Reviewed,
UniProtKB/Swiss-Prot Q02912 (DHSO_BOMMO)
Last modified
June 16, 2009.
Version 64.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Sorbitol dehydrogenase EC=1.1.1.14 Alternative name(s): L-iditol 2-dehydrogenase | ||
| Gene names |
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| Organism | Bombyx mori (Silk moth) | ||
| Taxonomic identifier | 7091 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Lepidoptera › Glossata › Ditrysia › Bombycoidea › Bombycidae › Bombycinae › Bombyx |
Protein attributes
| Sequence length | 348 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-iditol + NAD+ = L-sorbose + NADH. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subunit structure | Homotetramer By similarity. |
| Induction | By cold. |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to stressInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | L-iditol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "A cold-inducible Bombyx gene encoding a protein similar to mammalian sorbitol dehydrogenase. Yolk nuclei-dependent gene expression in diapause eggs." Niimi T., Yamashita O., Yaginuma T. Eur. J. Biochem. 213:1125-1131(1993) [PubMed: 8504807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Structure of the Bombyx sorbitol dehydrogenase gene: a possible alternative use of the promoter." Niimi T., Yamashita O., Yaginuma T. Insect Mol. Biol. 5:269-280(1996) [PubMed: 8933178] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Tokai X Asahi. Tissue: Fat body. |
Cross-references
Sequence databases | |
|---|---|
| D13371 mRNA. Translation: BAA02634.1. D66906 Genomic DNA. Translation: BAA11030.1. | |
| PIR | S32484. |
| RefSeq | NP_001037311.1. |
| UniGene | Bmo.3 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1E3J based on UniProtKB O96496. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 692742. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.14. 252. |
Family and domain databases | |
| InterPro | IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view] |
| PANTHER | PTHR11695. ADH_Sf_Zn. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| ProDom | PD040557. GroES_related. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DHSO_BOMMO | ||||||||
| Accession | Primary (citable) accession number: Q02912 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||

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