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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

CREB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the cAMP response element and activates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ02930.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
Gene namesi
Name:CREB5
Synonyms:CREBPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16844. CREB5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9586.
OpenTargetsiENSG00000146592.
PharmGKBiPA134930491.

Polymorphism and mutation databases

BioMutaiCREB5.
DMDMi334302918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766041 – 508Cyclic AMP-responsive element-binding protein 5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphothreonineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02930.
PaxDbiQ02930.
PeptideAtlasiQ02930.
PRIDEiQ02930.

PTM databases

iPTMnetiQ02930.
PhosphoSitePlusiQ02930.

Expressioni

Gene expression databases

BgeeiENSG00000146592.
CleanExiHS_CREB5.
ExpressionAtlasiQ02930. baseline and differential.
GenevisibleiQ02930. HS.

Organism-specific databases

HPAiHPA050020.
HPA061622.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-35EBI-10192698,EBI-10173507
COL8A1P276583EBI-10192698,EBI-747133
EFEMP2O959677EBI-10192698,EBI-743414
FOSQ6FG413EBI-10192698,EBI-10198738
FOSL1P154075EBI-10192698,EBI-744510
FOSL2P1540811EBI-10192698,EBI-3893419
KIFC3Q9BVG83EBI-10192698,EBI-2125614
KRT15P190123EBI-10192698,EBI-739566
KRT40Q6A1625EBI-10192698,EBI-10171697
KRTAP10-11P604125EBI-10192698,EBI-10217483
KRTAP10-5P603705EBI-10192698,EBI-10172150
KRTAP10-7P604094EBI-10192698,EBI-10172290
KRTAP10-8P604109EBI-10192698,EBI-10171774
KRTAP10-9P604115EBI-10192698,EBI-10172052
KRTAP3-2Q9BYR75EBI-10192698,EBI-751260
KRTAP4-12Q9BQ665EBI-10192698,EBI-739863
KRTAP4-2Q9BYR53EBI-10192698,EBI-10172511
KRTAP5-6Q6L8G93EBI-10192698,EBI-10250562
KRTAP9-2Q9BYQ47EBI-10192698,EBI-1044640
KRTAP9-4Q9BYQ25EBI-10192698,EBI-10185730
MDFIQ997507EBI-10192698,EBI-724076
MTUS2Q5JR593EBI-10192698,EBI-742948
NOTCH2NLQ7Z3S95EBI-10192698,EBI-945833
RBPMSQ930623EBI-10192698,EBI-740322
RGS20O760813EBI-10192698,EBI-1052678
RGS20O76081-65EBI-10192698,EBI-10178530
RIMBP3Q9UFD93EBI-10192698,EBI-10182375
SPRY1O436093EBI-10192698,EBI-3866665
SPRY2O435973EBI-10192698,EBI-742487
TRAF2Q129335EBI-10192698,EBI-355744
TRIM23P364063EBI-10192698,EBI-740098
TRIP6Q156543EBI-10192698,EBI-742327
TSGA10Q9BZW73EBI-10192698,EBI-744794

Protein-protein interaction databases

BioGridi114954. 51 interactors.
IntActiQ02930. 57 interactors.
MINTiMINT-267970.
STRINGi9606.ENSP00000350359.

Structurei

3D structure databases

ProteinModelPortaliQ02930.
SMRiQ02930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini375 – 438bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 397Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni403 – 431Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000020106.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiQ02930.
KOiK09047.
OMAiISMHNTV.
OrthoDBiEOG091G0AO8.
PhylomeDBiQ02930.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02930-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK
60 70 80 90 100
TDNMLSDQTP TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS
110 120 130 140 150
MHNAVGGAMT GPGTHQLSSA RLPNHDTNVV IQQAMPSPQS SSVITQAPST
160 170 180 190 200
NRQIGPVPGS LSSLLHLHNR QRQPMPASMP GTLPNPTMPG SSAVLMPMER
210 220 230 240 250
QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL THHPAAMSNG
260 270 280 290 300
NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
310 320 330 340 350
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM
360 370 380 390 400
QPTQTIQPPQ PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV
410 420 430 440 450
MSLEKKAEEL TQTNMQLQNE VSMLKNEVAQ LKQLLLTHKD CPITAMQKES
460 470 480 490 500
QGYLSPESSP PASPVPACSQ QQVIQHNTIT TSSSVSEVVG SSTLSQLTTH

RTDLNPIL
Length:508
Mass (Da):56,918
Last modified:May 31, 2011 - v3
Checksum:iDF96F33AE562F1AD
GO
Isoform 2 (identifier: Q02930-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:501
Mass (Da):56,037
Checksum:i9D67856759DB9957
GO
Isoform 3 (identifier: Q02930-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:475
Mass (Da):53,063
Checksum:iBD75DF80FE7145E9
GO
Isoform 4 (identifier: Q02930-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Show »
Length:369
Mass (Da):41,161
Checksum:i7DC1C71C6A74DEB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16F → S in AAA52072 (PubMed:8440710).Curated1
Sequence conflicti16F → S in AAC37525 (PubMed:8378084).Curated1
Sequence conflicti211 – 212MQ → IE in AAA52072 (PubMed:8440710).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37525 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37526 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37527 (PubMed:8378084).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0500111 – 33Missing in isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_0500121 – 16MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500101 – 7Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_05001317 – 155Missing in isoform 4. 3 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05515 mRNA. Translation: AAA52072.1.
L05911 mRNA. Translation: AAC37525.1.
L05912 mRNA. Translation: AAC37527.1.
L05913 mRNA. Translation: AAC37526.1.
AK292916 mRNA. Translation: BAF85605.1.
AK300455 mRNA. Translation: BAG62175.1.
AK316187 mRNA. Translation: BAH14558.1.
AB451409 mRNA. Translation: BAG70223.1.
AC003074 Genomic DNA. Translation: AAS00387.1.
AC005105 Genomic DNA. Translation: AAP22329.1.
AC005013 Genomic DNA. No translation available.
AC006331 Genomic DNA. No translation available.
AC006367 Genomic DNA. No translation available.
AC006980 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93908.1.
CH471073 Genomic DNA. Translation: EAW93910.1.
BC059400 mRNA. Translation: AAH59400.2.
CCDSiCCDS43562.1. [Q02930-3]
CCDS43563.1. [Q02930-4]
CCDS5417.1. [Q02930-1]
CCDS5418.1. [Q02930-2]
PIRiA45477.
I78877.
RefSeqiNP_001011666.1. NM_001011666.2. [Q02930-4]
NP_004895.2. NM_004904.3. [Q02930-2]
NP_878901.2. NM_182898.3. [Q02930-1]
NP_878902.2. NM_182899.4. [Q02930-3]
XP_005249963.1. XM_005249906.1. [Q02930-2]
XP_016868295.1. XM_017012806.1. [Q02930-2]
XP_016868297.1. XM_017012808.1. [Q02930-1]
UniGeneiHs.437075.

Genome annotation databases

EnsembliENST00000357727; ENSP00000350359; ENSG00000146592. [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592. [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592. [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592. [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592. [Q02930-3]
GeneIDi9586.
KEGGihsa:9586.
UCSCiuc003szo.4. human. [Q02930-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05515 mRNA. Translation: AAA52072.1.
L05911 mRNA. Translation: AAC37525.1.
L05912 mRNA. Translation: AAC37527.1.
L05913 mRNA. Translation: AAC37526.1.
AK292916 mRNA. Translation: BAF85605.1.
AK300455 mRNA. Translation: BAG62175.1.
AK316187 mRNA. Translation: BAH14558.1.
AB451409 mRNA. Translation: BAG70223.1.
AC003074 Genomic DNA. Translation: AAS00387.1.
AC005105 Genomic DNA. Translation: AAP22329.1.
AC005013 Genomic DNA. No translation available.
AC006331 Genomic DNA. No translation available.
AC006367 Genomic DNA. No translation available.
AC006980 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93908.1.
CH471073 Genomic DNA. Translation: EAW93910.1.
BC059400 mRNA. Translation: AAH59400.2.
CCDSiCCDS43562.1. [Q02930-3]
CCDS43563.1. [Q02930-4]
CCDS5417.1. [Q02930-1]
CCDS5418.1. [Q02930-2]
PIRiA45477.
I78877.
RefSeqiNP_001011666.1. NM_001011666.2. [Q02930-4]
NP_004895.2. NM_004904.3. [Q02930-2]
NP_878901.2. NM_182898.3. [Q02930-1]
NP_878902.2. NM_182899.4. [Q02930-3]
XP_005249963.1. XM_005249906.1. [Q02930-2]
XP_016868295.1. XM_017012806.1. [Q02930-2]
XP_016868297.1. XM_017012808.1. [Q02930-1]
UniGeneiHs.437075.

3D structure databases

ProteinModelPortaliQ02930.
SMRiQ02930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114954. 51 interactors.
IntActiQ02930. 57 interactors.
MINTiMINT-267970.
STRINGi9606.ENSP00000350359.

PTM databases

iPTMnetiQ02930.
PhosphoSitePlusiQ02930.

Polymorphism and mutation databases

BioMutaiCREB5.
DMDMi334302918.

Proteomic databases

MaxQBiQ02930.
PaxDbiQ02930.
PeptideAtlasiQ02930.
PRIDEiQ02930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357727; ENSP00000350359; ENSG00000146592. [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592. [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592. [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592. [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592. [Q02930-3]
GeneIDi9586.
KEGGihsa:9586.
UCSCiuc003szo.4. human. [Q02930-1]

Organism-specific databases

CTDi9586.
DisGeNETi9586.
GeneCardsiCREB5.
HGNCiHGNC:16844. CREB5.
HPAiHPA050020.
HPA061622.
neXtProtiNX_Q02930.
OpenTargetsiENSG00000146592.
PharmGKBiPA134930491.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000020106.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiQ02930.
KOiK09047.
OMAiISMHNTV.
OrthoDBiEOG091G0AO8.
PhylomeDBiQ02930.

Enzyme and pathway databases

SIGNORiQ02930.

Miscellaneous databases

ChiTaRSiCREB5. human.
GeneWikiiCREB5.
GenomeRNAii9586.
PROiQ02930.

Gene expression databases

BgeeiENSG00000146592.
CleanExiHS_CREB5.
ExpressionAtlasiQ02930. baseline and differential.
GenevisibleiQ02930. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCREB5_HUMAN
AccessioniPrimary (citable) accession number: Q02930
Secondary accession number(s): A8KA51
, B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 31, 2011
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.