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Q02863

- UBP16_YEAST

UniProt

Q02863 - UBP16_YEAST

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Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene

UBP16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621NucleophilePROSITE-ProRule annotation
Active sitei407 – 4071Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  1. protein deubiquitination Source: SGD
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-33980-MONOMER.

Protein family/group databases

MEROPSiC19.A18.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene namesi
Name:UBP16
Ordered Locus Names:YPL072W
ORF Names:LPF12W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL072w.
SGDiS000005993. UBP16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. mitochondrial outer membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Ubiquitin carboxyl-terminal hydrolase 16PRO_0000080601Add
BLAST

Proteomic databases

MaxQBiQ02863.
PaxDbiQ02863.

Expressioni

Gene expression databases

GenevestigatoriQ02863.

Interactioni

Protein-protein interaction databases

BioGridi36107. 12 interactions.
MINTiMINT-4504680.
STRINGi4932.YPL072W.

Structurei

3D structure databases

ProteinModelPortaliQ02863.
SMRiQ02863. Positions 39-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 497445USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiNOG40279.
InParanoidiQ02863.
KOiK11874.
OMAiYEATHAW.
OrthoDBiEOG7BCNMH.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWIKNVTES PTSLIKKVSC GLIIAASLYA IAPSLSALVF GDSKQSIGKY
60 70 80 90 100
TTVGLINRGN DCFITSSLQG LAGIPRFVEY LKRIRTVLLE LETKLSNNAK
110 120 130 140 150
GDNPTVDNTT RHSRLENSSN SLAPLHESLT SLILDLISVK DRKTSISPKI
160 170 180 190 200
VINTLESIFK SKISSKQNDA HEFTLILLQT LQEERSKLID YSKQICNLNI
210 220 230 240 250
PKFPFEGETS KFLVCLKCKG LSEPSYKQTF IRELSVPQQT SENLSNILAH
260 270 280 290 300
DETEIIDDYS CLICQIRAIL NHEEYRNFKD CTPDEILMLD RLKNYATKAP
310 320 330 340 350
INENLPFEVE QYVKRYSKGN LQVSNIKGKV IKKDVVVQLP DILIVHLSRS
360 370 380 390 400
TFNGITYSRN PCNVKFGERI TLSEYTLAES GTITENRQVK YNLKSVVKHT
410 420 430 440 450
GSHSSGHYMC YRRKTEIRFG KEDESSFRRA PVVNNEVNKN REQNVAHNDY
460 470 480 490
KKSRYKKVKN ALRYPYWQIS DTAIKESTAS TVLNEQKYAY MLYYERVNK
Length:499
Mass (Da):56,920
Last modified:November 1, 1996 - v1
Checksum:i292021C9A268B4D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41849 Genomic DNA. Translation: AAB68265.1.
BK006949 Genomic DNA. Translation: DAA11359.1.
PIRiS61114.
RefSeqiNP_015253.1. NM_001183886.1.

Genome annotation databases

EnsemblFungiiYPL072W; YPL072W; YPL072W.
GeneIDi856032.
KEGGisce:YPL072W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41849 Genomic DNA. Translation: AAB68265.1 .
BK006949 Genomic DNA. Translation: DAA11359.1 .
PIRi S61114.
RefSeqi NP_015253.1. NM_001183886.1.

3D structure databases

ProteinModelPortali Q02863.
SMRi Q02863. Positions 39-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36107. 12 interactions.
MINTi MINT-4504680.
STRINGi 4932.YPL072W.

Protein family/group databases

MEROPSi C19.A18.

Proteomic databases

MaxQBi Q02863.
PaxDbi Q02863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL072W ; YPL072W ; YPL072W .
GeneIDi 856032.
KEGGi sce:YPL072W.

Organism-specific databases

CYGDi YPL072w.
SGDi S000005993. UBP16.

Phylogenomic databases

eggNOGi NOG40279.
InParanoidi Q02863.
KOi K11874.
OMAi YEATHAW.
OrthoDBi EOG7BCNMH.

Enzyme and pathway databases

BioCyci YEAST:G3O-33980-MONOMER.

Miscellaneous databases

NextBioi 980959.

Gene expression databases

Genevestigatori Q02863.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP16_YEAST
AccessioniPrimary (citable) accession number: Q02863
Secondary accession number(s): D6W3U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3