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Q02878

- RL6_HUMAN

UniProt

Q02878 - RL6_HUMAN

Protein

60S ribosomal protein L6

Gene

RPL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I.

    GO - Molecular functioni

    1. DNA binding Source: ProtInc
    2. poly(A) RNA binding Source: UniProtKB
    3. RNA binding Source: ProtInc
    4. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. regulation of transcription, DNA-templated Source: ProtInc
    6. RNA metabolic process Source: Reactome
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: UniProtKB
    9. translational elongation Source: Reactome
    10. translational initiation Source: Reactome
    11. translational termination Source: Reactome
    12. viral life cycle Source: Reactome
    13. viral process Source: Reactome
    14. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L6
    Alternative name(s):
    Neoplasm-related protein C140
    Tax-responsive enhancer element-binding protein 107
    Short name:
    TaxREB107
    Gene namesi
    Name:RPL6
    Synonyms:TXREB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10362. RPL6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
    2. cytosol Source: Reactome
    3. cytosolic large ribosomal subunit Source: UniProtKB
    4. membrane Source: UniProtKB
    5. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34758.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 28828760S ribosomal protein L6PRO_0000171009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei127 – 1271Phosphoserine1 Publication
    Modified residuei218 – 2181N6-acetyllysine1 Publication
    Modified residuei239 – 2391N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ02878.
    PaxDbiQ02878.
    PRIDEiQ02878.

    2D gel databases

    SWISS-2DPAGEQ02878.

    PTM databases

    PhosphoSiteiQ02878.

    Expressioni

    Gene expression databases

    ArrayExpressiQ02878.
    BgeeiQ02878.
    CleanExiHS_RPL6.
    GenevestigatoriQ02878.

    Interactioni

    Subunit structurei

    May bind IPO9 with low affinity.1 Publication

    Protein-protein interaction databases

    BioGridi112048. 154 interactions.
    DIPiDIP-27547N.
    IntActiQ02878. 28 interactions.
    MINTiMINT-1159780.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Belectron microscopy5.00E1-288[»]
    ProteinModelPortaliQ02878.
    SMRiQ02878. Positions 27-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L6e family.Curated

    Phylogenomic databases

    eggNOGiCOG2163.
    HOVERGENiHBG002565.
    InParanoidiQ02878.
    KOiK02934.
    OMAiYELTEQR.
    OrthoDBiEOG78D7MH.
    PhylomeDBiQ02878.
    TreeFamiTF300115.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    InterProiIPR000915. 60S_ribosomal_L6E.
    IPR014722. Rib_L2_dom2.
    IPR005568. Ribosomal_L6_N.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR10715. PTHR10715. 1 hit.
    PfamiPF01159. Ribosomal_L6e. 1 hit.
    PF03868. Ribosomal_L6e_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02878-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGEKVEKPD TKEKKPEAKK VDAGGKVKKG NLKAKKPKKG KPHCSRNPVL    50
    VRGIGRYSRS AMYSRKAMYK RKYSAAKSKV EKKKKEKVLA TVTKPVGGDK 100
    NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRKL RASITPGTIL 150
    IILTGRHRGK RVVFLKQLAS GLLLVTGPLV LNRVPLRRTH QKFVIATSTK 200
    IDISNVKIPK HLTDAYFKKK KLRKPRHQEG EIFDTEKEKY EITEQRKIDQ 250
    KAVDSQILPK IKAIPQLQGY LRSVFALTNG IYPHKLVF 288
    Length:288
    Mass (Da):32,728
    Last modified:January 23, 2007 - v3
    Checksum:iD24A6168C7D0ECBF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 6321HCSRN…RSAMY → PLQPQPCPSQRNWQVFPICH V in CAA49188. (PubMed:8479925)CuratedAdd
    BLAST
    Sequence conflicti177 – 1837GPLVLNR → DLWSSIE in CAA49188. (PubMed:8479925)Curated
    Sequence conflicti181 – 20525LNRVP…IDISN → SIEFLYEEHTRNLSLPLQPK SISAI in AAB30819. (PubMed:8185817)CuratedAdd
    BLAST
    Sequence conflicti252 – 26817AVDSQ…IPQLQ → LWTHKFYQKSKLFLSSS in CAA49188. (PubMed:8479925)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti100 – 1001K → Q in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036437
    Natural varianti227 – 2271H → R.1 Publication
    Corresponds to variant rs17851813 [ dbSNP | Ensembl ].
    VAR_025313
    Natural varianti237 – 2371K → E.
    Corresponds to variant rs16942044 [ dbSNP | Ensembl ].
    VAR_051810

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69391 mRNA. Translation: CAA49188.1.
    D17554 mRNA. Translation: BAA04491.1.
    AB042820 Genomic DNA. Translation: BAB17292.1.
    BC004138 mRNA. Translation: AAH04138.1.
    BC020679 mRNA. Translation: AAH20679.1.
    BC032299 mRNA. Translation: AAH32299.1.
    BC071912 mRNA. Translation: AAH71912.1.
    BC104824 mRNA. Translation: AAI04825.1.
    BC104826 mRNA. Translation: AAI04827.1.
    S71022 mRNA. Translation: AAB30819.1.
    CCDSiCCDS9162.1.
    PIRiI51803.
    S33714.
    RefSeqiNP_000961.2. NM_000970.3.
    NP_001019833.1. NM_001024662.1.
    XP_006719609.1. XM_006719546.1.
    XP_006719610.1. XM_006719547.1.
    XP_006719611.1. XM_006719548.1.
    XP_006719612.1. XM_006719549.1.
    UniGeneiHs.546283.
    Hs.744897.

    Genome annotation databases

    EnsembliENST00000202773; ENSP00000202773; ENSG00000089009.
    ENST00000424576; ENSP00000403172; ENSG00000089009.
    GeneIDi6128.
    KEGGihsa:6128.
    UCSCiuc001ttu.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69391 mRNA. Translation: CAA49188.1 .
    D17554 mRNA. Translation: BAA04491.1 .
    AB042820 Genomic DNA. Translation: BAB17292.1 .
    BC004138 mRNA. Translation: AAH04138.1 .
    BC020679 mRNA. Translation: AAH20679.1 .
    BC032299 mRNA. Translation: AAH32299.1 .
    BC071912 mRNA. Translation: AAH71912.1 .
    BC104824 mRNA. Translation: AAI04825.1 .
    BC104826 mRNA. Translation: AAI04827.1 .
    S71022 mRNA. Translation: AAB30819.1 .
    CCDSi CCDS9162.1.
    PIRi I51803.
    S33714.
    RefSeqi NP_000961.2. NM_000970.3.
    NP_001019833.1. NM_001024662.1.
    XP_006719609.1. XM_006719546.1.
    XP_006719610.1. XM_006719547.1.
    XP_006719611.1. XM_006719548.1.
    XP_006719612.1. XM_006719549.1.
    UniGenei Hs.546283.
    Hs.744897.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3B electron microscopy 5.00 E 1-288 [» ]
    ProteinModelPortali Q02878.
    SMRi Q02878. Positions 27-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112048. 154 interactions.
    DIPi DIP-27547N.
    IntActi Q02878. 28 interactions.
    MINTi MINT-1159780.

    PTM databases

    PhosphoSitei Q02878.

    2D gel databases

    SWISS-2DPAGE Q02878.

    Proteomic databases

    MaxQBi Q02878.
    PaxDbi Q02878.
    PRIDEi Q02878.

    Protocols and materials databases

    DNASUi 6128.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000202773 ; ENSP00000202773 ; ENSG00000089009 .
    ENST00000424576 ; ENSP00000403172 ; ENSG00000089009 .
    GeneIDi 6128.
    KEGGi hsa:6128.
    UCSCi uc001ttu.3. human.

    Organism-specific databases

    CTDi 6128.
    GeneCardsi GC12M112842.
    H-InvDB HIX0164072.
    HGNCi HGNC:10362. RPL6.
    MIMi 603703. gene.
    neXtProti NX_Q02878.
    PharmGKBi PA34758.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2163.
    HOVERGENi HBG002565.
    InParanoidi Q02878.
    KOi K02934.
    OMAi YELTEQR.
    OrthoDBi EOG78D7MH.
    PhylomeDBi Q02878.
    TreeFami TF300115.

    Enzyme and pathway databases

    Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPL6. human.
    GeneWikii RPL6.
    GenomeRNAii 6128.
    NextBioi 23799.
    PROi Q02878.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02878.
    Bgeei Q02878.
    CleanExi HS_RPL6.
    Genevestigatori Q02878.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    InterProi IPR000915. 60S_ribosomal_L6E.
    IPR014722. Rib_L2_dom2.
    IPR005568. Ribosomal_L6_N.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR10715. PTHR10715. 1 hit.
    Pfami PF01159. Ribosomal_L6e. 1 hit.
    PF03868. Ribosomal_L6e_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    PROSITEi PS01170. RIBOSOMAL_L6E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a cDNA encoding human ribosomal protein L26 and of a cDNA probably encoding human ribosomal protein L6."
      Zaman G.J.R.
      Nucleic Acids Res. 21:1673-1673(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation of a cDNA clone encoding DNA-binding protein (TAXREB107) that binds specifically to domain C of the tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I."
      Morita T., Sato T., Nyunoya H., Tsujimoto A., Takahara J., Irino S., Shimotohno K.
      AIDS Res. Hum. Retroviruses 9:115-121(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human ribosomal protein L6 gene in a critical region for Noonan syndrome."
      Kenmochi N., Yoshihama M., Higa S., Tanaka T.
      J. Hum. Genet. 45:290-293(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-227.
      Tissue: Brain, Liver, Lung and Placenta.
    5. "Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues."
      Ohta K., Endo T., Gunji K., Onaya T.
      J. Mol. Endocrinol. 12:85-92(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-268.
    6. "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing."
      Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R., Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B., Karpova G.G.
      J. Protein Chem. 22:249-258(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-10, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Importins fulfill a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains."
      Jaekel S., Mingot J.-M., Schwarzmaier P., Hartmann E., Goerlich D.
      EMBO J. 21:377-386(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IPO9.
    8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
      J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-218 AND LYS-239, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) IN COMPLEX WITH THE 80S RIBOSOME, SUBUNIT.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-100.

    Entry informationi

    Entry nameiRL6_HUMAN
    AccessioniPrimary (citable) accession number: Q02878
    Secondary accession number(s): Q2M3Q3, Q8WW97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 156 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Ribosomal proteins
      Ribosomal proteins families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3