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Q02952

- AKA12_HUMAN

UniProt

Q02952 - AKA12_HUMAN

Protein

A-kinase anchor protein 12

Gene

AKAP12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 4 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

    GO - Molecular functioni

    1. adenylate cyclase binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. protein kinase A binding Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc
    2. positive regulation of cAMP biosynthetic process Source: UniProtKB
    3. positive regulation of protein kinase A signaling Source: UniProtKB
    4. protein targeting Source: InterPro
    5. regulation of protein kinase C signaling Source: InterPro

    Enzyme and pathway databases

    SignaLinkiQ02952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    A-kinase anchor protein 12
    Short name:
    AKAP-12
    Alternative name(s):
    A-kinase anchor protein 250 kDa
    Short name:
    AKAP 250
    Gravin
    Myasthenia gravis autoantigen
    Gene namesi
    Name:AKAP12
    Synonyms:AKAP250
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:370. AKAP12.

    Subcellular locationi

    Cytoplasmcell cortex Curated. Cytoplasmcytoskeleton Curated
    Note: May be part of the cortical cytoskeleton.

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. cytoplasm Source: ProtInc
    3. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 17821781A-kinase anchor protein 12PRO_0000064519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycine1 Publication
    Modified residuei75 – 751Phosphoserine1 Publication
    Modified residuei96 – 961Phosphoserine1 Publication
    Modified residuei219 – 2191Phosphoserine1 Publication
    Modified residuei371 – 3711Phosphoserine1 Publication
    Modified residuei374 – 3741PhosphotyrosineBy similarity
    Modified residuei381 – 3811Phosphoserine1 Publication
    Modified residuei483 – 4831Phosphoserine1 Publication
    Modified residuei505 – 5051Phosphoserine1 Publication
    Modified residuei557 – 5571Phosphoserine1 Publication
    Modified residuei598 – 5981Phosphoserine1 Publication
    Modified residuei612 – 6121Phosphoserine1 Publication
    Modified residuei627 – 6271Phosphoserine1 Publication
    Modified residuei645 – 6451Phosphoserine1 Publication
    Modified residuei696 – 6961PhosphoserineBy similarity
    Modified residuei697 – 6971PhosphoserineBy similarity
    Modified residuei698 – 6981PhosphoserineBy similarity
    Modified residuei1331 – 13311Phosphoserine1 Publication
    Modified residuei1395 – 13951Phosphoserine1 Publication
    Modified residuei1587 – 15871Phosphoserine1 Publication

    Keywords - PTMi

    Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    MaxQBiQ02952.
    PaxDbiQ02952.
    PRIDEiQ02952.

    PTM databases

    PhosphoSiteiQ02952.

    Expressioni

    Tissue specificityi

    Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.

    Inductioni

    Activated by lysophosphatidylcholine (lysoPC).

    Gene expression databases

    BgeeiQ02952.
    CleanExiHS_AKAP12.
    GenevestigatoriQ02952.

    Organism-specific databases

    HPAiHPA006344.

    Interactioni

    Subunit structurei

    Binds to dimeric RII-alpha regulatory subunit of PKC.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EGFRP005332EBI-2562430,EBI-297353

    Protein-protein interaction databases

    BioGridi114958. 13 interactions.
    IntActiQ02952. 7 interactions.
    MINTiMINT-2411728.
    STRINGi9606.ENSP00000253332.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02952.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini604 – 63431AKAP 1Add
    BLAST
    Domaini753 – 78331AKAP 2Add
    BLAST
    Domaini798 – 82831AKAP 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni266 – 557292Involved in PKC-bindingCuratedAdd
    BLAST
    Regioni1541 – 155414RII-bindingCuratedAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi98 – 1014Poly-Glu

    Domaini

    Polybasic regions located between residues 266 and 557 are involved in binding PKC.

    Sequence similaritiesi

    Contains 3 AKAP domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG050472.
    InParanoidiQ02952.
    KOiK16528.
    OMAiVEHSASD.
    OrthoDBiEOG7RFTGR.
    PhylomeDBiQ02952.
    TreeFamiTF105411.

    Family and domain databases

    InterProiIPR028540. AKAP12.
    IPR001573. Pkinase-A_anch_WSK-motif.
    IPR018459. RII_binding_1.
    [Graphical view]
    PANTHERiPTHR23209. PTHR23209. 1 hit.
    PfamiPF10522. RII_binding_1. 1 hit.
    PF03832. WSK. 3 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q02952-1) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGAGSSTEQR SPEQPPEGSS TPAEPEPSGG GPSAEAAPDT TADPAIAASD     50
    PATKLLQKNG QLSTINGVAE QDELSLQEGD LNGQKGALNG QGALNSQEEE 100
    EVIVTEVGQR DSEDVSKRDS DKEMATKSAV VHDITDDGQE ETPEIIEQIP 150
    SSESNLEELT QPTESQANDI GFKKVFKFVG FKFTVKKDKT EKPDTVQLLT 200
    VKKDEGEGAA GAGDHKDPSL GAGEAASKES EPKQSTEKPE ETLKREQSHA 250
    EISPPAESGQ AVEECKEEGE EKQEKEPSKS AESPTSPVTS ETGSTFKKFF 300
    TQGWAGWRKK TSFRKPKEDE VEASEKKKEQ EPEKVDTEED GKAEVASEKL 350
    TASEQAHPQE PAESAHEPRL SAEYEKVELP SEEQVSGSQG PSEEKPAPLA 400
    TEVFDEKIEV HQEEVVAEVH VSTVEERTEE QKTEVEETAG SVPAEELVEM 450
    DAEPQEAEPA KELVKLKETC VSGEDPTQGA DLSPDEKVLS KPPEGVVSEV 500
    EMLSSQERMK VQGSPLKKLF TSTGLKKLSG KKQKGKRGGG DEESGEHTQV 550
    PADSPDSQEE QKGESSASSP EEPEEITCLE KGLAEVQQDG EAEEGATSDG 600
    EKKREGVTPW ASFKKMVTPK KRVRRPSESD KEDELDKVKS ATLSSTESTA 650
    SEMQEEMKGS VEEPKPEEPK RKVDTSVSWE ALICVGSSKK RARRGSSSDE 700
    EGGPKAMGGD HQKADEAGKD KETGTDGILA GSQEHDPGQG SSSPEQAGSP 750
    TEGEGVSTWE SFKRLVTPRK KSKSKLEEKS EDSIAGSGVE HSTPDTEPGK 800
    EESWVSIKKF IPGRRKKRPD GKQEQAPVED AGPTGANEDD SDVPAVVPLS 850
    EYDAVEREKM EAQQAQKSAE QPEQKAATEV SKELSESQVH MMAAAVADGT 900
    RAATIIEERS PSWISASVTE PLEQVEAEAA LLTEEVLERE VIAEEEPPTV 950
    TEPLPENREA RGDTVVSEAE LTPEAVTAAE TAGPLGAEEG TEASAAEETT 1000
    EMVSAVSQLT DSPDTTEEAT PVQEVEGGVP DIEEQERRTQ EVLQAVAEKV 1050
    KEESQLPGTG GPEDVLQPVQ RAEAERPEEQ AEASGLKKET DVVLKVDAQE 1100
    AKTEPFTQGK VVGQTTPESF EKAPQVTESI ESSELVTTCQ AETLAGVKSQ 1150
    EMVMEQAIPP DSVETPTDSE TDGSTPVADF DAPGTTQKDE IVEIHEENEV 1200
    ASGTQSGGTE AEAVPAQKER PPAPSSFVFQ EETKEQSKME DTLEHTDKEV 1250
    SVETVSILSK TEGTQEADQY ADEKTKDVPF FEGLEGSIDT GITVSREKVT 1300
    EVALKGEGTE EAECKKDDAL ELQSHAKSPP SPVEREMVVQ VEREKTEAEP 1350
    THVNEEKLEH ETAVTVSEEV SKQLLQTVNV PIIDGAKEVS SLEGSPPPCL 1400
    GQEEAVCTKI QVQSSEASFT LTAAAEEEKV LGETANILET GETLEPAGAH 1450
    LVLEEKSSEK NEDFAAHPGE DAVPTGPDCQ AKSTPVIVSA TTKKGLSSDL 1500
    EGEKTTSLKW KSDEVDEQVA CQEVKVSVAI EDLEPENGIL ELETKSSKLV 1550
    QNIIQTAVDQ FVRTEETATE MLTSELQTQA HVIKADSQDA GQETEKEGEE 1600
    PQASAQDETP ITSAKEESES TAVGQAHSDI SKDMSEASEK TMTVEVEGST 1650
    VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK 1700
    GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK 1750
    VHSESDKAIT PQAQEELQKQ ERESAKSELT ES 1782
    Length:1,782
    Mass (Da):191,482
    Last modified:January 11, 2011 - v4
    Checksum:iDB9DBA4647E6DDD5
    GO
    Isoform 2 (identifier: Q02952-2) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-98: Missing.
         99-106: EEEVIVTE → MLGTITIT

