Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q02940

- PENA_BURM1

UniProt

Q02940 - PENA_BURM1

Protein

Beta-lactamase

Gene

penA

Organism
Burkholderia multivorans (strain ATCC 17616 / 249)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enables the organism to utilize penicillin as a carbon source.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei190 – 1901Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:penA
    OrganismiBurkholderia multivorans (strain ATCC 17616 / 249)
    Taxonomic identifieri395019 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

    Subcellular locationi

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Add
    BLAST
    Chaini16 – 313298Beta-lactamasePRO_0000016967Add
    BLAST

    Proteomic databases

    PRIDEiQ02940.

    Expressioni

    Inductioni

    By penicillin G, impenem and AmpR.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRIGVTDYT ILGTVKGAEL ELVRFTHPFM GFDVPAILGD HVTRMPVPVP    50
    FTPRLPRPGR LCDRSEIRPG KPLTRLARTA LICRALIRRW MARTSYSDSV 100
    NCHTQPISAI FDYKDLRFEP PSNRISPAGQ TSVDRLLQLS QGQAVEGQSA 150
    VARLTGEKKN HPGAQYANRL SPRIANNHPA TQQTLFELGS GAKERNAINV 200
    SYLTALGTPG FTLMLPARML CGIVSDNNFT QKQLCPSPAR CTRGPAEPAK 250
    RGPWLEPGLV IRKDGLRTGK LLSSLRGLCL TVLRFQPTVP CFCRLALSSS 300
    VAISSTGLVN FSR 313
    Length:313
    Mass (Da):34,328
    Last modified:June 1, 1994 - v1
    Checksum:iBF2A67C670A644F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02928 Genomic DNA. Translation: AAA25927.1.
    PIRiA48903.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L02928 Genomic DNA. Translation: AAA25927.1 .
    PIRi A48903.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q02940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Pseudomonas cepacia 249 chromosomal penicillinase is a member of the AmpC family of chromosomal beta-lactamases."
      Proenca R., Niu W.W., Cacalano G., Prince A.
      Antimicrob. Agents Chemother. 37:667-674(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPENA_BURM1
    AccessioniPrimary (citable) accession number: Q02940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    This protein could be artifactual, it seems to contain pieces of several different proteins.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3