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Q02863

- UBP16_YEAST

UniProt

Q02863 - UBP16_YEAST

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Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene
UBP16, YPL072W, LPF12W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Nucleophile By similarity
Active sitei407 – 4071Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  1. protein deubiquitination Source: SGD
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-33980-MONOMER.

Protein family/group databases

MEROPSiC19.A18.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene namesi
Name:UBP16
Ordered Locus Names:YPL072W
ORF Names:LPF12W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPL072w.
SGDiS000005993. UBP16.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. mitochondrial outer membrane Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Ubiquitin carboxyl-terminal hydrolase 16PRO_0000080601Add
BLAST

Proteomic databases

MaxQBiQ02863.
PaxDbiQ02863.

Expressioni

Gene expression databases

GenevestigatoriQ02863.

Interactioni

Protein-protein interaction databases

BioGridi36107. 12 interactions.
MINTiMINT-4504680.
STRINGi4932.YPL072W.

Structurei

3D structure databases

ProteinModelPortaliQ02863.
SMRiQ02863. Positions 39-411.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 497445USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiNOG40279.
KOiK11874.
OMAiYEATHAW.
OrthoDBiEOG7BCNMH.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02863-1 [UniParc]FASTAAdd to Basket

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MSWIKNVTES PTSLIKKVSC GLIIAASLYA IAPSLSALVF GDSKQSIGKY    50
TTVGLINRGN DCFITSSLQG LAGIPRFVEY LKRIRTVLLE LETKLSNNAK 100
GDNPTVDNTT RHSRLENSSN SLAPLHESLT SLILDLISVK DRKTSISPKI 150
VINTLESIFK SKISSKQNDA HEFTLILLQT LQEERSKLID YSKQICNLNI 200
PKFPFEGETS KFLVCLKCKG LSEPSYKQTF IRELSVPQQT SENLSNILAH 250
DETEIIDDYS CLICQIRAIL NHEEYRNFKD CTPDEILMLD RLKNYATKAP 300
INENLPFEVE QYVKRYSKGN LQVSNIKGKV IKKDVVVQLP DILIVHLSRS 350
TFNGITYSRN PCNVKFGERI TLSEYTLAES GTITENRQVK YNLKSVVKHT 400
GSHSSGHYMC YRRKTEIRFG KEDESSFRRA PVVNNEVNKN REQNVAHNDY 450
KKSRYKKVKN ALRYPYWQIS DTAIKESTAS TVLNEQKYAY MLYYERVNK 499
Length:499
Mass (Da):56,920
Last modified:November 1, 1996 - v1
Checksum:i292021C9A268B4D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41849 Genomic DNA. Translation: AAB68265.1.
BK006949 Genomic DNA. Translation: DAA11359.1.
PIRiS61114.
RefSeqiNP_015253.1. NM_001183886.1.

Genome annotation databases

EnsemblFungiiYPL072W; YPL072W; YPL072W.
GeneIDi856032.
KEGGisce:YPL072W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U41849 Genomic DNA. Translation: AAB68265.1 .
BK006949 Genomic DNA. Translation: DAA11359.1 .
PIRi S61114.
RefSeqi NP_015253.1. NM_001183886.1.

3D structure databases

ProteinModelPortali Q02863.
SMRi Q02863. Positions 39-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36107. 12 interactions.
MINTi MINT-4504680.
STRINGi 4932.YPL072W.

Protein family/group databases

MEROPSi C19.A18.

Proteomic databases

MaxQBi Q02863.
PaxDbi Q02863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPL072W ; YPL072W ; YPL072W .
GeneIDi 856032.
KEGGi sce:YPL072W.

Organism-specific databases

CYGDi YPL072w.
SGDi S000005993. UBP16.

Phylogenomic databases

eggNOGi NOG40279.
KOi K11874.
OMAi YEATHAW.
OrthoDBi EOG7BCNMH.

Enzyme and pathway databases

BioCyci YEAST:G3O-33980-MONOMER.

Miscellaneous databases

NextBioi 980959.

Gene expression databases

Genevestigatori Q02863.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP16_YEAST
AccessioniPrimary (citable) accession number: Q02863
Secondary accession number(s): D6W3U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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