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Protein

60S ribosomal protein L6

Gene

RPL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • DNA binding Source: ProtInc
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
Neoplasm-related protein C140
Tax-responsive enhancer element-binding protein 107
Short name:
TaxREB107
Gene namesi
Name:RPL6
Synonyms:TXREB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10362. RPL6.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34758.

Polymorphism and mutation databases

BioMutaiRPL6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 28828760S ribosomal protein L6PRO_0000171009Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei127 – 1271PhosphoserineCombined sources
Modified residuei239 – 2391N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ02878.
MaxQBiQ02878.
PaxDbiQ02878.
PeptideAtlasiQ02878.
PRIDEiQ02878.
TopDownProteomicsiQ02878.

2D gel databases

SWISS-2DPAGEQ02878.

PTM databases

iPTMnetiQ02878.
PhosphoSiteiQ02878.
SwissPalmiQ02878.

Expressioni

Gene expression databases

BgeeiENSG00000089009.
CleanExiHS_RPL6.
ExpressionAtlasiQ02878. baseline and differential.
GenevisibleiQ02878. HS.

Organism-specific databases

HPAiHPA060903.
HPA068418.

Interactioni

Subunit structurei

May bind IPO9 with low affinity.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi112048. 268 interactions.
DIPiDIP-27547N.
IntActiQ02878. 51 interactions.
MINTiMINT-1159780.
STRINGi9606.ENSP00000202773.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LE1-288[»]
4V6Xelectron microscopy5.00CE1-288[»]
5AJ0electron microscopy3.50AE1-288[»]
ProteinModelPortaliQ02878.
SMRiQ02878. Positions 27-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOVERGENiHBG002565.
InParanoidiQ02878.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
PhylomeDBiQ02878.
TreeFamiTF300115.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL
60 70 80 90 100
VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK
110 120 130 140 150
NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRKL RASITPGTIL
160 170 180 190 200
IILTGRHRGK RVVFLKQLAS GLLLVTGPLV LNRVPLRRTH QKFVIATSTK
210 220 230 240 250
IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY EITEQRKIDQ
260 270 280
KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF
Length:288
Mass (Da):32,728
Last modified:January 23, 2007 - v3
Checksum:iD24A6168C7D0ECBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 6321HCSRN…RSAMY → PLQPQPCPSQRNWQVFPICH V in CAA49188 (PubMed:8479925).CuratedAdd
BLAST
Sequence conflicti177 – 1837GPLVLNR → DLWSSIE in CAA49188 (PubMed:8479925).Curated
Sequence conflicti181 – 20525LNRVP…IDISN → SIEFLYEEHTRNLSLPLQPK SISAI in AAB30819 (PubMed:8185817).CuratedAdd
BLAST
Sequence conflicti252 – 26817AVDSQ…IPQLQ → LWTHKFYQKSKLFLSSS in CAA49188 (PubMed:8479925).CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001K → Q in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036437
Natural varianti227 – 2271H → R.1 Publication
Corresponds to variant rs17851813 [ dbSNP | Ensembl ].
VAR_025313
Natural varianti237 – 2371K → E.
Corresponds to variant rs16942044 [ dbSNP | Ensembl ].
VAR_051810

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69391 mRNA. Translation: CAA49188.1.
D17554 mRNA. Translation: BAA04491.1.
AB042820 Genomic DNA. Translation: BAB17292.1.
BC004138 mRNA. Translation: AAH04138.1.
BC020679 mRNA. Translation: AAH20679.1.
BC032299 mRNA. Translation: AAH32299.1.
BC071912 mRNA. Translation: AAH71912.1.
BC104824 mRNA. Translation: AAI04825.1.
BC104826 mRNA. Translation: AAI04827.1.
S71022 mRNA. Translation: AAB30819.1.
CCDSiCCDS9162.1.
PIRiI51803.
S33714.
RefSeqiNP_000961.2. NM_000970.4.
NP_001019833.1. NM_001024662.2.
NP_001307066.1. NM_001320137.1.
NP_001307067.1. NM_001320138.1.
NP_001307068.1. NM_001320139.1.
NP_001307069.1. NM_001320140.1.
NP_001307070.1. NM_001320141.1.
UniGeneiHs.528668.
Hs.546283.
Hs.744897.

Genome annotation databases

EnsembliENST00000202773; ENSP00000202773; ENSG00000089009.
ENST00000424576; ENSP00000403172; ENSG00000089009.
GeneIDi6128.
KEGGihsa:6128.
UCSCiuc001ttu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69391 mRNA. Translation: CAA49188.1.
D17554 mRNA. Translation: BAA04491.1.
AB042820 Genomic DNA. Translation: BAB17292.1.
BC004138 mRNA. Translation: AAH04138.1.
BC020679 mRNA. Translation: AAH20679.1.
BC032299 mRNA. Translation: AAH32299.1.
BC071912 mRNA. Translation: AAH71912.1.
BC104824 mRNA. Translation: AAI04825.1.
BC104826 mRNA. Translation: AAI04827.1.
S71022 mRNA. Translation: AAB30819.1.
CCDSiCCDS9162.1.
PIRiI51803.
S33714.
RefSeqiNP_000961.2. NM_000970.4.
NP_001019833.1. NM_001024662.2.
NP_001307066.1. NM_001320137.1.
NP_001307067.1. NM_001320138.1.
NP_001307068.1. NM_001320139.1.
NP_001307069.1. NM_001320140.1.
NP_001307070.1. NM_001320141.1.
UniGeneiHs.528668.
Hs.546283.
Hs.744897.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LE1-288[»]
4V6Xelectron microscopy5.00CE1-288[»]
5AJ0electron microscopy3.50AE1-288[»]
ProteinModelPortaliQ02878.
SMRiQ02878. Positions 27-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112048. 268 interactions.
DIPiDIP-27547N.
IntActiQ02878. 51 interactions.
MINTiMINT-1159780.
STRINGi9606.ENSP00000202773.

PTM databases

iPTMnetiQ02878.
PhosphoSiteiQ02878.
SwissPalmiQ02878.

Polymorphism and mutation databases

BioMutaiRPL6.

2D gel databases

SWISS-2DPAGEQ02878.

Proteomic databases

EPDiQ02878.
MaxQBiQ02878.
PaxDbiQ02878.
PeptideAtlasiQ02878.
PRIDEiQ02878.
TopDownProteomicsiQ02878.

Protocols and materials databases

DNASUi6128.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202773; ENSP00000202773; ENSG00000089009.
ENST00000424576; ENSP00000403172; ENSG00000089009.
GeneIDi6128.
KEGGihsa:6128.
UCSCiuc001ttu.4. human.

Organism-specific databases

CTDi6128.
GeneCardsiRPL6.
H-InvDBHIX0164072.
HGNCiHGNC:10362. RPL6.
HPAiHPA060903.
HPA068418.
MIMi603703. gene.
neXtProtiNX_Q02878.
PharmGKBiPA34758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOVERGENiHBG002565.
InParanoidiQ02878.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
PhylomeDBiQ02878.
TreeFamiTF300115.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL6. human.
GeneWikiiRPL6.
GenomeRNAii6128.
PROiQ02878.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089009.
CleanExiHS_RPL6.
ExpressionAtlasiQ02878. baseline and differential.
GenevisibleiQ02878. HS.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL6_HUMAN
AccessioniPrimary (citable) accession number: Q02878
Secondary accession number(s): Q2M3Q3, Q8WW97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 178 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.