Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q02817 (MUC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-2

Short name=MUC-2
Alternative name(s):
Intestinal mucin-2
Gene names
Name:MUC2
Synonyms:SMUC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length5179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Ref.11

Subunit structure

Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked. Ref.7 Ref.10 Ref.11

Subcellular location

Secreted. Note: In the intestine, secreted into the inner and outer mucus layers By similarity.

Tissue specificity

Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

Post-translational modification

O-glycosylated. Ref.6

May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria By similarity.

At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Polymorphism

The number of repeats is highly polymorphic and varies among different alleles.

Sequence similarities

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 TIL (trypsin inhibitory-like) domain.

Contains 2 VWFC domains.

Contains 4 VWFD domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 51795159Mucin-2
PRO_0000019281

Regions

Domain36 – 240205VWFD 1
Domain295 – 35157TIL
Domain390 – 604215VWFD 2
Domain859 – 1065207VWFD 3
Repeat1401 – 1416161
Repeat1417 – 1432162
Repeat1433 – 1448163
Repeat1449 – 1464164
Repeat1465 – 147175
Repeat1472 – 147876
Repeat1479 – 1494167A
Repeat1495 – 1517237B
Repeat1518 – 1533168A
Repeat1534 – 1556238B
Repeat1557 – 1572169A
Repeat1573 – 1596249B
Repeat1597 – 16121610A
Repeat1613 – 16352310B
Repeat1636 – 16511611A
Repeat1652 – 16752411B
Repeat1676 – 1683812
Repeat1684 – 16991613
Repeat1700 – 17151614
Repeat1716 – 17311615
Repeat1732 – 17471616
Domain4480 – 4690211VWFD 4
Domain4815 – 488672VWFC 1
Domain4924 – 499168VWFC 2
Domain5075 – 516086CTCK
Region1401 – 1747347Approximate repeats

Sites

Site4486 – 44872Cleavage; by autolysis; in vitro

Amino acid modifications

Modified residue211Phosphoserine Ref.9
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation4231N-linked (GlcNAc...) Potential
Glycosylation6701N-linked (GlcNAc...) Potential
Glycosylation7701N-linked (GlcNAc...) Potential
Glycosylation8941N-linked (GlcNAc...) Potential
Glycosylation11391N-linked (GlcNAc...) Potential
Glycosylation11541N-linked (GlcNAc...) Potential
Glycosylation12151N-linked (GlcNAc...) Potential
Glycosylation12301N-linked (GlcNAc...) Potential
Glycosylation12461N-linked (GlcNAc...) Potential
Glycosylation17871N-linked (GlcNAc...) Potential
Glycosylation18201N-linked (GlcNAc...) Potential
Glycosylation43391N-linked (GlcNAc...) Potential
Glycosylation43511N-linked (GlcNAc...) Potential
Glycosylation43621N-linked (GlcNAc...) Potential
Glycosylation43731N-linked (GlcNAc...) Potential
Glycosylation44221N-linked (GlcNAc...) Potential
Glycosylation44381N-linked (GlcNAc...) Potential
Glycosylation45021N-linked (GlcNAc...) Potential
Glycosylation46161N-linked (GlcNAc...) Potential
Glycosylation46271N-linked (GlcNAc...) Potential
Glycosylation47521N-linked (GlcNAc...) Potential
Glycosylation47871N-linked (GlcNAc...) Potential
Glycosylation48811N-linked (GlcNAc...) Potential
Glycosylation48881N-linked (GlcNAc...) Potential
Glycosylation49551N-linked (GlcNAc...) Potential
Glycosylation49701N-linked (GlcNAc...) Potential
Glycosylation50191N-linked (GlcNAc...) Potential
Glycosylation50381N-linked (GlcNAc...) Potential
Glycosylation50691N-linked (GlcNAc...) Potential
Disulfide bond59 ↔ 67 By similarity
Disulfide bond5075 ↔ 5122 By similarity
Disulfide bond5089 ↔ 5136 By similarity
Disulfide bond5098 ↔ 5152 By similarity
Disulfide bond5102 ↔ 5154 By similarity
Disulfide bond? ↔ 5159 By similarity

Natural variations

Natural variant581L → P.
Corresponds to variant rs2856111 [ dbSNP | Ensembl ].
VAR_056582
Natural variant1161V → M.
Corresponds to variant rs11825977 [ dbSNP | Ensembl ].
VAR_056583
Natural variant8321G → S.
Corresponds to variant rs11245936 [ dbSNP | Ensembl ].
VAR_056584
Natural variant16191S → R.
Corresponds to variant rs11245947 [ dbSNP | Ensembl ].
VAR_059531
Natural variant16891P → L.
Corresponds to variant rs11245949 [ dbSNP | Ensembl ].
VAR_059532
Natural variant17681P → H.
Corresponds to variant rs34493663 [ dbSNP | Ensembl ].
VAR_061487
Natural variant21541I → T.
Corresponds to variant rs6421972 [ dbSNP | Ensembl ].
VAR_059533
Natural variant25241T → P.
Corresponds to variant rs7480563 [ dbSNP | Ensembl ].
VAR_059534
Natural variant25241T → S.
Corresponds to variant rs7480563 [ dbSNP | Ensembl ].
VAR_059535
Natural variant26531Q → L.
Corresponds to variant rs7126405 [ dbSNP | Ensembl ].
VAR_059536
Natural variant26531Q → P.
Corresponds to variant rs7126405 [ dbSNP | Ensembl ].
VAR_059537

Experimental info

Sequence conflict13511H → L in AAA59875. Ref.3
Sequence conflict14121T → S in AAA59875. Ref.3
Sequence conflict14491L → P in AAA59875. Ref.3
Sequence conflict15041M → T in AAA59875. Ref.3
Sequence conflict4076 – 40838TGTQTPTT → NGLQAPTP Ref.4
Sequence conflict40871T → S Ref.4
Sequence conflict4130 – 41312TP → VL Ref.4
Sequence conflict41381V → M Ref.4
Sequence conflict4146 – 41527GTQTPTT → STKSTTV Ref.4
Sequence conflict41631P → A Ref.4
Sequence conflict4175 – 41762TT → MI Ref.4
Sequence conflict41791T → S Ref.4
Sequence conflict4192 – 41943GTQ → TGS Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q02817 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 85CD7571FB9A5663

FASTA5,179540,300
        10         20         30         40         50         60 
MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG DVFRFPGLCD 

        70         80         90        100        110        120 
YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP 

       130        140        150        160        170        180 
HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE 

       190        200        210        220        230        240 
FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL 

       250        260        270        280        290        300 
VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV 

       310        320        330        340        350        360 
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY 

       370        380        390        400        410        420 
TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG 

       430        440        450        460        470        480 
DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA 

       490        500        510        520        530        540 
SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK 

       550        560        570        580        590        600 
TASGLVEATG AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR 

       610        620        630        640        650        660 
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS 

       670        680        690        700        710        720 
CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC 

       730        740        750        760        770        780 
YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR 

       790        800        810        820        830        840 
ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN 

       850        860        870        880        890        900 
TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF 

       910        920        930        940        950        960 
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV 

       970        980        990       1000       1010       1020 
ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS 

      1030       1040       1050       1060       1070       1080 
WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC 

      1090       1100       1110       1120       1130       1140 
SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR 

      1150       1160       1170       1180       1190       1200 
SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA 

      1210       1220       1230       1240       1250       1260 
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT 

      1270       1280       1290       1300       1310       1320 
RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD 

      1330       1340       1350       1360       1370       1380 
GDREPFDGVC GAPEDIECRS VKDPHLSLEQ HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY 

      1390       1400       1410       1420       1430       1440 
DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP 

      1450       1460       1470       1480       1490       1500 
PITTTTTPLP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP 

      1510       1520       1530       1540       1550       1560 
SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP TSTTTLPPTT 

      1570       1580       1590       1600       1610       1620 
TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT TPSPPTTTTT TPPPTTTPSP 

      1630       1640       1650       1660       1670       1680 
PTTTPITPPT STTTLPPTTT PSPPPTTTTT PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT 

      1690       1700       1710       1720       1730       1740 
PSSPITTTPS PPTTTMTTPS PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP 

      1750       1760       1770       1780       1790       1800 
TTTMTTLPPT TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH 

      1810       1820       1830       1840       1850       1860 
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC KNEDQKPGGV 

      1870       1880       1890       1900       1910       1920 
IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP ITTTTTVTPT PTPTGTQTPT 

      1930       1940       1950       1960       1970       1980 
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP 

      1990       2000       2010       2020       2030       2040 
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT 

      2050       2060       2070       2080       2090       2100 
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 

      2110       2120       2130       2140       2150       2160 
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 

      2170       2180       2190       2200       2210       2220 
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 

      2230       2240       2250       2260       2270       2280 
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT 

      2290       2300       2310       2320       2330       2340 
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT 

      2350       2360       2370       2380       2390       2400 
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ 

      2410       2420       2430       2440       2450       2460 
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT 

      2470       2480       2490       2500       2510       2520 
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 

      2530       2540       2550       2560       2570       2580 
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 

      2590       2600       2610       2620       2630       2640 
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT 

      2650       2660       2670       2680       2690       2700 
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT 

      2710       2720       2730       2740       2750       2760 
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 

      2770       2780       2790       2800       2810       2820 
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP 

      2830       2840       2850       2860       2870       2880 
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT 

      2890       2900       2910       2920       2930       2940 
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT 

      2950       2960       2970       2980       2990       3000 
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP 

      3010       3020       3030       3040       3050       3060 
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT 

      3070       3080       3090       3100       3110       3120 
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI 

      3130       3140       3150       3160       3170       3180 
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG 

      3190       3200       3210       3220       3230       3240 
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT 

      3250       3260       3270       3280       3290       3300 
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT 

      3310       3320       3330       3340       3350       3360 
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP 

      3370       3380       3390       3400       3410       3420 
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT 

      3430       3440       3450       3460       3470       3480 
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 

      3490       3500       3510       3520       3530       3540 
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 

      3550       3560       3570       3580       3590       3600 
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 

      3610       3620       3630       3640       3650       3660 
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT 

      3670       3680       3690       3700       3710       3720 
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT 

      3730       3740       3750       3760       3770       3780 
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ 

      3790       3800       3810       3820       3830       3840 
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT 

      3850       3860       3870       3880       3890       3900 
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 

      3910       3920       3930       3940       3950       3960 
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 

      3970       3980       3990       4000       4010       4020 
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT 

      4030       4040       4050       4060       4070       4080 
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT 

      4090       4100       4110       4120       4130       4140 
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 

      4150       4160       4170       4180       4190       4200 
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH 

      4210       4220       4230       4240       4250       4260 
TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST APPSTPTAPT 

      4270       4280       4290       4300       4310       4320 
TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ TTTTSAWTPT PTPLSTPSII 

      4330       4340       4350       4360       4370       4380 
RTTGLRPYPS SVLICCVLND TYYAPGEEVY NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP 

      4390       4400       4410       4420       4430       4440 
SPTPTPSKST PTPSKPSSTP SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT 

      4450       4460       4470       4480       4490       4500 
VEIVKVECEP PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ 

      4510       4520       4530       4540       4550       4560 
GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI KTVHMMPMQV 

      4570       4580       4590       4600       4610       4620 
QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY NGLSFSVRLP YHRFGNNTKG 

      4630       4640       4650       4660       4670       4680 
QCGTCTNTTS DDCILPSGEI VSNCEAAADQ WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK 

      4690       4700       4710       4720       4730       4740 
TTPHKDCTPS PLCQLIKDSL FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL 

      4750       4760       4770       4780       4790       4800 
CAQQNICLDW RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG 

      4810       4820       4830       4840       4850       4860 
TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ PKRCSQKPVT 

      4870       4880       4890       4900       4910       4920 
HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP LGFEVKSKMV PGRCCPFYWC 

      4930       4940       4950       4960       4970       4980 
ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT DKVDNNTLLN VIACTHVPCN TSCSPGFELM 

      4990       5000       5010       5020       5030       5040 
EAPGECCKKC EQTHCIIKRP DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT 

      5050       5060       5070       5080       5090       5100 
CPNFDASICI PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG 

      5110       5120       5130       5140       5150       5160 
SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE SCQCQDTVCG 

      5170 
LPTGTSRRAR RSPRHLGSG 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor."
Gum J.R. Jr., Hicks J.W., Toribara N.W., Siddiki B., Kim Y.S.
J. Biol. Chem. 269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.
[2]"The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region."
Gum J.R. Jr., Hicks J.W., Toribara N.W., Rothe E.-M., Lagace R.E., Kim Y.S.
J. Biol. Chem. 267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 626-1895 AND 4196-5179.
Tissue: Colon.
[3]"MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism."
Toribara N.W., Gum J.R. Jr., Culhane P.J., Lagace R.E., Hicks J.W., Petersen G.M., Kim Y.S.
J. Clin. Invest. 88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1343-1895 AND 4176-4195.
[4]"Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism."
Gum J.R. Jr., Byrd J.C., Hicks J.W., Toribara N.W., Lamport D.T.A., Kim Y.S.
J. Biol. Chem. 264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4075-4352.
[5]"Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5."
Xu G., Huan L., Khatri I., Sajjan U.S., McCool D., Wang D., Jones C., Forstner G., Forstner J.
Biochem. Biophys. Res. Commun. 183:821-828(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4487-4627.
[6]"In vivo glycosylation of mucin tandem repeats."
Silverman H.S., Parry S., Sutton-Smith M., Burdick M.D., McDermott K., Reid C.J., Batra S.K., Morris H.R., Hollingsworth M.A., Dell A., Harris A.
Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES.
[7]"The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment."
Godl K., Johansson M.E.V., Lidell M.E., Moergelin M., Karlsson H., Olson F.J., Gum J.R. Jr., Kim Y.S., Hansson G.C.
J. Biol. Chem. 277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[8]"An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway."
Lidell M.E., Johansson M.E.V., Hansson G.C.
J. Biol. Chem. 278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: AUTOCATALYTIC CLEAVAGE.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."
Park S.-W., Zhen G., Verhaeghe C., Nakagami Y., Nguyenvu L.T., Barczak A.J., Killeen N., Erle D.J.
Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH AGR2.
[11]"Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
Johansson M.E.V., Thomsson K.A., Hansson G.C.
J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH FCGBP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L21998 mRNA. Translation: AAB95295.1.
M74027 Genomic DNA. Translation: AAA59875.1.
M94131 mRNA. Translation: AAA59163.1.
M94132 mRNA. Translation: AAA59164.1.
PIRA43932. A49963.
RefSeqNP_002448.3. NM_002457.3.
UniGeneHs.315.

3D structure databases

ProteinModelPortalQ02817.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110670. 3 interactions.
DIPDIP-48824N.
IntActQ02817. 2 interactions.
STRING9606.ENSP00000415183.

Chemistry

DrugBankDB01411. Pranlukast.

PTM databases

PhosphoSiteQ02817.
UniCarbKBQ02817.

Polymorphism databases

DMDM2506877.

Proteomic databases

PaxDbQ02817.
PRIDEQ02817.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359061; ENSP00000351956; ENSG00000198788.
GeneID4583.
KEGGhsa:4583.
UCSCuc001lsx.1. human.

Organism-specific databases

CTD4583.
GeneCardsGC11P001064.
HGNCHGNC:7512. MUC2.
HPACAB005317.
CAB016275.
HPA006197.
MIM158370. gene.
neXtProtNX_Q02817.
PharmGKBPA31316.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000168234.
HOVERGENHBG004380.
InParanoidQ02817.
KOK10955.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ02817.
BgeeQ02817.
CleanExHS_MUC2.
GenevestigatorQ02817.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PANTHERPTHR11339:SF261. PTHR11339:SF261. 1 hit.
PfamPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMSSF57567. SSF57567. 4 hits.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMUC2. human.
GeneWikiMUC2.
GenomeRNAi4583.
NextBio17613.
PROQ02817.
SOURCESearch...

Entry information

Entry nameMUC2_HUMAN
AccessionPrimary (citable) accession number: Q02817
Secondary accession number(s): Q14878
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM