Q02878 (RL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L6

Alternative name(s):
Neoplasm-related protein C140
Tax-responsive enhancer element-binding protein 107
Short name=TaxREB107

Gene names

Name:	RPL6
Synonyms:	TXREB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.
Subunit structure	May bind IPO9 with low affinity.
Sequence similarities	Belongs to the ribosomal protein L6e family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome regulation of transcription, DNA-dependent Traceable author statement Ref.2. Source: ProtInc translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	DNA binding Traceable author statement Ref.2. Source: ProtInc RNA binding Traceable author statement Ref.1. Source: ProtInc structural constituent of ribosome Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.6
	Chain	2 – 288	287	60S ribosomal protein L6		PRO_0000171009
Amino acid modifications
	Modified residue	127	1	Phosphoserine Ref.8
	Modified residue	218	1	N6-acetyllysine Ref.9
	Modified residue	239	1	N6-acetyllysine Ref.9
Natural variations
	Natural variant	100	1	K → Q in a colorectal cancer sample; somatic mutation. Ref.11		VAR_036437
	Natural variant	227	1	H → R. Ref.4 Corresponds to variant rs17851813 [ dbSNP | Ensembl ].		VAR_025313
	Natural variant	237	1	K → E. Corresponds to variant rs16942044 [ dbSNP | Ensembl ].		VAR_051810
Experimental info
	Sequence conflict	43 – 63	21	HCSRN…RSAMY → PLQPQPCPSQRNWQVFPICH V in CAA49188. Ref.1
	Sequence conflict	177 – 183	7	GPLVLNR → DLWSSIE in CAA49188. Ref.1
	Sequence conflict	181 – 205	25	LNRVP…IDISN → SIEFLYEEHTRNLSLPLQPK SISAI in AAB30819. Ref.5
	Sequence conflict	252 – 268	17	AVDSQ…IPQLQ → LWTHKFYQKSKLFLSSS in CAA49188. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q02878 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: D24A6168C7D0ECBF	FASTA	288	32,728
	10 20 30 40 50 60 MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL VRGIGRYSRS 70 80 90 100 110 120 AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK NGGTRVVKLR KMPRYYPTED 130 140 150 160 170 180 VPRKLLSHGK KPFSQHVRKL RASITPGTIL IILTGRHRGK RVVFLKQLAS GLLLVTGPLV 190 200 210 220 230 240 LNRVPLRRTH QKFVIATSTK IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY 250 260 270 280 EITEQRKIDQ KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6." Zaman G.J.R. Nucleic Acids Res. 21:1673-1673(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I." Morita T., Sato T., Nyunoya H., Tsujimoto A., Takahara J., Irino S., Shimotohno K. AIDS Res. Hum. Retroviruses 9:115-121(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The human ribosomal protein L6 gene in a critical region for Noonan syndrome." Kenmochi N., Yoshihama M., Higa S., Tanaka T. J. Hum. Genet. 45:290-293(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-227. Tissue: Brain, Liver, Lung and Placenta.
[5]	"Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues." Ohta K., Endo T., Gunji K., Onaya T. J. Mol. Endocrinol. 12:85-92(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-268.
[6]	"Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing." Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G. J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-10, MASS SPECTROMETRY.
[7]	"Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains." Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D. EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH IPO9.
[8]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-218 AND LYS-239, MASS SPECTROMETRY.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-100.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69391 mRNA. Translation: CAA49188.1. D17554 mRNA. Translation: BAA04491.1. AB042820 Genomic DNA. Translation: BAB17292.1. BC004138 mRNA. Translation: AAH04138.1. BC020679 mRNA. Translation: AAH20679.1. BC032299 mRNA. Translation: AAH32299.1. BC071912 mRNA. Translation: AAH71912.1. BC104824 mRNA. Translation: AAI04825.1. BC104826 mRNA. Translation: AAI04827.1. S71022 mRNA. Translation: AAB30819.1.
IPI	IPI00790342.
PIR	I51803. S33714.
RefSeq	NP_000961.2. NM_000970.3. NP_001019833.1. NM_001024662.1.
UniGene	Hs.546283. Hs.703523.
3D structure databases
ProteinModelPortal	Q02878.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27547N.
IntAct	Q02878. 19 interactions.
MINT	MINT-1159780.
PTM databases
PhosphoSite	Q02878.
Polymorphism databases
DMDM	1350762.
2D gel databases
SWISS-2DPAGE	Q02878.
Proteomic databases
PaxDb	Q02878.
PRIDE	Q02878.
Protocols and materials databases
DNASU	6128.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000202773; ENSP00000202773; ENSG00000089009. ENST00000424576; ENSP00000403172; ENSG00000089009.
GeneID	6128.
KEGG	hsa:6128.
UCSC	uc001ttu.3. human.
Organism-specific databases
CTD	6128.
GeneCards	GC12M112842.
H-InvDB	HIX0164072.
HGNC	HGNC:10362. RPL6.
MIM	603703. gene.
neXtProt	NX_Q02878.
PharmGKB	PA34758.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2163.
HOVERGEN	HBG002565.
InParanoid	Q02878.
KO	K02934.
OMA	KYELTEQ.
OrthoDB	EOG4W0XDZ.
PhylomeDB	Q02878.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q02878.
Bgee	Q02878.
CleanEx	HS_RPL6.
Genevestigator	Q02878.
GermOnline	ENSG00000089009. Homo sapiens.
Family and domain databases
Gene3D	2.30.30.30. 1 hit.
InterPro	IPR014722. Rib_L2_dom2. IPR005568. Ribosomal_L6_N. IPR000915. Ribosomal_L6E. [Graphical view]
PANTHER	PTHR10715. PTHR10715. 1 hit.
Pfam	PF01159. Ribosomal_L6e. 1 hit. PF03868. Ribosomal_L6e_N. 1 hit. [Graphical view]
PROSITE	PS01170. RIBOSOMAL_L6E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPL6. human.
GenomeRNAi	6128.
NextBio	23799.
SOURCE	Search...

Entry information

Entry name

RL6_HUMAN

Accession

Primary (citable) accession number: Q02878
Secondary accession number(s): Q2M3Q3, Q8WW97

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 141 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.