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Q02878 (RL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 151. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L6
Alternative name(s):
Neoplasm-related protein C140
Tax-responsive enhancer element-binding protein 107
Short name=TaxREB107
Gene names
Name:RPL6
Synonyms:TXREB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

Subunit structure

May bind IPO9 with low affinity. Ref.11

Sequence similarities

Belongs to the ribosomal protein L6e family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

regulation of transcription, DNA-templated

Traceable author statement Ref.2. Source: ProtInc

translation

Non-traceable author statement Ref.6. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

cytosolic large ribosomal subunit

Inferred from direct assay Ref.6. Source: UniProtKB

   Molecular_functionDNA binding

Traceable author statement Ref.2. Source: ProtInc

RNA binding

Traceable author statement Ref.1. Source: ProtInc

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

structural constituent of ribosome

Non-traceable author statement Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 28828760S ribosomal protein L6
PRO_0000171009

Amino acid modifications

Modified residue1271Phosphoserine Ref.8
Modified residue2181N6-acetyllysine Ref.9
Modified residue2391N6-acetyllysine Ref.9

Natural variations

Natural variant1001K → Q in a colorectal cancer sample; somatic mutation. Ref.12
VAR_036437
Natural variant2271H → R. Ref.4
Corresponds to variant rs17851813 [ dbSNP | Ensembl ].
VAR_025313
Natural variant2371K → E.
Corresponds to variant rs16942044 [ dbSNP | Ensembl ].
VAR_051810

Experimental info

Sequence conflict43 – 6321HCSRN…RSAMY → PLQPQPCPSQRNWQVFPICH V in CAA49188. Ref.1
Sequence conflict177 – 1837GPLVLNR → DLWSSIE in CAA49188. Ref.1
Sequence conflict181 – 20525LNRVP…IDISN → SIEFLYEEHTRNLSLPLQPK SISAI in AAB30819. Ref.5
Sequence conflict252 – 26817AVDSQ…IPQLQ → LWTHKFYQKSKLFLSSS in CAA49188. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q02878 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: D24A6168C7D0ECBF

FASTA28832,728
        10         20         30         40         50         60 
MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS 

        70         80         90        100        110        120 
AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED 

       130        140        150        160        170        180 
VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV 

       190        200        210        220        230        240 
LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY 

       250        260        270        280 
EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6."
Zaman G.J.R.
Nucleic Acids Res. 21:1673-1673(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I."
Morita T., Sato T., Nyunoya H., Tsujimoto A., Takahara J., Irino S., Shimotohno K.
AIDS Res. Hum. Retroviruses 9:115-121(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The human ribosomal protein L6 gene in a critical region for Noonan syndrome."
Kenmochi N., Yoshihama M., Higa S., Tanaka T.
J. Hum. Genet. 45:290-293(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-227.
Tissue: Brain, Liver, Lung and Placenta.
[5]"Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues."
Ohta K., Endo T., Gunji K., Onaya T.
J. Mol. Endocrinol. 12:85-92(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-268.
[6]"Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-10, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH IPO9.
[8]"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-218 AND LYS-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) IN COMPLEX WITH THE 80S RIBOSOME, SUBUNIT.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-100.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69391 mRNA. Translation: CAA49188.1.
D17554 mRNA. Translation: BAA04491.1.
AB042820 Genomic DNA. Translation: BAB17292.1.
BC004138 mRNA. Translation: AAH04138.1.
BC020679 mRNA. Translation: AAH20679.1.
BC032299 mRNA. Translation: AAH32299.1.
BC071912 mRNA. Translation: AAH71912.1.
BC104824 mRNA. Translation: AAI04825.1.
BC104826 mRNA. Translation: AAI04827.1.
S71022 mRNA. Translation: AAB30819.1.
PIRI51803.
S33714.
RefSeqNP_000961.2. NM_000970.3.
NP_001019833.1. NM_001024662.1.
UniGeneHs.546283.
Hs.744897.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00E1-288[»]
ProteinModelPortalQ02878.
SMRQ02878. Positions 27-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112048. 151 interactions.
DIPDIP-27547N.
IntActQ02878. 27 interactions.
MINTMINT-1159780.

PTM databases

PhosphoSiteQ02878.

2D gel databases

SWISS-2DPAGEQ02878.

Proteomic databases

PaxDbQ02878.
PRIDEQ02878.

Protocols and materials databases

DNASU6128.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000202773; ENSP00000202773; ENSG00000089009.
ENST00000424576; ENSP00000403172; ENSG00000089009.
GeneID6128.
KEGGhsa:6128.
UCSCuc001ttu.3. human.

Organism-specific databases

CTD6128.
GeneCardsGC12M112842.
H-InvDBHIX0164072.
HGNCHGNC:10362. RPL6.
MIM603703. gene.
neXtProtNX_Q02878.
PharmGKBPA34758.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2163.
HOVERGENHBG002565.
InParanoidQ02878.
KOK02934.
OMAYELTEQR.
OrthoDBEOG78D7MH.
PhylomeDBQ02878.
TreeFamTF300115.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ02878.
BgeeQ02878.
CleanExHS_RPL6.
GenevestigatorQ02878.

Family and domain databases

Gene3D2.30.30.30. 1 hit.
InterProIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERPTHR10715. PTHR10715. 1 hit.
PfamPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMSSF50104. SSF50104. 1 hit.
PROSITEPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRPL6. human.
GeneWikiRPL6.
GenomeRNAi6128.
NextBio23799.
PROQ02878.
SOURCESearch...

Entry information

Entry nameRL6_HUMAN
AccessionPrimary (citable) accession number: Q02878
Secondary accession number(s): Q2M3Q3, Q8WW97
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM