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Q02952

- AKA12_HUMAN

UniProt

Q02952 - AKA12_HUMAN

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Protein

A-kinase anchor protein 12

Gene

AKAP12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

GO - Molecular functioni

  1. adenylate cyclase binding Source: UniProtKB
  2. protein kinase A binding Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. positive regulation of cAMP biosynthetic process Source: UniProtKB
  3. positive regulation of protein kinase A signaling Source: UniProtKB
  4. protein targeting Source: InterPro
  5. regulation of protein kinase C signaling Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ02952.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 12
Short name:
AKAP-12
Alternative name(s):
A-kinase anchor protein 250 kDa
Short name:
AKAP 250
Gravin
Myasthenia gravis autoantigen
Gene namesi
Name:AKAP12
Synonyms:AKAP250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:370. AKAP12.

Subcellular locationi

Cytoplasmcell cortex Curated. Cytoplasmcytoskeleton Curated
Note: May be part of the cortical cytoskeleton.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. cytoskeleton Source: UniProtKB-KW
  3. focal adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 17821781A-kinase anchor protein 12PRO_0000064519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication
Modified residuei75 – 751Phosphoserine1 Publication
Modified residuei96 – 961Phosphoserine1 Publication
Modified residuei219 – 2191Phosphoserine1 Publication
Modified residuei371 – 3711Phosphoserine1 Publication
Modified residuei374 – 3741PhosphotyrosineBy similarity
Modified residuei381 – 3811Phosphoserine1 Publication
Modified residuei483 – 4831Phosphoserine1 Publication
Modified residuei505 – 5051Phosphoserine1 Publication
Modified residuei557 – 5571Phosphoserine1 Publication
Modified residuei598 – 5981Phosphoserine1 Publication
Modified residuei612 – 6121Phosphoserine1 Publication
Modified residuei627 – 6271Phosphoserine1 Publication
Modified residuei645 – 6451Phosphoserine1 Publication
Modified residuei696 – 6961PhosphoserineBy similarity
Modified residuei697 – 6971PhosphoserineBy similarity
Modified residuei698 – 6981PhosphoserineBy similarity
Modified residuei1331 – 13311Phosphoserine1 Publication
Modified residuei1395 – 13951Phosphoserine1 Publication
Modified residuei1587 – 15871Phosphoserine1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

MaxQBiQ02952.
PaxDbiQ02952.
PRIDEiQ02952.

PTM databases

PhosphoSiteiQ02952.

Expressioni

Tissue specificityi

Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.

Inductioni

Activated by lysophosphatidylcholine (lysoPC).

Gene expression databases

BgeeiQ02952.
CleanExiHS_AKAP12.
GenevestigatoriQ02952.

Organism-specific databases

HPAiHPA006344.

Interactioni

Subunit structurei

Binds to dimeric RII-alpha regulatory subunit of PKC.

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2562430,EBI-297353

Protein-protein interaction databases

BioGridi114958. 18 interactions.
IntActiQ02952. 7 interactions.
MINTiMINT-2411728.
STRINGi9606.ENSP00000253332.

Structurei

3D structure databases

ProteinModelPortaliQ02952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini604 – 63431AKAP 1Add
BLAST
Domaini753 – 78331AKAP 2Add
BLAST
Domaini798 – 82831AKAP 3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni266 – 557292Involved in PKC-bindingCuratedAdd
BLAST
Regioni1541 – 155414RII-bindingCuratedAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 1014Poly-Glu

Domaini

Polybasic regions located between residues 266 and 557 are involved in binding PKC.

Sequence similaritiesi

Contains 3 AKAP domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111244.
HOVERGENiHBG050472.
InParanoidiQ02952.
KOiK16528.
OMAiVEHSASD.
OrthoDBiEOG7RFTGR.
PhylomeDBiQ02952.
TreeFamiTF105411.

