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Q02817

- MUC2_HUMAN

UniProt

Q02817 - MUC2_HUMAN

Protein

Mucin-2

Gene

MUC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei4486 – 44872Cleavage; by autolysis; in vitro

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. maintenance of gastrointestinal epithelium Source: UniProt
    3. O-glycan processing Source: Reactome
    4. post-translational protein modification Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-2
    Short name:
    MUC-2
    Alternative name(s):
    Intestinal mucin-2
    Gene namesi
    Name:MUC2
    Synonyms:SMUC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7512. MUC2.

    Subcellular locationi

    Secreted
    Note: In the intestine, secreted into the inner and outer mucus layers.By similarity

    GO - Cellular componenti

    1. Golgi lumen Source: Reactome
    2. inner mucus layer Source: UniProtKB
    3. outer mucus layer Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31316.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 51795159Mucin-2PRO_0000019281Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi? ↔ 5159By similarity
    Modified residuei21 – 211Phosphoserine1 Publication
    Disulfide bondi59 ↔ 67By similarity
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi894 – 8941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1139 – 11391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1154 – 11541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1215 – 12151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1230 – 12301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1246 – 12461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1787 – 17871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1820 – 18201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4339 – 43391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4351 – 43511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4362 – 43621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4373 – 43731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4422 – 44221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4438 – 44381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4502 – 45021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4616 – 46161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4627 – 46271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4752 – 47521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4787 – 47871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4881 – 48811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4888 – 48881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4955 – 49551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4970 – 49701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5019 – 50191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5038 – 50381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5069 – 50691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5075 ↔ 5122By similarity
    Disulfide bondi5089 ↔ 5136By similarity
    Disulfide bondi5098 ↔ 5152By similarity
    Disulfide bondi5102 ↔ 5154By similarity

    Post-translational modificationi

    O-glycosylated.
    May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.By similarity
    At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

    Keywords - PTMi

    Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ02817.
    PRIDEiQ02817.

    PTM databases

    PhosphoSiteiQ02817.
    UniCarbKBiQ02817.

    Expressioni

    Tissue specificityi

    Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

    Gene expression databases

    ArrayExpressiQ02817.
    BgeeiQ02817.
    CleanExiHS_MUC2.
    GenevestigatoriQ02817.

    Organism-specific databases

    HPAiCAB005317.
    CAB016275.
    HPA006197.

    Interactioni

    Subunit structurei

    Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.3 Publications

    Protein-protein interaction databases

    BioGridi110670. 3 interactions.
    DIPiDIP-48824N.
    IntActiQ02817. 2 interactions.
    STRINGi9606.ENSP00000415183.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02817.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 240205VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini295 – 35157TILAdd
    BLAST
    Domaini390 – 604215VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini859 – 1065207VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati1401 – 1416161Add
    BLAST
    Repeati1417 – 1432162Add
    BLAST
    Repeati1433 – 1448163Add
    BLAST
    Repeati1449 – 1464164Add
    BLAST
    Repeati1465 – 147175
    Repeati1472 – 147876
    Repeati1479 – 1494167AAdd
    BLAST
    Repeati1495 – 1517237BAdd
    BLAST
    Repeati1518 – 1533168AAdd
    BLAST
    Repeati1534 – 1556238BAdd
    BLAST
    Repeati1557 – 1572169AAdd
    BLAST
    Repeati1573 – 1596249BAdd
    BLAST
    Repeati1597 – 16121610AAdd
    BLAST
    Repeati1613 – 16352310BAdd
    BLAST
    Repeati1636 – 16511611AAdd
    BLAST
    Repeati1652 – 16752411BAdd
    BLAST
    Repeati1676 – 1683812
    Repeati1684 – 16991613Add
    BLAST
    Repeati1700 – 17151614Add
    BLAST
    Repeati1716 – 17311615Add
    BLAST
    Repeati1732 – 17471616Add
    BLAST
    Domaini4480 – 4690211VWFD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini4815 – 488672VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini4924 – 499168VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini5075 – 516086CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1401 – 1747347Approximate repeatsAdd
    BLAST

