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Q02955 (IL1R1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-1 receptor type 1

Short name=IL-1R-1
Short name=IL-1RT-1
Short name=IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name=IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen=CD121a

Cleaved into the following 2 chains:

  1. Interleukin-1 receptor type 1, membrane form
    Short name=mIL-1R1
    Short name=mIL-1RI
  2. Interleukin-1 receptor type 1, soluble form
    Short name=sIL-1R1
    Short name=sIL-1RI
Gene names
Name:Il1r1
Synonyms:Il1ra
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex By similarity.

Subunit structure

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein. Cell membrane Probable. Secreted By similarity.

Post-translational modification

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding) By similarity.

Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1 By similarity.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

Sequence caution

The sequence AAA16196.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
Secreted
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to glucose stimulus

Inferred from expression pattern PubMed 20034811. Source: RGD

interleukin-1-mediated signaling pathway

Inferred from mutant phenotype PubMed 20967881. Source: RGD

ovulation

Inferred from expression pattern PubMed 10375024. Source: RGD

response to interleukin-1

Inferred from expression pattern PubMed 10375024. Source: RGD

response to nitric oxide

Inferred from expression pattern PubMed 10375024. Source: RGD

   Cellular_componentcell surface

Inferred from direct assay PubMed 21925583. Source: RGD

extracellular space

Inferred from direct assay PubMed 17681838. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay PubMed 20034811. Source: RGD

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

postsynaptic density

Inferred from direct assay PubMed 21314939. Source: RGD

protein complex

Inferred from direct assay PubMed 21314939. Source: RGD

   Molecular_functioninterleukin-1, Type I, activating receptor activity

Inferred from electronic annotation. Source: InterPro

ionotropic glutamate receptor binding

Inferred from physical interaction PubMed 21314939. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 576557Interleukin-1 receptor type 1, membrane form
PRO_0000015437
Chain20 – ?Interleukin-1 receptor type 1, soluble formPRO_0000415346

Regions

Topological domain20 – 338319Extracellular Potential
Transmembrane339 – 35921Helical; Potential
Topological domain360 – 576217Cytoplasmic Potential
Domain20 – 11596Ig-like C2-type 1
Domain121 – 21797Ig-like C2-type 2
Domain229 – 331103Ig-like C2-type 3
Domain386 – 544159TIR

Amino acid modifications

Modified residue4991Phosphotyrosine By similarity
Modified residue5561Phosphothreonine; by PKC By similarity
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Disulfide bond25 ↔ 107 By similarity
Disulfide bond46 ↔ 99 By similarity
Disulfide bond145 ↔ 199 By similarity
Disulfide bond251 ↔ 315 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02955 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 55BE20C92385A34A

FASTA57666,759
        10         20         30         40         50         60 
MENMKVLLGF ICLIVPLLSL ETDKCTEYPN EVISFSSVNE IDIRSCPLTP NEMHGGTIIW 

        70         80         90        100        110        120 
YKNDSKTPIS ADKDSRIHQQ NEHLWFVPAK MEDSGYYYCI MRNSTYCLKT KITMSVLEND 

       130        140        150        160        170        180 
PGLCYNTQAS FIQRLHVAGD GSLVCPYLDF FKDENNELPK VQWYKNCKPL PLDDGNFFGF 

       190        200        210        220        230        240 
KNKLMVMNVA EEHRGNYTCR TSYTYQGKQY PVTRVITFIT IDDSKRDRPV IMSPRNETME 

       250        260        270        280        290        300 
ADPGSTIQLI CNVTGQFTDL VYWKWNGSEI EWDDPILAED YQFLEHPSAK RKYTLITTLN 

       310        320        330        340        350        360 
VSEVKSQFYR YPFICFVKNT HILETAHVRL VYPVPDFKNY LIGGFAIFTA TAVFCACIYK 

       370        380        390        400        410        420 
VFKVDIVLWY RDSCSDFLPR KASDGRTYDA YVLYPKTYGE GSFAYLDTFV FKLLPEVLEG 

       430        440        450        460        470        480 
QFGYKLFICG RDDYVGEDTI EVTNENVKRS RRLIIILVRD MGSFSCLGQS SEEQIAIYDA 

       490        500        510        520        530        540 
LIREGIKIIL LELEKIQDYE KMPESIQFIK QKHGAICWSG DFKERPQSAK TRFWKNLRYQ 

       550        560        570 
MPAQRRSPLS KHHLLTLDPV LDTKEKLQAE THLPLG 

« Hide

References

[1]"An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia."
Hart R.P., Liu C., Shadiack A.M., McCormack R.J., Jonakait G.M.
J. Neuroimmunol. 44:49-56(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ganglion.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95578 mRNA. Translation: AAA16196.1. Different initiation.
PIRI56526.
UniGeneRn.9758.

3D structure databases

ProteinModelPortalQ02955.
SMRQ02955. Positions 23-334.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ02955.
PRIDEQ02955.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2892. rat.

Organism-specific databases

RGD2892. Il1r1.

Phylogenomic databases

eggNOGNOG40914.
HOVERGENHBG052103.
InParanoidQ02955.
PhylomeDBQ02955.

Gene expression databases

GenevestigatorQ02955.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERPTHR11890. PTHR11890. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PRINTSPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTSM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ02955.

Entry information

Entry nameIL1R1_RAT
AccessionPrimary (citable) accession number: Q02955
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families