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Q02931

- UTP17_YEAST

UniProt

Q02931 - UTP17_YEAST

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Protein

NET1-associated nuclear protein 1

Gene

NAN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

GO - Molecular functioni

  1. snoRNA binding Source: SGD

GO - Biological processi

  1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  2. positive regulation of transcription from RNA polymerase I promoter Source: SGD
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription

Enzyme and pathway databases

BioCyciYEAST:G3O-34025-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NET1-associated nuclear protein 1
Alternative name(s):
U three protein 17
Short name:
t-17
U3 protein 17 required for transcription
U3 small nucleolar RNA-associated protein 17
Short name:
U3 snoRNA-associated protein 17
Gene namesi
Name:NAN1
Synonyms:UTP17
Ordered Locus Names:YPL126W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL126w.
SGDiS000006047. NAN1.

Subcellular locationi

Nucleusnucleolus 2 Publications
Note: Associated with ribosomal chromatin, even in the absence of transcription.

GO - Cellular componenti

  1. nucleolus Source: SGD
  2. rDNA heterochromatin Source: SGD
  3. small-subunit processome Source: SGD
  4. t-UTP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 896896NET1-associated nuclear protein 1PRO_0000051088Add
BLAST

Proteomic databases

MaxQBiQ02931.
PaxDbiQ02931.
PeptideAtlasiQ02931.

Expressioni

Gene expression databases

GenevestigatoriQ02931.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

Protein-protein interaction databases

BioGridi36055. 72 interactions.
DIPiDIP-3999N.
IntActiQ02931. 32 interactions.
MINTiMINT-507029.
STRINGi4932.YPL126W.

Structurei

3D structure databases

ProteinModelPortaliQ02931.
SMRiQ02931. Positions 255-326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati295 – 33440WD 1Add
BLAST
Repeati490 – 54253WD 2Add
BLAST
Repeati552 – 59544WD 3Add
BLAST
Repeati605 – 64541WD 4Add
BLAST

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG251328.
HOGENOMiHOG000141926.
InParanoidiQ02931.
KOiK14552.
OMAiVFWQLET.
OrthoDBiEOG7BS4JW.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02931-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQSLGIEQY KLSVVSGGKP ALNNLSSVTG NKNIARLSQD QRNYIIPFNN
60 70 80 90 100
QIKVYSVETR QCVKTLKFAN NSLLSGIFLQ EEENNESIVK ILLGDITVPQ
110 120 130 140 150
QEDAHLITVF TNNGHVIVLN YKGKLVESPK HFKISLADEK LANVFHSEGN
160 170 180 190 200
YRILTTFKDP SQKAHNSLQS YRLYALTFDD AKKQFEVAHQ AEWHNVILSN
210 220 230 240 250
ISSNGKLLAH MCKDVSTKDH EHKSISVVSL FDDSVNLSFP LGSILSSQTQ
260 270 280 290 300
SLSYNTRYVS SMAIDNMGQQ LAVGFASGVI SIVSLADLQI RLLKWHIDSV
310 320 330 340 350
LSLSFSHDGS YLLSGGWEKV MSLWQLETNS QQFLPRLNGI IIDCQVLGPQ
360 370 380 390 400
GNYYSLILQM TENNSNSDYQ FLLLNASDLT SKLSINGPLP VFNSTIKHIQ
410 420 430 440 450
QPISAMNTKN SNSITSLNHS KKKQSRKLIK SRRQDFTTNV EINPINKNLY
460 470 480 490 500
FPHISAVQIF DFYKNEQVNY QYLTSGVNNS MGKVRFELNL QDPIITDLKF
510 520 530 540 550
TKDGQWMITY EIEYPPNDLL SSKDLTHILK FWTKNDNETN WNLKTKVINP
560 570 580 590 600
HGISVPITKI LPSPRSVNNS QGCLTADNNG GLKFWSFDSH ESNWCLKKIS
610 620 630 640 650
LPNFNHFSNS VSLAWSQDGS LIFHGFDDKL QILDFDTFKK FESLENTKTV
660 670 680 690 700
SEFTLDSEIQ TVKLINDTNL IVATRTTLNA INLLRGQVIN SFDLYPFVNG
710 720 730 740 750
VYKNGHMDRL ITCDERTGNI ALVINQQLTD LDGVPTINYK SRIIIFDSDL
760 770 780 790 800
STKLGNFTHH EYISWIGWNY DTDFIFLDIE STLGVVGTTV NTQLSDEVNN
810 820 830 840 850
EGILDGLVSN TITTSASNSD IFAEQLHKLS SRGKKSDTRD KNTNDNDEDE
860 870 880 890
EDIALEFING EKKDKLVNMN SFTSMFDNIQ NVQMDTFFDR VMKVLT
Length:896
Mass (Da):101,237
Last modified:November 1, 1996 - v1
Checksum:iF4E3687BD328230E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43503 Genomic DNA. Translation: AAB68236.1.
BK006949 Genomic DNA. Translation: DAA11307.1.
PIRiS61996.
RefSeqiNP_015199.1. NM_001183940.1.

Genome annotation databases

EnsemblFungiiYPL126W; YPL126W; YPL126W.
GeneIDi855977.
KEGGisce:YPL126W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43503 Genomic DNA. Translation: AAB68236.1 .
BK006949 Genomic DNA. Translation: DAA11307.1 .
PIRi S61996.
RefSeqi NP_015199.1. NM_001183940.1.

3D structure databases

ProteinModelPortali Q02931.
SMRi Q02931. Positions 255-326.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36055. 72 interactions.
DIPi DIP-3999N.
IntActi Q02931. 32 interactions.
MINTi MINT-507029.
STRINGi 4932.YPL126W.

Proteomic databases

MaxQBi Q02931.
PaxDbi Q02931.
PeptideAtlasi Q02931.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL126W ; YPL126W ; YPL126W .
GeneIDi 855977.
KEGGi sce:YPL126W.

Organism-specific databases

CYGDi YPL126w.
SGDi S000006047. NAN1.

Phylogenomic databases

eggNOGi NOG251328.
HOGENOMi HOG000141926.
InParanoidi Q02931.
KOi K14552.
OMAi VFWQLET.
OrthoDBi EOG7BS4JW.

Enzyme and pathway databases

BioCyci YEAST:G3O-34025-MONOMER.

Miscellaneous databases

NextBioi 980804.

Gene expression databases

Genevestigatori Q02931.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
    Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
    Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUTP17_YEAST
AccessioniPrimary (citable) accession number: Q02931
Secondary accession number(s): D6W3P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6560 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3