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Q02930 (CREB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclic AMP-responsive element-binding protein 5

Short name=CREB-5
Short name=cAMP-responsive element-binding protein 5
Alternative name(s):
CRE-BPa
Gene names
Name:CREB5
Synonyms:CREBPA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the cAMP response element and activates transcription. Ref.2

Subunit structure

Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1. Ref.1

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the bZIP family.

Contains 1 bZIP (basic-leucine zipper) domain.

Contains 1 C2H2-type zinc finger.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q02930-1)

Also known as: Alpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q02930-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.
Isoform 3 (identifier: Q02930-3)

Also known as: Gamma;

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
Isoform 4 (identifier: Q02930-4)

Also known as: Delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MIYEESKMNLEQERPF → MFCTSGGNSASVMSMR
     17-155: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Cyclic AMP-responsive element-binding protein 5
PRO_0000076604

Regions

Domain375 – 43864bZIP
Zinc finger16 – 4025C2H2-type
Region377 – 39721Basic motif By similarity
Region403 – 43129Leucine-zipper By similarity

Amino acid modifications

Modified residue591Phosphothreonine Ref.8
Modified residue611Phosphothreonine Ref.8
Modified residue1371Phosphoserine Ref.8

Natural variations

Alternative sequence1 – 3333Missing in isoform 3.
VSP_050011
Alternative sequence1 – 1616MIYEE…QERPF → MFCTSGGNSASVMSMR in isoform 4.
VSP_050012
Alternative sequence1 – 77Missing in isoform 2.
VSP_050010
Alternative sequence17 – 155139Missing in isoform 4.
VSP_050013

Experimental info

Sequence conflict161F → S in AAA52072. Ref.1
Sequence conflict161F → S in AAC37525. Ref.2
Sequence conflict211 – 2122MQ → IE in AAA52072. Ref.1
Sequence conflict211 – 2122MQ → IE in AAC37525. Ref.2
Sequence conflict211 – 2122MQ → IE in AAC37526. Ref.2
Sequence conflict211 – 2122MQ → IE in AAC37527. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Alpha) [UniParc].

Last modified May 31, 2011. Version 3.
Checksum: DF96F33AE562F1AD

FASTA50856,918
        10         20         30         40         50         60 
MIYEESKMNL EQERPFVCSA PGCSQRFPTE DHLMIHRHKH EMTLKFPSIK TDNMLSDQTP 

        70         80         90        100        110        120 
TPTRFLKNCE EVGLFSELDC SLEHEFRKAQ EEESSKRNIS MHNAVGGAMT GPGTHQLSSA 

       130        140        150        160        170        180 
RLPNHDTNVV IQQAMPSPQS SSVITQAPST NRQIGPVPGS LSSLLHLHNR QRQPMPASMP 

       190        200        210        220        230        240 
GTLPNPTMPG SSAVLMPMER QMSVNSSIMG MQGPNLSNPC ASPQVQPMHS EAKMRLKAAL 

       250        260        270        280        290        300 
THHPAAMSNG NMNTMGHMME MMGSRQDQTP HHHMHSHPHQ HQTLPPHHPY PHQHQHPAHH 

       310        320        330        340        350        360 
PHPQPHHQQN HPHHHSHSHL HAHPAHHQTS PHPPLHTGNQ AQVSPATQQM QPTQTIQPPQ 

       370        380        390        400        410        420 
PTGGRRRRVV DEDPDERRRK FLERNRAAAT RCRQKRKVWV MSLEKKAEEL TQTNMQLQNE 

       430        440        450        460        470        480 
VSMLKNEVAQ LKQLLLTHKD CPITAMQKES QGYLSPESSP PASPVPACSQ QQVIQHNTIT 

       490        500 
TSSSVSEVVG SSTLSQLTTH RTDLNPIL 

« Hide

Isoform 2 (Beta) [UniParc].

Checksum: 9D67856759DB9957
Show »

FASTA50156,037
Isoform 3 (Gamma) [UniParc].

Checksum: BD75DF80FE7145E9
Show »

FASTA47553,063
Isoform 4 (Delta) [UniParc].

Checksum: 7DC1C71C6A74DEB5
Show »

FASTA36941,161

References

« Hide 'large scale' references
[1]"Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1."
Nomura N., Zu Y.-L., Maekawa T., Tabata S., Akiyama T., Ishii S.
J. Biol. Chem. 268:4259-4266(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT.
[2]"Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA."
Zu Y.-L., Maekawa T., Nomura N., Nakata T., Ishii S.
Oncogene 8:2749-2758(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), FUNCTION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Embryo, Placenta and Trachea.
[4]"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. expand/collapse author list , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Placenta.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-59; THR-61 AND SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05515 mRNA. Translation: AAA52072.1.
L05911 mRNA. Translation: AAC37525.1.
L05912 mRNA. Translation: AAC37527.1.
L05913 mRNA. Translation: AAC37526.1.
AK292916 mRNA. Translation: BAF85605.1.
AK300455 mRNA. Translation: BAG62175.1.
AK316187 mRNA. Translation: BAH14558.1.
AB451409 mRNA. Translation: BAG70223.1.
AC003074 Genomic DNA. Translation: AAS00387.1.
AC005105 Genomic DNA. Translation: AAP22329.1.
AC005013 Genomic DNA. No translation available.
AC006331 Genomic DNA. No translation available.
AC006367 Genomic DNA. No translation available.
AC006980 Genomic DNA. No translation available.
CH471073 Genomic DNA. Translation: EAW93908.1.
CH471073 Genomic DNA. Translation: EAW93910.1.
BC059400 mRNA. Translation: AAH59400.2.
PIRA45477.
I78877.
RefSeqNP_001011666.1. NM_001011666.1.
NP_004895.2. NM_004904.2.
NP_878901.2. NM_182898.2.
NP_878902.2. NM_182899.3.
XP_005249963.1. XM_005249906.1.
XP_005249964.1. XM_005249907.1.
UniGeneHs.437075.

3D structure databases

ProteinModelPortalQ02930.
SMRQ02930. Positions 10-46, 377-436.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114954. 4 interactions.
IntActQ02930. 2 interactions.
MINTMINT-267970.
STRING9606.ENSP00000350359.

PTM databases

PhosphoSiteQ02930.

Polymorphism databases

DMDM119370343.

Proteomic databases

PaxDbQ02930.
PRIDEQ02930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357727; ENSP00000350359; ENSG00000146592. [Q02930-1]
ENST00000396298; ENSP00000379592; ENSG00000146592. [Q02930-4]
ENST00000396299; ENSP00000379593; ENSG00000146592. [Q02930-3]
ENST00000396300; ENSP00000379594; ENSG00000146592. [Q02930-2]
ENST00000409603; ENSP00000387197; ENSG00000146592. [Q02930-3]
GeneID9586.
KEGGhsa:9586.
UCSCuc003szo.3. human. [Q02930-1]
uc003szs.3. human. [Q02930-4]

Organism-specific databases

CTD9586.
GeneCardsGC07P028305.
HGNCHGNC:16844. CREB5.
HPAHPA050020.
neXtProtNX_Q02930.
PharmGKBPA134930491.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286140.
HOGENOMHOG000220894.
HOVERGENHBG004300.
InParanoidQ02930.
KOK09047.
OMAISMHNTV.
OrthoDBEOG741Z31.
PhylomeDBQ02930.

Gene expression databases

ArrayExpressQ02930.
BgeeQ02930.
CleanExHS_CREB5.
GenevestigatorQ02930.

Family and domain databases

Gene3D3.30.160.60. 1 hit.
InterProIPR004827. bZIP.
IPR016378. TF_cAMP-dep.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTSM00338. BRLZ. 1 hit.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCREB5. human.
GeneWikiCREB5.
GenomeRNAi9586.
NextBio35963.
PROQ02930.

Entry information

Entry nameCREB5_HUMAN
AccessionPrimary (citable) accession number: Q02930
Secondary accession number(s): A8KA51 expand/collapse secondary AC list , B4DU13, B5BUH3, C9JK47, Q05886, Q06246, Q75N02, Q86UJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 31, 2011
Last modified: March 19, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM