Q02930 (CREB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name=CREB-5
Short name=cAMP-responsive element-binding protein 5

Alternative name(s):
CRE-BPa

Gene names

Name:	CREB5
Synonyms:	CREBPA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the cAMP response element and activates transcription. Ref.2
Subunit structure	Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1. Ref.1
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the bZIP family. Contains 1 bZIP (basic-leucine zipper) domain. Contains 1 C2H2-type zinc finger.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adipose tissue development Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.2. Source: UniProtKB transcription from RNA polymerase II promoter Traceable author statement Ref.2. Source: ProtInc
Cellular_component	nucleus Inferred by curator Ref.2. Source: UniProtKB
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.2. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q02930-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q02930-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Isoform 3 (identifier: Q02930-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Isoform 4 (identifier: Q02930-4)

Also known as: Delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Cyclic AMP-responsive element-binding protein 5		PRO_0000076604
Regions
	Domain	375 – 438	64	bZIP
	Zinc finger	16 – 40	25	C2H2-type
	Region	377 – 397	21	Basic motif By similarity
	Region	403 – 431	29	Leucine-zipper By similarity
Amino acid modifications
	Modified residue	59	1	Phosphothreonine Ref.8
	Modified residue	61	1	Phosphothreonine Ref.8
	Modified residue	137	1	Phosphoserine Ref.8
Natural variations
	Alternative sequence	1 – 33	33	Missing in isoform 3.		VSP_050011
	Alternative sequence	1 – 16	16	MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4.		VSP_050012
	Alternative sequence	1 – 7	7	Missing in isoform 2.		VSP_050010
	Alternative sequence	17 – 155	139	Missing in isoform 4.		VSP_050013
Experimental info
	Sequence conflict	16	1	F → S in AAA52072. Ref.1
	Sequence conflict	16	1	F → S in AAC37525. Ref.2
	Sequence conflict	211 – 212	2	MQ → IE in AAA52072. Ref.1
	Sequence conflict	211 – 212	2	MQ → IE in AAC37525. Ref.2
	Sequence conflict	211 – 212	2	MQ → IE in AAC37526. Ref.2
	Sequence conflict	211 – 212	2	MQ → IE in AAC37527. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha) [UniParc]. Last modified May 31, 2011. Version 3. Checksum: DF96F33AE562F1AD	FASTA	508	56,918
	10 20 30 40 50 60 MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK TDNMLSDQTP 70 80 90 100 110 120 TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS MHNAVGGAMT GPGTHQLSSA 130 140 150 160 170 180 RLPNHDTNVV IQQAMPSPQS SSVITQAPST NRQIGPVPGS LSSLLHLHNR QRQPMPASMP 190 200 210 220 230 240 GTLPNPTMPG SSAVLMPMER QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL 250 260 270 280 290 300 THHPAAMSNG NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH 310 320 330 340 350 360 PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM QPTQTIQPPQ 370 380 390 400 410 420 PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV MSLEKKAEEL TQTNMQLQNE 430 440 450 460 470 480 VSMLKNEVAQ LKQLLLTHKD CPITAMQKES QGYLSPESSP PASPVPACSQ QQVIQHNTIT 490 500 TSSSVSEVVG SSTLSQLTTH RTDLNPIL
	Isoform 2 (Beta) [UniParc]. Checksum: 9D67856759DB9957	FASTA	501	56,037
	10 20 30 40 50 60 MNLEQERPFV CSAPGCSQRF PTEDHLMIHR HKHEMTLKFP SIKTDNMLSD QTPTPTRFLK 70 80 90 100 110 120 NCEEVGLFSE LDCSLEHEFR KAQEEESSKR NISMHNAVGG AMTGPGTHQL SSARLPNHDT 130 140 150 160 170 180 NVVIQQAMPS PQSSSVITQA PSTNRQIGPV PGSLSSLLHL HNRQRQPMPA SMPGTLPNPT 190 200 210 220 230 240 MPGSSAVLMP MERQMSVNSS IMGMQGPNLS NPCASPQVQP MHSEAKMRLK AALTHHPAAM 250 260 270 280 290 300 SNGNMNTMGH MMEMMGSRQD QTPHHHMHSH PHQHQTLPPH HPYPHQHQHP AHHPHPQPHH 310 320 330 340 350 360 QQNHPHHHSH SHLHAHPAHH QTSPHPPLHT GNQAQVSPAT QQMQPTQTIQ PPQPTGGRRR 370 380 390 400 410 420 RVVDEDPDER RRKFLERNRA AATRCRQKRK VWVMSLEKKA EELTQTNMQL QNEVSMLKNE 430 440 450 460 470 480 VAQLKQLLLT HKDCPITAMQ KESQGYLSPE SSPPASPVPA CSQQQVIQHN TITTSSSVSE 490 500 VVGSSTLSQL TTHRTDLNPI L
	Isoform 3 (Gamma) [UniParc]. Checksum: BD75DF80FE7145E9	FASTA	475	53,063
	10 20 30 40 50 60 MIHRHKHEMT LKFPSIKTDN MLSDQTPTPT RFLKNCEEVG LFSELDCSLE HEFRKAQEEE 70 80 90 100 110 120 SSKRNISMHN AVGGAMTGPG THQLSSARLP NHDTNVVIQQ AMPSPQSSSV ITQAPSTNRQ 130 140 150 160 170 180 IGPVPGSLSS LLHLHNRQRQ PMPASMPGTL PNPTMPGSSA VLMPMERQMS VNSSIMGMQG 190 200 210 220 230 240 PNLSNPCASP QVQPMHSEAK MRLKAALTHH PAAMSNGNMN TMGHMMEMMG SRQDQTPHHH 250 260 270 280 290 300 MHSHPHQHQT LPPHHPYPHQ HQHPAHHPHP QPHHQQNHPH HHSHSHLHAH PAHHQTSPHP 310 320 330 340 350 360 PLHTGNQAQV SPATQQMQPT QTIQPPQPTG GRRRRVVDED PDERRRKFLE RNRAAATRCR 370 380 390 400 410 420 QKRKVWVMSL EKKAEELTQT NMQLQNEVSM LKNEVAQLKQ LLLTHKDCPI TAMQKESQGY 430 440 450 460 470 LSPESSPPAS PVPACSQQQV IQHNTITTSS SVSEVVGSST LSQLTTHRTD LNPIL
	Isoform 4 (Delta) [UniParc]. Checksum: 7DC1C71C6A74DEB5	FASTA	369	41,161
	10 20 30 40 50 60 MFCTSGGNSA SVMSMRPVPG SLSSLLHLHN RQRQPMPASM PGTLPNPTMP GSSAVLMPME 70 80 90 100 110 120 RQMSVNSSIM GMQGPNLSNP CASPQVQPMH SEAKMRLKAA LTHHPAAMSN GNMNTMGHMM 130 140 150 160 170 180 EMMGSRQDQT PHHHMHSHPH QHQTLPPHHP YPHQHQHPAH HPHPQPHHQQ NHPHHHSHSH 190 200 210 220 230 240 LHAHPAHHQT SPHPPLHTGN QAQVSPATQQ MQPTQTIQPP QPTGGRRRRV VDEDPDERRR 250 260 270 280 290 300 KFLERNRAAA TRCRQKRKVW VMSLEKKAEE LTQTNMQLQN EVSMLKNEVA QLKQLLLTHK 310 320 330 340 350 360 DCPITAMQKE SQGYLSPESS PPASPVPACS QQQVIQHNTI TTSSSVSEVV GSSTLSQLTT HRTDLNPIL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1." Nomura N., Zu Y.-L., Maekawa T., Tabata S., Akiyama T., Ishii S. J. Biol. Chem. 268:4259-4266(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT.
[2]	"Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA." Zu Y.-L., Maekawa T., Nomura N., Nakata T., Ishii S. Oncogene 8:2749-2758(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), FUNCTION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4). Tissue: Embryo, Placenta and Trachea.
[4]	"Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N. Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Placenta.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-59; THR-61 AND SER-137, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05515 mRNA. Translation: AAA52072.1. L05911 mRNA. Translation: AAC37525.1. L05912 mRNA. Translation: AAC37527.1. L05913 mRNA. Translation: AAC37526.1. AK292916 mRNA. Translation: BAF85605.1. AK300455 mRNA. Translation: BAG62175.1. AK316187 mRNA. Translation: BAH14558.1. AB451409 mRNA. Translation: BAG70223.1. AC003074 Genomic DNA. Translation: AAS00387.1. AC005105 Genomic DNA. Translation: AAP22329.1. AC005013 Genomic DNA. No translation available. AC006331 Genomic DNA. No translation available. AC006367 Genomic DNA. No translation available. AC006980 Genomic DNA. No translation available. CH471073 Genomic DNA. Translation: EAW93908.1. CH471073 Genomic DNA. Translation: EAW93910.1. BC059400 mRNA. Translation: AAH59400.2.
IPI	IPI00027461. IPI00397362. IPI00410078. IPI00478946.
PIR	A45477. I78877.
RefSeq	NP_001011666.1. NM_001011666.1. NP_004895.2. NM_004904.2. NP_878901.2. NM_182898.2. NP_878902.2. NM_182899.3.
UniGene	Hs.437075.
3D structure databases
ProteinModelPortal	Q02930.
SMR	Q02930. Positions 10-46, 377-436.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000350359.
PTM databases
PhosphoSite	Q02930.
Polymorphism databases
DMDM	119370343.
Proteomic databases
PaxDb	Q02930.
PRIDE	Q02930.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357727; ENSP00000350359; ENSG00000146592. ENST00000396298; ENSP00000379592; ENSG00000146592. ENST00000396299; ENSP00000379593; ENSG00000146592. ENST00000396300; ENSP00000379594; ENSG00000146592. ENST00000409603; ENSP00000387197; ENSG00000146592.
GeneID	9586.
KEGG	hsa:9586.
UCSC	uc003szo.3. human.
Organism-specific databases
CTD	9586.
GeneCards	GC07P028305.
HGNC	HGNC:16844. CREB5.
neXtProt	NX_Q02930.
PharmGKB	PA134930491.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286140.
HOGENOM	HOG000220894.
HOVERGEN	HBG004300.
InParanoid	Q02930.
KO	K09047.
OMA	ISMHNTV.
PhylomeDB	Q02930.
Gene expression databases
ArrayExpress	Q02930.
Bgee	Q02930.
CleanEx	HS_CREB5.
Genevestigator	Q02930.
Family and domain databases
Gene3D	3.30.160.60. 1 hit.
InterPro	IPR004827. bZIP. IPR016378. TF_cAMP-dep. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PIRSF	PIRSF003153. ATF2_CRE-BP1. 1 hit.
SMART	SM00338. BRLZ. 1 hit. SM00355. ZnF_C2H2. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CREB5. human.
GenomeRNAi	9586.
NextBio	35963.

Entry information

Entry name

CREB5_HUMAN

Accession

Primary (citable) accession number: Q02930
Secondary accession number(s): A8KA51 , B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	May 31, 2011
Last modified:	April 3, 2013
This is version 114 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.