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Q02952

- AKA12_HUMAN

UniProt

Q02952 - AKA12_HUMAN

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Protein
A-kinase anchor protein 12
Gene
AKAP12, AKAP250
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

GO - Molecular functioni

  1. adenylate cyclase binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. protein kinase A binding Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. positive regulation of cAMP biosynthetic process Source: UniProtKB
  3. positive regulation of protein kinase A signaling Source: UniProtKB
  4. protein targeting Source: InterPro
  5. regulation of protein kinase C signaling Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ02952.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 12
Short name:
AKAP-12
Alternative name(s):
A-kinase anchor protein 250 kDa
Short name:
AKAP 250
Gravin
Myasthenia gravis autoantigen
Gene namesi
Name:AKAP12
Synonyms:AKAP250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:370. AKAP12.

Subcellular locationi

Cytoplasmcell cortex Inferred. Cytoplasmcytoskeleton Inferred
Note: May be part of the cortical cytoskeleton.

GO - Cellular componenti

  1. cell cortex Source: UniProtKB-SubCell
  2. cytoplasm Source: ProtInc
  3. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 17821781A-kinase anchor protein 12
PRO_0000064519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei75 – 751Phosphoserine1 Publication
Modified residuei96 – 961Phosphoserine1 Publication
Modified residuei219 – 2191Phosphoserine1 Publication
Modified residuei371 – 3711Phosphoserine1 Publication
Modified residuei374 – 3741Phosphotyrosine By similarity
Modified residuei381 – 3811Phosphoserine1 Publication
Modified residuei483 – 4831Phosphoserine1 Publication
Modified residuei505 – 5051Phosphoserine1 Publication
Modified residuei557 – 5571Phosphoserine1 Publication
Modified residuei598 – 5981Phosphoserine1 Publication
Modified residuei612 – 6121Phosphoserine1 Publication
Modified residuei627 – 6271Phosphoserine1 Publication
Modified residuei645 – 6451Phosphoserine1 Publication
Modified residuei696 – 6961Phosphoserine By similarity
Modified residuei697 – 6971Phosphoserine By similarity
Modified residuei698 – 6981Phosphoserine By similarity
Modified residuei1331 – 13311Phosphoserine1 Publication
Modified residuei1395 – 13951Phosphoserine1 Publication
Modified residuei1587 – 15871Phosphoserine1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ02952.
PaxDbiQ02952.
PRIDEiQ02952.

PTM databases

PhosphoSiteiQ02952.

Expressioni

Tissue specificityi

Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.

Inductioni

Activated by lysophosphatidylcholine (lysoPC).

Gene expression databases

BgeeiQ02952.
CleanExiHS_AKAP12.
GenevestigatoriQ02952.

Organism-specific databases

HPAiHPA006344.

Interactioni

Subunit structurei

Binds to dimeric RII-alpha regulatory subunit of PKC.

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2562430,EBI-297353

Protein-protein interaction databases

BioGridi114958. 13 interactions.
IntActiQ02952. 7 interactions.
MINTiMINT-2411728.
STRINGi9606.ENSP00000253332.

Structurei

3D structure databases

ProteinModelPortaliQ02952.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini604 – 63431AKAP 1
Add
BLAST
Domaini753 – 78331AKAP 2
Add
BLAST
Domaini798 – 82831AKAP 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni266 – 557292Involved in PKC-binding Inferred
Add
BLAST
Regioni1541 – 155414RII-binding Inferred
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 1014Poly-Glu

Domaini

Polybasic regions located between residues 266 and 557 are involved in binding PKC.

Sequence similaritiesi

Contains 3 AKAP domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG050472.
InParanoidiQ02952.
KOiK16528.
OMAiVEHSASD.
OrthoDBiEOG7RFTGR.
PhylomeDBiQ02952.
TreeFamiTF105411.

Family and domain databases

InterProiIPR028540. AKAP12.
IPR001573. Pkinase-A_anch_WSK-motif.
IPR018459. RII_binding_1.
[Graphical view]
PANTHERiPTHR23209. PTHR23209. 1 hit.
PfamiPF10522. RII_binding_1. 1 hit.
PF03832. WSK. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02952-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGAGSSTEQR SPEQPPEGSS TPAEPEPSGG GPSAEAAPDT TADPAIAASD     50
PATKLLQKNG QLSTINGVAE QDELSLQEGD LNGQKGALNG QGALNSQEEE 100
EVIVTEVGQR DSEDVSKRDS DKEMATKSAV VHDITDDGQE ETPEIIEQIP 150
SSESNLEELT QPTESQANDI GFKKVFKFVG FKFTVKKDKT EKPDTVQLLT 200
VKKDEGEGAA GAGDHKDPSL GAGEAASKES EPKQSTEKPE ETLKREQSHA 250
EISPPAESGQ AVEECKEEGE EKQEKEPSKS AESPTSPVTS ETGSTFKKFF 300
TQGWAGWRKK TSFRKPKEDE VEASEKKKEQ EPEKVDTEED GKAEVASEKL 350
TASEQAHPQE PAESAHEPRL SAEYEKVELP SEEQVSGSQG PSEEKPAPLA 400
TEVFDEKIEV HQEEVVAEVH VSTVEERTEE QKTEVEETAG SVPAEELVEM 450
DAEPQEAEPA KELVKLKETC VSGEDPTQGA DLSPDEKVLS KPPEGVVSEV 500
EMLSSQERMK VQGSPLKKLF TSTGLKKLSG KKQKGKRGGG DEESGEHTQV 550
PADSPDSQEE QKGESSASSP EEPEEITCLE KGLAEVQQDG EAEEGATSDG 600
EKKREGVTPW ASFKKMVTPK KRVRRPSESD KEDELDKVKS ATLSSTESTA 650
SEMQEEMKGS VEEPKPEEPK RKVDTSVSWE ALICVGSSKK RARRGSSSDE 700
EGGPKAMGGD HQKADEAGKD KETGTDGILA GSQEHDPGQG SSSPEQAGSP 750
TEGEGVSTWE SFKRLVTPRK KSKSKLEEKS EDSIAGSGVE HSTPDTEPGK 800
EESWVSIKKF IPGRRKKRPD GKQEQAPVED AGPTGANEDD SDVPAVVPLS 850
EYDAVEREKM EAQQAQKSAE QPEQKAATEV SKELSESQVH MMAAAVADGT 900
RAATIIEERS PSWISASVTE PLEQVEAEAA LLTEEVLERE VIAEEEPPTV 950
TEPLPENREA RGDTVVSEAE LTPEAVTAAE TAGPLGAEEG TEASAAEETT 1000
EMVSAVSQLT DSPDTTEEAT PVQEVEGGVP DIEEQERRTQ EVLQAVAEKV 1050
KEESQLPGTG GPEDVLQPVQ RAEAERPEEQ AEASGLKKET DVVLKVDAQE 1100
AKTEPFTQGK VVGQTTPESF EKAPQVTESI ESSELVTTCQ AETLAGVKSQ 1150
EMVMEQAIPP DSVETPTDSE TDGSTPVADF DAPGTTQKDE IVEIHEENEV 1200
ASGTQSGGTE AEAVPAQKER PPAPSSFVFQ EETKEQSKME DTLEHTDKEV 1250
SVETVSILSK TEGTQEADQY ADEKTKDVPF FEGLEGSIDT GITVSREKVT 1300
EVALKGEGTE EAECKKDDAL ELQSHAKSPP SPVEREMVVQ VEREKTEAEP 1350
THVNEEKLEH ETAVTVSEEV SKQLLQTVNV PIIDGAKEVS SLEGSPPPCL 1400
GQEEAVCTKI QVQSSEASFT LTAAAEEEKV LGETANILET GETLEPAGAH 1450
LVLEEKSSEK NEDFAAHPGE DAVPTGPDCQ AKSTPVIVSA TTKKGLSSDL 1500
EGEKTTSLKW KSDEVDEQVA CQEVKVSVAI EDLEPENGIL ELETKSSKLV 1550
QNIIQTAVDQ FVRTEETATE MLTSELQTQA HVIKADSQDA GQETEKEGEE 1600
PQASAQDETP ITSAKEESES TAVGQAHSDI SKDMSEASEK TMTVEVEGST 1650
VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK 1700
GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK 1750
VHSESDKAIT PQAQEELQKQ ERESAKSELT ES 1782
Length:1,782
Mass (Da):191,482
Last modified:January 11, 2011 - v4
Checksum:iDB9DBA4647E6DDD5
GO
Isoform 2 (identifier: Q02952-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     99-106: EEEVIVTE → MLGTITIT

Show »
Length:1,684
Mass (Da):181,690
Checksum:i384AEDA06CC83D93
GO
Isoform 3 (identifier: Q02952-3) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-106: E → M

