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Protein

Cyclic AMP-responsive element-binding protein 5

Gene

CREB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the cAMP response element and activates transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: ProtInc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ02930.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 5
Short name:
CREB-5
Short name:
cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
Gene namesi
Name:CREB5
Synonyms:CREBPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146592.16.
HGNCiHGNC:16844. CREB5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9586.
OpenTargetsiENSG00000146592.
PharmGKBiPA134930491.

Polymorphism and mutation databases

BioMutaiCREB5.
DMDMi334302918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766041 – 508Cyclic AMP-responsive element-binding protein 5Add BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei59PhosphothreonineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ02930.
PaxDbiQ02930.
PeptideAtlasiQ02930.
PRIDEiQ02930.

PTM databases

iPTMnetiQ02930.
PhosphoSitePlusiQ02930.

Expressioni

Gene expression databases

BgeeiENSG00000146592.
CleanExiHS_CREB5.
ExpressionAtlasiQ02930. baseline and differential.
GenevisibleiQ02930. HS.

Organism-specific databases

HPAiHPA050020.
HPA061622.

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114954. 53 interactors.
IntActiQ02930. 119 interactors.
MINTiMINT-267970.
STRINGi9606.ENSP00000350359.

Structurei

3D structure databases

ProteinModelPortaliQ02930.
SMRiQ02930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini375 – 438bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni377 – 397Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni403 – 431Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 40C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000020106.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiQ02930.
KOiK09047.
OMAiISMHNTV.
OrthoDBiEOG091G0AO8.
PhylomeDBiQ02930.

Family and domain databases

InterProiView protein in InterPro
IPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF57667. SSF57667. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q02930-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK
60 70 80 90 100
TDNMLSDQTP TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS
110 120 130 140 150
MHNAVGGAMT GPGTHQLSSA RLPNHDTNVV IQQAMPSPQS SSVITQAPST
160 170 180 190 200
NRQIGPVPGS LSSLLHLHNR QRQPMPASMP GTLPNPTMPG SSAVLMPMER
210 220 230 240 250
QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL THHPAAMSNG
260 270 280 290 300
NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH
310 320 330 340 350
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM
360 370 380 390 400
QPTQTIQPPQ PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV
410 420 430 440 450
MSLEKKAEEL TQTNMQLQNE VSMLKNEVAQ LKQLLLTHKD CPITAMQKES
460 470 480 490 500
QGYLSPESSP PASPVPACSQ QQVIQHNTIT TSSSVSEVVG SSTLSQLTTH

RTDLNPIL
Length:508
Mass (Da):56,918
Last modified:May 31, 2011 - v3
Checksum:iDF96F33AE562F1AD
GO
Isoform 2 (identifier: Q02930-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.

Show »
Length:501
Mass (Da):56,037
Checksum:i9D67856759DB9957
GO
Isoform 3 (identifier: Q02930-3) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:475
Mass (Da):53,063
Checksum:iBD75DF80FE7145E9
GO
Isoform 4 (identifier: Q02930-4) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Show »
Length:369
Mass (Da):41,161
Checksum:i7DC1C71C6A74DEB5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16F → S in AAA52072 (PubMed:8440710).Curated1
Sequence conflicti16F → S in AAC37525 (PubMed:8378084).Curated1
Sequence conflicti211 – 212MQ → IE in AAA52072 (PubMed:8440710).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37525 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37526 (PubMed:8378084).Curated2
Sequence conflicti211 – 212MQ → IE in AAC37527 (PubMed:8378084).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0500111 – 33Missing in isoform 3. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_0500121 – 16MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4. 3 PublicationsAdd BLAST16
Alternative sequenceiVSP_0500101 – 7Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_05001317 – 155Missing in isoform 4. 3 PublicationsAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05515 mRNA. Translation: AAA52072.1.
L05911 mRNA. Translation: AAC37525.1.
L05912 mRNA. Translation: AAC37527.1.
L05913 mRNA. Translation: AAC37526.1.
AK292916 mRNA. Translation: BAF85605.1.
AK300455 mRNA. Translation: BAG62175.1.
AK316187 mRNA. Translation: BAH14558.1.
AB451409 mRNA. Translation: BAG70223.1.
AC003074 Genomic DNA. Translation: AAS00387.1.
AC005105 Genomic DNA. Translation: AAP22329.1.
AC005013 Genomic DNA. No translation available.
AC006331 Genomic DNA. No translation available.
AC006367 Genomic DNA. No translation available.
AC006980 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93908.1.
CH471073 Genomic DNA. Translation: EAW93910.1.
BC059400 mRNA. Translation: AAH59400.2.
CCDSiCCDS43562.1. [Q02930-3]
CCDS43563.1. [Q02930-4]
CCDS5417.1. [Q02930-1]
CCDS5418.1. [Q02930-2]
PIRiA45477.
I78877.
RefSeqiNP_001011666.1. NM_001011666.2. [Q02930-4]
NP_004895.2. NM_004904.3. [Q02930-2]
NP_878901.2. NM_182898.3. [Q02930-1]
NP_878902.2. NM_182899.4. [Q02930-3]
XP_005249963.1. XM_005249906.1. [Q02930-2]
XP_016868295.1. XM_017012806.1. [Q02930-2]
XP_016868297.1. XM_017012808.1. [Q02930-1]
UniGeneiHs.437075.
Hs.729524.

Genome annotation databases

EnsembliENST00000357727; ENSP00000350359; ENSG00000146592. [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592. [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592. [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592. [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592. [Q02930-3]
GeneIDi9586.
KEGGihsa:9586.
UCSCiuc003szo.4. human. [Q02930-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCREB5_HUMAN
AccessioniPrimary (citable) accession number: Q02930
Secondary accession number(s): A8KA51
, B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 31, 2011
Last modified: September 27, 2017
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families