Q02846 (GUC2D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinal guanylyl cyclase 1
Short name=RETGC-1
EC=4.6.1.2

Alternative name(s):
Guanylate cyclase 2D, retinal
Rod outer segment membrane guanylate cyclase
Short name=ROS-GC

Gene names

Name:	GUCY2D
Synonyms:	CORD6, GUC1A4, GUC2D, RETGC, RETGC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1103 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
Catalytic activity	GTP = 3',5'-cyclic GMP + diphosphate.
Enzyme regulation	Activated by GCAP-1; inhibited by calcium.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Retina. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells.
Involvement in disease	Leber congenital amaurosis 1 (LCA1) [MIM:204000]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.9 Ref.10 Ref.11 Ref.13 Ref.15 Ref.17 Cone-rod dystrophy 6 (CORD6) [MIM:601777]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8 Ref.12
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Sensory transduction Vision cGMP biosynthesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Cone-rod dystrophy Disease mutation Leber congenital amaurosis
Domain	Signal Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Lyase
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro receptor guanylyl cyclase signaling pathway Traceable author statement Ref.1. Source: ProtInc visual perception Traceable author statement Ref.9. Source: ProtInc
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc nuclear outer membrane Traceable author statement PubMed 7777544. Source: ProtInc
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate cyclase activity Traceable author statement Ref.9. Source: ProtInc protein kinase activity Inferred from electronic annotation. Source: InterPro receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FYN	P06241	1	EBI-1756902,EBI-515315

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 51

51

Potential

Chain

52 – 1103

1052

Retinal guanylyl cyclase 1

PRO_0000012381

Regions

Topological domain

52 – 462

411

Extracellular Potential

Transmembrane

463 – 487

25

Helical; Potential

Topological domain

488 – 1103

616

Cytoplasmic Potential

Domain

525 – 808

284

Protein kinase

Domain

880 – 1010

131

Guanylate cyclase

Amino acid modifications

Glycosylation

297

1

N-linked (GlcNAc...) Potential

Disulfide bond

449

Interchain Probable

Disulfide bond

457

Interchain Probable

Natural variations

Natural variant

21

1

W → R. Ref.17

VAR_067168

Natural variant

52

1

A → S in LCA1; could be a rare polymorphism. Ref.6 Ref.17

VAR_003435

Natural variant

55

1

T → M in LCA1. Ref.17

VAR_067169

Natural variant

103

1

E → V in LCA1. Ref.17

VAR_067170

Natural variant

105

1

C → Y in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. Ref.10 Ref.13

VAR_023770

Natural variant

312

1

T → M in LCA1. Ref.17

VAR_067171

Natural variant

325

1

L → P in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. Ref.10 Ref.13

VAR_023771

Natural variant

325

1

L → R Found in a patient with LCA1. Ref.15

VAR_067172

Natural variant

328

1

A → V. Ref.16
Corresponds to variant rs56280231 [ dbSNP | Ensembl ].

VAR_042229

Natural variant

331

1

R → S.
Corresponds to variant rs34596269 [ dbSNP | Ensembl ].

VAR_049254

Natural variant

362

1

A → S in LCA1.

VAR_009129

Natural variant

405 – 406

2

LD → PN in LCA1.

VAR_067173

Natural variant

431

1

G → D in a metastatic melanoma sample; somatic mutation. Ref.16

VAR_042230

Natural variant

438

1

R → C in LCA1. Ref.17

VAR_067174

Natural variant

507

1

V → M. Ref.16

VAR_042231

Natural variant

565

1

F → S in LCA1; loss of activity. Ref.9

VAR_009131

Natural variant

573

1

I → V in LCA1.

VAR_009130

Natural variant

602

1

R → W.
Corresponds to variant rs34331388 [ dbSNP | Ensembl ].

VAR_049255

Natural variant

640

1

W → L in LCA1. Ref.17

VAR_067175

Natural variant

660

1

R → Q in LCA1. Ref.17

VAR_067176

Natural variant

693

1

A → E. Ref.16
Corresponds to variant rs35146471 [ dbSNP | Ensembl ].

VAR_042232

Natural variant

701

1

P → S Polymorphism that at homozygosity may be associated with Leber congenital amaurosis in some populations. Ref.14 Ref.15 Ref.16 Ref.17
Corresponds to variant rs34598902 [ dbSNP | Ensembl ].

VAR_009132

Natural variant

722

1

R → W.
Corresponds to variant rs34331388 [ dbSNP | Ensembl ].

VAR_049256

Natural variant

728

1

D → H in LCA1. Ref.17

VAR_067177

Natural variant

734

1

I → A in LCA1; requires 2 nucleotide substitutions. Ref.17

VAR_067178

Natural variant

768

1

R → W in LCA1. Ref.15 Ref.17

VAR_067179

Natural variant

782

1

L → H Rare polymorphism. Ref.16
Corresponds to variant rs8069344 [ dbSNP | Ensembl ].

VAR_009133

Natural variant

784

1

M → R in LCA1. Ref.17

VAR_067180

Natural variant

795

1

R → Q in LCA1. Ref.15

VAR_067181

Natural variant

837 – 839

3

ERT → DCM in CORD6.

VAR_003438

Natural variant

837

1

E → D in CORD6. Ref.8
Corresponds to variant rs28933695 [ dbSNP | Ensembl ].

VAR_003436

Natural variant

838

1

R → C in CORD6. Ref.8 Ref.12

VAR_003437

Natural variant

838

1

R → H in CORD6. Ref.12

VAR_015373

Natural variant

858

1

P → S in LCA1; severely impairs basal and GCAP-1 induced activity. Ref.10 Ref.13

VAR_009134

Natural variant

954

1

L → P in LCA1; severely impairs basal and GCAP-1 induced activity. Ref.11 Ref.13

VAR_009135

Natural variant

1007

1

S → L in LCA1. Ref.17

VAR_067182

Natural variant

1027

1

I → IGI in LCA1.

VAR_067183

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1103

Helix Strand Turn

Details...

Beta strand

882 – 885

4

Helix

888 – 892

5

Beta strand

896 – 898

3

Helix

899 – 902

4

Helix

904 – 913

10

Turn

914 – 917

4

Beta strand

918 – 922

5

Beta strand

934 – 936

3

Helix

944 – 947

4

Helix

949 – 966

18

Beta strand

991 – 993

3

Beta strand

998 – 1000

3

Helix

1001 – 1004

4

Helix

1005 – 1007

3

Turn

1008 – 1011

4

Beta strand

1015 – 1017

3

Helix

1022 – 1025

4

Sequences

	Sequence		Length	Mass (Da)
	Q02846 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 28631557E7CBDFA4	FASTA	1,103	120,059
	10 20 30 40 50 60 MTACARRAGG LPDPGLCGPA WWAPSLPRLP RALPRLPLLL LLLLLQPPAL SAVFTVGVLG 70 80 90 100 110 120 PWACDPIFSR ARPDLAARLA AARLNRDPGL AGGPRFEVAL LPEPCRTPGS LGAVSSALAR 130 140 150 160 170 180 VSGLVGPVNP AACRPAELLA EEAGIALVPW GCPWTQAEGT TAPAVTPAAD ALYALLRAFG 190 200 210 220 230 240 WARVALVTAP QDLWVEAGRS LSTALRARGL PVASVTSMEP LDLSGAREAL RKVRDGPRVT 250 260 270 280 290 300 AVIMVMHSVL LGGEEQRYLL EAAEELGLTD GSLVFLPFDT IHYALSPGPE ALAALANSSQ 310 320 330 340 350 360 LRRAHDAVLT LTRHCPSEGS VLDSLRRAQE RRELPSDLNL QQVSPLFGTI YDAVFLLARG 370 380 390 400 410 420 VAEARAAAGG RWVSGAAVAR HIRDAQVPGF CGDLGGDEEP PFVLLDTDAA GDRLFATYML 430 440 450 460 470 480 DPARGSFLSA GTRMHFPRGG SAPGPDPSCW FDPNNICGGG LEPGLVFLGF LLVVGMGLAG 490 500 510 520 530 540 AFLAHYVRHR LLHMQMVSGP NKIILTVDDI TFLHPHGGTS RKVAQGSRSS LGARSMSDIR 550 560 570 580 590 600 SGPSQHLDSP NIGVYEGDRV WLKKFPGDQH IAIRPATKTA FSKLQELRHE NVALYLGLFL 610 620 630 640 650 660 ARGAEGPAAL WEGNLAVVSE HCTRGSLQDL LAQREIKLDW MFKSSLLLDL IKGIRYLHHR 670 680 690 700 710 720 GVAHGRLKSR NCIVDGRFVL KITDHGHGRL LEAQKVLPEP PRAEDQLWTA PELLRDPALE 730 740 750 760 770 780 RRGTLAGDVF SLAIIMQEVV CRSAPYAMLE LTPEEVVQRV RSPPPLCRPL VSMDQAPVEC 790 800 810 820 830 840 ILLMKQCWAE QPELRPSMDH TFDLFKNINK GRKTNIIDSM LRMLEQYSSN LEDLIRERTE 850 860 870 880 890 900 ELELEKQKTD RLLTQMLPPS VAEALKTGTP VEPEYFEQVT LYFSDIVGFT TISAMSEPIE 910 920 930 940 950 960 VVDLLNDLYT LFDAIIGSHD VYKVETIGDA YMVASGLPQR NGQRHAAEIA NMSLDILSAV 970 980 990 1000 1010 1020 GTFRMRHMPE VPVRIRIGLH SGPCVAGVVG LTMPRYCLFG DTVNTASRME STGLPYRIHV 1030 1040 1050 1060 1070 1080 NLSTVGILRA LDSGYQVELR GRTELKGKGA EDTFWLVGRR GFNKPIPKPP DLQPGSSNHG 1090 1100 ISLQEIPPER RRKLEKARPG QFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a retina-specific membrane guanylyl cyclase." Shyjan A.W., de Sauvage F.J., Gillett N.A., Goeddel D.V., Lowe D.G. Neuron 9:727-737(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina.
[2]	Lowe D.G. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	Perrault I. Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1." Oliveira L., Miniou P., Viegas-Pequignot E., Rozet J.-M., Dollfus H., Pittler S.J. Genomics 22:478-481(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1009-1088.
[5]	"Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis." Liu Y., Ruoho A.E., Rao V.D., Hurley J.H. Proc. Natl. Acad. Sci. U.S.A. 94:13414-13419(1997) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 871-1028.
[6]	"Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis." Perrault I., Rozet J.-M., Calvas P., Gerber S., Camuzat A., Dollfus H., Chatelin S., Souied E., Ghazi I., Leowski C., Bonnemaison M., le Paslier D., Frezal J., Dufier J.-L., Pittler S., Munnich A., Kaplan J. Nat. Genet. 14:461-464(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LCA1 SER-52.
[7]	"A retGC-1 mutation in autosomal dominant cone-rod dystrophy." Perrault I., Rozet J.-M., Gerber S., Kelsell R.E., Souied E., Cabot A., Hunt D.M., Munnich A., Kaplan J. Am. J. Hum. Genet. 63:651-654(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT CORD6 837-ASP--MET-839.
[8]	"Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy." Kelsell R.E., Gregory-Evans K., Payne A.M., Perrault I., Kaplan J., Yang R.-B., Garbers D.L., Bird A.C., Moore A.T., Hunt D.M. Hum. Mol. Genet. 7:1179-1184(1998) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CORD6 ASP-837 AND CYS-838.
[9]	"Functional consequences of a rod outer segment membrane guanylate cyclase (ROS-GC1) gene mutation linked with Leber's congenital amaurosis." Duda T., Venkataraman V., Goraczniak R., Lange C., Koch K.-W., Sharma R.K. Biochemistry 38:509-515(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANT LCA1 SER-565.
[10]	"Mutational analysis and clinical correlation in Leber congenital amaurosis." Dharmaraj S.R., Silva E.R., Pina A.-L., Li Y.Y., Yang J.M., Carter C.R., Loyer M.K., El-Hilali H.K., Traboulsi E.K., Sundin O.K., Zhu D.K., Koenekoop R.K., Maumenee I.H. Ophthalmic Genet. 21:135-150(2000) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LCA1 TYR-105; PRO-325 AND SER-858.
[11]	"Electroretinographic abnormalities in parents of patients with Leber congenital amaurosis who have heterozygous GUCY2D mutations." Koenekoop R.K., Fishman G.A., Iannaccone A., Ezzeldin H., Ciccarelli M.L., Baldi A., Sunness J.S., Lotery A.J., Jablonski M.M., Pittler S.J., Maumenee I. Arch. Ophthalmol. 120:1325-1330(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT LCA1 PRO-954.
[12]	"Identification of GUCY2D gene mutations in CORD5 families and evidence of incomplete penetrance." Udar N., Yelchits S., Chalukya M., Yellore V., Nusinowitz S., Silva-Garcia R., Vrabec T., Hussles Maumenee I., Donoso L., Small K.W. Hum. Mutat. 21:170-171(2003) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS CORD6 CYS-838 AND HIS-838, DISCUSSION OF PHENOTYPIC VARIABILITY.
[13]	"Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects." Tucker C.L., Ramamurthy V., Pina A.-L., Loyer M., Dharmaraj S., Li Y., Maumenee I.H., Hurley J.B., Koenekoop R.K. Mol. Vis. 10:297-303(2004) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION OF VARIANTS LCA1 TYR-105; PRO-325; SER-858 AND PRO-954.
[14]	"Genotyping microarray (disease chip) for Leber congenital amaurosis: detection of modifier alleles." Zernant J., Kulm M., Dharmaraj S., den Hollander A.I., Perrault I., Preising M.N., Lorenz B., Kaplan J., Cremers F.P., Maumenee I., Koenekoop R.K., Allikmets R. Invest. Ophthalmol. Vis. Sci. 46:3052-3059(2005) [PubMed] [Europe PMC] [Abstract] Cited for: POSSIBLE INVOLVEMENT OF VARIANT SER-701 IN LEBER CONGENITAL AMAUROSIS.
[15]	"Clinical and molecular genetics of Leber's congenital amaurosis: a multicenter study of Italian patients." Simonelli F., Ziviello C., Testa F., Rossi S., Fazzi E., Bianchi P.E., Fossarello M., Signorini S., Bertone C., Galantuomo S., Brancati F., Valente E.M., Ciccodicola A., Rinaldi E., Auricchio A., Banfi S. Invest. Ophthalmol. Vis. Sci. 48:4284-4290(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LCA1 TRP-768 AND GLN-795, VARIANTS ARG-325 AND SER-701, POSSIBLE INVOLVEMENT OF VARIANT SER-701 IN LEBER CONGENITAL AMAUROSIS.
[16]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-328; ASP-431; MET-507; GLU-693; SER-701 AND HIS-782.
[17]	"Detection of variants in 15 genes in 87 unrelated Chinese patients with Leber congenital amaurosis." Li L., Xiao X., Li S., Jia X., Wang P., Guo X., Jiao X., Zhang Q., Hejtmancik J.F. PLoS ONE 6:E19458-E19458(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LCA1 MET-55; VAL-103; MET-312; 405-PRO-ASN-406; CYS-438; LEU-640; GLN-660; HIS-728; ALA-734; TRP-768; ARG-784 AND LEU-1007; GLY-ILE-1027 INS, VARIANTS ARG-21; SER-52 AND SER-701.
+	Additional computationally mapped references.

Web resources

Mutations of the GUCY2D gene

Retina International's Scientific Newsletter

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M92432 mRNA. Translation: AAA60547.1.
AJ222657 Genomic DNA. Translation: CAA10914.1.
L26921 Genomic DNA. Translation: AAA60366.1.

IPI

IPI00027242.

PIR

JH0717.

RefSeq

NP_000171.1. NM_000180.3.

UniGene

Hs.592109.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AWL	model	-	A/B	871-1028	[»]

ProteinModelPortal

Q02846.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q02846. 2 interactions.

MINT

MINT-7241905.

STRING

9606.ENSP00000254854.

PTM databases

PhosphoSite

Q02846.

Polymorphism databases

DMDM

1345920.

Proteomic databases

PaxDb

Q02846.

PeptideAtlas

Q02846.

PRIDE

Q02846.

Protocols and materials databases

DNASU

3000.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000254854; ENSP00000254854; ENSG00000132518.

GeneID

3000.

KEGG

hsa:3000.

UCSC

uc002gjt.2. human.

Organism-specific databases

CTD

3000.

GeneCards

GC17P007905.

HGNC

HGNC:4689. GUCY2D.

MIM

204000. phenotype.
600179. gene.
601777. phenotype.

neXtProt

NX_Q02846.

Orphanet

1872. Cone rod dystrophy.
65. Leber congenital amaurosis.

PharmGKB

PA187.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0515.

HOGENOM

HOG000293307.

HOVERGEN

HBG098487.

InParanoid

Q02846.

KO

K12321.

OMA

LTLTRHC.

OrthoDB

EOG4XD3QC.

PhylomeDB

Q02846.

Enzyme and pathway databases

Pathway_Interaction_DB

cone_pathway. Visual signal transduction: Cones.
rhodopsin_pathway. Visual signal transduction: Rods.

Gene expression databases

Bgee

Q02846.

CleanEx

HS_GUCY2D.

Genevestigator

Q02846.

GermOnline

ENSG00000132518. Homo sapiens.

Family and domain databases

Gene3D

3.30.70.1230. 1 hit.

InterPro

IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]

Pfam

PF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]

SMART

SM00044. CYCc. 1 hit.
[Graphical view]

SUPFAM

SSF55073. A/G_cyclase. 1 hit.
SSF56112. Kinase_like. 1 hit.

PROSITE

PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

3000.

NextBio

11896.

SOURCE

Search...

Entry information

Entry name

GUC2D_HUMAN

Accession

Primary (citable) accession number: Q02846
Secondary accession number(s): Q6LEA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 156 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.