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Protein

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • heat acclimation Source: RGD
  • interleukin-1-mediated signaling pathway Source: RGD
  • ovulation Source: RGD
  • positive regulation of neuron migration Source: RGD
  • response to epidermal growth factor Source: RGD
  • response to interleukin-1 Source: RGD
  • response to nitric oxide Source: RGD
  • response to odorant Source: RGD
  • response to radiation Source: RGD
  • response to transforming growth factor beta Source: RGD

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:Il1r1
Synonyms:Il1ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2892 Il1r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 338ExtracellularSequence analysisAdd BLAST319
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 576CytoplasmicSequence analysisAdd BLAST217

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001543720 – 576Interleukin-1 receptor type 1, membrane formAdd BLAST557
ChainiPRO_000041534620 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 107PROSITE-ProRule annotation
Disulfide bondi46 ↔ 99PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi251 ↔ 315PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei556Phosphothreonine; by PKCBy similarity1

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ02955
PRIDEiQ02955

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019673

Structurei

3D structure databases

ProteinModelPortaliQ02955
SMRiQ02955
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 115Ig-like C2-type 1Add BLAST96
Domaini121 – 217Ig-like C2-type 2Add BLAST97
Domaini229 – 331Ig-like C2-type 3Add BLAST103
Domaini386 – 544TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC Eukaryota
ENOG410Z3W1 LUCA
HOVERGENiHBG052103
InParanoidiQ02955
PhylomeDBiQ02955

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004076 IL-1_rcpt_I-typ
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01538 INTRLEUKN1R1
PR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMKVLLGF ICLIVPLLSL ETDKCTEYPN EVISFSSVNE IDIRSCPLTP
60 70 80 90 100
NEMHGGTIIW YKNDSKTPIS ADKDSRIHQQ NEHLWFVPAK MEDSGYYYCI
110 120 130 140 150
MRNSTYCLKT KITMSVLEND PGLCYNTQAS FIQRLHVAGD GSLVCPYLDF
160 170 180 190 200
FKDENNELPK VQWYKNCKPL PLDDGNFFGF KNKLMVMNVA EEHRGNYTCR
210 220 230 240 250
TSYTYQGKQY PVTRVITFIT IDDSKRDRPV IMSPRNETME ADPGSTIQLI
260 270 280 290 300
CNVTGQFTDL VYWKWNGSEI EWDDPILAED YQFLEHPSAK RKYTLITTLN
310 320 330 340 350
VSEVKSQFYR YPFICFVKNT HILETAHVRL VYPVPDFKNY LIGGFAIFTA
360 370 380 390 400
TAVFCACIYK VFKVDIVLWY RDSCSDFLPR KASDGRTYDA YVLYPKTYGE
410 420 430 440 450
GSFAYLDTFV FKLLPEVLEG QFGYKLFICG RDDYVGEDTI EVTNENVKRS
460 470 480 490 500
RRLIIILVRD MGSFSCLGQS SEEQIAIYDA LIREGIKIIL LELEKIQDYE
510 520 530 540 550
KMPESIQFIK QKHGAICWSG DFKERPQSAK TRFWKNLRYQ MPAQRRSPLS
560 570
KHHLLTLDPV LDTKEKLQAE THLPLG
Length:576
Mass (Da):66,759
Last modified:July 1, 1993 - v1
Checksum:i55BE20C92385A34A
GO

Sequence cautioni

The sequence AAA16196 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95578 mRNA Translation: AAA16196.1 Different initiation.
PIRiI56526
UniGeneiRn.9758

Genome annotation databases

UCSCiRGD:2892 rat

Similar proteinsi

Entry informationi

Entry nameiIL1R1_RAT
AccessioniPrimary (citable) accession number: Q02955
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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