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Protein

A-kinase anchor protein 12

Gene

AKAP12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

GO - Molecular functioni

  • adenylate cyclase binding Source: UniProtKB
  • protein kinase A binding Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of cAMP biosynthetic process Source: UniProtKB
  • positive regulation of protein kinase A signaling Source: UniProtKB
  • protein targeting Source: InterPro
  • regulation of protein kinase C signaling Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131016-MONOMER.
SignaLinkiQ02952.

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 12
Short name:
AKAP-12
Alternative name(s):
A-kinase anchor protein 250 kDa
Short name:
AKAP 250
Gravin
Myasthenia gravis autoantigen
Gene namesi
Name:AKAP12
Synonyms:AKAP250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:370. AKAP12.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB-SubCell
  • cytoplasm Source: HPA
  • cytoskeleton Source: UniProtKB-SubCell
  • focal adhesion Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9590.
OpenTargetsiENSG00000131016.
PharmGKBiPA24664.

Polymorphism and mutation databases

BioMutaiAKAP12.
DMDMi317373554.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000645192 – 1782A-kinase anchor protein 12Add BLAST1781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine3 Publications1
Modified residuei11PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei28PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei248PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei280PhosphoserineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1
Modified residuei374PhosphotyrosineBy similarity1
Modified residuei381PhosphoserineCombined sources1
Modified residuei392PhosphoserineBy similarity1
Modified residuei483PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1
Modified residuei554PhosphoserineBy similarity1
Modified residuei557PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1
Modified residuei612PhosphoserineCombined sources1
Modified residuei627PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei642PhosphothreonineBy similarity1
Modified residuei644PhosphoserineBy similarity1
Modified residuei645PhosphoserineCombined sources1
Modified residuei648PhosphoserineBy similarity1
Modified residuei651PhosphoserineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei698PhosphoserineCombined sources1
Modified residuei749PhosphoserineBy similarity1
Modified residuei761PhosphoserineCombined sources1
Modified residuei787PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1
Cross-linki1051Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1331PhosphoserineCombined sources1
Modified residuei1391PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1587PhosphoserineCombined sources1
Modified residuei1727PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02952.
MaxQBiQ02952.
PaxDbiQ02952.
PeptideAtlasiQ02952.
PRIDEiQ02952.

PTM databases

iPTMnetiQ02952.
PhosphoSitePlusiQ02952.
SwissPalmiQ02952.

Expressioni

Tissue specificityi

Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells.

Inductioni

Activated by lysophosphatidylcholine (lysoPC).

Gene expression databases

BgeeiENSG00000131016.
CleanExiHS_AKAP12.
GenevisibleiQ02952. HS.

Organism-specific databases

HPAiCAB026379.
HPA006344.
HPA056230.

Interactioni

Subunit structurei

Binds to dimeric RII-alpha regulatory subunit of PKC.

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-2562430,EBI-297353

GO - Molecular functioni

  • adenylate cyclase binding Source: UniProtKB
  • protein kinase A binding Source: ProtInc

Protein-protein interaction databases

BioGridi114958. 33 interactors.
IntActiQ02952. 24 interactors.
MINTiMINT-2411728.
STRINGi9606.ENSP00000253332.

Structurei

3D structure databases

ProteinModelPortaliQ02952.
SMRiQ02952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini604 – 634AKAP 1Add BLAST31
Domaini753 – 783AKAP 2Add BLAST31
Domaini798 – 828AKAP 3Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni266 – 557Involved in PKC-bindingCuratedAdd BLAST292
Regioni1541 – 1554RII-bindingCuratedAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 101Poly-Glu4

Domaini

Polybasic regions located between residues 266 and 557 are involved in binding PKC.

Sequence similaritiesi

Contains 3 AKAP domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFC9. Eukaryota.
ENOG4110Y3C. LUCA.
GeneTreeiENSGT00730000111244.
HOVERGENiHBG050472.
InParanoidiQ02952.
KOiK16528.
OMAiCLEKGLA.
OrthoDBiEOG091G01X9.
PhylomeDBiQ02952.
TreeFamiTF105411.

Family and domain databases

InterProiIPR028540. AKAP12.
IPR001573. Pkinase-A_anch_WSK-motif.
IPR018459. RII_binding_1.
[Graphical view]
PANTHERiPTHR23209. PTHR23209. 1 hit.
PfamiPF10522. RII_binding_1. 1 hit.
PF03832. WSK. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02952-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAGSSTEQR SPEQPPEGSS TPAEPEPSGG GPSAEAAPDT TADPAIAASD
60 70 80 90 100
PATKLLQKNG QLSTINGVAE QDELSLQEGD LNGQKGALNG QGALNSQEEE
110 120 130 140 150
EVIVTEVGQR DSEDVSKRDS DKEMATKSAV VHDITDDGQE ETPEIIEQIP
160 170 180 190 200
SSESNLEELT QPTESQANDI GFKKVFKFVG FKFTVKKDKT EKPDTVQLLT
210 220 230 240 250
VKKDEGEGAA GAGDHKDPSL GAGEAASKES EPKQSTEKPE ETLKREQSHA
260 270 280 290 300
EISPPAESGQ AVEECKEEGE EKQEKEPSKS AESPTSPVTS ETGSTFKKFF
310 320 330 340 350
TQGWAGWRKK TSFRKPKEDE VEASEKKKEQ EPEKVDTEED GKAEVASEKL
360 370 380 390 400
TASEQAHPQE PAESAHEPRL SAEYEKVELP SEEQVSGSQG PSEEKPAPLA
410 420 430 440 450
TEVFDEKIEV HQEEVVAEVH VSTVEERTEE QKTEVEETAG SVPAEELVEM
460 470 480 490 500
DAEPQEAEPA KELVKLKETC VSGEDPTQGA DLSPDEKVLS KPPEGVVSEV
510 520 530 540 550
EMLSSQERMK VQGSPLKKLF TSTGLKKLSG KKQKGKRGGG DEESGEHTQV
560 570 580 590 600
PADSPDSQEE QKGESSASSP EEPEEITCLE KGLAEVQQDG EAEEGATSDG
610 620 630 640 650
EKKREGVTPW ASFKKMVTPK KRVRRPSESD KEDELDKVKS ATLSSTESTA
660 670 680 690 700
SEMQEEMKGS VEEPKPEEPK RKVDTSVSWE ALICVGSSKK RARRGSSSDE
710 720 730 740 750
EGGPKAMGGD HQKADEAGKD KETGTDGILA GSQEHDPGQG SSSPEQAGSP
760 770 780 790 800
TEGEGVSTWE SFKRLVTPRK KSKSKLEEKS EDSIAGSGVE HSTPDTEPGK
810 820 830 840 850
EESWVSIKKF IPGRRKKRPD GKQEQAPVED AGPTGANEDD SDVPAVVPLS
860 870 880 890 900
EYDAVEREKM EAQQAQKSAE QPEQKAATEV SKELSESQVH MMAAAVADGT
910 920 930 940 950
RAATIIEERS PSWISASVTE PLEQVEAEAA LLTEEVLERE VIAEEEPPTV
960 970 980 990 1000
TEPLPENREA RGDTVVSEAE LTPEAVTAAE TAGPLGAEEG TEASAAEETT
1010 1020 1030 1040 1050
EMVSAVSQLT DSPDTTEEAT PVQEVEGGVP DIEEQERRTQ EVLQAVAEKV
1060 1070 1080 1090 1100
KEESQLPGTG GPEDVLQPVQ RAEAERPEEQ AEASGLKKET DVVLKVDAQE
1110 1120 1130 1140 1150
AKTEPFTQGK VVGQTTPESF EKAPQVTESI ESSELVTTCQ AETLAGVKSQ
1160 1170 1180 1190 1200
EMVMEQAIPP DSVETPTDSE TDGSTPVADF DAPGTTQKDE IVEIHEENEV
1210 1220 1230 1240 1250
ASGTQSGGTE AEAVPAQKER PPAPSSFVFQ EETKEQSKME DTLEHTDKEV
1260 1270 1280 1290 1300
SVETVSILSK TEGTQEADQY ADEKTKDVPF FEGLEGSIDT GITVSREKVT
1310 1320 1330 1340 1350
EVALKGEGTE EAECKKDDAL ELQSHAKSPP SPVEREMVVQ VEREKTEAEP
1360 1370 1380 1390 1400
THVNEEKLEH ETAVTVSEEV SKQLLQTVNV PIIDGAKEVS SLEGSPPPCL
1410 1420 1430 1440 1450
GQEEAVCTKI QVQSSEASFT LTAAAEEEKV LGETANILET GETLEPAGAH
1460 1470 1480 1490 1500
LVLEEKSSEK NEDFAAHPGE DAVPTGPDCQ AKSTPVIVSA TTKKGLSSDL
1510 1520 1530 1540 1550
EGEKTTSLKW KSDEVDEQVA CQEVKVSVAI EDLEPENGIL ELETKSSKLV
1560 1570 1580 1590 1600
QNIIQTAVDQ FVRTEETATE MLTSELQTQA HVIKADSQDA GQETEKEGEE
1610 1620 1630 1640 1650
PQASAQDETP ITSAKEESES TAVGQAHSDI SKDMSEASEK TMTVEVEGST
1660 1670 1680 1690 1700
VNDQQLEEVV LPSEEEGGGA GTKSVPEDDG HALLAERIEK SLVEPKEDEK
1710 1720 1730 1740 1750
GDDVDDPENQ NSALADTDAS GGLTKESPDT NGPKQKEKED AQEVELQEGK
1760 1770 1780
VHSESDKAIT PQAQEELQKQ ERESAKSELT ES
Length:1,782
Mass (Da):191,482
Last modified:January 11, 2011 - v4
Checksum:iDB9DBA4647E6DDD5
GO
Isoform 2 (identifier: Q02952-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     99-106: EEEVIVTE → MLGTITIT

Show »
Length:1,684
Mass (Da):181,690
Checksum:i384AEDA06CC83D93
GO
Isoform 3 (identifier: Q02952-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.
     106-106: E → M

Show »
Length:1,677
Mass (Da):180,990
Checksum:i8533672E99E8A1D6
GO

Sequence cautioni

The sequence BAE06085 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142 – 145TPEI → NRN in AAC51366 (PubMed:9000000).Curated4
Sequence conflicti423T → I in BAE06085 (Ref. 3) Curated1
Sequence conflicti449E → G in AAC51366 (PubMed:9000000).Curated1
Sequence conflicti695G → R in AAC51366 (PubMed:9000000).Curated1
Sequence conflicti868S → G in AAC51366 (PubMed:9000000).Curated1
Sequence conflicti946E → G in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1182A → T in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1531E → EE in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1531E → EE in BAE06085 (Ref. 3) Curated1
Sequence conflicti1531E → EE in AAB58938 (Ref. 6) Curated1
Sequence conflicti1531E → EE in AAA35931 (PubMed:1522245).Curated1
Sequence conflicti1582V → M in CAH18338 (PubMed:17974005).Curated1
Sequence conflicti1582V → M in AAA35931 (PubMed:1522245).Curated1
Sequence conflicti1602Q → L in BAA19927 (PubMed:9604001).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035115117K → E.Combined sources3 PublicationsCorresponds to variant rs10872670dbSNPEnsembl.1
Natural variantiVAR_035116216K → Q.4 PublicationsCorresponds to variant rs3734799dbSNPEnsembl.1
Natural variantiVAR_035780240E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs552053449dbSNPEnsembl.1
Natural variantiVAR_035117920E → G.1 PublicationCorresponds to variant rs13212161dbSNPEnsembl.1
Natural variantiVAR_056731987A → S.1 PublicationCorresponds to variant rs1042069dbSNPEnsembl.1
Natural variantiVAR_0351181096V → I.Corresponds to variant rs3734797dbSNPEnsembl.1
Natural variantiVAR_0351191296R → L.Corresponds to variant rs9478198dbSNPEnsembl.1
Natural variantiVAR_0351201355E → K.1 PublicationCorresponds to variant rs12201388dbSNPEnsembl.1
Natural variantiVAR_0351211600E → D.1 PublicationCorresponds to variant rs3823310dbSNPEnsembl.1
Natural variantiVAR_0351221689E → D.Corresponds to variant rs3734795dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0281331 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0041101 – 98Missing in isoform 2. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_00411199 – 106EEEVIVTE → MLGTITIT in isoform 2. 1 Publication8
Alternative sequenceiVSP_028134106E → M in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81607 mRNA. Translation: AAC51366.1.
AB003476 mRNA. Translation: BAA19927.1.
AB210003 mRNA. Translation: BAE06085.1. Different initiation.
CR749527 mRNA. Translation: CAH18338.1.
AL590413, AL033392, AL356535 Genomic DNA. Translation: CAI13590.1.
AL356535, AL033392, AL590413 Genomic DNA. Translation: CAI16151.1.
AL033392, AL356535, AL590413 Genomic DNA. Translation: CAI20467.1.
AL590413, AL033392 Genomic DNA. Translation: CAI13591.1.
AL033392, AL590413 Genomic DNA. Translation: CAI20468.1.
AF001504 mRNA. Translation: AAB58938.1.
M96322 mRNA. Translation: AAA35931.1.
CCDSiCCDS5229.1. [Q02952-1]
CCDS5230.1. [Q02952-2]
PIRiA43922.
JW0057.
RefSeqiNP_005091.2. NM_005100.3. [Q02952-1]
NP_653080.1. NM_144497.2. [Q02952-2]
XP_005267292.1. XM_005267235.2. [Q02952-3]
XP_016867006.1. XM_017011517.1. [Q02952-1]
UniGeneiHs.371240.

Genome annotation databases

EnsembliENST00000253332; ENSP00000253332; ENSG00000131016. [Q02952-1]
ENST00000354675; ENSP00000346702; ENSG00000131016. [Q02952-2]
ENST00000359755; ENSP00000352794; ENSG00000131016. [Q02952-3]
ENST00000402676; ENSP00000384537; ENSG00000131016. [Q02952-1]
GeneIDi9590.
KEGGihsa:9590.
UCSCiuc003qoe.5. human. [Q02952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81607 mRNA. Translation: AAC51366.1.
AB003476 mRNA. Translation: BAA19927.1.
AB210003 mRNA. Translation: BAE06085.1. Different initiation.
CR749527 mRNA. Translation: CAH18338.1.
AL590413, AL033392, AL356535 Genomic DNA. Translation: CAI13590.1.
AL356535, AL033392, AL590413 Genomic DNA. Translation: CAI16151.1.
AL033392, AL356535, AL590413 Genomic DNA. Translation: CAI20467.1.
AL590413, AL033392 Genomic DNA. Translation: CAI13591.1.
AL033392, AL590413 Genomic DNA. Translation: CAI20468.1.
AF001504 mRNA. Translation: AAB58938.1.
M96322 mRNA. Translation: AAA35931.1.
CCDSiCCDS5229.1. [Q02952-1]
CCDS5230.1. [Q02952-2]
PIRiA43922.
JW0057.
RefSeqiNP_005091.2. NM_005100.3. [Q02952-1]
NP_653080.1. NM_144497.2. [Q02952-2]
XP_005267292.1. XM_005267235.2. [Q02952-3]
XP_016867006.1. XM_017011517.1. [Q02952-1]
UniGeneiHs.371240.

3D structure databases

ProteinModelPortaliQ02952.
SMRiQ02952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114958. 33 interactors.
IntActiQ02952. 24 interactors.
MINTiMINT-2411728.
STRINGi9606.ENSP00000253332.

PTM databases

iPTMnetiQ02952.
PhosphoSitePlusiQ02952.
SwissPalmiQ02952.

Polymorphism and mutation databases

BioMutaiAKAP12.
DMDMi317373554.

Proteomic databases

EPDiQ02952.
MaxQBiQ02952.
PaxDbiQ02952.
PeptideAtlasiQ02952.
PRIDEiQ02952.

Protocols and materials databases

DNASUi9590.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253332; ENSP00000253332; ENSG00000131016. [Q02952-1]
ENST00000354675; ENSP00000346702; ENSG00000131016. [Q02952-2]
ENST00000359755; ENSP00000352794; ENSG00000131016. [Q02952-3]
ENST00000402676; ENSP00000384537; ENSG00000131016. [Q02952-1]
GeneIDi9590.
KEGGihsa:9590.
UCSCiuc003qoe.5. human. [Q02952-1]

Organism-specific databases

CTDi9590.
DisGeNETi9590.
GeneCardsiAKAP12.
H-InvDBHIX0025002.
HGNCiHGNC:370. AKAP12.
HPAiCAB026379.
HPA006344.
HPA056230.
MIMi604698. gene.
neXtProtiNX_Q02952.
OpenTargetsiENSG00000131016.
PharmGKBiPA24664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFC9. Eukaryota.
ENOG4110Y3C. LUCA.
GeneTreeiENSGT00730000111244.
HOVERGENiHBG050472.
InParanoidiQ02952.
KOiK16528.
OMAiCLEKGLA.
OrthoDBiEOG091G01X9.
PhylomeDBiQ02952.
TreeFamiTF105411.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131016-MONOMER.
SignaLinkiQ02952.

Miscellaneous databases

ChiTaRSiAKAP12. human.
GeneWikiiAKAP12.
GenomeRNAii9590.
PROiQ02952.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131016.
CleanExiHS_AKAP12.
GenevisibleiQ02952. HS.

Family and domain databases

InterProiIPR028540. AKAP12.
IPR001573. Pkinase-A_anch_WSK-motif.
IPR018459. RII_binding_1.
[Graphical view]
PANTHERiPTHR23209. PTHR23209. 1 hit.
PfamiPF10522. RII_binding_1. 1 hit.
PF03832. WSK. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKA12_HUMAN
AccessioniPrimary (citable) accession number: Q02952
Secondary accession number(s): O00310
, O00498, Q4LE68, Q5SZ80, Q5TGN1, Q68D82, Q99970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 154 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.