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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

NDUFC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:NDUFC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei57 – 76HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188361 – 120NADH dehydrogenase [ubiquinone] 1 subunit C2Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Post-translational modificationi

There is a minor unacetylated form of subunit B14.5b.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ02827.
PRIDEiQ02827.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018188.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

IntActiQ02827. 1 interactor.
STRINGi9913.ENSBTAP00000024209.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35d29-97[»]
5LDWelectron microscopy4.27d29-96[»]
5LDXelectron microscopy5.60d29-97[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ02827.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
TreeFamiTF314723.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTGRQGRAT FQFLPDEARS LPPPKLTDPR LAFVGFLGYC SGLIDNAIRR
60 70 80 90 100
RPVLLAGLHR QLLYITSFVF VGYYLLKRQD YMYAVRDHDM FSYIKSHPED
110 120
FPEKDKKTYG EVFEEFHPVR
Length:120
Mass (Da):14,096
Last modified:June 1, 1994 - v1
Checksum:iAF35707C2C3F2B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68647 mRNA. Translation: CAA48607.1.
BC102739 mRNA. Translation: AAI02740.1.
PIRiS27227.
RefSeqiNP_788815.1. NM_176642.3.
UniGeneiBt.64366.

Genome annotation databases

EnsembliENSBTAT00000024209; ENSBTAP00000024209; ENSBTAG00000018188.
GeneIDi338046.
KEGGibta:338046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68647 mRNA. Translation: CAA48607.1.
BC102739 mRNA. Translation: AAI02740.1.
PIRiS27227.
RefSeqiNP_788815.1. NM_176642.3.
UniGeneiBt.64366.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LC5electron microscopy4.35d29-97[»]
5LDWelectron microscopy4.27d29-96[»]
5LDXelectron microscopy5.60d29-97[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02827. 1 interactor.
STRINGi9913.ENSBTAP00000024209.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02827.
PRIDEiQ02827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024209; ENSBTAP00000024209; ENSBTAG00000018188.
GeneIDi338046.
KEGGibta:338046.

Organism-specific databases

CTDi4718.

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ02827.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG091G0ZKK.
TreeFamiTF314723.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-6799198. Complex I biogenesis.

Gene expression databases

BgeeiENSBTAG00000018188.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUC2_BOVIN
AccessioniPrimary (citable) accession number: Q02827
Secondary accession number(s): Q3SZR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.