Q02940 (PENA_BURM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-lactamase
EC=3.5.2.6

Alternative name(s):
Penicillinase

Gene names

Name:

penA

Organism

Burkholderia multivorans (strain ATCC 17616 / 249)

Taxonomic identifier

395019 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia multivorans

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Enables the organism to utilize penicillin as a carbon source.
Catalytic activity	A beta-lactam + H2O = a substituted beta-amino acid.
Induction	By penicillin G, impenem and AmpR.
Sequence similarities	Belongs to the class-C beta-lactamase family.
Caution	This protein could be artifactual, it seems to contain pieces of several different proteins.

Ontologies

Keywords
Biological process	Antibiotic resistance
Domain	Signal
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	antibiotic catabolic process Inferred from electronic annotation. Source: InterPro response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular_function	beta-lactamase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15
	Chain	16 – 313	298	Beta-lactamase		PRO_0000016967
Sites
	Active site	190	1	Acyl-ester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02940 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: BF2A67C670A644F2	FASTA	313	34,328
	10 20 30 40 50 60 MQRIGVTDYT ILGTVKGAEL ELVRFTHPFM GFDVPAILGD HVTRMPVPVP FTPRLPRPGR 70 80 90 100 110 120 LCDRSEIRPG KPLTRLARTA LICRALIRRW MARTSYSDSV NCHTQPISAI FDYKDLRFEP 130 140 150 160 170 180 PSNRISPAGQ TSVDRLLQLS QGQAVEGQSA VARLTGEKKN HPGAQYANRL SPRIANNHPA 190 200 210 220 230 240 TQQTLFELGS GAKERNAINV SYLTALGTPG FTLMLPARML CGIVSDNNFT QKQLCPSPAR 250 260 270 280 290 300 CTRGPAEPAK RGPWLEPGLV IRKDGLRTGK LLSSLRGLCL TVLRFQPTVP CFCRLALSSS 310 VAISSTGLVN FSR

References

[1]	"The Pseudomonas cepacia 249 chromosomal penicillinase is a member of the AmpC family of chromosomal beta-lactamases." Proenca R., Niu W.W., Cacalano G., Prince A. Antimicrob. Agents Chemother. 37:667-674(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L02928 Genomic DNA. Translation: AAA25927.1.
PIR	A48903.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q02940.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001586. Beta-lactam_class-C_AS. [Graphical view]
PROSITE	PS00336. BETA_LACTAMASE_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PENA_BURM1

Accession

Primary (citable) accession number: Q02940

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program