Show »
Length:1,677
Mass (Da):180,990
Checksum:i8533672E99E8A1D6
GO

Sequence cautioni

The sequence BAE06085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171K → E.3 Publications
Corresponds to variant rs10872670 [ dbSNP | Ensembl ].
VAR_035115
Natural varianti216 – 2161K → Q.4 Publications
Corresponds to variant rs3734799 [ dbSNP | Ensembl ].
VAR_035116
Natural varianti240 – 2401E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035780
Natural varianti920 – 9201E → G.1 Publication
Corresponds to variant rs13212161 [ dbSNP | Ensembl ].
VAR_035117
Natural varianti987 – 9871A → S.1 Publication
Corresponds to variant rs1042069 [ dbSNP | Ensembl ].
VAR_056731
Natural varianti1096 – 10961V → I.
Corresponds to variant rs3734797 [ dbSNP | Ensembl ].
VAR_035118
Natural varianti1296 – 12961R → L.
Corresponds to variant rs9478198 [ dbSNP | Ensembl ].
VAR_035119
Natural varianti1355 – 13551E → K.1 Publication
Corresponds to variant rs12201388 [ dbSNP | Ensembl ].
VAR_035120
Natural varianti1600 – 16001E → D.1 Publication
Corresponds to variant rs3823310 [ dbSNP | Ensembl ].
VAR_035121
Natural varianti1689 – 16891E → D.
Corresponds to variant rs3734795 [ dbSNP | Ensembl ].
VAR_035122

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 105105Missing in isoform 3.
VSP_028133Add
BLAST
Alternative sequencei1 – 9898Missing in isoform 2.
VSP_004110Add
BLAST
Alternative sequencei99 – 1068EEEVIVTE → MLGTITIT in isoform 2.
VSP_004111
Alternative sequencei106 – 1061E → M in isoform 3.
VSP_028134

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1454TPEI → NRN in AAC51366. 1 Publication
Sequence conflicti423 – 4231T → I in BAE06085. 1 Publication
Sequence conflicti449 – 4491E → G in AAC51366. 1 Publication
Sequence conflicti695 – 6951G → R in AAC51366. 1 Publication
Sequence conflicti868 – 8681S → G in AAC51366. 1 Publication
Sequence conflicti946 – 9461E → G in CAH18338. 1 Publication
Sequence conflicti1182 – 11821A → T in CAH18338. 1 Publication
Sequence conflicti1531 – 15311E → EE in CAH18338. 1 Publication
Sequence conflicti1531 – 15311E → EE in BAE06085. 1 Publication
Sequence conflicti1531 – 15311E → EE in AAB58938. 1 Publication
Sequence conflicti1531 – 15311E → EE in AAA35931. 1 Publication
Sequence conflicti1582 – 15821V → M in CAH18338. 1 Publication
Sequence conflicti1582 – 15821V → M in AAA35931. 1 Publication
Sequence conflicti1602 – 16021Q → L in BAA19927. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U81607 mRNA. Translation: AAC51366.1.
AB003476 mRNA. Translation: BAA19927.1.
AB210003 mRNA. Translation: BAE06085.1. Different initiation.
CR749527 mRNA. Translation: CAH18338.1.
AL590413, AL033392, AL356535 Genomic DNA. Translation: CAI13590.1.
AL356535, AL033392, AL590413 Genomic DNA. Translation: CAI16151.1.
AL033392, AL356535, AL590413 Genomic DNA. Translation: CAI20467.1.
AL590413, AL033392 Genomic DNA. Translation: CAI13591.1.
AL033392, AL590413 Genomic DNA. Translation: CAI20468.1.
AF001504 mRNA. Translation: AAB58938.1.
M96322 mRNA. Translation: AAA35931.1.
CCDSiCCDS5229.1. [Q02952-1]
CCDS5230.1. [Q02952-2]
PIRiA43922.
JW0057.
RefSeqiNP_005091.2. NM_005100.3. [Q02952-1]
NP_653080.1. NM_144497.2. [Q02952-2]
XP_005267290.1. XM_005267233.1. [Q02952-1]
XP_005267291.1. XM_005267234.2. [Q02952-2]
XP_005267292.1. XM_005267235.1. [Q02952-3]
UniGeneiHs.371240.

Genome annotation databases

EnsembliENST00000253332; ENSP00000253332; ENSG00000131016. [Q02952-1]
ENST00000354675; ENSP00000346702; ENSG00000131016. [Q02952-2]
ENST00000359755; ENSP00000352794; ENSG00000131016. [Q02952-3]
ENST00000402676; ENSP00000384537; ENSG00000131016. [Q02952-1]
GeneIDi9590.
KEGGihsa:9590.
UCSCiuc003qoe.3. human. [Q02952-1]
uc003qof.3. human. [Q02952-2]
uc003qog.3. human. [Q02952-3]

Polymorphism databases

DMDMi317373554.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U81607 mRNA. Translation: AAC51366.1 .
AB003476 mRNA. Translation: BAA19927.1 .
AB210003 mRNA. Translation: BAE06085.1 . Different initiation.
CR749527 mRNA. Translation: CAH18338.1 .
AL590413 , AL033392 , AL356535 Genomic DNA. Translation: CAI13590.1 .
AL356535 , AL033392 , AL590413 Genomic DNA. Translation: CAI16151.1 .
AL033392 , AL356535 , AL590413 Genomic DNA. Translation: CAI20467.1 .
AL590413 , AL033392 Genomic DNA. Translation: CAI13591.1 .
AL033392 , AL590413 Genomic DNA. Translation: CAI20468.1 .
AF001504 mRNA. Translation: AAB58938.1 .
M96322 mRNA. Translation: AAA35931.1 .
CCDSi CCDS5229.1. [Q02952-1 ]
CCDS5230.1. [Q02952-2 ]
PIRi A43922.
JW0057.
RefSeqi NP_005091.2. NM_005100.3. [Q02952-1 ]
NP_653080.1. NM_144497.2. [Q02952-2 ]
XP_005267290.1. XM_005267233.1. [Q02952-1 ]
XP_005267291.1. XM_005267234.2. [Q02952-2 ]
XP_005267292.1. XM_005267235.1. [Q02952-3 ]
UniGenei Hs.371240.

3D structure databases

ProteinModelPortali Q02952.
ModBasei Search...

Protein-protein interaction databases

BioGridi 114958. 13 interactions.
IntActi Q02952. 7 interactions.
MINTi MINT-2411728.
STRINGi 9606.ENSP00000253332.

PTM databases

PhosphoSitei Q02952.

Polymorphism databases

DMDMi 317373554.

Proteomic databases

MaxQBi Q02952.
PaxDbi Q02952.
PRIDEi Q02952.

Protocols and materials databases

DNASUi 9590.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253332 ; ENSP00000253332 ; ENSG00000131016 . [Q02952-1 ]
ENST00000354675 ; ENSP00000346702 ; ENSG00000131016 . [Q02952-2 ]
ENST00000359755 ; ENSP00000352794 ; ENSG00000131016 . [Q02952-3 ]
ENST00000402676 ; ENSP00000384537 ; ENSG00000131016 . [Q02952-1 ]
GeneIDi 9590.
KEGGi hsa:9590.
UCSCi uc003qoe.3. human. [Q02952-1 ]
uc003qof.3. human. [Q02952-2 ]
uc003qog.3. human. [Q02952-3 ]

Organism-specific databases

CTDi 9590.
GeneCardsi GC06P151561.
H-InvDB HIX0025002.
HGNCi HGNC:370. AKAP12.
HPAi HPA006344.
MIMi 604698. gene.
neXtProti NX_Q02952.
PharmGKBi PA24664.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG050472.
InParanoidi Q02952.
KOi K16528.
OMAi VEHSASD.
OrthoDBi EOG7RFTGR.
PhylomeDBi Q02952.
TreeFami TF105411.

Enzyme and pathway databases

SignaLinki Q02952.

Miscellaneous databases

ChiTaRSi AKAP12. human.
GeneWikii AKAP12.
GenomeRNAii 9590.
NextBioi 35991.
PROi Q02952.
SOURCEi Search...

Gene expression databases

Bgeei Q02952.
CleanExi HS_AKAP12.
Genevestigatori Q02952.

Family and domain databases

InterProi IPR028540. AKAP12.
IPR001573. Pkinase-A_anch_WSK-motif.
IPR018459. RII_binding_1.
[Graphical view ]
PANTHERi PTHR23209. PTHR23209. 1 hit.
Pfami PF10522. RII_binding_1. 1 hit.
PF03832. WSK. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein."
    Nauert J.B., Klauck T.M., Langeberg L.K., Scott J.D.
    Curr. Biol. 7:52-62(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-117; GLN-216 AND SER-987.
    Tissue: Heart.
  2. "Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others."
    Sato N., Kokame K., Shimokado K., Kato H., Miyata T.
    J. Biochem. 123:1119-1126(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Umbilical vein endothelial cell.
  3. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-117; GLN-216 AND ASP-1600.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS GLN-216; GLY-920 AND LYS-1355.
    Tissue: Testis.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Sequence of gravin cDNA isolated from a human umbilical vein endothelial cell library."
    Bowditch R.D., Ginsberg M.H.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-1782, VARIANTS GLU-117 AND GLN-216.
    Tissue: Umbilical vein endothelial cell.
  7. "Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera."
    Gordon T., Grove B., Loftus J.C., O'Toole T., McMillan R., Lindstrom J., Ginsberg M.H.
    J. Clin. Invest. 90:992-999(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1478-1782.
    Tissue: Umbilical vein endothelial cell.
  8. "Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles."
    Streb J.W., Kitchen C.M., Gelman I.H., Miano J.M.
    J. Biol. Chem. 279:56014-56023(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-96; SER-371; SER-381; SER-483; SER-557; SER-598; SER-612; SER-627; SER-645; SER-1331 AND SER-1587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-240.

Entry informationi

Entry nameiAKA12_HUMAN
AccessioniPrimary (citable) accession number: Q02952
Secondary accession number(s): O00310
, O00498, Q4LE68, Q5SZ80, Q5TGN1, Q68D82, Q99970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 132 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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