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Protein

Retinal guanylyl cyclase 1

Gene

GUCY2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Enzyme regulationi

Activated by GCAP-1; inhibited by calcium.

GO - Molecular functioni

  • ATP binding Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: Reactome
  • protein kinase activity Source: InterPro
  • receptor activity Source: ProtInc

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • receptor guanylyl cyclase signaling pathway Source: ProtInc
  • regulation of rhodopsin mediated signaling pathway Source: Reactome
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis, Sensory transduction, Vision

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS05649-MONOMER.
BRENDAi4.6.1.2. 2681.
ReactomeiR-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Protein family/group databases

TCDBi8.A.85.1.3. the guanylate cyclase (gc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal guanylyl cyclase 1 (EC:4.6.1.2)
Short name:
RETGC-1
Alternative name(s):
Guanylate cyclase 2D, retinal
Rod outer segment membrane guanylate cyclase
Short name:
ROS-GC
Gene namesi
Name:GUCY2D
Synonyms:CORD6, GUC1A4, GUC2D, RETGC, RETGC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4689. GUCY2D.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini52 – 462ExtracellularSequence analysisAdd BLAST411
Transmembranei463 – 487HelicalSequence analysisAdd BLAST25
Topological domaini488 – 1103CytoplasmicSequence analysisAdd BLAST616

GO - Cellular componenti

  • guanylate cyclase complex, soluble Source: GO_Central
  • integral component of plasma membrane Source: ProtInc
  • nuclear outer membrane Source: ProtInc
  • photoreceptor disc membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Leber congenital amaurosis 1 (LCA1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
See also OMIM:204000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00343552A → S in LCA1; unknown pathological significance. 2 PublicationsCorresponds to variant rs61749665dbSNPEnsembl.1
Natural variantiVAR_06716955T → M in LCA1. 1 PublicationCorresponds to variant rs201414567dbSNPEnsembl.1
Natural variantiVAR_067170103E → V in LCA1. 1 Publication1
Natural variantiVAR_023770105C → Y in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61749669dbSNPEnsembl.1
Natural variantiVAR_067171312T → M in LCA1. 1 PublicationCorresponds to variant rs61749673dbSNPEnsembl.1
Natural variantiVAR_023771325L → P in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61749675dbSNPEnsembl.1
Natural variantiVAR_067172325L → R Found in a patient with LCA1. 1 Publication1
Natural variantiVAR_009129362A → S in LCA1. Corresponds to variant rs61749677dbSNPEnsembl.1
Natural variantiVAR_067173405 – 406LD → PN in LCA1. 2
Natural variantiVAR_067174438R → C in LCA1. 1 PublicationCorresponds to variant rs565948960dbSNPEnsembl.1
Natural variantiVAR_009131565F → S in LCA1; loss of activity. 1 PublicationCorresponds to variant rs61749755dbSNPEnsembl.1
Natural variantiVAR_009130573I → V in LCA1. Corresponds to variant rs61749756dbSNPEnsembl.1
Natural variantiVAR_067175640W → L in LCA1. 1 Publication1
Natural variantiVAR_067176660R → Q in LCA1. 1 PublicationCorresponds to variant rs61750162dbSNPEnsembl.1
Natural variantiVAR_067177728D → H in LCA1. 1 Publication1
Natural variantiVAR_067178734I → A in LCA1; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_067179768R → W in LCA1. 2 PublicationsCorresponds to variant rs61750168dbSNPEnsembl.1
Natural variantiVAR_067180784M → R in LCA1. 1 Publication1
Natural variantiVAR_067181795R → Q in LCA1. 1 PublicationCorresponds to variant rs61750171dbSNPEnsembl.1
Natural variantiVAR_009134858P → S in LCA1; severely impairs basal and GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61750176dbSNPEnsembl.1
Natural variantiVAR_009135954L → P in LCA1; severely impairs basal and GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61750182dbSNPEnsembl.1
Natural variantiVAR_0671821007S → L in LCA1. 1 Publication1
Natural variantiVAR_0671831027I → IGI in LCA1. 1
Cone-rod dystrophy 6 (CORD6)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
See also OMIM:601777
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003438837 – 839ERT → DCM in CORD6. 3
Natural variantiVAR_003436837E → D in CORD6. 1 PublicationCorresponds to variant rs28933695dbSNPEnsembl.1
Natural variantiVAR_003437838R → C in CORD6. 3 PublicationsCorresponds to variant rs61750172dbSNPEnsembl.1
Natural variantiVAR_071605838R → G in CORD6. 1 Publication1
Natural variantiVAR_015373838R → H in CORD6. 4 PublicationsCorresponds to variant rs61750173dbSNPEnsembl.1
Natural variantiVAR_071606838R → P in CORD6. 1 Publication1
Natural variantiVAR_071607849T → A in CORD6. 1 Publication1
Natural variantiVAR_071608949I → T in CORD6. 1 PublicationCorresponds to variant rs267606857dbSNPEnsembl.1

Keywords - Diseasei

Cone-rod dystrophy, Disease mutation, Leber congenital amaurosis

Organism-specific databases

DisGeNETi3000.
MalaCardsiGUCY2D.
MIMi204000. phenotype.
601777. phenotype.
OpenTargetsiENSG00000132518.
Orphaneti75377. Central areolar choroidal dystrophy.
1872. Cone rod dystrophy.
65. Leber congenital amaurosis.
PharmGKBiPA187.

Polymorphism and mutation databases

BioMutaiGUCY2D.
DMDMi1345920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 51Sequence analysisAdd BLAST51
ChainiPRO_000001238152 – 1103Retinal guanylyl cyclase 1Add BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi449InterchainCurated
Disulfide bondi457InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ02846.
PaxDbiQ02846.
PeptideAtlasiQ02846.
PRIDEiQ02846.

PTM databases

iPTMnetiQ02846.
PhosphoSitePlusiQ02846.

Expressioni

Tissue specificityi

Retina. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells.

Gene expression databases

BgeeiENSG00000132518.
CleanExiHS_GUCY2D.
GenevisibleiQ02846. HS.

Interactioni

Protein-protein interaction databases

BioGridi109255. 2 interactors.
IntActiQ02846. 2 interactors.
MINTiMINT-7241905.
STRINGi9606.ENSP00000254854.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AWLmodel-A/B871-1028[»]
ProteinModelPortaliQ02846.
SMRiQ02846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini525 – 808Protein kinasePROSITE-ProRule annotationAdd BLAST284
Domaini880 – 1010Guanylate cyclasePROSITE-ProRule annotationAdd BLAST131

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000118959.
HOGENOMiHOG000293307.
HOVERGENiHBG098487.
InParanoidiQ02846.
KOiK12321.
OMAiAMLELTP.
OrthoDBiEOG091G00VM.
PhylomeDBiQ02846.
TreeFamiTF106338.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. HNOB_dom_associated.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTACARRAGG LPDPGLCGPA WWAPSLPRLP RALPRLPLLL LLLLLQPPAL
60 70 80 90 100
SAVFTVGVLG PWACDPIFSR ARPDLAARLA AARLNRDPGL AGGPRFEVAL
110 120 130 140 150
LPEPCRTPGS LGAVSSALAR VSGLVGPVNP AACRPAELLA EEAGIALVPW
160 170 180 190 200
GCPWTQAEGT TAPAVTPAAD ALYALLRAFG WARVALVTAP QDLWVEAGRS
210 220 230 240 250
LSTALRARGL PVASVTSMEP LDLSGAREAL RKVRDGPRVT AVIMVMHSVL
260 270 280 290 300
LGGEEQRYLL EAAEELGLTD GSLVFLPFDT IHYALSPGPE ALAALANSSQ
310 320 330 340 350
LRRAHDAVLT LTRHCPSEGS VLDSLRRAQE RRELPSDLNL QQVSPLFGTI
360 370 380 390 400
YDAVFLLARG VAEARAAAGG RWVSGAAVAR HIRDAQVPGF CGDLGGDEEP
410 420 430 440 450
PFVLLDTDAA GDRLFATYML DPARGSFLSA GTRMHFPRGG SAPGPDPSCW
460 470 480 490 500
FDPNNICGGG LEPGLVFLGF LLVVGMGLAG AFLAHYVRHR LLHMQMVSGP
510 520 530 540 550
NKIILTVDDI TFLHPHGGTS RKVAQGSRSS LGARSMSDIR SGPSQHLDSP
560 570 580 590 600
NIGVYEGDRV WLKKFPGDQH IAIRPATKTA FSKLQELRHE NVALYLGLFL
610 620 630 640 650
ARGAEGPAAL WEGNLAVVSE HCTRGSLQDL LAQREIKLDW MFKSSLLLDL
660 670 680 690 700
IKGIRYLHHR GVAHGRLKSR NCIVDGRFVL KITDHGHGRL LEAQKVLPEP
710 720 730 740 750
PRAEDQLWTA PELLRDPALE RRGTLAGDVF SLAIIMQEVV CRSAPYAMLE
760 770 780 790 800
LTPEEVVQRV RSPPPLCRPL VSMDQAPVEC ILLMKQCWAE QPELRPSMDH
810 820 830 840 850
TFDLFKNINK GRKTNIIDSM LRMLEQYSSN LEDLIRERTE ELELEKQKTD
860 870 880 890 900
RLLTQMLPPS VAEALKTGTP VEPEYFEQVT LYFSDIVGFT TISAMSEPIE
910 920 930 940 950
VVDLLNDLYT LFDAIIGSHD VYKVETIGDA YMVASGLPQR NGQRHAAEIA
960 970 980 990 1000
NMSLDILSAV GTFRMRHMPE VPVRIRIGLH SGPCVAGVVG LTMPRYCLFG
1010 1020 1030 1040 1050
DTVNTASRME STGLPYRIHV NLSTVGILRA LDSGYQVELR GRTELKGKGA
1060 1070 1080 1090 1100
EDTFWLVGRR GFNKPIPKPP DLQPGSSNHG ISLQEIPPER RRKLEKARPG

