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Protein

Ubiquitin carboxyl-terminal hydrolase 16

Gene

UBP16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 450 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62NucleophilePROSITE-ProRule annotation1
Active sitei407Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • thiol-dependent ubiquitin-specific protease activity Source: SGD

GO - Biological processi

  • protein deubiquitination Source: SGD
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-33980-MONOMER

Protein family/group databases

MEROPSiC19.A18

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 16 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 16
Ubiquitin thioesterase 16
Ubiquitin-specific-processing protease 16
Gene namesi
Name:UBP16
Ordered Locus Names:YPL072W
ORF Names:LPF12W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL072W
SGDiS000005993 UBP16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806011 – 499Ubiquitin carboxyl-terminal hydrolase 16Add BLAST499

Proteomic databases

MaxQBiQ02863
PaxDbiQ02863
PRIDEiQ02863

Interactioni

Protein-protein interaction databases

BioGridi36107, 58 interactors
STRINGi4932.YPL072W

Structurei

3D structure databases

ProteinModelPortaliQ02863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 497USPAdd BLAST445

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

InParanoidiQ02863
KOiK11874
OMAiLNACFDG
OrthoDBiEOG092C4KM6

Family and domain databases

InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q02863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWIKNVTES PTSLIKKVSC GLIIAASLYA IAPSLSALVF GDSKQSIGKY
60 70 80 90 100
TTVGLINRGN DCFITSSLQG LAGIPRFVEY LKRIRTVLLE LETKLSNNAK
110 120 130 140 150
GDNPTVDNTT RHSRLENSSN SLAPLHESLT SLILDLISVK DRKTSISPKI
160 170 180 190 200
VINTLESIFK SKISSKQNDA HEFTLILLQT LQEERSKLID YSKQICNLNI
210 220 230 240 250
PKFPFEGETS KFLVCLKCKG LSEPSYKQTF IRELSVPQQT SENLSNILAH
260 270 280 290 300
DETEIIDDYS CLICQIRAIL NHEEYRNFKD CTPDEILMLD RLKNYATKAP
310 320 330 340 350
INENLPFEVE QYVKRYSKGN LQVSNIKGKV IKKDVVVQLP DILIVHLSRS
360 370 380 390 400
TFNGITYSRN PCNVKFGERI TLSEYTLAES GTITENRQVK YNLKSVVKHT
410 420 430 440 450
GSHSSGHYMC YRRKTEIRFG KEDESSFRRA PVVNNEVNKN REQNVAHNDY
460 470 480 490
KKSRYKKVKN ALRYPYWQIS DTAIKESTAS TVLNEQKYAY MLYYERVNK
Length:499
Mass (Da):56,920
Last modified:November 1, 1996 - v1
Checksum:i292021C9A268B4D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41849 Genomic DNA Translation: AAB68265.1
BK006949 Genomic DNA Translation: DAA11359.1
PIRiS61114
RefSeqiNP_015253.1, NM_001183886.1

Genome annotation databases

EnsemblFungiiYPL072W; YPL072W; YPL072W
GeneIDi856032
KEGGisce:YPL072W

Similar proteinsi

Entry informationi

Entry nameiUBP16_YEAST
AccessioniPrimary (citable) accession number: Q02863
Secondary accession number(s): D6W3U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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