    Sequence similaritiesi

    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 2 VWFC domains.PROSITE-ProRule annotation
    Contains 4 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000168234.
    HOVERGENiHBG004380.
    InParanoidiQ02817.
    KOiK10955.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR028580. MUC2.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    IPR025155. WxxW_domain.
    [Graphical view]
    PANTHERiPTHR11339:SF261. PTHR11339:SF261. 1 hit.
    PfamiPF08742. C8. 4 hits.
    PF13330. Mucin2_WxxW. 2 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 4 hits.
    [Graphical view]
    SMARTiSM00832. C8. 4 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 4 hits.
    [Graphical view]
    SUPFAMiSSF57567. SSF57567. 4 hits.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02817-1 [UniParc]FASTAAdd to Basket

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    MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG     50
    DVFRFPGLCD YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD 100
    DTIYLTRHLA VLNGAVVSTP HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE 150
    DALMLELDTK FRNHTCGLCG DYNGLQSYSE FLSDGVLFSP LEFGNMQKIN 200
    QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL VPLEPYLRAC 250
    QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV 300
    YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ 350
    CHCRLHGHLY TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT 400
    TFDGKTYTFH GDCYYVLAKG DHNDSYALLG ELAPCGSTDK QTCLKTVVLL 450
    ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA SFSVFRPSSY HIMVSMAIGV 500
    RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK TASGLVEATG 550
    AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR 600
    CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR 650
    EHVCNKDVGS CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC 700
    PDHTFLDEKG RCVPLAKCSC YHRGLYLEAG DVVVRQEERC VCRDGRLHCR 750
    QIRLIGQSCT APKIHMDCSN LTALATSKPR ALSCQTLAAG YYHTECVSGC 800
    VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN TCTCKRGRWV 850
    CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF 900
    SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT 950
    TREVGQYLVV ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN 1000
    NDFTTRDHMV VSSELDFGNS WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ 1050
    CSILKSSVFS ICHSKVDPKP FYEACVHDSC SCDTGGDCEC FCSAVASYAQ 1100
    ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR SFETCRTING 1150
    IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA 1200
    SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE 1250
    KHFNICSITT RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK 1300
    LCCLWSDWIN EDHPSSGSDD GDREPFDGVC GAPEDIECRS VKDPHLSLEQ 1350
    HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY DYKIRVNCCW PMDKCITTPS 1400
    PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP PITTTTTPLP 1450
    TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP 1500
    SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP 1550
    TSTTTLPPTT TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT 1600
    TPSPPTTTTT TPPPTTTPSP PTTTPITPPT STTTLPPTTT PSPPPTTTTT 1650
    PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT PSSPITTTPS PPTTTMTTPS 1700
    PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP TTTMTTLPPT 1750
    TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH 1800
    KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC 1850
    KNEDQKPGGV IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP 1900
    ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT 1950
    TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT 2000
    PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT 2050
    PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 2100
    QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT 2150
    TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI 2200
    TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT 2250
    TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 2300
    TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 2350
    TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ 2400
    TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 2450
    TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT 2500
    TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT 2550
    VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT 2600
    PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT 2650
    GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT 2700
    PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 2750
    PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT 2800
    TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 2850
    TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP 2900
    TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG 2950
    TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP 3000
    TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP 3050
    ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT 3100
    TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT 3150
    PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT 3200
    PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 3250
    QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT 3300
    TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI 3350
    TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT 3400
    TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 3450
    TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 3500
    TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ 3550
    TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 3600
    TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT 3650
    TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT 3700
    VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT 3750
    PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT 3800
    GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT 3850
    PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 3900
    PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT 3950
    TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 4000
    TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP 4050
    TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG 4100
    TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP 4150
    TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH 4200
    TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST 4250
    APPSTPTAPT TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ 4300
    TTTTSAWTPT PTPLSTPSII RTTGLRPYPS SVLICCVLND TYYAPGEEVY 4350
    NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST PTPSKPSSTP 4400
    SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP 4450
    PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ 4500
    GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI 4550
    KTVHMMPMQV QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY 4600
    NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS DDCILPSGEI VSNCEAAADQ 4650
    WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS PLCQLIKDSL 4700
    FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW 4750
    RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG 4800
    TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ 4850
    PKRCSQKPVT HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP 4900
    LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT 4950
    DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC EQTHCIIKRP 5000
    DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI 5050
    PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG 5100
    SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE 5150
    SCQCQDTVCG LPTGTSRRAR RSPRHLGSG 5179
    Length:5,179
    Mass (Da):540,300
    Last modified:November 1, 1997 - v2
    Checksum:i85CD7571FB9A5663
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1351 – 13511H → L in AAA59875. (PubMed:1885763)Curated
    Sequence conflicti1412 – 14121T → S in AAA59875. (PubMed:1885763)Curated
    Sequence conflicti1449 – 14491L → P in AAA59875. (PubMed:1885763)Curated
    Sequence conflicti1504 – 15041M → T in AAA59875. (PubMed:1885763)Curated
    Sequence conflicti4076 – 40838TGTQTPTT → NGLQAPTP(PubMed:2703501)Curated
    Sequence conflicti4087 – 40871T → S(PubMed:2703501)Curated
    Sequence conflicti4130 – 41312TP → VL(PubMed:2703501)Curated
    Sequence conflicti4138 – 41381V → M(PubMed:2703501)Curated
    Sequence conflicti4146 – 41527GTQTPTT → STKSTTV(PubMed:2703501)Curated
    Sequence conflicti4163 – 41631P → A(PubMed:2703501)Curated
    Sequence conflicti4175 – 41762TT → MI(PubMed:2703501)Curated
    Sequence conflicti4179 – 41791T → S(PubMed:2703501)Curated
    Sequence conflicti4192 – 41943GTQ → TGS(PubMed:2703501)Curated

    Polymorphismi

    The number of repeats is highly polymorphic and varies among different alleles.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581L → P.
    Corresponds to variant rs2856111 [ dbSNP | Ensembl ].
    VAR_056582
    Natural varianti116 – 1161V → M.
    Corresponds to variant rs11825977 [ dbSNP | Ensembl ].
    VAR_056583
    Natural varianti832 – 8321G → S.
    Corresponds to variant rs11245936 [ dbSNP | Ensembl ].
    VAR_056584
    Natural varianti1619 – 16191S → R.
    Corresponds to variant rs11245947 [ dbSNP | Ensembl ].
    VAR_059531
    Natural varianti1689 – 16891P → L.
    Corresponds to variant rs11245949 [ dbSNP | Ensembl ].
    VAR_059532
    Natural varianti1768 – 17681P → H.
    Corresponds to variant rs34493663 [ dbSNP | Ensembl ].
    VAR_061487
    Natural varianti2154 – 21541I → T.
    Corresponds to variant rs6421972 [ dbSNP | Ensembl ].
    VAR_059533
    Natural varianti2524 – 25241T → P.
    Corresponds to variant rs7480563 [ dbSNP | Ensembl ].
    VAR_059534
    Natural varianti2524 – 25241T → S.
    Corresponds to variant rs7480563 [ dbSNP | Ensembl ].
    VAR_059535
    Natural varianti2653 – 26531Q → L.
    Corresponds to variant rs7126405 [ dbSNP | Ensembl ].
    VAR_059536
    Natural varianti2653 – 26531Q → P.
    Corresponds to variant rs7126405 [ dbSNP | Ensembl ].
    VAR_059537

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21998 mRNA. Translation: AAB95295.1.
    M74027 Genomic DNA. Translation: AAA59875.1.
    M94131 mRNA. Translation: AAA59163.1.
    M94132 mRNA. Translation: AAA59164.1.
    PIRiA49963. A43932.
    RefSeqiNP_002448.3. NM_002457.3.
    UniGeneiHs.315.

    Genome annotation databases

    EnsembliENST00000359061; ENSP00000351956; ENSG00000198788.
    GeneIDi4583.
    KEGGihsa:4583.
    UCSCiuc001lsx.1. human.

    Polymorphism databases

    DMDMi2506877.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Mucin database
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21998 mRNA. Translation: AAB95295.1 .
    M74027 Genomic DNA. Translation: AAA59875.1 .
    M94131 mRNA. Translation: AAA59163.1 .
    M94132 mRNA. Translation: AAA59164.1 .
    PIRi A49963. A43932.
    RefSeqi NP_002448.3. NM_002457.3.
    UniGenei Hs.315.

    3D structure databases

    ProteinModelPortali Q02817.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110670. 3 interactions.
    DIPi DIP-48824N.
    IntActi Q02817. 2 interactions.
    STRINGi 9606.ENSP00000415183.

    Chemistry

    DrugBanki DB01411. Pranlukast.

    PTM databases

    PhosphoSitei Q02817.
    UniCarbKBi Q02817.

    Polymorphism databases

    DMDMi 2506877.

    Proteomic databases

    PaxDbi Q02817.
    PRIDEi Q02817.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359061 ; ENSP00000351956 ; ENSG00000198788 .
    GeneIDi 4583.
    KEGGi hsa:4583.
    UCSCi uc001lsx.1. human.

    Organism-specific databases

    CTDi 4583.
    GeneCardsi GC11P001064.
    HGNCi HGNC:7512. MUC2.
    HPAi CAB005317.
    CAB016275.
    HPA006197.
    MIMi 158370. gene.
    neXtProti NX_Q02817.
    PharmGKBi PA31316.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000168234.
    HOVERGENi HBG004380.
    InParanoidi Q02817.
    KOi K10955.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    ChiTaRSi MUC2. human.
    GeneWikii MUC2.
    GenomeRNAii 4583.
    NextBioi 17613.
    PROi Q02817.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02817.
    Bgeei Q02817.
    CleanExi HS_MUC2.
    Genevestigatori Q02817.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR028580. MUC2.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR006552. VWC_out.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    IPR025155. WxxW_domain.
    [Graphical view ]
    PANTHERi PTHR11339:SF261. PTHR11339:SF261. 1 hit.
    Pfami PF08742. C8. 4 hits.
    PF13330. Mucin2_WxxW. 2 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 4 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 4 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00215. VWC_out. 1 hit.
    SM00216. VWD. 4 hits.
    [Graphical view ]
    SUPFAMi SSF57567. SSF57567. 4 hits.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    PS51233. VWFD. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor."
      Gum J.R. Jr., Hicks J.W., Toribara N.W., Siddiki B., Kim Y.S.
      J. Biol. Chem. 269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.
    2. "The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region."
      Gum J.R. Jr., Hicks J.W., Toribara N.W., Rothe E.-M., Lagace R.E., Kim Y.S.
      J. Biol. Chem. 267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 626-1895 AND 4196-5179.
      Tissue: Colon.
    3. "MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism."
      Toribara N.W., Gum J.R. Jr., Culhane P.J., Lagace R.E., Hicks J.W., Petersen G.M., Kim Y.S.
      J. Clin. Invest. 88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1343-1895 AND 4176-4195.
    4. "Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism."
      Gum J.R. Jr., Byrd J.C., Hicks J.W., Toribara N.W., Lamport D.T.A., Kim Y.S.
      J. Biol. Chem. 264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4075-4352.
    5. "Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5."
      Xu G., Huan L., Khatri I., Sajjan U.S., McCool D., Wang D., Jones C., Forstner G., Forstner J.
      Biochem. Biophys. Res. Commun. 183:821-828(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4487-4627.
    6. Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES.
    7. "The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment."
      Godl K., Johansson M.E.V., Lidell M.E., Moergelin M., Karlsson H., Olson F.J., Gum J.R. Jr., Kim Y.S., Hansson G.C.
      J. Biol. Chem. 277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    8. "An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway."
      Lidell M.E., Johansson M.E.V., Hansson G.C.
      J. Biol. Chem. 278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: AUTOCATALYTIC CLEAVAGE.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."
      Park S.-W., Zhen G., Verhaeghe C., Nakagami Y., Nguyenvu L.T., Barczak A.J., Killeen N., Erle D.J.
      Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AGR2.
    11. "Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
      Johansson M.E.V., Thomsson K.A., Hansson G.C.
      J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH FCGBP.

    Entry informationi

    Entry nameiMUC2_HUMAN
    AccessioniPrimary (citable) accession number: Q02817
    Secondary accession number(s): Q14878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3