Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q02931

- UTP17_YEAST

UniProt

Q02931 - UTP17_YEAST

Protein

NET1-associated nuclear protein 1

Gene

NAN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs).2 Publications

    GO - Molecular functioni

    1. snoRNA binding Source: SGD

    GO - Biological processi

    1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. positive regulation of transcription from RNA polymerase I promoter Source: SGD
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing, Transcription

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34025-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NET1-associated nuclear protein 1
    Alternative name(s):
    U three protein 17
    Short name:
    t-17
    U3 protein 17 required for transcription
    U3 small nucleolar RNA-associated protein 17
    Short name:
    U3 snoRNA-associated protein 17
    Gene namesi
    Name:NAN1
    Synonyms:UTP17
    Ordered Locus Names:YPL126W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPL126w.
    SGDiS000006047. NAN1.

    Subcellular locationi

    Nucleusnucleolus 2 Publications
    Note: Associated with ribosomal chromatin, even in the absence of transcription.

    GO - Cellular componenti

    1. nucleolus Source: SGD
    2. rDNA heterochromatin Source: SGD
    3. small-subunit processome Source: SGD
    4. t-UTP complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 896896NET1-associated nuclear protein 1PRO_0000051088Add
    BLAST

    Proteomic databases

    MaxQBiQ02931.
    PaxDbiQ02931.
    PeptideAtlasiQ02931.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02931.

    Interactioni

    Subunit structurei

    Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs.2 Publications

    Protein-protein interaction databases

    BioGridi36055. 71 interactions.
    DIPiDIP-3999N.
    IntActiQ02931. 32 interactions.
    MINTiMINT-507029.
    STRINGi4932.YPL126W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02931.
    SMRiQ02931. Positions 557-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati295 – 33440WD 1Add
    BLAST
    Repeati490 – 54253WD 2Add
    BLAST
    Repeati552 – 59544WD 3Add
    BLAST
    Repeati605 – 64541WD 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG251328.
    HOGENOMiHOG000141926.
    KOiK14552.
    OMAiVFWQLET.
    OrthoDBiEOG7BS4JW.

    Family and domain databases

    Gene3Di2.130.10.10. 3 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.
    PROSITEiPS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02931-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQSLGIEQY KLSVVSGGKP ALNNLSSVTG NKNIARLSQD QRNYIIPFNN    50
    QIKVYSVETR QCVKTLKFAN NSLLSGIFLQ EEENNESIVK ILLGDITVPQ 100
    QEDAHLITVF TNNGHVIVLN YKGKLVESPK HFKISLADEK LANVFHSEGN 150
    YRILTTFKDP SQKAHNSLQS YRLYALTFDD AKKQFEVAHQ AEWHNVILSN 200
    ISSNGKLLAH MCKDVSTKDH EHKSISVVSL FDDSVNLSFP LGSILSSQTQ 250
    SLSYNTRYVS SMAIDNMGQQ LAVGFASGVI SIVSLADLQI RLLKWHIDSV 300
    LSLSFSHDGS YLLSGGWEKV MSLWQLETNS QQFLPRLNGI IIDCQVLGPQ 350
    GNYYSLILQM TENNSNSDYQ FLLLNASDLT SKLSINGPLP VFNSTIKHIQ 400
    QPISAMNTKN SNSITSLNHS KKKQSRKLIK SRRQDFTTNV EINPINKNLY 450
    FPHISAVQIF DFYKNEQVNY QYLTSGVNNS MGKVRFELNL QDPIITDLKF 500
    TKDGQWMITY EIEYPPNDLL SSKDLTHILK FWTKNDNETN WNLKTKVINP 550
    HGISVPITKI LPSPRSVNNS QGCLTADNNG GLKFWSFDSH ESNWCLKKIS 600
    LPNFNHFSNS VSLAWSQDGS LIFHGFDDKL QILDFDTFKK FESLENTKTV 650
    SEFTLDSEIQ TVKLINDTNL IVATRTTLNA INLLRGQVIN SFDLYPFVNG 700
    VYKNGHMDRL ITCDERTGNI ALVINQQLTD LDGVPTINYK SRIIIFDSDL 750
    STKLGNFTHH EYISWIGWNY DTDFIFLDIE STLGVVGTTV NTQLSDEVNN 800
    EGILDGLVSN TITTSASNSD IFAEQLHKLS SRGKKSDTRD KNTNDNDEDE 850
    EDIALEFING EKKDKLVNMN SFTSMFDNIQ NVQMDTFFDR VMKVLT 896
    Length:896
    Mass (Da):101,237
    Last modified:November 1, 1996 - v1
    Checksum:iF4E3687BD328230E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43503 Genomic DNA. Translation: AAB68236.1.
    BK006949 Genomic DNA. Translation: DAA11307.1.
    PIRiS61996.
    RefSeqiNP_015199.1. NM_001183940.1.

    Genome annotation databases

    EnsemblFungiiYPL126W; YPL126W; YPL126W.
    GeneIDi855977.
    KEGGisce:YPL126W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U43503 Genomic DNA. Translation: AAB68236.1 .
    BK006949 Genomic DNA. Translation: DAA11307.1 .
    PIRi S61996.
    RefSeqi NP_015199.1. NM_001183940.1.

    3D structure databases

    ProteinModelPortali Q02931.
    SMRi Q02931. Positions 557-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36055. 71 interactions.
    DIPi DIP-3999N.
    IntActi Q02931. 32 interactions.
    MINTi MINT-507029.
    STRINGi 4932.YPL126W.

    Proteomic databases

    MaxQBi Q02931.
    PaxDbi Q02931.
    PeptideAtlasi Q02931.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPL126W ; YPL126W ; YPL126W .
    GeneIDi 855977.
    KEGGi sce:YPL126W.

    Organism-specific databases

    CYGDi YPL126w.
    SGDi S000006047. NAN1.

    Phylogenomic databases

    eggNOGi NOG251328.
    HOGENOMi HOG000141926.
    KOi K14552.
    OMAi VFWQLET.
    OrthoDBi EOG7BS4JW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34025-MONOMER.

    Miscellaneous databases

    NextBioi 980804.

    Gene expression databases

    Genevestigatori Q02931.

    Family and domain databases

    Gene3Di 2.130.10.10. 3 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    PROSITEi PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
      Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
      Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUTP17_YEAST
    AccessioniPrimary (citable) accession number: Q02931
    Secondary accession number(s): D6W3P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 6560 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3