Family and domain databases

InterProiIPR028540. AKAP12.
IPR001573. Pkinase-A_anch_WSK-motif.
IPR018459. RII_binding_1.
[Graphical view]
PANTHERiPTHR23209. PTHR23209. 1 hit.
PfamiPF10522. RII_binding_1. 1 hit.
PF03832. WSK. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q02952-1) [UniParc]FASTAAdd to Basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAGSSTEQR SPEQPPEGSS TPAEPEPSGG GPSAEAAPDT TADPAIAASD
60 70 80 90 100
PATKLLQKNG QLSTINGVAE QDELSLQEGD LNGQKGALNG QGALNSQEEE
110 120 130 140 150
EVIVTEVGQR DSEDVSKRDS DKEMATKSAV VHDITDDGQE ETPEIIEQIP
160 170 180 190 200
SSESNLEELT QPTESQANDI GFKKVFKFVG FKFTVKKDKT EKPDTVQLLT
210 220 230 240 250
VKKDEGEGAA GAGDHKDPSL GAGEAASKES EPKQSTEKPE ETLKREQSHA
260 270 280 290 300
EISPPAESGQ AVEECKEEGE EKQEKEPSKS AESPTSPVTS ETGSTFKKFF
310 320 330 340 350
TQGWAGWRKK TSFRKPKEDE VEASEKKKEQ EPEKVDTEED GKAEVASEKL
360 370 380 390 400
TASEQAHPQE PAESAHEPRL SAEYEKVELP SEEQVSGSQG PSEEKPAPLA
410 420 430 440 450
TEVFDEKIEV HQEEVVAEVH VSTVEERTEE QKTEVEETAG SVPAEELVEM
460 470 480 490 500
DAEPQEAEPA KELVKLKETC VSGEDPTQGA DLSPDEKVLS KPPEGVVSEV
510 520 530 540 550
EMLSSQERMK VQGSPLKKLF TSTGLKKLSG KKQKGKRGGG DEESGEHTQV
560 570 580 590 600
PADSPDSQEE QKGESSASSP EEPEEITCLE KGLAEVQQDG EAEEGATSDG
610 620 630 640 650
EKKREGVTPW ASFKKMVTPK KRVRRPSESD KEDELDKVKS ATLSSTESTA
660 670 680 690 700
SEMQEEMKGS VEEPKPEEPK RKVDTSVSWE ALICVGSSKK RARRGSSSDE
710 720 730 740 750
EGGPKAMGGD HQKADEAGKD KETGTDGILA GSQEHDPGQG SSSPEQAGSP
760 770 780 790 800
TEGEGVSTWE SFKRLVTPRK KSKSKLEEKS EDSIAGSGVE HSTPDTEPGK
810 820 830 840 850
EESWVSIKKF IPGRRKKRPD GKQEQAPVED AGPTGANEDD SDVPAVVPLS
860 870 880 890 900
EYDAVEREKM EAQQAQKSAE QPEQKAATEV SKELSESQVH MMAAAVADGT
910 920 930 940 950
RAATIIEERS PSWISASVTE PLEQVEAEAA LLTEEVLERE VIAEEEPPTV
960 970 980 990 1000
TEPLPENREA RGDTVVSEAE LTPEAVTAAE TAGPLGAEEG TEASAAEETT
1010 1020 1030 1040 1050
EMVSAVSQLT DSPDTTEEAT PVQEVEGGVP DIEEQERRTQ EVLQAVAEKV
1060 1070 1080 1090 1100
KEESQLPGTG GPEDVLQPVQ RAEAERPEEQ AEASGLKKET DVVLKVDAQE
1110 1120 1130 1140 1150
AKTEPFTQGK VVGQTTPESF EKAPQVTESI ESSELVTTCQ AETLAGVKSQ
1160 1170 1180 1190 1200
EMVMEQAIPP DSVETPTDSE TDGSTPVADF DAPGTTQKDE IVEIHEENEV
1210 1220 1230 1240 1250
ASGTQSGGTE AEAVPAQKER PPAPSSFVFQ EETKEQSKME DTLEHTDKEV
1260 1270 1280 1290 1300
SVETVSILSK TEGTQEADQY ADEKTKDVPF FEGLEGSIDT GITVSREKVT
1310 1320 1330 1340 1350
EVALKGEGTE EAECKKDDAL ELQSHAKSPP SPVEREMVVQ VEREKTEAEP
1360 1370 1380 1390 1400
THVNEEKLEH ETAVTVSEEV SKQLLQTVNV PIIDGAKEVS SLEGSPPPCL
1410 1420 1430 1440 1450
GQEEAVCTKI QVQSSEASFT LTAAAEEEKV LGETANILET GETLEPAGAH
1460 1470 1480 1490 1500
LVLEEKSSEK NEDFAAHPGE DAVPTGPDCQ AKSTPVIVSA TTKKGLSSDL
1510 1520 1530 1540 1550
EGEKTTSLKW KSDEVDEQVA CQEVKVSVAI EDLEPENGIL ELETKSSKLV
1560 1570 1580 1590 1600
QNIIQTAVDQ FVRTEETATE MLTSELQTQA HVIKADSQDA GQETEKEGEE
1610 1620 1630 1640 1650
PQASAQDETP ITSAKEESES TAVGQAHSDI SKDMSEASEK TMTVEVEGST
1660 1670 1680 1690 1700
VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK
1710 1720 1730 1740 1750
GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK
1760 1770 1780
VHSESDKAIT PQAQEELQKQ ERESAKSELT ES
Length:1,782
Mass (Da):191,482
Last modified:January 11, 2011 - v4
Checksum:iDB9DBA4647E6DDD5
GO
Isoform 2 (identifier: Q02952-2) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     99-106: EEEVIVTE → MLGTITIT

Show »
Length:1,684
Mass (Da):181,690
Checksum:i384AEDA06CC83D93
GO
Isoform 3 (identifier: Q02952-3) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-106: E → M

Show »
Length:1,677
Mass (Da):180,990
Checksum:i8533672E99E8A1D6
GO

Sequence cautioni

The sequence BAE06085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1454TPEI → NRN in AAC51366. (PubMed:9000000)Curated
Sequence conflicti423 – 4231T → I in BAE06085. 1 PublicationCurated
Sequence conflicti449 – 4491E → G in AAC51366. (PubMed:9000000)Curated
Sequence conflicti695 – 6951G → R in AAC51366. (PubMed:9000000)Curated
Sequence conflicti868 – 8681S → G in AAC51366. (PubMed:9000000)Curated
Sequence conflicti946 – 9461E → G in CAH18338. (PubMed:17974005)Curated
Sequence conflicti1182 – 11821A → T in CAH18338. (PubMed:17974005)Curated
Sequence conflicti1531 – 15311E → EE in CAH18338. (PubMed:17974005)Curated
Sequence conflicti1531 – 15311E → EE in BAE06085. 1 PublicationCurated
Sequence conflicti1531 – 15311E → EE in AAB58938. 1 PublicationCurated
Sequence conflicti1531 – 15311E → EE in AAA35931. (PubMed:1522245)Curated
Sequence conflicti1582 – 15821V → M in CAH18338. (PubMed:17974005)Curated
Sequence conflicti1582 – 15821V → M in AAA35931. (PubMed:1522245)Curated
Sequence conflicti1602 – 16021Q → L in BAA19927. (PubMed:9604001)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171K → E.3 Publications
Corresponds to variant rs10872670 [ dbSNP | Ensembl ].
VAR_035115
Natural varianti216 – 2161K → Q.4 Publications
Corresponds to variant rs3734799 [ dbSNP | Ensembl ].
VAR_035116
Natural varianti240 – 2401E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035780
Natural varianti920 – 9201E → G.1 Publication
Corresponds to variant rs13212161 [ dbSNP | Ensembl ].
VAR_035117
Natural varianti987 – 9871A → S.1 Publication
Corresponds to variant rs1042069 [ dbSNP | Ensembl ].
VAR_056731
Natural varianti1096 – 10961V → I.
Corresponds to variant rs3734797 [ dbSNP | Ensembl ].
VAR_035118
Natural varianti1296 – 12961R → L.
Corresponds to variant rs9478198 [ dbSNP | Ensembl ].
VAR_035119
Natural varianti1355 – 13551E → K.1 Publication
Corresponds to variant rs12201388 [ dbSNP | Ensembl ].
VAR_035120
Natural varianti1600 – 16001E → D.1 Publication
Corresponds to variant rs3823310 [ dbSNP | Ensembl ].
VAR_035121
Natural varianti1689 – 16891E → D.
Corresponds to variant rs3734795 [ dbSNP | Ensembl ].
VAR_035122

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 105105Missing in isoform 3. 1 PublicationVSP_028133Add
BLAST
Alternative sequencei1 – 9898Missing in isoform 2. 1 PublicationVSP_004110Add
BLAST
Alternative sequencei99 – 1068EEEVIVTE → MLGTITIT in isoform 2. 1 PublicationVSP_004111
Alternative sequencei106 – 1061E → M in isoform 3. 1 PublicationVSP_028134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81607 mRNA. Translation: AAC51366.1.
AB003476 mRNA. Translation: BAA19927.1.
AB210003 mRNA. Translation: BAE06085.1. Different initiation.
CR749527 mRNA. Translation: CAH18338.1.
AL590413, AL033392, AL356535 Genomic DNA. Translation: CAI13590.1.
AL356535, AL033392, AL590413 Genomic DNA. Translation: CAI16151.1.
AL033392, AL356535, AL590413 Genomic DNA. Translation: CAI20467.1.
AL590413, AL033392 Genomic DNA. Translation: CAI13591.1.
AL033392, AL590413 Genomic DNA. Translation: CAI20468.1.
AF001504 mRNA. Translation: AAB58938.1.
M96322 mRNA. Translation: AAA35931.1.
CCDSiCCDS5229.1. [Q02952-1]
CCDS5230.1. [Q02952-2]
PIRiA43922.
JW0057.
RefSeqiNP_005091.2. NM_005100.3. [Q02952-1]
NP_653080.1. NM_144497.2. [Q02952-2]
XP_005267290.1. XM_005267233.1. [Q02952-1]
XP_005267291.1. XM_005267234.2. [Q02952-2]
XP_005267292.1. XM_005267235.1. [Q02952-3]
UniGeneiHs.371240.

Genome annotation databases

EnsembliENST00000253332; ENSP00000253332; ENSG00000131016. [Q02952-1]
ENST00000354675; ENSP00000346702; ENSG00000131016. [Q02952-2]
ENST00000359755; ENSP00000352794; ENSG00000131016. [Q02952-3]
ENST00000402676; ENSP00000384537; ENSG00000131016. [Q02952-1]
GeneIDi9590.
KEGGihsa:9590.
UCSCiuc003qoe.3. human. [Q02952-1]
uc003qof.3. human. [Q02952-2]
uc003qog.3. human. [Q02952-3]

Polymorphism databases

DMDMi317373554.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81607 mRNA. Translation: AAC51366.1 .
AB003476 mRNA. Translation: BAA19927.1 .
AB210003 mRNA. Translation: BAE06085.1 . Different initiation.
CR749527 mRNA. Translation: CAH18338.1 .
AL590413 , AL033392 , AL356535 Genomic DNA. Translation: CAI13590.1 .
AL356535 , AL033392 , AL590413 Genomic DNA. Translation: CAI16151.1 .
AL033392 , AL356535 , AL590413 Genomic DNA. Translation: CAI20467.1 .
AL590413 , AL033392 Genomic DNA. Translation: CAI13591.1 .
AL033392 , AL590413 Genomic DNA. Translation: CAI20468.1 .
AF001504 mRNA. Translation: AAB58938.1 .
M96322 mRNA. Translation: AAA35931.1 .
CCDSi CCDS5229.1. [Q02952-1 ]
CCDS5230.1. [Q02952-2 ]
PIRi A43922.
JW0057.
RefSeqi NP_005091.2. NM_005100.3. [Q02952-1 ]
NP_653080.1. NM_144497.2. [Q02952-2 ]
XP_005267290.1. XM_005267233.1. [Q02952-1 ]
XP_005267291.1. XM_005267234.2. [Q02952-2 ]
XP_005267292.1. XM_005267235.1. [Q02952-3 ]
UniGenei Hs.371240.

