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Q02959

- HOS3_YEAST

UniProt

Q02959 - HOS3_YEAST

Protein

Histone deacetylase HOS3

Gene

HOS3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei196 – 1961By similarity

    GO - Molecular functioni

    1. histone deacetylase activity Source: SGD
    2. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    5. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. histone deacetylation Source: SGD
    2. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    3. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34016-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase HOS3 (EC:3.5.1.98)
    Gene namesi
    Name:HOS3
    Ordered Locus Names:YPL116W
    ORF Names:LPH11W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPL116w.
    SGDiS000006037. HOS3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Histone deacetylase HOS3PRO_0000114727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei582 – 5821Phosphoserine1 Publication
    Modified residuei583 – 5831Phosphoserine1 Publication
    Modified residuei613 – 6131Phosphoserine1 Publication
    Modified residuei629 – 6291Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ02959.
    PaxDbiQ02959.
    PeptideAtlasiQ02959.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02959.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    BioGridi36065. 57 interactions.
    DIPiDIP-8047N.
    IntActiQ02959. 45 interactions.
    MINTiMINT-2781063.
    STRINGi4932.YPL116W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02959.
    SMRiQ02959. Positions 145-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni40 – 440401Histone deacetylaseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000246666.
    KOiK11484.
    OMAiFAEFPKV.
    OrthoDBiEOG75J0WK.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q02959-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSKHSDPLE RFYKQFQAFV QNNPNVISAA RAAAQIPESA KAVVVLSPYS    50
    LQHVFPREWV TKSYRKTIVE RPERLLASSM GISAAITMYP SLFTLKSSHQ 100
    RKGSLMAPHV LKVHGSSWPA ELIELCQMAD AKLLKGEIEV PDTWNSGDIY 150
    LSSKTIKALQ GTIGAIETGV DSIFKGPSAE HISNRAFVAI RPPGHHCHYG 200
    TPSGFCLLNN AHVAIEYAYD TYNVTHVVVL DFDLHHGDGT QDICWKRAGF 250
    KPEEEPEDSS YDDFGKKFAE FPKVGYFSMH DINSFPTESG FATKENIKNA 300
    STCIMNSHDL NIWNIHLSKW TTEEEFNVLY RTKYRTLFAK ADEFFRSAKL 350
    EMNQQGRPFK GLVVISAGFD ASEFEQTSMQ RHSVNVPTSF YTTFTKDALK 400
    LAQMHCHGKV LSLMEGGYSD KAICSGVFAH LIGLQNQDWV KEWGSEQVVK 450
    EIVRGCKPAW KPYKTKRAKD VIRIWAEEVI RLGRAMIPEF DDIIFKDAVN 500
    SAPSNSLLKA TVEPASTSTI AQRIIRSHRS NASPEKELHE NKPRSTEKQE 550
    QREIRSDTKV KQLSSNNRAA ETQIPFLQQE FSSEDEDEEY VYDEELNKTF 600
    NRTVEDITID DISRHLETLE IEKKGDEDSD HELKEKNWKN SHQRRLQGNG 650
    MYKIPSNTKP HRIRQPQNAN TPTYDDSDIS MISHVSRKHT TRSGGRW 697
    Length:697
    Mass (Da):79,200
    Last modified:November 1, 1996 - v1
    Checksum:iF2B5D09E87B097E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43503 Genomic DNA. Translation: AAB68246.1.
    BK006949 Genomic DNA. Translation: DAA11318.1.
    PIRiS62006.
    RefSeqiNP_015209.1. NM_001183930.1.

    Genome annotation databases

    EnsemblFungiiYPL116W; YPL116W; YPL116W.
    GeneIDi855987.
    KEGGisce:YPL116W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43503 Genomic DNA. Translation: AAB68246.1 .
    BK006949 Genomic DNA. Translation: DAA11318.1 .
    PIRi S62006.
    RefSeqi NP_015209.1. NM_001183930.1.

    3D structure databases

    ProteinModelPortali Q02959.
    SMRi Q02959. Positions 145-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36065. 57 interactions.
    DIPi DIP-8047N.
    IntActi Q02959. 45 interactions.
    MINTi MINT-2781063.
    STRINGi 4932.YPL116W.

    Proteomic databases

    MaxQBi Q02959.
    PaxDbi Q02959.
    PeptideAtlasi Q02959.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPL116W ; YPL116W ; YPL116W .
    GeneIDi 855987.
    KEGGi sce:YPL116W.

    Organism-specific databases

    CYGDi YPL116w.
    SGDi S000006037. HOS3.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000246666.
    KOi K11484.
    OMAi FAEFPKV.
    OrthoDBi EOG75J0WK.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34016-MONOMER.

    Miscellaneous databases

    NextBioi 980834.

    Gene expression databases

    Genevestigatori Q02959.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription."
      Rundlett S.E., Carmen A.A., Kobayashi R., Bavykin S., Turner B.M., Grunstein M.
      Proc. Natl. Acad. Sci. U.S.A. 93:14503-14508(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE NAME.
    4. "Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity."
      Carmen A.A., Griffin P.R., Calaycay J.R., Rundlett S.E., Suka Y., Grunstein M.
      Proc. Natl. Acad. Sci. U.S.A. 96:12356-12361(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, HOMODIMERIZATION.
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582; SER-583 AND SER-613, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHOS3_YEAST
    AccessioniPrimary (citable) accession number: Q02959
    Secondary accession number(s): D6W3Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 4420 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3