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Q02912 (DHSO_BOMMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorbitol dehydrogenase

EC=1.1.1.14
Alternative name(s):
L-iditol 2-dehydrogenase
Gene names
Name:SDH
OrganismBombyx mori (Silk moth) [Reference proteome]
Taxonomic identifier7091 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-iditol + NAD+ = L-sorbose + NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Induction

By cold.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
   Biological processStress response
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionL-iditol 2-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Sorbitol dehydrogenase
PRO_0000160820

Sites

Metal binding401Zinc; catalytic By similarity
Metal binding651Zinc; catalytic By similarity
Metal binding661Zinc; catalytic By similarity
Binding site2951Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02912 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: 2985304E9ADE6FF0

FASTA34837,158
        10         20         30         40         50         60 
MTENYAAVLH GANDVRIEKI PVPEINDDEV LIKIDCVGIC GSDVKLYSTG TCGADVIDKP 

        70         80         90        100        110        120 
IVIGHEGAGT VVKVGDKVSS LRVGDRVAIE PTQPCRSCEL CKRGKYNLCV EPRYCSSMGA 

       130        140        150        160        170        180 
PGNLCRYYKH VADFCHKLPD NLTMEEGAAV QPLAIVIHAC NRAKITLGSK IVILGAGPIG 

       190        200        210        220        230        240 
ILCAMSAKAM GASKIILTDV VQSRLDAALE LGADNVLLVR REYTDEEVVE KIVKLLGDRP 

       250        260        270        280        290        300 
DVSIDACGYG SAQRVALLVT KTAGLVLVVG IADKTVELPL SQALLREVDV VGSFRIMNTY 

       310        320        330        340 
QPALAAVSSG AIPLDKFITH RFPLNKTKEA LDLAKSGAAM KILIHVQN 

« Hide

References

[1]"A cold-inducible Bombyx gene encoding a protein similar to mammalian sorbitol dehydrogenase. Yolk nuclei-dependent gene expression in diapause eggs."
Niimi T., Yamashita O., Yaginuma T.
Eur. J. Biochem. 213:1125-1131(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the Bombyx sorbitol dehydrogenase gene: a possible alternative use of the promoter."
Niimi T., Yamashita O., Yaginuma T.
Insect Mol. Biol. 5:269-280(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Tokai X Asahi.
Tissue: Fat body.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D13371 mRNA. Translation: BAA02634.1.
D66906 Genomic DNA. Translation: BAA11030.1.
PIRS32484.
RefSeqNP_001037311.1. NM_001043846.1.
UniGeneBmo.3.

3D structure databases

ProteinModelPortalQ02912.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID692742.

Organism-specific databases

CTD5656977.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHSO_BOMMO
AccessionPrimary (citable) accession number: Q02912
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families