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Protein

Nucleolar GTP-binding protein 1

Gene

NOG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biogenesis of the 60S ribosomal subunit.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 1818GTPPROSITE-ProRule annotation
Nucleotide bindingi220 – 2245GTPPROSITE-ProRule annotation
Nucleotide bindingi288 – 2914GTPPROSITE-ProRule annotation

GO - Molecular functioni

  • GTP binding Source: SGD

GO - Biological processi

  • assembly of large subunit precursor of preribosome Source: SGD
  • ribosomal large subunit biogenesis Source: SGD
  • ribosomal subunit export from nucleus Source: SGD
  • rRNA processing Source: SGD
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33997-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar GTP-binding protein 1
Gene namesi
Name:NOG1
Ordered Locus Names:YPL093W
ORF Names:LPG15W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL093W.
SGDiS000006014. NOG1.

Subcellular locationi

  • Nucleusnucleolus 1 Publication

GO - Cellular componenti

  • nucleolus Source: SGD
  • preribosome, large subunit precursor Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 647647Nucleolar GTP-binding protein 1PRO_0000195035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei563 – 5631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ02892.
PeptideAtlasiQ02892.

PTM databases

iPTMnetiQ02892.

Interactioni

Subunit structurei

Associated with nucleolar and cytoplasmic pre-60S particles. Directly interacts with RLP24.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ERB1Q046602EBI-12105,EBI-28098
HAS1Q035322EBI-12105,EBI-8170
LOC1P435864EBI-12105,EBI-22906
MAK21Q121763EBI-12105,EBI-10944
NOP2P409913EBI-12105,EBI-12110
NOP4P378384EBI-12105,EBI-12122
NOP7P532614EBI-12105,EBI-13145
NSA1P531364EBI-12105,EBI-23920
NSA2P400785EBI-12105,EBI-22681
RLP7P406933EBI-12105,EBI-15415
RPF2P361607EBI-12105,EBI-15881
RPL20BP0C2I02EBI-12105,EBI-15298
RPL2BP057363EBI-12105,EBI-15328
RPL5P263212EBI-12105,EBI-15398

Protein-protein interaction databases

BioGridi36088. 136 interactions.
DIPiDIP-2785N.
IntActiQ02892. 97 interactions.
MINTiMINT-654878.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V7Felectron microscopy8.70o1-647[»]
5FL8electron microscopy9.50o1-647[»]
ProteinModelPortaliQ02892.
SMRiQ02892. Positions 1-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 340173OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018475.
HOGENOMiHOG000164071.
InParanoidiQ02892.
KOiK06943.
OMAiLQTEGFP.
OrthoDBiEOG7GQZ4F.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSWKDIPT VAPANDLLDI VLNRTQRKTP TVIRPGFKIT RIRAFYMRKV
60 70 80 90 100
KYTGEGFVEK FEDILKGFPN INDVHPFHRD LMDTLYEKNH YKISLAAISR
110 120 130 140 150
AKSLVEQVAR DYVRLLKFGQ SLFQCKQLKR AALGRMATIV KKLRDPLAYL
160 170 180 190 200
EQVRQHIGRL PSIDPNTRTL LICGYPNVGK SSFLRCITKS DVDVQPYAFT
210 220 230 240 250
TKSLYVGHFD YKYLRFQAID TPGILDRPTE EMNNIEMQSI YAIAHLRSCV
260 270 280 290 300
LYFMDLSEQC GFTIEAQVKL FHSIKPLFAN KSVMVVINKT DIIRPEDLDE
310 320 330 340 350
ERAQLLESVK EVPGVEIMTS SCQLEENVME VRNKACEKLL ASRIENKLKS
360 370 380 390 400
QSRINNVLNK IHVAQPQARD DVKRTPFIPE SVKNLKKYDP EDPNRRKLAR
410 420 430 440 450
DIEAENGGAG VFNVNLKDKY LLEDDEWKND IMPEILDGKN VYDFLDPEIA
460 470 480 490 500
AKLQALEEEE EKLENEGFYN SDDEEEIYDG FEASEVDDIK EKAAWIRNRQ
510 520 530 540 550
KTMIAEARNR KSLKNKAIMP RSKLTKSFGK MEEHMSTLGH DMSALQDKQN
560 570 580 590 600
RAARKNRYVE RGSDVVFGDQ DALTASTENG VKLRQTDRLL DGVADGSMRS
610 620 630 640
KADRMAKMER RERNRHAKQG ESDRHNAVSL SKHLFSGKRG VGKTDFR
Length:647
Mass (Da):74,410
Last modified:November 1, 1996 - v1
Checksum:i640324779AE4D716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43281 Genomic DNA. Translation: AAB68206.1.
BK006949 Genomic DNA. Translation: DAA11340.1.
PIRiS61973.
RefSeqiNP_015232.1. NM_001183907.1.

Genome annotation databases

EnsemblFungiiYPL093W; YPL093W; YPL093W.
GeneIDi856012.
KEGGisce:YPL093W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43281 Genomic DNA. Translation: AAB68206.1.
BK006949 Genomic DNA. Translation: DAA11340.1.
PIRiS61973.
RefSeqiNP_015232.1. NM_001183907.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V7Felectron microscopy8.70o1-647[»]
5FL8electron microscopy9.50o1-647[»]
ProteinModelPortaliQ02892.
SMRiQ02892. Positions 1-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36088. 136 interactions.
DIPiDIP-2785N.
IntActiQ02892. 97 interactions.
MINTiMINT-654878.

PTM databases

iPTMnetiQ02892.

Proteomic databases

MaxQBiQ02892.
PeptideAtlasiQ02892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL093W; YPL093W; YPL093W.
GeneIDi856012.
KEGGisce:YPL093W.

Organism-specific databases

EuPathDBiFungiDB:YPL093W.
SGDiS000006014. NOG1.

Phylogenomic databases

GeneTreeiENSGT00390000018475.
HOGENOMiHOG000164071.
InParanoidiQ02892.
KOiK06943.
OMAiLQTEGFP.
OrthoDBiEOG7GQZ4F.

Enzyme and pathway databases

BioCyciYEAST:G3O-33997-MONOMER.

Miscellaneous databases

NextBioi980902.
PROiQ02892.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR031167. G_OBG.
IPR006073. GTP_binding_domain.
IPR024926. NOG1.
IPR010674. NOG1_Rossman_fold_dom.
IPR012973. NOG_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06858. NOG1. 1 hit.
PF08155. NOGCT. 1 hit.
[Graphical view]
PIRSFiPIRSF038919. NOG1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "A novel nucleolar G-protein conserved in eukaryotes."
    Park J.-H., Jensen B.C., Kifer C.T., Parsons M.
    J. Cell Sci. 114:173-185(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. Cited for: FUNCTION, INTERACTION WITH RLP24.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNOG1_YEAST
AccessioniPrimary (citable) accession number: Q02892
Secondary accession number(s): D6W3S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2001
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 28000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.