QFS
Length:1,103
Mass (Da):120,059
Last modified:February 1, 1996 - v2
Checksum:i28631557E7CBDFA4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06716821W → R.1 PublicationCorresponds to variant rs9905402dbSNPEnsembl.1
Natural variantiVAR_00343552A → S in LCA1; unknown pathological significance. 2 PublicationsCorresponds to variant rs61749665dbSNPEnsembl.1
Natural variantiVAR_06716955T → M in LCA1. 1 PublicationCorresponds to variant rs201414567dbSNPEnsembl.1
Natural variantiVAR_067170103E → V in LCA1. 1 Publication1
Natural variantiVAR_023770105C → Y in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61749669dbSNPEnsembl.1
Natural variantiVAR_067171312T → M in LCA1. 1 PublicationCorresponds to variant rs61749673dbSNPEnsembl.1
Natural variantiVAR_023771325L → P in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61749675dbSNPEnsembl.1
Natural variantiVAR_067172325L → R Found in a patient with LCA1. 1 Publication1
Natural variantiVAR_042229328A → V.1 PublicationCorresponds to variant rs56280231dbSNPEnsembl.1
Natural variantiVAR_049254331R → S.Corresponds to variant rs34596269dbSNPEnsembl.1
Natural variantiVAR_009129362A → S in LCA1. Corresponds to variant rs61749677dbSNPEnsembl.1
Natural variantiVAR_067173405 – 406LD → PN in LCA1. 2
Natural variantiVAR_042230431G → D in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_067174438R → C in LCA1. 1 PublicationCorresponds to variant rs565948960dbSNPEnsembl.1
Natural variantiVAR_042231507V → M.1 PublicationCorresponds to variant rs746002871dbSNPEnsembl.1
Natural variantiVAR_009131565F → S in LCA1; loss of activity. 1 PublicationCorresponds to variant rs61749755dbSNPEnsembl.1
Natural variantiVAR_009130573I → V in LCA1. Corresponds to variant rs61749756dbSNPEnsembl.1
Natural variantiVAR_049255602R → W.Corresponds to variant rs34331388dbSNPEnsembl.1
Natural variantiVAR_067175640W → L in LCA1. 1 Publication1
Natural variantiVAR_067176660R → Q in LCA1. 1 PublicationCorresponds to variant rs61750162dbSNPEnsembl.1
Natural variantiVAR_042232693A → E.1 PublicationCorresponds to variant rs35146471dbSNPEnsembl.1
Natural variantiVAR_009132701P → S Polymorphism that at homozygosity may be associated with Leber congenital amaurosis in some populations. 3 PublicationsCorresponds to variant rs34598902dbSNPEnsembl.1
Natural variantiVAR_049256722R → W.Corresponds to variant rs34331388dbSNPEnsembl.1
Natural variantiVAR_067177728D → H in LCA1. 1 Publication1
Natural variantiVAR_067178734I → A in LCA1; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_067179768R → W in LCA1. 2 PublicationsCorresponds to variant rs61750168dbSNPEnsembl.1
Natural variantiVAR_009133782L → H Rare polymorphism. 1 PublicationCorresponds to variant rs8069344dbSNPEnsembl.1
Natural variantiVAR_067180784M → R in LCA1. 1 Publication1
Natural variantiVAR_067181795R → Q in LCA1. 1 PublicationCorresponds to variant rs61750171dbSNPEnsembl.1
Natural variantiVAR_003438837 – 839ERT → DCM in CORD6. 3
Natural variantiVAR_003436837E → D in CORD6. 1 PublicationCorresponds to variant rs28933695dbSNPEnsembl.1
Natural variantiVAR_003437838R → C in CORD6. 3 PublicationsCorresponds to variant rs61750172dbSNPEnsembl.1
Natural variantiVAR_071605838R → G in CORD6. 1 Publication1
Natural variantiVAR_015373838R → H in CORD6. 4 PublicationsCorresponds to variant rs61750173dbSNPEnsembl.1
Natural variantiVAR_071606838R → P in CORD6. 1 Publication1
Natural variantiVAR_071607849T → A in CORD6. 1 Publication1
Natural variantiVAR_009134858P → S in LCA1; severely impairs basal and GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61750176dbSNPEnsembl.1
Natural variantiVAR_071608949I → T in CORD6. 1 PublicationCorresponds to variant rs267606857dbSNPEnsembl.1
Natural variantiVAR_009135954L → P in LCA1; severely impairs basal and GCAP-1 induced activity. 2 PublicationsCorresponds to variant rs61750182dbSNPEnsembl.1
Natural variantiVAR_0671821007S → L in LCA1. 1 Publication1
Natural variantiVAR_0671831027I → IGI in LCA1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92432 mRNA. Translation: AAA60547.1.
AJ222657 Genomic DNA. Translation: CAA10914.1.
L26921 Genomic DNA. Translation: AAA60366.1.
CCDSiCCDS11127.1.
PIRiJH0717.
RefSeqiNP_000171.1. NM_000180.3.
XP_011522118.1. XM_011523816.1.
UniGeneiHs.592109.

Genome annotation databases

EnsembliENST00000254854; ENSP00000254854; ENSG00000132518.
GeneIDi3000.
KEGGihsa:3000.
UCSCiuc002gjt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mutations of the GUCY2D gene

Retina International's Scientific Newsletter

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92432 mRNA. Translation: AAA60547.1.
AJ222657 Genomic DNA. Translation: CAA10914.1.
L26921 Genomic DNA. Translation: AAA60366.1.
CCDSiCCDS11127.1.
PIRiJH0717.
RefSeqiNP_000171.1. NM_000180.3.
XP_011522118.1. XM_011523816.1.
UniGeneiHs.592109.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AWLmodel-A/B871-1028[»]
ProteinModelPortaliQ02846.
SMRiQ02846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109255. 2 interactors.
IntActiQ02846. 2 interactors.
MINTiMINT-7241905.
STRINGi9606.ENSP00000254854.

Protein family/group databases

TCDBi8.A.85.1.3. the guanylate cyclase (gc) family.

PTM databases

iPTMnetiQ02846.
PhosphoSitePlusiQ02846.

Polymorphism and mutation databases

BioMutaiGUCY2D.
DMDMi1345920.

Proteomic databases

MaxQBiQ02846.
PaxDbiQ02846.
PeptideAtlasiQ02846.
PRIDEiQ02846.

Protocols and materials databases

DNASUi3000.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254854; ENSP00000254854; ENSG00000132518.
GeneIDi3000.
KEGGihsa:3000.
UCSCiuc002gjt.3. human.

Organism-specific databases

CTDi3000.
DisGeNETi3000.
GeneCardsiGUCY2D.
GeneReviewsiGUCY2D.
HGNCiHGNC:4689. GUCY2D.
MalaCardsiGUCY2D.
MIMi204000. phenotype.
600179. gene.
601777. phenotype.
neXtProtiNX_Q02846.
OpenTargetsiENSG00000132518.
Orphaneti75377. Central areolar choroidal dystrophy.
1872. Cone rod dystrophy.
65. Leber congenital amaurosis.
PharmGKBiPA187.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
GeneTreeiENSGT00760000118959.
HOGENOMiHOG000293307.
HOVERGENiHBG098487.
InParanoidiQ02846.
KOiK12321.
OMAiAMLELTP.
OrthoDBiEOG091G00VM.
PhylomeDBiQ02846.
TreeFamiTF106338.

Enzyme and pathway databases

BioCyciZFISH:HS05649-MONOMER.
BRENDAi4.6.1.2. 2681.
ReactomeiR-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

GenomeRNAii3000.
PROiQ02846.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132518.
CleanExiHS_GUCY2D.
GenevisibleiQ02846. HS.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. HNOB_dom_associated.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2D_HUMAN
AccessioniPrimary (citable) accession number: Q02846
Secondary accession number(s): Q6LEA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 192 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.