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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C2

Gene

NDUFC2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C2
Alternative name(s):
Complex I-B14.5b
Short name:
CI-B14.5b
NADH-ubiquinone oxidoreductase subunit B14.5b
Gene namesi
Name:NDUFC2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7620HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120NADH dehydrogenase [ubiquinone] 1 subunit C2PRO_0000118836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine

Post-translational modificationi

There is a minor unacetylated form of subunit B14.5b.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ02827.
PRIDEiQ02827.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

IntActiQ02827. 1 interaction.
STRINGi9913.ENSBTAP00000024209.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC2 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ02827.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG7VHT0D.
TreeFamiTF314723.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTGRQGRAT FQFLPDEARS LPPPKLTDPR LAFVGFLGYC SGLIDNAIRR
60 70 80 90 100
RPVLLAGLHR QLLYITSFVF VGYYLLKRQD YMYAVRDHDM FSYIKSHPED
110 120
FPEKDKKTYG EVFEEFHPVR
Length:120
Mass (Da):14,096
Last modified:June 1, 1994 - v1
Checksum:iAF35707C2C3F2B89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68647 mRNA. Translation: CAA48607.1.
BC102739 mRNA. Translation: AAI02740.1.
PIRiS27227.
RefSeqiNP_788815.1. NM_176642.3.
UniGeneiBt.64366.

Genome annotation databases

EnsembliENSBTAT00000024209; ENSBTAP00000024209; ENSBTAG00000018188.
GeneIDi338046.
KEGGibta:338046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68647 mRNA. Translation: CAA48607.1.
BC102739 mRNA. Translation: AAI02740.1.
PIRiS27227.
RefSeqiNP_788815.1. NM_176642.3.
UniGeneiBt.64366.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ02827. 1 interaction.
STRINGi9913.ENSBTAP00000024209.

Protein family/group databases

TCDBi3.D.1.6.1. the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.

Proteomic databases

PaxDbiQ02827.
PRIDEiQ02827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024209; ENSBTAP00000024209; ENSBTAG00000018188.
GeneIDi338046.
KEGGibta:338046.

Organism-specific databases

CTDi4718.

Phylogenomic databases

eggNOGiKOG4516. Eukaryota.
ENOG410Y341. LUCA.
GeneTreeiENSGT00390000010352.
HOGENOMiHOG000113753.
HOVERGENiHBG001727.
InParanoidiQ02827.
KOiK03968.
OMAiGRVPLQF.
OrthoDBiEOG7VHT0D.
TreeFamiTF314723.

Enzyme and pathway databases

ReactomeiR-BTA-611105. Respiratory electron transport.
R-BTA-6799198. Complex I biogenesis.

Family and domain databases

InterProiIPR009423. NADH-UbQ_OxRdtase_b14.5b_su.
[Graphical view]
PANTHERiPTHR13099. PTHR13099. 1 hit.
PfamiPF06374. NDUF_C2. 1 hit.
[Graphical view]
PIRSFiPIRSF017834. NADH-UbQ_OxRdtase_b14.5b. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complementary DNA sequences of two 14.5 kDa subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Completion of the primary structure of the complex?"
    Arizmendi J.M., Skehel J.M., Runswick M.J., Fearnley I.M., Walker J.E.
    FEBS Lett. 313:80-84(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Testis.
  3. "Subunit analysis of bovine heart complex I by reversed-phase high-performance liquid chromatography, electrospray ionization-tandem mass spectrometry, and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry."
    Lemma-Gray P., Valusova E., Carroll C.A., Weintraub S.T., Musatov A., Robinson N.C.
    Anal. Biochem. 382:116-121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN COMPLEX I.

Entry informationi

Entry nameiNDUC2_BOVIN
AccessioniPrimary (citable) accession number: Q02827
Secondary accession number(s): Q3SZR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.