMIPEF DDIIFKDAVN
510 520 530 540 550
SAPSNSLLKA TVEPASTSTI AQRIIRSHRS NASPEKELHE NKPRSTEKQE
560 570 580 590 600
QREIRSDTKV KQLSSNNRAA ETQIPFLQQE FSSEDEDEEY VYDEELNKTF
610 620 630 640 650
NRTVEDITID DISRHLETLE IEKKGDEDSD HELKEKNWKN SHQRRLQGNG
660 670 680 690
MYKIPSNTKP HRIRQPQNAN TPTYDDSDIS MISHVSRKHT TRSGGRW
Length:697
Mass (Da):79,200
Last modified:November 1, 1996 - v1
Checksum:iF2B5D09E87B097E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43503 Genomic DNA. Translation: AAB68246.1.
BK006949 Genomic DNA. Translation: DAA11318.1.
PIRiS62006.
RefSeqiNP_015209.1. NM_001183930.1.

Genome annotation databases

EnsemblFungiiYPL116W; YPL116W; YPL116W.
GeneIDi855987.
KEGGisce:YPL116W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43503 Genomic DNA. Translation: AAB68246.1 .
BK006949 Genomic DNA. Translation: DAA11318.1 .
PIRi S62006.
RefSeqi NP_015209.1. NM_001183930.1.

3D structure databases

ProteinModelPortali Q02959.
SMRi Q02959. Positions 145-424.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36065. 57 interactions.
DIPi DIP-8047N.
IntActi Q02959. 45 interactions.
MINTi MINT-2781063.
STRINGi 4932.YPL116W.

Proteomic databases

MaxQBi Q02959.
PaxDbi Q02959.
PeptideAtlasi Q02959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL116W ; YPL116W ; YPL116W .
GeneIDi 855987.
KEGGi sce:YPL116W.

Organism-specific databases

CYGDi YPL116w.
SGDi S000006037. HOS3.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000246666.
InParanoidi Q02959.
KOi K11484.
OMAi FAEFPKV.
OrthoDBi EOG75J0WK.

Enzyme and pathway databases

BioCyci YEAST:G3O-34016-MONOMER.

Miscellaneous databases

NextBioi 980834.

Gene expression databases

Genevestigatori Q02959.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
    Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
    Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE NAME.
  4. "Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity."
    Carmen A.A., Griffin P.R., Calaycay J.R., Rundlett S.E., Suka Y., Grunstein M.
    Proc. Natl. Acad. Sci. U.S.A. 96:12356-12361(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, HOMODIMERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582; SER-583 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHOS3_YEAST
AccessioniPrimary (citable) accession number: Q02959
Secondary accession number(s): D6W3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4420 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3