3D structure databases

ProteinModelPortali Q02952.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114958. 18 interactions.
IntActi Q02952. 7 interactions.
MINTi MINT-2411728.
STRINGi 9606.ENSP00000253332.

PTM databases

PhosphoSitei Q02952.

Polymorphism databases

DMDMi 317373554.

Proteomic databases

MaxQBi Q02952.
PaxDbi Q02952.
PRIDEi Q02952.

Protocols and materials databases

DNASUi 9590.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253332 ; ENSP00000253332 ; ENSG00000131016 . [Q02952-1 ]
ENST00000354675 ; ENSP00000346702 ; ENSG00000131016 . [Q02952-2 ]
ENST00000359755 ; ENSP00000352794 ; ENSG00000131016 . [Q02952-3 ]
ENST00000402676 ; ENSP00000384537 ; ENSG00000131016 . [Q02952-1 ]
GeneIDi 9590.
KEGGi hsa:9590.
UCSCi uc003qoe.3. human. [Q02952-1 ]
uc003qof.3. human. [Q02952-2 ]
uc003qog.3. human. [Q02952-3 ]

Organism-specific databases

CTDi 9590.
GeneCardsi GC06P151561.
H-InvDB HIX0025002.
HGNCi HGNC:370. AKAP12.
HPAi HPA006344.
MIMi 604698. gene.
neXtProti NX_Q02952.
PharmGKBi PA24664.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111244.
HOVERGENi HBG050472.
InParanoidi Q02952.
KOi K16528.
OMAi VEHSASD.
OrthoDBi EOG7RFTGR.
PhylomeDBi Q02952.
TreeFami TF105411.

Enzyme and pathway databases

SignaLinki Q02952.

Miscellaneous databases

ChiTaRSi AKAP12. human.
GeneWikii AKAP12.
GenomeRNAii 9590.
NextBioi 35991.
PROi Q02952.
SOURCEi Search...

Gene expression databases

Bgeei Q02952.
CleanExi HS_AKAP12.
Genevestigatori Q02952.

Family and domain databases

InterProi IPR028540. AKAP12.
IPR001573. Pkinase-A_anch_WSK-motif.
IPR018459. RII_binding_1.
[Graphical view ]
PANTHERi PTHR23209. PTHR23209. 1 hit.
Pfami PF10522. RII_binding_1. 1 hit.
PF03832. WSK. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein."
    Nauert J.B., Klauck T.M., Langeberg L.K., Scott J.D.
    Curr. Biol. 7:52-62(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-117; GLN-216 AND SER-987.
    Tissue: Heart.
  2. "Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others."
    Sato N., Kokame K., Shimokado K., Kato H., Miyata T.
    J. Biochem. 123:1119-1126(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Umbilical vein endothelial cell.
  3. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-117; GLN-216 AND ASP-1600.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS GLN-216; GLY-920 AND LYS-1355.
    Tissue: Testis.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Sequence of gravin cDNA isolated from a human umbilical vein endothelial cell library."
    Bowditch R.D., Ginsberg M.H.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-1782, VARIANTS GLU-117 AND GLN-216.
    Tissue: Umbilical vein endothelial cell.
  7. "Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera."
    Gordon T., Grove B., Loftus J.C., O'Toole T., McMillan R., Lindstrom J., Ginsberg M.H.
    J. Clin. Invest. 90:992-999(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1478-1782.
    Tissue: Umbilical vein endothelial cell.
  8. "Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles."
    Streb J.W., Kitchen C.M., Gelman I.H., Miano J.M.
    J. Biol. Chem. 279:56014-56023(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
    Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
    Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION AT GLY-2.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-96; SER-371; SER-381; SER-483; SER-557; SER-598; SER-612; SER-627; SER-645; SER-1331 AND SER-1587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-240.

Entry informationi

Entry nameiAKA12_HUMAN
AccessioniPrimary (citable) accession number: Q02952
Secondary accession number(s): O00310
, O00498, Q4LE68, Q5SZ80, Q5TGN1, Q68D82, Q99970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3