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Q02846 (GUC2D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 168. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinal guanylyl cyclase 1

Short name=RETGC-1
EC=4.6.1.2
Alternative name(s):
Guanylate cyclase 2D, retinal
Rod outer segment membrane guanylate cyclase
Short name=ROS-GC
Gene names
Name:GUCY2D
Synonyms:CORD6, GUC1A4, GUC2D, RETGC, RETGC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1103 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Enzyme regulation

Activated by GCAP-1; inhibited by calcium.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Retina. Localized exclusively in the nuclei and inner segments of the rod and cone photoreceptor cells.

Involvement in disease

Leber congenital amaurosis 1 (LCA1) [MIM:204000]: A severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.9 Ref.10 Ref.11 Ref.13 Ref.15 Ref.17

Cone-rod dystrophy 6 (CORD6) [MIM:601777]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7 Ref.8 Ref.12

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 1 guanylate cyclase domain.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processcGMP biosynthesis
Sensory transduction
Vision
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DiseaseCone-rod dystrophy
Disease mutation
Leber congenital amaurosis
   DomainSignal
Transmembrane
Transmembrane helix
   LigandGTP-binding
Nucleotide-binding
   Molecular functionLyase
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular signal transduction

Inferred from electronic annotation. Source: InterPro

phototransduction, visible light

Traceable author statement. Source: Reactome

receptor guanylyl cyclase signaling pathway

Traceable author statement Ref.1. Source: ProtInc

regulation of rhodopsin mediated signaling pathway

Traceable author statement. Source: Reactome

rhodopsin mediated signaling pathway

Traceable author statement. Source: Reactome

visual perception

Traceable author statement Ref.9. Source: ProtInc

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

nuclear outer membrane

Traceable author statement PubMed 7777544. Source: ProtInc

photoreceptor disc membrane

Traceable author statement. Source: Reactome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

guanylate cyclase activity

Traceable author statement Ref.9. Source: ProtInc

protein kinase activity

Inferred from electronic annotation. Source: InterPro

receptor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5151 Potential
Chain52 – 11031052Retinal guanylyl cyclase 1
PRO_0000012381

Regions

Topological domain52 – 462411Extracellular Potential
Transmembrane463 – 48725Helical; Potential
Topological domain488 – 1103616Cytoplasmic Potential
Domain525 – 808284Protein kinase
Domain880 – 1010131Guanylate cyclase

Amino acid modifications

Glycosylation2971N-linked (GlcNAc...) Potential
Disulfide bond449Interchain Probable
Disulfide bond457Interchain Probable

Natural variations

Natural variant211W → R. Ref.17
Corresponds to variant rs9905402 [ dbSNP | Ensembl ].
VAR_067168
Natural variant521A → S in LCA1; unknown pathological significance. Ref.6 Ref.17
Corresponds to variant rs61749665 [ dbSNP | Ensembl ].
VAR_003435
Natural variant551T → M in LCA1. Ref.17
Corresponds to variant rs201414567 [ dbSNP | Ensembl ].
VAR_067169
Natural variant1031E → V in LCA1. Ref.17
VAR_067170
Natural variant1051C → Y in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. Ref.10 Ref.13
VAR_023770
Natural variant3121T → M in LCA1. Ref.17
VAR_067171
Natural variant3251L → P in LCA1; does not affect basal activity; reduces GCAP-1 induced activity. Ref.10 Ref.13
VAR_023771
Natural variant3251L → R Found in a patient with LCA1. Ref.15
VAR_067172
Natural variant3281A → V. Ref.16
Corresponds to variant rs56280231 [ dbSNP | Ensembl ].
VAR_042229
Natural variant3311R → S.
Corresponds to variant rs34596269 [ dbSNP | Ensembl ].
VAR_049254
Natural variant3621A → S in LCA1.
VAR_009129
Natural variant405 – 4062LD → PN in LCA1.
VAR_067173
Natural variant4311G → D in a metastatic melanoma sample; somatic mutation. Ref.16
VAR_042230
Natural variant4381R → C in LCA1. Ref.17
VAR_067174
Natural variant5071V → M. Ref.16
VAR_042231
Natural variant5651F → S in LCA1; loss of activity. Ref.9
VAR_009131
Natural variant5731I → V in LCA1.
VAR_009130
Natural variant6021R → W.
Corresponds to variant rs34331388 [ dbSNP | Ensembl ].
VAR_049255
Natural variant6401W → L in LCA1. Ref.17
VAR_067175
Natural variant6601R → Q in LCA1. Ref.17
VAR_067176
Natural variant6931A → E. Ref.16
Corresponds to variant rs35146471 [ dbSNP | Ensembl ].
VAR_042232
Natural variant7011P → S Polymorphism that at homozygosity may be associated with Leber congenital amaurosis in some populations. Ref.14 Ref.15 Ref.16 Ref.17
Corresponds to variant rs34598902 [ dbSNP | Ensembl ].
VAR_009132
Natural variant7221R → W.
Corresponds to variant rs34331388 [ dbSNP | Ensembl ].
VAR_049256
Natural variant7281D → H in LCA1. Ref.17
VAR_067177
Natural variant7341I → A in LCA1; requires 2 nucleotide substitutions. Ref.17
VAR_067178
Natural variant7681R → W in LCA1. Ref.15 Ref.17
VAR_067179
Natural variant7821L → H Rare polymorphism. Ref.16
Corresponds to variant rs8069344 [ dbSNP | Ensembl ].
VAR_009133
Natural variant7841M → R in LCA1. Ref.17
VAR_067180
Natural variant7951R → Q in LCA1. Ref.15
VAR_067181
Natural variant837 – 8393ERT → DCM in CORD6.
VAR_003438
Natural variant8371E → D in CORD6. Ref.8
Corresponds to variant rs28933695 [ dbSNP | Ensembl ].
VAR_003436
Natural variant8381R → C in CORD6. Ref.8 Ref.12
VAR_003437
Natural variant8381R → H in CORD6. Ref.12
VAR_015373
Natural variant8581P → S in LCA1; severely impairs basal and GCAP-1 induced activity. Ref.10 Ref.13
VAR_009134
Natural variant9541L → P in LCA1; severely impairs basal and GCAP-1 induced activity. Ref.11 Ref.13
VAR_009135
Natural variant10071S → L in LCA1. Ref.17
VAR_067182
Natural variant10271I → IGI in LCA1.
VAR_067183

Secondary structure

............................. 1103
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q02846 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 28631557E7CBDFA4

FASTA1,103120,059
        10         20         30         40         50         60 
MTACARRAGG LPDPGLCGPA WWAPSLPRLP RALPRLPLLL LLLLLQPPAL SAVFTVGVLG 

        70         80         90        100        110        120 
PWACDPIFSR ARPDLAARLA AARLNRDPGL AGGPRFEVAL LPEPCRTPGS LGAVSSALAR 

       130        140        150        160        170        180 
VSGLVGPVNP AACRPAELLA EEAGIALVPW GCPWTQAEGT TAPAVTPAAD ALYALLRAFG 

       190        200        210        220        230        240 
WARVALVTAP QDLWVEAGRS LSTALRARGL PVASVTSMEP LDLSGAREAL RKVRDGPRVT 

       250        260        270        280        290        300 
AVIMVMHSVL LGGEEQRYLL EAAEELGLTD GSLVFLPFDT IHYALSPGPE ALAALANSSQ 

       310        320        330        340        350        360 
LRRAHDAVLT LTRHCPSEGS VLDSLRRAQE RRELPSDLNL QQVSPLFGTI YDAVFLLARG 

       370        380        390        400        410        420 
VAEARAAAGG RWVSGAAVAR HIRDAQVPGF CGDLGGDEEP PFVLLDTDAA GDRLFATYML 

       430        440        450        460        470        480 
DPARGSFLSA GTRMHFPRGG SAPGPDPSCW FDPNNICGGG LEPGLVFLGF LLVVGMGLAG 

       490        500        510        520        530        540 
AFLAHYVRHR LLHMQMVSGP NKIILTVDDI TFLHPHGGTS RKVAQGSRSS LGARSMSDIR 

       550        560        570        580        590        600 
SGPSQHLDSP NIGVYEGDRV WLKKFPGDQH IAIRPATKTA FSKLQELRHE NVALYLGLFL 

       610        620        630        640        650        660 
ARGAEGPAAL WEGNLAVVSE HCTRGSLQDL LAQREIKLDW MFKSSLLLDL IKGIRYLHHR 

       670        680        690        700        710        720 
GVAHGRLKSR NCIVDGRFVL KITDHGHGRL LEAQKVLPEP PRAEDQLWTA PELLRDPALE 

       730        740        750        760        770        780 
RRGTLAGDVF SLAIIMQEVV CRSAPYAMLE LTPEEVVQRV RSPPPLCRPL VSMDQAPVEC 

       790        800        810        820        830        840 
ILLMKQCWAE QPELRPSMDH TFDLFKNINK GRKTNIIDSM LRMLEQYSSN LEDLIRERTE 

       850        860        870        880        890        900 
ELELEKQKTD RLLTQMLPPS VAEALKTGTP VEPEYFEQVT LYFSDIVGFT TISAMSEPIE 

       910        920        930        940        950        960 
VVDLLNDLYT LFDAIIGSHD VYKVETIGDA YMVASGLPQR NGQRHAAEIA NMSLDILSAV 

       970        980        990       1000       1010       1020 
GTFRMRHMPE VPVRIRIGLH SGPCVAGVVG LTMPRYCLFG DTVNTASRME STGLPYRIHV 

      1030       1040       1050       1060       1070       1080 
NLSTVGILRA LDSGYQVELR GRTELKGKGA EDTFWLVGRR GFNKPIPKPP DLQPGSSNHG 

      1090       1100 
ISLQEIPPER RRKLEKARPG QFS 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a retina-specific membrane guanylyl cyclase."
Shyjan A.W., de Sauvage F.J., Gillett N.A., Goeddel D.V., Lowe D.G.
Neuron 9:727-737(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]Lowe D.G.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]Perrault I.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Human retinal guanylate cyclase (GUC2D) maps to chromosome 17p13.1."
Oliveira L., Miniou P., Viegas-Pequignot E., Rozet J.-M., Dollfus H., Pittler S.J.
Genomics 22:478-481(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1009-1088.
[5]"Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis."
Liu Y., Ruoho A.E., Rao V.D., Hurley J.H.
Proc. Natl. Acad. Sci. U.S.A. 94:13414-13419(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 871-1028.
[6]"Retinal-specific guanylate cyclase gene mutations in Leber's congenital amaurosis."
Perrault I., Rozet J.-M., Calvas P., Gerber S., Camuzat A., Dollfus H., Chatelin S., Souied E., Ghazi I., Leowski C., Bonnemaison M., le Paslier D., Frezal J., Dufier J.-L., Pittler S., Munnich A., Kaplan J.
Nat. Genet. 14:461-464(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LCA1 SER-52.
[7]"A retGC-1 mutation in autosomal dominant cone-rod dystrophy."
Perrault I., Rozet J.-M., Gerber S., Kelsell R.E., Souied E., Cabot A., Hunt D.M., Munnich A., Kaplan J.
Am. J. Hum. Genet. 63:651-654(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT CORD6 837-ASP--MET-839.
[8]"Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy."
Kelsell R.E., Gregory-Evans K., Payne A.M., Perrault I., Kaplan J., Yang R.-B., Garbers D.L., Bird A.C., Moore A.T., Hunt D.M.
Hum. Mol. Genet. 7:1179-1184(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS CORD6 ASP-837 AND CYS-838.
[9]"Functional consequences of a rod outer segment membrane guanylate cyclase (ROS-GC1) gene mutation linked with Leber's congenital amaurosis."
Duda T., Venkataraman V., Goraczniak R., Lange C., Koch K.-W., Sharma R.K.
Biochemistry 38:509-515(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANT LCA1 SER-565.
[10]"Mutational analysis and clinical correlation in Leber congenital amaurosis."
Dharmaraj S.R., Silva E.R., Pina A.-L., Li Y.Y., Yang J.M., Carter C.R., Loyer M.K., El-Hilali H.K., Traboulsi E.K., Sundin O.K., Zhu D.K., Koenekoop R.K., Maumenee I.H.
Ophthalmic Genet. 21:135-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LCA1 TYR-105; PRO-325 AND SER-858.
[11]"Electroretinographic abnormalities in parents of patients with Leber congenital amaurosis who have heterozygous GUCY2D mutations."
Koenekoop R.K., Fishman G.A., Iannaccone A., Ezzeldin H., Ciccarelli M.L., Baldi A., Sunness J.S., Lotery A.J., Jablonski M.M., Pittler S.J., Maumenee I.
Arch. Ophthalmol. 120:1325-1330(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LCA1 PRO-954.
[12]"Identification of GUCY2D gene mutations in CORD5 families and evidence of incomplete penetrance."
Udar N., Yelchits S., Chalukya M., Yellore V., Nusinowitz S., Silva-Garcia R., Vrabec T., Hussles Maumenee I., Donoso L., Small K.W.
Hum. Mutat. 21:170-171(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS CORD6 CYS-838 AND HIS-838, DISCUSSION OF PHENOTYPIC VARIABILITY.
[13]"Functional analyses of mutant recessive GUCY2D alleles identified in Leber congenital amaurosis patients: protein domain comparisons and dominant negative effects."
Tucker C.L., Ramamurthy V., Pina A.-L., Loyer M., Dharmaraj S., Li Y., Maumenee I.H., Hurley J.B., Koenekoop R.K.
Mol. Vis. 10:297-303(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS LCA1 TYR-105; PRO-325; SER-858 AND PRO-954.
[14]"Genotyping microarray (disease chip) for Leber congenital amaurosis: detection of modifier alleles."
Zernant J., Kulm M., Dharmaraj S., den Hollander A.I., Perrault I., Preising M.N., Lorenz B., Kaplan J., Cremers F.P., Maumenee I., Koenekoop R.K., Allikmets R.
Invest. Ophthalmol. Vis. Sci. 46:3052-3059(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: POSSIBLE INVOLVEMENT OF VARIANT SER-701 IN LEBER CONGENITAL AMAUROSIS.
[15]"Clinical and molecular genetics of Leber's congenital amaurosis: a multicenter study of Italian patients."
Simonelli F., Ziviello C., Testa F., Rossi S., Fazzi E., Bianchi P.E., Fossarello M., Signorini S., Bertone C., Galantuomo S., Brancati F., Valente E.M., Ciccodicola A., Rinaldi E., Auricchio A., Banfi S.
Invest. Ophthalmol. Vis. Sci. 48:4284-4290(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LCA1 TRP-768 AND GLN-795, VARIANTS ARG-325 AND SER-701, POSSIBLE INVOLVEMENT OF VARIANT SER-701 IN LEBER CONGENITAL AMAUROSIS.
[16]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-328; ASP-431; MET-507; GLU-693; SER-701 AND HIS-782.
[17]"Detection of variants in 15 genes in 87 unrelated Chinese patients with Leber congenital amaurosis."
Li L., Xiao X., Li S., Jia X., Wang P., Guo X., Jiao X., Zhang Q., Hejtmancik J.F.
PLoS ONE 6:E19458-E19458(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LCA1 MET-55; VAL-103; MET-312; 405-PRO-ASN-406; CYS-438; LEU-640; GLN-660; HIS-728; ALA-734; TRP-768; ARG-784 AND LEU-1007; GLY-ILE-1027 INS, VARIANTS ARG-21; SER-52 AND SER-701.
+Additional computationally mapped references.

Web resources

Mutations of the GUCY2D gene

Retina International's Scientific Newsletter

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M92432 mRNA. Translation: AAA60547.1.
AJ222657 Genomic DNA. Translation: CAA10914.1.
L26921 Genomic DNA. Translation: AAA60366.1.
CCDSCCDS11127.1.
PIRJH0717.
RefSeqNP_000171.1. NM_000180.3.
UniGeneHs.592109.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AWLmodel-A/B871-1028[»]
ProteinModelPortalQ02846.
SMRQ02846. Positions 542-838, 871-1045.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109255. 1 interaction.
IntActQ02846. 2 interactions.
MINTMINT-7241905.
STRING9606.ENSP00000254854.

PTM databases

PhosphoSiteQ02846.

Polymorphism databases

DMDM1345920.

Proteomic databases

PaxDbQ02846.
PeptideAtlasQ02846.
PRIDEQ02846.

Protocols and materials databases

DNASU3000.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254854; ENSP00000254854; ENSG00000132518.
GeneID3000.
KEGGhsa:3000.
UCSCuc002gjt.2. human.

Organism-specific databases

CTD3000.
GeneCardsGC17P007905.
GeneReviewsGUCY2D.
HGNCHGNC:4689. GUCY2D.
MIM204000. phenotype.
600179. gene.
601777. phenotype.
neXtProtNX_Q02846.
Orphanet75377. Central areolar choroidal dystrophy.
1872. Cone rod dystrophy.
65. Leber congenital amaurosis.
PharmGKBPA187.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000293307.
HOVERGENHBG098487.
InParanoidQ02846.
KOK12321.
OMAAMLELTP.
OrthoDBEOG7QVM1V.
PhylomeDBQ02846.
TreeFamTF106338.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

BgeeQ02846.
CleanExHS_GUCY2D.
GenevestigatorQ02846.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi3000.
NextBio11896.
PROQ02846.
SOURCESearch...

Entry information

Entry nameGUC2D_HUMAN
AccessionPrimary (citable) accession number: Q02846
Secondary accession number(s): Q6LEA7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM