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Q02854

- NUXM_NEUCR

UniProt

Q02854 - NUXM_NEUCR

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Protein
NADH-ubiquinone oxidoreductase 20.9 kDa subunit
Gene
nuo20.9, NCU01859
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Protein family/group databases

TCDBi3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 20.9 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-20.9kD
Short name:
CI-20.9kD
Gene namesi
Name:nuo20.9
ORF Names:NCU01859
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 1, Linkage Group I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 8816Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 189189NADH-ubiquinone oxidoreductase 20.9 kDa subunit
PRO_0000118782Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Interactioni

Subunit structurei

Complex I is composed of about 40 different subunits.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81489.
HOGENOMiHOG000170196.

Family and domain databases

InterProiIPR024549. NADH-UbQ_OxRdtase_su21_C_fun.
IPR019721. NADH-UbQ_OxRdtase_su21_N.
[Graphical view]
PfamiPF10785. NADH-u_ox-rdase. 1 hit.
PF12853. NADH_u_ox_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02854-1 [UniParc]FASTAAdd to Basket

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MSSTSSPTYT ISKTLNTNYP LIDNDPHFRR VIGYARPSDY VHGTVAGAAG    50
PGLLYLMEKM APSGVGKGGF PKAMRLATAV GFFGGFLYFY QRSILRFYGM 100
SENAREVQMD MREMVDKVKA GQPLYGVSTL PVDVQGMAAR QSRYSALFFA 150
VLPWFNFVNH NQHGVDTAKY YQQAERELEA ERLGKGSSS 189
Length:189
Mass (Da):20,977
Last modified:February 1, 1994 - v1
Checksum:iE3F23FD959092EC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60829 mRNA. Translation: CAA43221.1.
CM002236 Genomic DNA. Translation: EAA36254.3.
PIRiS27171.
RefSeqiXP_965490.2. XM_960397.2.

Genome annotation databases

EnsemblFungiiEFNCRT00000001025; EFNCRP00000001025; EFNCRG00000001024.
GeneIDi3881668.
KEGGincr:NCU01859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X60829 mRNA. Translation: CAA43221.1 .
CM002236 Genomic DNA. Translation: EAA36254.3 .
PIRi S27171.
RefSeqi XP_965490.2. XM_960397.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000001025 ; EFNCRP00000001025 ; EFNCRG00000001024 .
GeneIDi 3881668.
KEGGi ncr:NCU01859.

Phylogenomic databases

eggNOGi NOG81489.
HOGENOMi HOG000170196.

Family and domain databases

InterProi IPR024549. NADH-UbQ_OxRdtase_su21_C_fun.
IPR019721. NADH-UbQ_OxRdtase_su21_N.
[Graphical view ]
Pfami PF10785. NADH-u_ox-rdase. 1 hit.
PF12853. NADH_u_ox_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure and mitochondrial import in vitro of the 20.9 kDa subunit of complex I from Neurospora crassa."
    Azevedo J.E., Nehls U., Eckerskorn C., Heinrich H., Rothe H., Weiss H., Werner S.
    Biochem. J. 288:29-34(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 138-155.
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiNUXM_NEUCR
AccessioniPrimary (citable) accession number: Q02854
Secondary accession number(s): Q7SHE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

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