Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q02931 (UTP17_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NET1-associated nuclear protein 1
Alternative name(s):
U three protein 17
Short name=t-17
U3 protein 17 required for transcription
U3 small nucleolar RNA-associated protein 17
Short name=U3 snoRNA-associated protein 17
Gene names
Name:NAN1
Synonyms:UTP17
Ordered Locus Names:YPL126W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length896 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). Ref.3 Ref.5

Subunit structure

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. In the absence of snoRNA3, forms a complex with other t-UTPs. This complex can associate with pre-18S ribosomal RNAs. Ref.3 Ref.5

Subcellular location

Nucleusnucleolus. Note: Associated with ribosomal chromatin, even in the absence of transcription. Ref.3 Ref.5

Miscellaneous

Present with 6560 molecules/cell in log phase SD medium.

Sequence similarities

Contains 4 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 896896NET1-associated nuclear protein 1
PRO_0000051088

Regions

Repeat295 – 33440WD 1
Repeat490 – 54253WD 2
Repeat552 – 59544WD 3
Repeat605 – 64541WD 4

Sequences

Sequence LengthMass (Da)Tools
Q02931 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F4E3687BD328230E

FASTA896101,237
        10         20         30         40         50         60 
MTQSLGIEQY KLSVVSGGKP ALNNLSSVTG NKNIARLSQD QRNYIIPFNN QIKVYSVETR 

        70         80         90        100        110        120 
QCVKTLKFAN NSLLSGIFLQ EEENNESIVK ILLGDITVPQ QEDAHLITVF TNNGHVIVLN 

       130        140        150        160        170        180 
YKGKLVESPK HFKISLADEK LANVFHSEGN YRILTTFKDP SQKAHNSLQS YRLYALTFDD 

       190        200        210        220        230        240 
AKKQFEVAHQ AEWHNVILSN ISSNGKLLAH MCKDVSTKDH EHKSISVVSL FDDSVNLSFP 

       250        260        270        280        290        300 
LGSILSSQTQ SLSYNTRYVS SMAIDNMGQQ LAVGFASGVI SIVSLADLQI RLLKWHIDSV 

       310        320        330        340        350        360 
LSLSFSHDGS YLLSGGWEKV MSLWQLETNS QQFLPRLNGI IIDCQVLGPQ GNYYSLILQM 

       370        380        390        400        410        420 
TENNSNSDYQ FLLLNASDLT SKLSINGPLP VFNSTIKHIQ QPISAMNTKN SNSITSLNHS 

       430        440        450        460        470        480 
KKKQSRKLIK SRRQDFTTNV EINPINKNLY FPHISAVQIF DFYKNEQVNY QYLTSGVNNS 

       490        500        510        520        530        540 
MGKVRFELNL QDPIITDLKF TKDGQWMITY EIEYPPNDLL SSKDLTHILK FWTKNDNETN 

       550        560        570        580        590        600 
WNLKTKVINP HGISVPITKI LPSPRSVNNS QGCLTADNNG GLKFWSFDSH ESNWCLKKIS 

       610        620        630        640        650        660 
LPNFNHFSNS VSLAWSQDGS LIFHGFDDKL QILDFDTFKK FESLENTKTV SEFTLDSEIQ 

       670        680        690        700        710        720 
TVKLINDTNL IVATRTTLNA INLLRGQVIN SFDLYPFVNG VYKNGHMDRL ITCDERTGNI 

       730        740        750        760        770        780 
ALVINQQLTD LDGVPTINYK SRIIIFDSDL STKLGNFTHH EYISWIGWNY DTDFIFLDIE 

       790        800        810        820        830        840 
STLGVVGTTV NTQLSDEVNN EGILDGLVSN TITTSASNSD IFAEQLHKLS SRGKKSDTRD 

       850        860        870        880        890 
KNTNDNDEDE EDIALEFING EKKDKLVNMN SFTSMFDNIQ NVQMDTFFDR VMKVLT 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
Dragon F., Gallagher J.E.G., Compagnone-Post P.A., Mitchell B.M., Porwancher K.A., Wehner K.A., Wormsley S., Settlage R.E., Shabanowitz J., Osheim Y., Beyer A.L., Hunt D.F., Baserga S.J.
Nature 417:967-970(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components."
Gallagher J.E.G., Dunbar D.A., Granneman S., Mitchell B.M., Osheim Y., Beyer A.L., Baserga S.J.
Genes Dev. 18:2506-2517(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH OTHER T-UTPS, SUBCELLULAR LOCATION.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U43503 Genomic DNA. Translation: AAB68236.1.
BK006949 Genomic DNA. Translation: DAA11307.1.
PIRS61996.
RefSeqNP_015199.1. NM_001183940.1.

3D structure databases

ProteinModelPortalQ02931.
SMRQ02931. Positions 258-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36055. 71 interactions.
DIPDIP-3999N.
IntActQ02931. 32 interactions.
MINTMINT-507029.
STRING4932.YPL126W.

Proteomic databases

PaxDbQ02931.
PeptideAtlasQ02931.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL126W; YPL126W; YPL126W.
GeneID855977.
KEGGsce:YPL126W.

Organism-specific databases

CYGDYPL126w.
SGDS000006047. NAN1.

Phylogenomic databases

eggNOGNOG251328.
HOGENOMHOG000141926.
KOK14552.
OMAVFWQLET.
OrthoDBEOG7BS4JW.

Enzyme and pathway databases

BioCycYEAST:G3O-34025-MONOMER.

Gene expression databases

GenevestigatorQ02931.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 1 hit.
[Graphical view]
SMARTSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
PROSITEPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980804.

Entry information

Entry nameUTP17_YEAST
AccessionPrimary (citable) accession number: Q02931
Secondary accession number(s): D6W3P1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families