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Reviewed, UniProtKB/Swiss-Prot Q02866 (MUK1_YEAST)

Last modified June 16, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein MUK1
Gene names
Name: MUK1
Ordered Locus Names: YPL070W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length612 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Putative GTPase-activating protein.

Subcellular location

Cytoplasm. Ref.2

Sequence similarities

Contains 1 VPS9 domain.

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Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionGTPase activation
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm Ref.2

Inferred from direct assay. Source: SGD

   Molecular functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 612612Protein MUK1
PRO_0000255969

Regions

Domain273 – 414142VPS9
Compositional bias115 – 19581Ser-rich
Compositional bias512 – 55443Ser-rich

Amino acid modifications

Modified residue671Phosphoserine Ref.5
Modified residue1631Phosphoserine Ref.5
Modified residue1841Phosphoserine Ref.5 Ref.4
Modified residue1851Phosphoserine Ref.5 Ref.4 Ref.3
Modified residue2441Phosphoserine Ref.5
Modified residue2451Phosphoserine Ref.5
Modified residue4751Phosphoserine Ref.5
Modified residue5221Phosphoserine Ref.5
Modified residue5231Phosphoserine Ref.5

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Sequences

Sequence LengthMass (Da)Tools
Q02866-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C743D0436E541978

FASTA61269,538
        10         20         30         40         50         60 
MARQLFTPPI TNPRFDPNQS IRESYKNTTG GMQFQQNLHE DQNDNERSSC DGDENSTTGE 

        70         80         90        100        110        120 
RLENNKSPIL TKQEIDEALN TVTNLPPELS KLIDIFIDDL KQPKYVRPLS VLQLSSLFQS 

       130        140        150        160        170        180 
FYIKFDKASF QHVSSANNNG YYFSGGGSSS FLAAKETLSS GLSGIFGRSR SSSGNSLMRP 

       190        200        210        220        230        240 
RRSSSLFSNE SISNSTNATQ MLSPEEIKKQ LKINELNNMK IEKYMELCER DVFKKILIVG 

       250        260        270        280        290        300 
TSVSSPNKMK TFKPHQLQTF KVGNLFRNSV EFTEYNKLLN EKILCLSKLS TMNKINLIKF 

       310        320        330        340        350        360 
LSLNNGIDPE PKFEEIKDIL YEFTYHSISP CEKIKALLKL HEIMTYSQEM SNDDYLSLLI 

       370        380        390        400        410        420 
YYIITIVPRD IFLNAEFIRL FRYKKKLVET ESFALTNLEA ALVFVEGLTK NDFSNELQDK 

       430        440        450        460        470        480 
LTVNESKILE NSISSRVSLP SKTAIMHKNN GNNGSNLGDI VTPTIQRPDV TRSNSYDGFR 

       490        500        510        520        530        540 
TVFDSSLKNI IGKIRSYTPP HPNNTSNNNL HSSNNLNIPR SSSQLSMELS NRDTTEMSRD 

       550        560        570        580        590        600 
GSRSTSSSSR SSASLEHGNR EFTGDLTVTA SINGADKKEF QKSWKKYKGY KFEDLTICEL 

       610 
RDLFEIYQKM MQ

« Hide

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References

[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[3]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed: 17330950] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185, MASS SPECTROMETRY.
[4]"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases."
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed: 17563356] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184 AND SER-185, MASS SPECTROMETRY.
[5]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-163; SER-184; SER-185; SER-244; SER-245; SER-475; SER-522 AND SER-523, MASS SPECTROMETRY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U41849 Genomic DNA. Translation: AAB68267.1.
PIRS61116.
RefSeqNP_015255.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1326N.
IntActQ02866. 45 interactions.

Proteomic databases

PeptideAtlasQ02866.

Genome annotation databases

EnsemblYPL070W. Saccharomyces cerevisiae. [Contig view]
GeneID856035.
GenomeReviewsGene locus YPL070W in contig U00094_GR.
KEGGsce:YPL070W.
NMPDRfig|4932.3.peg.6388.

Organism-specific databases

CYGDYPL070w.
SGDS000005991. MUK1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ02866.
OMAQ02866. DDLKQPK.

Gene expression databases

ArrayExpressQ02866.
GermOnlineYPL070W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003123. VPS9.
IPR013995. VPS9_sub.
[Graphical view]
PfamPF02204. VPS9. 1 hit.
[Graphical view]
SMARTSM00167. VPS9. 1 hit.
[Graphical view]
PROSITEPS51205. VPS9. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio980965.

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Entry information

Entry nameMUK1_YEAST
AccessionPrimary (citable) accession number: Q02866
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents