SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02940

- PENA_BURM1

UniProt

Q02940 - PENA_BURM1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Beta-lactamase
Gene
penA
Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Enables the organism to utilize penicillin as a carbon source.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei190 – 1901Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:penA
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Subcellular locationi

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515
Add
BLAST
Chaini16 – 313298Beta-lactamase
PRO_0000016967Add
BLAST

Proteomic databases

PRIDEiQ02940.

Expressioni

Inductioni

By penicillin G, impenem and AmpR.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02940-1 [UniParc]FASTAAdd to Basket

« Hide

MQRIGVTDYT ILGTVKGAEL ELVRFTHPFM GFDVPAILGD HVTRMPVPVP    50
FTPRLPRPGR LCDRSEIRPG KPLTRLARTA LICRALIRRW MARTSYSDSV 100
NCHTQPISAI FDYKDLRFEP PSNRISPAGQ TSVDRLLQLS QGQAVEGQSA 150
VARLTGEKKN HPGAQYANRL SPRIANNHPA TQQTLFELGS GAKERNAINV 200
SYLTALGTPG FTLMLPARML CGIVSDNNFT QKQLCPSPAR CTRGPAEPAK 250
RGPWLEPGLV IRKDGLRTGK LLSSLRGLCL TVLRFQPTVP CFCRLALSSS 300
VAISSTGLVN FSR 313
Length:313
Mass (Da):34,328
Last modified:June 1, 1994 - v1
Checksum:iBF2A67C670A644F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02928 Genomic DNA. Translation: AAA25927.1.
PIRiA48903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02928 Genomic DNA. Translation: AAA25927.1 .
PIRi A48903.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q02940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Pseudomonas cepacia 249 chromosomal penicillinase is a member of the AmpC family of chromosomal beta-lactamases."
    Proenca R., Niu W.W., Cacalano G., Prince A.
    Antimicrob. Agents Chemother. 37:667-674(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPENA_BURM1
AccessioniPrimary (citable) accession number: Q02940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This protein could be artifactual, it seems to contain pieces of several different proteins.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3