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Q02863

- UBP16_YEAST

UniProt

Q02863 - UBP16_YEAST

Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene

UBP16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei62 – 621NucleophilePROSITE-ProRule annotation
    Active sitei407 – 4071Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: SGD

    GO - Biological processi

    1. protein deubiquitination Source: SGD
    2. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33980-MONOMER.

    Protein family/group databases

    MEROPSiC19.A18.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 16
    Ubiquitin thioesterase 16
    Ubiquitin-specific-processing protease 16
    Gene namesi
    Name:UBP16
    Ordered Locus Names:YPL072W
    ORF Names:LPF12W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPL072w.
    SGDiS000005993. UBP16.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. mitochondrial outer membrane Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 499499Ubiquitin carboxyl-terminal hydrolase 16PRO_0000080601Add
    BLAST

    Proteomic databases

    MaxQBiQ02863.
    PaxDbiQ02863.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02863.

    Interactioni

    Protein-protein interaction databases

    BioGridi36107. 12 interactions.
    MINTiMINT-4504680.
    STRINGi4932.YPL072W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02863.
    SMRiQ02863. Positions 39-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 497445USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiNOG40279.
    KOiK11874.
    OMAiYEATHAW.
    OrthoDBiEOG7BCNMH.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02863-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWIKNVTES PTSLIKKVSC GLIIAASLYA IAPSLSALVF GDSKQSIGKY    50
    TTVGLINRGN DCFITSSLQG LAGIPRFVEY LKRIRTVLLE LETKLSNNAK 100
    GDNPTVDNTT RHSRLENSSN SLAPLHESLT SLILDLISVK DRKTSISPKI 150
    VINTLESIFK SKISSKQNDA HEFTLILLQT LQEERSKLID YSKQICNLNI 200
    PKFPFEGETS KFLVCLKCKG LSEPSYKQTF IRELSVPQQT SENLSNILAH 250
    DETEIIDDYS CLICQIRAIL NHEEYRNFKD CTPDEILMLD RLKNYATKAP 300
    INENLPFEVE QYVKRYSKGN LQVSNIKGKV IKKDVVVQLP DILIVHLSRS 350
    TFNGITYSRN PCNVKFGERI TLSEYTLAES GTITENRQVK YNLKSVVKHT 400
    GSHSSGHYMC YRRKTEIRFG KEDESSFRRA PVVNNEVNKN REQNVAHNDY 450
    KKSRYKKVKN ALRYPYWQIS DTAIKESTAS TVLNEQKYAY MLYYERVNK 499
    Length:499
    Mass (Da):56,920
    Last modified:November 1, 1996 - v1
    Checksum:i292021C9A268B4D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41849 Genomic DNA. Translation: AAB68265.1.
    BK006949 Genomic DNA. Translation: DAA11359.1.
    PIRiS61114.
    RefSeqiNP_015253.1. NM_001183886.1.

    Genome annotation databases

    EnsemblFungiiYPL072W; YPL072W; YPL072W.
    GeneIDi856032.
    KEGGisce:YPL072W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U41849 Genomic DNA. Translation: AAB68265.1 .
    BK006949 Genomic DNA. Translation: DAA11359.1 .
    PIRi S61114.
    RefSeqi NP_015253.1. NM_001183886.1.

    3D structure databases

    ProteinModelPortali Q02863.
    SMRi Q02863. Positions 39-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36107. 12 interactions.
    MINTi MINT-4504680.
    STRINGi 4932.YPL072W.

    Protein family/group databases

    MEROPSi C19.A18.

    Proteomic databases

    MaxQBi Q02863.
    PaxDbi Q02863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPL072W ; YPL072W ; YPL072W .
    GeneIDi 856032.
    KEGGi sce:YPL072W.

    Organism-specific databases

    CYGDi YPL072w.
    SGDi S000005993. UBP16.

    Phylogenomic databases

    eggNOGi NOG40279.
    KOi K11874.
    OMAi YEATHAW.
    OrthoDBi EOG7BCNMH.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33980-MONOMER.

    Miscellaneous databases

    NextBioi 980959.

    Gene expression databases

    Genevestigatori Q02863.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiUBP16_YEAST
    AccessioniPrimary (citable) accession number: Q02863
    Secondary accession number(s): D6W3U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 450 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3