Q02912 (DHSO_BOMMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorbitol dehydrogenase
EC=1.1.1.14

Alternative name(s):
L-iditol 2-dehydrogenase

Gene names

Name:

SDH

Organism

Bombyx mori (Silk moth) [Reference proteome]

Taxonomic identifier

7091 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Amphiesmenoptera › Lepidoptera › Glossata › Neolepidoptera › Heteroneura › Ditrysia › Obtectomera › Bombycoidea › Bombyciformes › Bombycidae › Bombycinae › Bombyx

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	L-iditol + NAD+ = L-sorbose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Induction	By cold.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Biological process	Stress response
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	L-iditol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Sorbitol dehydrogenase		PRO_0000160820
Sites
	Metal binding	40	1	Zinc; catalytic By similarity
	Metal binding	65	1	Zinc; catalytic By similarity
	Metal binding	66	1	Zinc; catalytic By similarity
	Binding site	295	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02912 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 2985304E9ADE6FF0	FASTA	348	37,158
	10 20 30 40 50 60 MTENYAAVLH GANDVRIEKI PVPEINDDEV LIKIDCVGIC GSDVKLYSTG TCGADVIDKP 70 80 90 100 110 120 IVIGHEGAGT VVKVGDKVSS LRVGDRVAIE PTQPCRSCEL CKRGKYNLCV EPRYCSSMGA 130 140 150 160 170 180 PGNLCRYYKH VADFCHKLPD NLTMEEGAAV QPLAIVIHAC NRAKITLGSK IVILGAGPIG 190 200 210 220 230 240 ILCAMSAKAM GASKIILTDV VQSRLDAALE LGADNVLLVR REYTDEEVVE KIVKLLGDRP 250 260 270 280 290 300 DVSIDACGYG SAQRVALLVT KTAGLVLVVG IADKTVELPL SQALLREVDV VGSFRIMNTY 310 320 330 340 QPALAAVSSG AIPLDKFITH RFPLNKTKEA LDLAKSGAAM KILIHVQN

References

[1]	"A cold-inducible Bombyx gene encoding a protein similar to mammalian sorbitol dehydrogenase. Yolk nuclei-dependent gene expression in diapause eggs." Niimi T., Yamashita O., Yaginuma T. Eur. J. Biochem. 213:1125-1131(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure of the Bombyx sorbitol dehydrogenase gene: a possible alternative use of the promoter." Niimi T., Yamashita O., Yaginuma T. Insect Mol. Biol. 5:269-280(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Tokai X Asahi. Tissue: Fat body.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13371 mRNA. Translation: BAA02634.1. D66906 Genomic DNA. Translation: BAA11030.1.
PIR	S32484.
RefSeq	NP_001037311.1. NM_001043846.1.
UniGene	Bmo.3.
3D structure databases
ProteinModelPortal	Q02912.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	692742.
Organism-specific databases
CTD	5656977.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11695. PTHR11695. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSO_BOMMO

Accession

Primary (citable) accession number: Q02912

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)