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Protein

Beta-lactamase

Gene

penA

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enables the organism to utilize penicillin as a carbon source.

Caution

This protein could be artifactual, it seems to contain pieces of several different proteins.Curated

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:penA
OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifieri395019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Add BLAST15
ChainiPRO_000001696716 – 313Beta-lactamaseAdd BLAST298

Proteomic databases

PRIDEiQ02940

Expressioni

Inductioni

By penicillin G, impenem and AmpR.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR001586 Beta-lactam_class-C_AS
PROSITEiView protein in PROSITE
PS00336 BETA_LACTAMASE_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRIGVTDYT ILGTVKGAEL ELVRFTHPFM GFDVPAILGD HVTRMPVPVP
60 70 80 90 100
FTPRLPRPGR LCDRSEIRPG KPLTRLARTA LICRALIRRW MARTSYSDSV
110 120 130 140 150
NCHTQPISAI FDYKDLRFEP PSNRISPAGQ TSVDRLLQLS QGQAVEGQSA
160 170 180 190 200
VARLTGEKKN HPGAQYANRL SPRIANNHPA TQQTLFELGS GAKERNAINV
210 220 230 240 250
SYLTALGTPG FTLMLPARML CGIVSDNNFT QKQLCPSPAR CTRGPAEPAK
260 270 280 290 300
RGPWLEPGLV IRKDGLRTGK LLSSLRGLCL TVLRFQPTVP CFCRLALSSS
310
VAISSTGLVN FSR
Length:313
Mass (Da):34,328
Last modified:June 1, 1994 - v1
Checksum:iBF2A67C670A644F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02928 Genomic DNA Translation: AAA25927.1
PIRiA48903

Entry informationi

Entry nameiPENA_BURM1
AccessioniPrimary (citable) accession number: Q02940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health