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Q02854

- NUXM_NEUCR

UniProt

Q02854 - NUXM_NEUCR

Protein

NADH-ubiquinone oxidoreductase 20.9 kDa subunit

Gene

nuo20.9

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Protein family/group databases

    TCDBi3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 20.9 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-20.9kD
    Short name:
    CI-20.9kD
    Gene namesi
    Name:nuo20.9
    ORF Names:NCU01859
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 1, Linkage Group I

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189NADH-ubiquinone oxidoreductase 20.9 kDa subunitPRO_0000118782Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Interactioni

    Subunit structurei

    Complex I is composed of about 40 different subunits.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 8816HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81489.
    HOGENOMiHOG000170196.

    Family and domain databases

    InterProiIPR024549. NADH-UbQ_OxRdtase_su21_C_fun.
    IPR019721. NADH-UbQ_OxRdtase_su21_N.
    [Graphical view]
    PfamiPF10785. NADH-u_ox-rdase. 1 hit.
    PF12853. NADH_u_ox_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02854-1 [UniParc]FASTAAdd to Basket

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    MSSTSSPTYT ISKTLNTNYP LIDNDPHFRR VIGYARPSDY VHGTVAGAAG    50
    PGLLYLMEKM APSGVGKGGF PKAMRLATAV GFFGGFLYFY QRSILRFYGM 100
    SENAREVQMD MREMVDKVKA GQPLYGVSTL PVDVQGMAAR QSRYSALFFA 150
    VLPWFNFVNH NQHGVDTAKY YQQAERELEA ERLGKGSSS 189
    Length:189
    Mass (Da):20,977
    Last modified:February 1, 1994 - v1
    Checksum:iE3F23FD959092EC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60829 mRNA. Translation: CAA43221.1.
    CM002236 Genomic DNA. Translation: EAA36254.3.
    PIRiS27171.
    RefSeqiXP_965490.2. XM_960397.2.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000001025; EFNCRP00000001025; EFNCRG00000001024.
    GeneIDi3881668.
    KEGGincr:NCU01859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60829 mRNA. Translation: CAA43221.1 .
    CM002236 Genomic DNA. Translation: EAA36254.3 .
    PIRi S27171.
    RefSeqi XP_965490.2. XM_960397.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 3.D.1.6.2. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000001025 ; EFNCRP00000001025 ; EFNCRG00000001024 .
    GeneIDi 3881668.
    KEGGi ncr:NCU01859.

    Phylogenomic databases

    eggNOGi NOG81489.
    HOGENOMi HOG000170196.

    Family and domain databases

    InterProi IPR024549. NADH-UbQ_OxRdtase_su21_C_fun.
    IPR019721. NADH-UbQ_OxRdtase_su21_N.
    [Graphical view ]
    Pfami PF10785. NADH-u_ox-rdase. 1 hit.
    PF12853. NADH_u_ox_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and mitochondrial import in vitro of the 20.9 kDa subunit of complex I from Neurospora crassa."
      Azevedo J.E., Nehls U., Eckerskorn C., Heinrich H., Rothe H., Weiss H., Werner S.
      Biochem. J. 288:29-34(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 138-155.
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNUXM_NEUCR
    AccessioniPrimary (citable) accession number: Q02854
    Secondary accession number(s): Q7SHE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    External Data

    Dasty 3