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Q02863 (UBP16_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 16

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene names
Name:UBP16
Ordered Locus Names:YPL072W
ORF Names:LPF12W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Ubiquitin carboxyl-terminal hydrolase 16
PRO_0000080601

Regions

Domain53 – 497445USP

Sites

Active site621Nucleophile By similarity
Active site4071Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02863 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 292021C9A268B4D1

FASTA49956,920
        10         20         30         40         50         60 
MSWIKNVTES PTSLIKKVSC GLIIAASLYA IAPSLSALVF GDSKQSIGKY TTVGLINRGN 

        70         80         90        100        110        120 
DCFITSSLQG LAGIPRFVEY LKRIRTVLLE LETKLSNNAK GDNPTVDNTT RHSRLENSSN 

       130        140        150        160        170        180 
SLAPLHESLT SLILDLISVK DRKTSISPKI VINTLESIFK SKISSKQNDA HEFTLILLQT 

       190        200        210        220        230        240 
LQEERSKLID YSKQICNLNI PKFPFEGETS KFLVCLKCKG LSEPSYKQTF IRELSVPQQT 

       250        260        270        280        290        300 
SENLSNILAH DETEIIDDYS CLICQIRAIL NHEEYRNFKD CTPDEILMLD RLKNYATKAP 

       310        320        330        340        350        360 
INENLPFEVE QYVKRYSKGN LQVSNIKGKV IKKDVVVQLP DILIVHLSRS TFNGITYSRN 

       370        380        390        400        410        420 
PCNVKFGERI TLSEYTLAES GTITENRQVK YNLKSVVKHT GSHSSGHYMC YRRKTEIRFG 

       430        440        450        460        470        480 
KEDESSFRRA PVVNNEVNKN REQNVAHNDY KKSRYKKVKN ALRYPYWQIS DTAIKESTAS 

       490 
TVLNEQKYAY MLYYERVNK 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U41849 Genomic DNA. Translation: AAB68265.1.
BK006949 Genomic DNA. Translation: DAA11359.1.
PIRS61114.
RefSeqNP_015253.1. NM_001183886.1.

3D structure databases

ProteinModelPortalQ02863.
SMRQ02863. Positions 39-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36107. 12 interactions.
MINTMINT-4504680.
STRING4932.YPL072W.

Protein family/group databases

MEROPSC19.A18.

Proteomic databases

MaxQBQ02863.
PaxDbQ02863.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPL072W; YPL072W; YPL072W.
GeneID856032.
KEGGsce:YPL072W.

Organism-specific databases

CYGDYPL072w.
SGDS000005993. UBP16.

Phylogenomic databases

eggNOGNOG40279.
KOK11874.
OMAYEATHAW.
OrthoDBEOG7BCNMH.

Enzyme and pathway databases

BioCycYEAST:G3O-33980-MONOMER.

Gene expression databases

GenevestigatorQ02863.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio980959.

Entry information

Entry nameUBP16_YEAST
AccessionPrimary (citable) accession number: Q02863
Secondary accession number(s): D6W3U3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries