Q02853MMP11_MOUSEStromelysin-3SL-3ST33.4.24.-Matrix metalloproteinase-11MMP-11Mmp11Mus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusThe breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.NUCLEOTIDE SEQUENCE [MRNA]SEQUENCE REVISIONCrystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state.X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 102-265May play an important role in the progression of epithelial malignancies.Ca(2+)Binds 1 Ca(2+) ion per subunit.Zn(2+)Binds 2 Zn(2+) ions per subunit.SecretedExtracellular spaceExtracellular matrixSpecifically expressed in the mammary gland during apoptosis.The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.The precursor is cleaved by a furin endopeptidase.Belongs to the peptidase M10A family.3D-structureCalciumCleavage on pair of basic residuesCollagen degradationDisulfide bondExtracellular matrixHydrolaseMetal-bindingMetalloproteaseProteaseReference proteomeRepeatSecretedSignalZincZymogenZn(2+)catalyticZn(2+)Zn(2+)Ca(2+)Ca(2+)Ca(2+)Ca(2+)Zn(2+)Zn(2+)Zn(2+)catalyticZn(2+)catalyticZn(2+)catalyticMARAACLLRAISRVLLLPLPLLLLLLLLLPSPLMARARPPESHRHHPVKKGPRLLHAALPNTLTSVPASHWVPSPAGSSRPLRCGVPDLPDVLNARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVREQVRQTVAEALQVWSEVTPLTFTEVHEGRADIMIDFARYWHGDNLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDNQGTDLLQVAAHEFGHVLGLQHTTAAKALMSPFYTFRYPLSLSPDDRRGIQHLYGRPQMAPTSPAPTLSSQAGTDTNEIALLEPETPPDVCETSFDAVSTIRGELFFFKAGFVWRLRSGRLQPGYPALASRHWQGLPSPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLGPAPLSKLGLQGSPVHAALVWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRSTDWRGVPSEIDAAFQDAEGYAYFLRGHLYWKFDPVKVKVLEGFPRPVGPDFFDCAEPANTFR
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