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Q02955

- IL1R1_RAT

UniProt

Q02955 - IL1R1_RAT

Protein

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-1, Type I, activating receptor activity Source: InterPro
    2. ionotropic glutamate receptor binding Source: RGD
    3. protein binding Source: RGD

    GO - Biological processi

    1. cellular response to glucose stimulus Source: RGD
    2. heat acclimation Source: RGD
    3. interleukin-1-mediated signaling pathway Source: RGD
    4. ovulation Source: RGD
    5. response to epidermal growth factor Source: RGD
    6. response to interleukin-1 Source: RGD
    7. response to nitric oxide Source: RGD
    8. response to radiation Source: RGD
    9. response to transforming growth factor beta Source: RGD

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor type 1
    Short name:
    IL-1R-1
    Short name:
    IL-1RT-1
    Short name:
    IL-1RT1
    Alternative name(s):
    CD121 antigen-like family member A
    Interleukin-1 receptor alpha
    Short name:
    IL-1R-alpha
    Interleukin-1 receptor type I
    p80
    CD_antigen: CD121a
    Cleaved into the following 2 chains:
    Interleukin-1 receptor type 1, membrane form
    Short name:
    mIL-1R1
    Short name:
    mIL-1RI
    Interleukin-1 receptor type 1, soluble form
    Short name:
    sIL-1R1
    Short name:
    sIL-1RI
    Gene namesi
    Name:Il1r1
    Synonyms:Il1ra
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2892. Il1r1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: RGD
    2. cell surface Source: RGD
    3. extracellular space Source: RGD
    4. integral component of membrane Source: UniProtKB-KW
    5. nucleus Source: RGD
    6. plasma membrane Source: UniProtKB-SubCell
    7. postsynaptic density Source: RGD
    8. protein complex Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 576557Interleukin-1 receptor type 1, membrane formPRO_0000015437Add
    BLAST
    Chaini20 – ?Interleukin-1 receptor type 1, soluble formPRO_0000415346

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi25 ↔ 107PROSITE-ProRule annotation
    Disulfide bondi46 ↔ 99PROSITE-ProRule annotation
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi251 ↔ 315PROSITE-ProRule annotation
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence Analysis
    Modified residuei499 – 4991PhosphotyrosineBy similarity
    Modified residuei556 – 5561Phosphothreonine; by PKCBy similarity

    Post-translational modificationi

    A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
    Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ02955.
    PRIDEiQ02955.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02955.

    Interactioni

    Subunit structurei

    The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ02955.
    SMRiQ02955. Positions 23-334.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 338319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini360 – 576217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei339 – 35921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 11596Ig-like C2-type 1Add
    BLAST
    Domaini121 – 21797Ig-like C2-type 2Add
    BLAST
    Domaini229 – 331103Ig-like C2-type 3Add
    BLAST
    Domaini386 – 544159TIRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the interleukin-1 receptor family.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40914.
    HOVERGENiHBG052103.
    InParanoidiQ02955.
    PhylomeDBiQ02955.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.40.50.10140. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view]
    PANTHERiPTHR11890. PTHR11890. 1 hit.
    PfamiPF01582. TIR. 1 hit.
    [Graphical view]
    PRINTSiPR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTiSM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENMKVLLGF ICLIVPLLSL ETDKCTEYPN EVISFSSVNE IDIRSCPLTP    50
    NEMHGGTIIW YKNDSKTPIS ADKDSRIHQQ NEHLWFVPAK MEDSGYYYCI 100
    MRNSTYCLKT KITMSVLEND PGLCYNTQAS FIQRLHVAGD GSLVCPYLDF 150
    FKDENNELPK VQWYKNCKPL PLDDGNFFGF KNKLMVMNVA EEHRGNYTCR 200
    TSYTYQGKQY PVTRVITFIT IDDSKRDRPV IMSPRNETME ADPGSTIQLI 250
    CNVTGQFTDL VYWKWNGSEI EWDDPILAED YQFLEHPSAK RKYTLITTLN 300
    VSEVKSQFYR YPFICFVKNT HILETAHVRL VYPVPDFKNY LIGGFAIFTA 350
    TAVFCACIYK VFKVDIVLWY RDSCSDFLPR KASDGRTYDA YVLYPKTYGE 400
    GSFAYLDTFV FKLLPEVLEG QFGYKLFICG RDDYVGEDTI EVTNENVKRS 450
    RRLIIILVRD MGSFSCLGQS SEEQIAIYDA LIREGIKIIL LELEKIQDYE 500
    KMPESIQFIK QKHGAICWSG DFKERPQSAK TRFWKNLRYQ MPAQRRSPLS 550
    KHHLLTLDPV LDTKEKLQAE THLPLG 576
    Length:576
    Mass (Da):66,759
    Last modified:July 1, 1993 - v1
    Checksum:i55BE20C92385A34A
    GO

    Sequence cautioni

    The sequence AAA16196.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95578 mRNA. Translation: AAA16196.1. Different initiation.
    PIRiI56526.
    UniGeneiRn.9758.

    Genome annotation databases

    UCSCiRGD:2892. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95578 mRNA. Translation: AAA16196.1 . Different initiation.
    PIRi I56526.
    UniGenei Rn.9758.

    3D structure databases

    ProteinModelPortali Q02955.
    SMRi Q02955. Positions 23-334.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q02955.
    PRIDEi Q02955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2892. rat.

    Organism-specific databases

    RGDi 2892. Il1r1.

    Phylogenomic databases

    eggNOGi NOG40914.
    HOVERGENi HBG052103.
    InParanoidi Q02955.
    PhylomeDBi Q02955.

    Miscellaneous databases

    PROi Q02955.

    Gene expression databases

    Genevestigatori Q02955.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.40.50.10140. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR015621. IL-1_rcpt_fam.
    IPR004076. IL-1_rcpt_I-typ.
    IPR004074. IL-1_rcpt_I/II-typ.
    IPR000157. TIR_dom.
    [Graphical view ]
    PANTHERi PTHR11890. PTHR11890. 1 hit.
    Pfami PF01582. TIR. 1 hit.
    [Graphical view ]
    PRINTSi PR01538. INTRLEUKN1R1.
    PR01536. INTRLKN1R12F.
    SMARTi SM00409. IG. 2 hits.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An mRNA homologous to interleukin-1 receptor type I is expressed in cultured rat sympathetic ganglia."
      Hart R.P., Liu C., Shadiack A.M., McCormack R.J., Jonakait G.M.
      J. Neuroimmunol. 44:49-56(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ganglion.

    Entry informationi

    Entry nameiIL1R1_RAT
    AccessioniPrimary (citable) accession number: Q02955
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3