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Q02940 (PENA_BURM1) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:penA
OrganismBurkholderia multivorans (strain ATCC 17616 / 249)
Taxonomic identifier395019 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Enables the organism to utilize penicillin as a carbon source.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Induction

By penicillin G, impenem and AmpR.

Sequence similarities

Belongs to the class-C beta-lactamase family.

Caution

This protein could be artifactual, it seems to contain pieces of several different proteins.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515
Chain16 – 313298Beta-lactamase
PRO_0000016967

Sites

Active site1901Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02940 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: BF2A67C670A644F2

FASTA31334,328
        10         20         30         40         50         60 
MQRIGVTDYT ILGTVKGAEL ELVRFTHPFM GFDVPAILGD HVTRMPVPVP FTPRLPRPGR 

        70         80         90        100        110        120 
LCDRSEIRPG KPLTRLARTA LICRALIRRW MARTSYSDSV NCHTQPISAI FDYKDLRFEP 

       130        140        150        160        170        180 
PSNRISPAGQ TSVDRLLQLS QGQAVEGQSA VARLTGEKKN HPGAQYANRL SPRIANNHPA 

       190        200        210        220        230        240 
TQQTLFELGS GAKERNAINV SYLTALGTPG FTLMLPARML CGIVSDNNFT QKQLCPSPAR 

       250        260        270        280        290        300 
CTRGPAEPAK RGPWLEPGLV IRKDGLRTGK LLSSLRGLCL TVLRFQPTVP CFCRLALSSS 

       310 
VAISSTGLVN FSR 

« Hide

References

[1]"The Pseudomonas cepacia 249 chromosomal penicillinase is a member of the AmpC family of chromosomal beta-lactamases."
Proenca R., Niu W.W., Cacalano G., Prince A.
Antimicrob. Agents Chemother. 37:667-674(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L02928 Genomic DNA. Translation: AAA25927.1.
PIRA48903.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ02940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PROSITEPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePENA_BURM1
AccessionPrimary (citable) accession number: Q02940
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families