Reviewed, UniProtKB/Swiss-Prot Q02833 (RASF7_HUMAN)

Names and origin

Protein names

Recommended name:
    Ras association domain-containing protein 7
Alternative name(s):
    HRAS1-related cluster protein 1

Gene names

Name:	RASSF7
Synonyms:	C11orf13, HRC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 Ras-associating domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Non-traceable author statement. Source: UniProtKB signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular function	DNA binding Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DISC1	Q9NRI5	2	EBI-929013,EBI-529989

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q02833-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q02833-2)

The sequence of this isoform differs from the canonical sequence as follows:
     318-337: GPLPPAREESLLGAPSESHA → VGVVLGGGWEVRTWPSPTPS
     338-373: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 373	373	Ras association domain-containing protein 7		PRO_0000097173
Regions
	Domain	6 – 89	84	Ras-associating
	Coiled coil	175 – 227	53	Potential
	Coiled coil	248 – 297	50	Potential
	Compositional bias	130 – 149	20	Pro-rich
	Compositional bias	228 – 236	9	Pro-rich
	Compositional bias	304 – 322	19	Pro-rich
Natural variations
	Alternative sequence	318 – 337	20	GPLPP…SESHA → VGVVLGGGWEVRTWPSPTPS in isoform 2.		VSP_004136
	Alternative sequence	338 – 373	36	Missing in isoform 2.		VSP_004137
	Natural variant	89	1	P → A: dbSNP rs2242183.		VAR_021859
	Natural variant	156	1	R → Q: dbSNP rs2242182.		VAR_021860

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 55DF1DDB1C37CAF3	FASTA	373	39,945
	10 20 30 40 50 60 MLLGLAAMEL KVWVDGIQRV VCGVSEQTTC QEVVIALAQA IGQTGRFVLV QRLREKERQL 70 80 90 100 110 120 LPQECPVGAQ ATCGQFASDV QFVLRRTGPS LAGRPSSDSC PPPERCLIRA SLPVKPRAAL 130 140 150 160 170 180 GCEPRKTLTP EPAPSLSRPG PAAPVTPTPG CCTDLRGLEL RVQRNAEELG HEAFWEQELR 190 200 210 220 230 240 REQAREREGQ ARLQALSAAT AEHAARLQAL DAQARALEAE LQLAAEAPGP PSPMASATER 250 260 270 280 290 300 LHQDLAVQER QSAEVQGSLA LVSRALEAAE RALQAQAQEL EELNRELRQC NLQQFIQQTG 310 320 330 340 350 360 AALPPPPRPD RGPPGTQGPL PPAREESLLG APSESHAGAQ PRPRGGPHDA ELLEVAAAPA 370 PEWCPLAAQP QAL
	Isoform 2 [UniParc]. Checksum: 0235F06486060BCE		337	36,343
	10 20 30 40 50 60 MLLGLAAMEL KVWVDGIQRV VCGVSEQTTC QEVVIALAQA IGQTGRFVLV QRLREKERQL 70 80 90 100 110 120 LPQECPVGAQ ATCGQFASDV QFVLRRTGPS LAGRPSSDSC PPPERCLIRA SLPVKPRAAL 130 140 150 160 170 180 GCEPRKTLTP EPAPSLSRPG PAAPVTPTPG CCTDLRGLEL RVQRNAEELG HEAFWEQELR 190 200 210 220 230 240 REQAREREGQ ARLQALSAAT AEHAARLQAL DAQARALEAE LQLAAEAPGP PSPMASATER 250 260 270 280 290 300 LHQDLAVQER QSAEVQGSLA LVSRALEAAE RALQAQAQEL EELNRELRQC NLQQFIQQTG 310 320 330 AALPPPPRPD RGPPGTQVGV VLGGGWEVRT WPSPTPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain." Weitzel J.N., Kasperczyk A., Mohan C., Krontiris T.G. Genomics 14:309-319(1992) [PubMed: 1339391] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBLGenBankDDBJ	M91083 mRNA. Translation: AAA58667.1. BC106921 mRNA. Translation: AAI06922.1.
PIR	A44478. B44478.
RefSeq	NP_003466.1.
UniGene	Hs.72925
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q02833.
Genome annotation databases
Ensembl	ENSG00000099849. Homo sapiens. [Contig view]
GeneID	8045.
KEGG	hsa:8045.
Organism-specific databases
H-InvDB	HIX0036006.
HGNC	HGNC:1166. RASSF7.
MIM	143023. gene.
PharmGKB	PA25480.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q02833.
HOVERGEN	Q02833.
Gene expression databases
ArrayExpress	Q02833.
CleanEx	HS_RASSF7.
GermOnline	ENSG00000099849. Homo sapiens.
Family and domain databases
InterPro	IPR000159. Ras-assoc. [Graphical view]
Pfam	PF00788. RA. 1 hit. [Graphical view]
SMART	SM00314. RA. 1 hit. [Graphical view]
PROSITE	PS50200. RA. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	30636.
SOURCE	Search...

Entry information

Entry name

RASF7_HUMAN

Accession

Primary (citable) accession number: Q02833
Secondary accession number(s): Q3KP42

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)