    Show »
    Length:1,684
    Mass (Da):181,690
    Checksum:i384AEDA06CC83D93
    GO
    Isoform 3 (identifier: Q02952-3) [UniParc]FASTAAdd to Basket

    Also known as: Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-105: Missing.
         106-106: E → M

    Show »
    Length:1,677
    Mass (Da):180,990
    Checksum:i8533672E99E8A1D6
    GO

    Sequence cautioni

    The sequence BAE06085.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1454TPEI → NRN in AAC51366. (PubMed:9000000)Curated
    Sequence conflicti423 – 4231T → I in BAE06085. 1 PublicationCurated
    Sequence conflicti449 – 4491E → G in AAC51366. (PubMed:9000000)Curated
    Sequence conflicti695 – 6951G → R in AAC51366. (PubMed:9000000)Curated
    Sequence conflicti868 – 8681S → G in AAC51366. (PubMed:9000000)Curated
    Sequence conflicti946 – 9461E → G in CAH18338. (PubMed:17974005)Curated
    Sequence conflicti1182 – 11821A → T in CAH18338. (PubMed:17974005)Curated
    Sequence conflicti1531 – 15311E → EE in CAH18338. (PubMed:17974005)Curated
    Sequence conflicti1531 – 15311E → EE in BAE06085. 1 PublicationCurated
    Sequence conflicti1531 – 15311E → EE in AAB58938. 1 PublicationCurated
    Sequence conflicti1531 – 15311E → EE in AAA35931. (PubMed:1522245)Curated
    Sequence conflicti1582 – 15821V → M in CAH18338. (PubMed:17974005)Curated
    Sequence conflicti1582 – 15821V → M in AAA35931. (PubMed:1522245)Curated
    Sequence conflicti1602 – 16021Q → L in BAA19927. (PubMed:9604001)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171K → E.3 Publications
    Corresponds to variant rs10872670 [ dbSNP | Ensembl ].
    VAR_035115
    Natural varianti216 – 2161K → Q.4 Publications
    Corresponds to variant rs3734799 [ dbSNP | Ensembl ].
    VAR_035116
    Natural varianti240 – 2401E → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035780
    Natural varianti920 – 9201E → G.1 Publication
    Corresponds to variant rs13212161 [ dbSNP | Ensembl ].
    VAR_035117
    Natural varianti987 – 9871A → S.1 Publication
    Corresponds to variant rs1042069 [ dbSNP | Ensembl ].
    VAR_056731
    Natural varianti1096 – 10961V → I.
    Corresponds to variant rs3734797 [ dbSNP | Ensembl ].
    VAR_035118
    Natural varianti1296 – 12961R → L.
    Corresponds to variant rs9478198 [ dbSNP | Ensembl ].
    VAR_035119
    Natural varianti1355 – 13551E → K.1 Publication
    Corresponds to variant rs12201388 [ dbSNP | Ensembl ].
    VAR_035120
    Natural varianti1600 – 16001E → D.1 Publication
    Corresponds to variant rs3823310 [ dbSNP | Ensembl ].
    VAR_035121
    Natural varianti1689 – 16891E → D.
    Corresponds to variant rs3734795 [ dbSNP | Ensembl ].
    VAR_035122

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 105105Missing in isoform 3. 1 PublicationVSP_028133Add
    BLAST
    Alternative sequencei1 – 9898Missing in isoform 2. 1 PublicationVSP_004110Add
    BLAST
    Alternative sequencei99 – 1068EEEVIVTE → MLGTITIT in isoform 2. 1 PublicationVSP_004111
    Alternative sequencei106 – 1061E → M in isoform 3. 1 PublicationVSP_028134

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81607 mRNA. Translation: AAC51366.1.
    AB003476 mRNA. Translation: BAA19927.1.
    AB210003 mRNA. Translation: BAE06085.1. Different initiation.
    CR749527 mRNA. Translation: CAH18338.1.
    AL590413, AL033392, AL356535 Genomic DNA. Translation: CAI13590.1.
    AL356535, AL033392, AL590413 Genomic DNA. Translation: CAI16151.1.
    AL033392, AL356535, AL590413 Genomic DNA. Translation: CAI20467.1.
    AL590413, AL033392 Genomic DNA. Translation: CAI13591.1.
    AL033392, AL590413 Genomic DNA. Translation: CAI20468.1.
    AF001504 mRNA. Translation: AAB58938.1.
    M96322 mRNA. Translation: AAA35931.1.
    CCDSiCCDS5229.1. [Q02952-1]
    CCDS5230.1. [Q02952-2]
    PIRiA43922.
    JW0057.
    RefSeqiNP_005091.2. NM_005100.3. [Q02952-1]
    NP_653080.1. NM_144497.2. [Q02952-2]
    XP_005267290.1. XM_005267233.1. [Q02952-1]
    XP_005267291.1. XM_005267234.2. [Q02952-2]
    XP_005267292.1. XM_005267235.1. [Q02952-3]
    UniGeneiHs.371240.

    Genome annotation databases

    EnsembliENST00000253332; ENSP00000253332; ENSG00000131016. [Q02952-1]
    ENST00000354675; ENSP00000346702; ENSG00000131016. [Q02952-2]
    ENST00000359755; ENSP00000352794; ENSG00000131016. [Q02952-3]
    ENST00000402676; ENSP00000384537; ENSG00000131016. [Q02952-1]
    GeneIDi9590.
    KEGGihsa:9590.
    UCSCiuc003qoe.3. human. [Q02952-1]
    uc003qof.3. human. [Q02952-2]
    uc003qog.3. human. [Q02952-3]

    Polymorphism databases

    DMDMi317373554.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81607 mRNA. Translation: AAC51366.1 .
    AB003476 mRNA. Translation: BAA19927.1 .
    AB210003 mRNA. Translation: BAE06085.1 . Different initiation.
    CR749527 mRNA. Translation: CAH18338.1 .
    AL590413 , AL033392 , AL356535 Genomic DNA. Translation: CAI13590.1 .
    AL356535 , AL033392 , AL590413 Genomic DNA. Translation: CAI16151.1 .
    AL033392 , AL356535 , AL590413 Genomic DNA. Translation: CAI20467.1 .
    AL590413 , AL033392 Genomic DNA. Translation: CAI13591.1 .
    AL033392 , AL590413 Genomic DNA. Translation: CAI20468.1 .
    AF001504 mRNA. Translation: AAB58938.1 .
    M96322 mRNA. Translation: AAA35931.1 .
    CCDSi CCDS5229.1. [Q02952-1 ]
    CCDS5230.1. [Q02952-2 ]
    PIRi A43922.
    JW0057.
    RefSeqi NP_005091.2. NM_005100.3. [Q02952-1 ]
    NP_653080.1. NM_144497.2. [Q02952-2 ]
    XP_005267290.1. XM_005267233.1. [Q02952-1 ]
    XP_005267291.1. XM_005267234.2. [Q02952-2 ]
    XP_005267292.1. XM_005267235.1. [Q02952-3 ]
    UniGenei Hs.371240.

    3D structure databases

    ProteinModelPortali Q02952.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114958. 13 interactions.
    IntActi Q02952. 7 interactions.
    MINTi MINT-2411728.
    STRINGi 9606.ENSP00000253332.

    PTM databases

    PhosphoSitei Q02952.

    Polymorphism databases

    DMDMi 317373554.

    Proteomic databases

    MaxQBi Q02952.
    PaxDbi Q02952.
    PRIDEi Q02952.

    Protocols and materials databases

    DNASUi 9590.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253332 ; ENSP00000253332 ; ENSG00000131016 . [Q02952-1 ]
    ENST00000354675 ; ENSP00000346702 ; ENSG00000131016 . [Q02952-2 ]
    ENST00000359755 ; ENSP00000352794 ; ENSG00000131016 . [Q02952-3 ]
    ENST00000402676 ; ENSP00000384537 ; ENSG00000131016 . [Q02952-1 ]
    GeneIDi 9590.
    KEGGi hsa:9590.
    UCSCi uc003qoe.3. human. [Q02952-1 ]
    uc003qof.3. human. [Q02952-2 ]
    uc003qog.3. human. [Q02952-3 ]

    Organism-specific databases

    CTDi 9590.
    GeneCardsi GC06P151561.
    H-InvDB HIX0025002.
    HGNCi HGNC:370. AKAP12.
    HPAi HPA006344.
    MIMi 604698. gene.
    neXtProti NX_Q02952.
    PharmGKBi PA24664.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG050472.
    InParanoidi Q02952.
    KOi K16528.
    OMAi VEHSASD.
    OrthoDBi EOG7RFTGR.
    PhylomeDBi Q02952.
    TreeFami TF105411.

    Enzyme and pathway databases

    SignaLinki Q02952.

    Miscellaneous databases

    ChiTaRSi AKAP12. human.
    GeneWikii AKAP12.
    GenomeRNAii 9590.
    NextBioi 35991.
    PROi Q02952.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02952.
    CleanExi HS_AKAP12.
    Genevestigatori Q02952.

    Family and domain databases

    InterProi IPR028540. AKAP12.
    IPR001573. Pkinase-A_anch_WSK-motif.
    IPR018459. RII_binding_1.
    [Graphical view ]
    PANTHERi PTHR23209. PTHR23209. 1 hit.
    Pfami PF10522. RII_binding_1. 1 hit.
    PF03832. WSK. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein."
      Nauert J.B., Klauck T.M., Langeberg L.K., Scott J.D.
      Curr. Biol. 7:52-62(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLU-117; GLN-216 AND SER-987.
      Tissue: Heart.
    2. "Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others."
      Sato N., Kokame K., Shimokado K., Kato H., Miyata T.
      J. Biochem. 123:1119-1126(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Umbilical vein endothelial cell.
    3. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLU-117; GLN-216 AND ASP-1600.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS GLN-216; GLY-920 AND LYS-1355.
      Tissue: Testis.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Sequence of gravin cDNA isolated from a human umbilical vein endothelial cell library."
      Bowditch R.D., Ginsberg M.H.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 43-1782, VARIANTS GLU-117 AND GLN-216.
      Tissue: Umbilical vein endothelial cell.
    7. "Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera."
      Gordon T., Grove B., Loftus J.C., O'Toole T., McMillan R., Lindstrom J., Ginsberg M.H.
      J. Clin. Invest. 90:992-999(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1478-1782.
      Tissue: Umbilical vein endothelial cell.
    8. "Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles."
      Streb J.W., Kitchen C.M., Gelman I.H., Miano J.M.
      J. Biol. Chem. 279:56014-56023(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING.
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1395, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
      Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E., Tsunasawa S., Utsumi T.
      Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYRISTOYLATION AT GLY-2.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-96; SER-371; SER-381; SER-483; SER-557; SER-598; SER-612; SER-627; SER-645; SER-1331 AND SER-1587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-240.

    Entry informationi

    Entry nameiAKA12_HUMAN
    AccessioniPrimary (citable) accession number: Q02952
    Secondary accession number(s): O00310
    , O00498, Q4LE68, Q5SZ80, Q5TGN1, Q68D82, Q99970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 133 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3