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Protein

Interleukin-1 receptor type 1

Gene

Il1r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose stimulus Source: RGD
  • heat acclimation Source: RGD
  • interleukin-1-mediated signaling pathway Source: RGD
  • ovulation Source: RGD
  • positive regulation of neuron migration Source: RGD
  • response to epidermal growth factor Source: RGD
  • response to interleukin-1 Source: RGD
  • response to nitric oxide Source: RGD
  • response to odorant Source: RGD
  • response to radiation Source: RGD
  • response to transforming growth factor beta Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:Il1r1
Synonyms:Il1ra
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2892. Il1r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 338ExtracellularSequence analysisAdd BLAST319
Transmembranei339 – 359HelicalSequence analysisAdd BLAST21
Topological domaini360 – 576CytoplasmicSequence analysisAdd BLAST217

GO - Cellular componenti

  • axon Source: RGD
  • cell surface Source: RGD
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • nucleus Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
  • postsynaptic density Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001543720 – 576Interleukin-1 receptor type 1, membrane formAdd BLAST557
ChainiPRO_000041534620 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 107PROSITE-ProRule annotation
Disulfide bondi46 ↔ 99PROSITE-ProRule annotation
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi103N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 199PROSITE-ProRule annotation
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi251 ↔ 315PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei556Phosphothreonine; by PKCBy similarity1

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).By similarity
Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ02955.
PRIDEiQ02955.

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1 (By similarity).By similarity

GO - Molecular functioni

  • ionotropic glutamate receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019673.

Structurei

3D structure databases

ProteinModelPortaliQ02955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 115Ig-like C2-type 1Add BLAST96
Domaini121 – 217Ig-like C2-type 2Add BLAST97
Domaini229 – 331Ig-like C2-type 3Add BLAST103
Domaini386 – 544TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
HOVERGENiHBG052103.
InParanoidiQ02955.
PhylomeDBiQ02955.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMKVLLGF ICLIVPLLSL ETDKCTEYPN EVISFSSVNE IDIRSCPLTP
60 70 80 90 100
NEMHGGTIIW YKNDSKTPIS ADKDSRIHQQ NEHLWFVPAK MEDSGYYYCI
110 120 130 140 150
MRNSTYCLKT KITMSVLEND PGLCYNTQAS FIQRLHVAGD GSLVCPYLDF
160 170 180 190 200
FKDENNELPK VQWYKNCKPL PLDDGNFFGF KNKLMVMNVA EEHRGNYTCR
210 220 230 240 250
TSYTYQGKQY PVTRVITFIT IDDSKRDRPV IMSPRNETME ADPGSTIQLI
260 270 280 290 300
CNVTGQFTDL VYWKWNGSEI EWDDPILAED YQFLEHPSAK RKYTLITTLN
310 320 330 340 350
VSEVKSQFYR YPFICFVKNT HILETAHVRL VYPVPDFKNY LIGGFAIFTA
360 370 380 390 400
TAVFCACIYK VFKVDIVLWY RDSCSDFLPR KASDGRTYDA YVLYPKTYGE
410 420 430 440 450
GSFAYLDTFV FKLLPEVLEG QFGYKLFICG RDDYVGEDTI EVTNENVKRS
460 470 480 490 500
RRLIIILVRD MGSFSCLGQS SEEQIAIYDA LIREGIKIIL LELEKIQDYE
510 520 530 540 550
KMPESIQFIK QKHGAICWSG DFKERPQSAK TRFWKNLRYQ MPAQRRSPLS
560 570
KHHLLTLDPV LDTKEKLQAE THLPLG
Length:576
Mass (Da):66,759
Last modified:July 1, 1993 - v1
Checksum:i55BE20C92385A34A
GO

Sequence cautioni

The sequence AAA16196 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95578 mRNA. Translation: AAA16196.1. Different initiation.
PIRiI56526.
UniGeneiRn.9758.

Genome annotation databases

UCSCiRGD:2892. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95578 mRNA. Translation: AAA16196.1. Different initiation.
PIRiI56526.
UniGeneiRn.9758.

3D structure databases

ProteinModelPortaliQ02955.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019673.

Proteomic databases

PaxDbiQ02955.
PRIDEiQ02955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2892. rat.

Organism-specific databases

RGDi2892. Il1r1.

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
HOVERGENiHBG052103.
InParanoidiQ02955.
PhylomeDBiQ02955.

Miscellaneous databases

PROiQ02955.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1R1_RAT
AccessioniPrimary (citable) accession number: Q02955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.