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Q02853

- MMP11_MOUSE

UniProt

Q02853 - MMP11_MOUSE

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Protein
Stromelysin-3
Gene
Mmp11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play an important role in the progression of epithelial malignancies.

Cofactori

Binds 1 calcium ion per subunit.
Binds 2 zinc ions per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Zinc 2; in inhibited form By similarity
Metal bindingi168 – 1681Zinc 1
Metal bindingi170 – 1701Zinc 1
Metal bindingi175 – 1751Calcium
Metal bindingi176 – 1761Calcium; via carbonyl oxygen
Metal bindingi178 – 1781Calcium; via carbonyl oxygen
Metal bindingi180 – 1801Calcium; via carbonyl oxygen
Metal bindingi183 – 1831Zinc 1
Metal bindingi196 – 1961Zinc 1
Metal bindingi219 – 2191Zinc 2; catalytic
Active sitei220 – 2201
Metal bindingi223 – 2231Zinc 2; catalytic
Metal bindingi229 – 2291Zinc 2; catalytic

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. metalloendopeptidase activity Source: InterPro
  3. metallopeptidase activity Source: MGI
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. basement membrane organization Source: MGI
  2. collagen catabolic process Source: MGI
  3. collagen fibril organization Source: MGI
  4. extracellular matrix organization Source: MGI
  5. multicellular organismal development Source: InterPro
  6. negative regulation of fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Biological processi

Collagen degradation

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.
REACT_199055. Collagen degradation.

Protein family/group databases

MEROPSiM10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Stromelysin-3 (EC:3.4.24.-)
Short name:
SL-3
Short name:
ST3
Alternative name(s):
Matrix metalloproteinase-11
Short name:
MMP-11
Gene namesi
Name:Mmp11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:97008. Mmp11.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Propeptidei36 – 10166Activation peptide By similarity
PRO_0000028772Add
BLAST
Chaini102 – 492391Stromelysin-3
PRO_0000028773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi298 ↔ 484 By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Zymogen

Proteomic databases

MaxQBiQ02853.
PRIDEiQ02853.

PTM databases

PhosphoSiteiQ02853.

Miscellaneous databases

PMAP-CutDBQ02853.

Expressioni

Tissue specificityi

Specifically expressed in the mammary gland during apoptosis.

Gene expression databases

ArrayExpressiQ02853.
BgeeiQ02853.
CleanExiMM_MMP11.
GenevestigatoriQ02853.

Interactioni

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi102 – 1054
Beta strandi108 – 1114
Beta strandi113 – 1186
Helixi127 – 14216
Beta strandi148 – 1514
Beta strandi153 – 1564
Beta strandi158 – 1647
Beta strandi168 – 1714
Beta strandi176 – 1794
Beta strandi182 – 1854
Beta strandi190 – 1989
Beta strandi203 – 2064
Beta strandi208 – 2125
Helixi213 – 22412
Helixi251 – 26010

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HV5X-ray2.60A/B/C/D/E/F102-265[»]
ProteinModelPortaliQ02853.
SMRiQ02853. Positions 102-463.

Miscellaneous databases

EvolutionaryTraceiQ02853.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati295 – 34349Hemopexin 1
Add
BLAST
Repeati344 – 38643Hemopexin 2
Add
BLAST
Repeati388 – 43649Hemopexin 3
Add
BLAST
Repeati437 – 48448Hemopexin 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi82 – 898Cysteine switch By similarity

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.
Contains 4 hemopexin repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG236137.
HOGENOMiHOG000217927.
HOVERGENiHBG052484.
InParanoidiQ02853.
KOiK07993.
OMAiVDTNEIA.
OrthoDBiEOG7XPZ57.
PhylomeDBiQ02853.
TreeFamiTF315428.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR028705. Stromelysin-3.
[Graphical view]
PANTHERiPTHR10201:SF20. PTHR10201:SF20. 1 hit.
PfamiPF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view]
PIRSFiPIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSiPR00138. MATRIXIN.
SMARTiSM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiPS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02853-1 [UniParc]FASTAAdd to Basket

« Hide

MARAACLLRA ISRVLLLPLP LLLLLLLLLP SPLMARARPP ESHRHHPVKK    50
GPRLLHAALP NTLTSVPASH WVPSPAGSSR PLRCGVPDLP DVLNARNRQK 100
RFVLSGGRWE KTDLTYRILR FPWQLVREQV RQTVAEALQV WSEVTPLTFT 150
EVHEGRADIM IDFARYWHGD NLPFDGPGGI LAHAFFPKTH REGDVHFDYD 200
ETWTIGDNQG TDLLQVAAHE FGHVLGLQHT TAAKALMSPF YTFRYPLSLS 250
PDDRRGIQHL YGRPQMAPTS PAPTLSSQAG TDTNEIALLE PETPPDVCET 300
SFDAVSTIRG ELFFFKAGFV WRLRSGRLQP GYPALASRHW QGLPSPVDAA 350
FEDAQGQIWF FQGAQYWVYD GEKPVLGPAP LSKLGLQGSP VHAALVWGPE 400
KNKIYFFRGG DYWRFHPRTQ RVDNPVPRRS TDWRGVPSEI DAAFQDAEGY 450
AYFLRGHLYW KFDPVKVKVL EGFPRPVGPD FFDCAEPANT FR 492
Length:492
Mass (Da):55,441
Last modified:February 1, 1996 - v2
Checksum:iB54E260E4AB3D7C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12604 mRNA. Translation: CAA78248.1.
CCDSiCCDS23937.1.
PIRiA44399.
RefSeqiNP_032632.1. NM_008606.2.
XP_006513381.1. XM_006513318.1.
UniGeneiMm.4561.

Genome annotation databases

EnsembliENSMUST00000000924; ENSMUSP00000000924; ENSMUSG00000000901.
ENSMUST00000120281; ENSMUSP00000112940; ENSMUSG00000000901.
GeneIDi17385.
KEGGimmu:17385.
UCSCiuc007fto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z12604 mRNA. Translation: CAA78248.1 .
CCDSi CCDS23937.1.
PIRi A44399.
RefSeqi NP_032632.1. NM_008606.2.
XP_006513381.1. XM_006513318.1.
UniGenei Mm.4561.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1HV5 X-ray 2.60 A/B/C/D/E/F 102-265 [» ]
ProteinModelPortali Q02853.
SMRi Q02853. Positions 102-463.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q02853.
ChEMBLi CHEMBL3412.

Protein family/group databases

MEROPSi M10.007.

PTM databases

PhosphoSitei Q02853.

Proteomic databases

MaxQBi Q02853.
PRIDEi Q02853.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000924 ; ENSMUSP00000000924 ; ENSMUSG00000000901 .
ENSMUST00000120281 ; ENSMUSP00000112940 ; ENSMUSG00000000901 .
GeneIDi 17385.
KEGGi mmu:17385.
UCSCi uc007fto.1. mouse.

Organism-specific databases

CTDi 4320.
MGIi MGI:97008. Mmp11.

Phylogenomic databases

eggNOGi NOG236137.
HOGENOMi HOG000217927.
HOVERGENi HBG052484.
InParanoidi Q02853.
KOi K07993.
OMAi VDTNEIA.
OrthoDBi EOG7XPZ57.
PhylomeDBi Q02853.
TreeFami TF315428.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.
REACT_199055. Collagen degradation.

Miscellaneous databases

EvolutionaryTracei Q02853.
NextBioi 291992.
PMAP-CutDB Q02853.
PROi Q02853.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q02853.
Bgeei Q02853.
CleanExi MM_MMP11.
Genevestigatori Q02853.

Family and domain databases

Gene3Di 2.110.10.10. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR024079. MetalloPept_cat_dom.
IPR001818. Pept_M10_metallopeptidase.
IPR021190. Pept_M10A.
IPR016293. Pept_M10A_stromelysin-type.
IPR006026. Peptidase_Metallo.
IPR028705. Stromelysin-3.
[Graphical view ]
PANTHERi PTHR10201:SF20. PTHR10201:SF20. 1 hit.
Pfami PF00045. Hemopexin. 4 hits.
PF00413. Peptidase_M10. 1 hit.
[Graphical view ]
PIRSFi PIRSF001191. Peptidase_M10A_matrix. 1 hit.
PRINTSi PR00138. MATRIXIN.
SMARTi SM00120. HX. 4 hits.
SM00235. ZnMc. 1 hit.
[Graphical view ]
SUPFAMi SSF50923. SSF50923. 1 hit.
PROSITEi PS00024. HEMOPEXIN. 1 hit.
PS51642. HEMOPEXIN_2. 4 hits.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis."
    Lefebvre O., Wolf C., Limacher J.-M., Hutin P., Wendling C., Lemeur M., Basset P., Rio M.C.
    J. Cell Biol. 119:997-1002(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Lefebvre O.
    Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state."
    Gall A.-L., Ruff M., Kannan R., Cuniasse P., Yiotakis A., Dive V., Rio M.-C., Basset P., Moras D.
    J. Mol. Biol. 307:577-586(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 102-265.

Entry informationi

Entry nameiMMP11_MOUSE
AccessioniPrimary (citable) accession number: Q02853
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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