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Q02817

- MUC2_HUMAN

UniProt

Q02817 - MUC2_HUMAN

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Protein

Mucin-2

Gene

MUC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4486 – 44872Cleavage; by autolysis; in vitro

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. maintenance of gastrointestinal epithelium Source: UniProt
  3. O-glycan processing Source: Reactome
  4. post-translational protein modification Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.954.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-2
Short name:
MUC-2
Alternative name(s):
Intestinal mucin-2
Gene namesi
Name:MUC2
Synonyms:SMUC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:7512. MUC2.

Subcellular locationi

Secreted
Note: In the intestine, secreted into the inner and outer mucus layers.By similarity

GO - Cellular componenti

  1. Golgi lumen Source: Reactome
  2. inner mucus layer Source: UniProtKB
  3. outer mucus layer Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 51795159Mucin-2PRO_0000019281Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi? ↔ 5159By similarity
Modified residuei21 – 211Phosphoserine1 Publication
Disulfide bondi59 ↔ 67By similarity
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi894 – 8941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1139 – 11391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1154 – 11541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1215 – 12151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1230 – 12301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1246 – 12461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1787 – 17871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1820 – 18201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4339 – 43391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4351 – 43511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4362 – 43621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4373 – 43731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4422 – 44221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4438 – 44381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4502 – 45021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4616 – 46161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4627 – 46271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4752 – 47521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4787 – 47871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4881 – 48811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4888 – 48881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4955 – 49551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4970 – 49701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5019 – 50191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5038 – 50381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5069 – 50691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5075 ↔ 5122By similarity
Disulfide bondi5089 ↔ 5136By similarity
Disulfide bondi5098 ↔ 5152By similarity
Disulfide bondi5102 ↔ 5154By similarity

Post-translational modificationi

O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.By similarity
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ02817.
PRIDEiQ02817.

PTM databases

PhosphoSiteiQ02817.
UniCarbKBiQ02817.

Expressioni

Tissue specificityi

Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

Gene expression databases

BgeeiQ02817.
CleanExiHS_MUC2.
GenevestigatoriQ02817.

Organism-specific databases

HPAiCAB005317.
CAB016275.
HPA006197.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.3 Publications

Protein-protein interaction databases

BioGridi110670. 3 interactions.
DIPiDIP-48824N.
IntActiQ02817. 2 interactions.
STRINGi9606.ENSP00000415183.

Structurei

3D structure databases

ProteinModelPortaliQ02817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 240205VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini295 – 35157TILAdd
BLAST
Domaini390 – 604215VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini859 – 1065207VWFD 3PROSITE-ProRule annotationAdd
BLAST
Repeati1401 – 1416161Add
BLAST
Repeati1417 – 1432162Add
BLAST
Repeati1433 – 1448163Add
BLAST
Repeati1449 – 1464164Add
BLAST
Repeati1465 – 147175
Repeati1472 – 147876
Repeati1479 – 1494167AAdd
BLAST
Repeati1495 – 1517237BAdd
BLAST
Repeati1518 – 1533168AAdd
BLAST
Repeati1534 – 1556238BAdd
BLAST
Repeati1557 – 1572169AAdd
BLAST
Repeati1573 – 1596249BAdd
BLAST
Repeati1597 – 16121610AAdd
BLAST
Repeati1613 – 16352310BAdd
BLAST
Repeati1636 – 16511611AAdd
BLAST
Repeati1652 – 16752411BAdd
BLAST
Repeati1676 – 1683812
Repeati1684 – 16991613Add
BLAST
Repeati1700 – 17151614Add
BLAST
Repeati1716 – 17311615Add
BLAST
Repeati1732 – 17471616Add
BLAST
Domaini4480 – 4690211VWFD 4PROSITE-ProRule annotationAdd
BLAST
Domaini4815 – 488672VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini4924 – 499168VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini5075 – 516086CTCKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1401 – 1747347Approximate repeatsAdd
BLAST

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 4 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000168234.
HOVERGENiHBG004380.
InParanoidiQ02817.
KOiK10955.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PANTHERiPTHR11339:SF261. PTHR11339:SF261. 1 hit.
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02817-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG
60 70 80 90 100
DVFRFPGLCD YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD
110 120 130 140 150
DTIYLTRHLA VLNGAVVSTP HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE
160 170 180 190 200
DALMLELDTK FRNHTCGLCG DYNGLQSYSE FLSDGVLFSP LEFGNMQKIN
210 220 230 240 250
QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL VPLEPYLRAC
260 270 280 290 300
QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
310 320 330 340 350
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ
360 370 380 390 400
CHCRLHGHLY TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT
410 420 430 440 450
TFDGKTYTFH GDCYYVLAKG DHNDSYALLG ELAPCGSTDK QTCLKTVVLL
460 470 480 490 500
ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA SFSVFRPSSY HIMVSMAIGV
510 520 530 540 550
RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK TASGLVEATG
560 570 580 590 600
AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
610 620 630 640 650
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR
660 670 680 690 700
EHVCNKDVGS CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC
710 720 730 740 750
PDHTFLDEKG RCVPLAKCSC YHRGLYLEAG DVVVRQEERC VCRDGRLHCR
760 770 780 790 800
QIRLIGQSCT APKIHMDCSN LTALATSKPR ALSCQTLAAG YYHTECVSGC
810 820 830 840 850
VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN TCTCKRGRWV
860 870 880 890 900
CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
910 920 930 940 950
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT
960 970 980 990 1000
TREVGQYLVV ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN
1010 1020 1030 1040 1050
NDFTTRDHMV VSSELDFGNS WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ
1060 1070 1080 1090 1100
CSILKSSVFS ICHSKVDPKP FYEACVHDSC SCDTGGDCEC FCSAVASYAQ
1110 1120 1130 1140 1150
ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR SFETCRTING
1160 1170 1180 1190 1200
IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
1210 1220 1230 1240 1250
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE
1260 1270 1280 1290 1300
KHFNICSITT RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK
1310 1320 1330 1340 1350
LCCLWSDWIN EDHPSSGSDD GDREPFDGVC GAPEDIECRS VKDPHLSLEQ
1360 1370 1380 1390 1400
HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY DYKIRVNCCW PMDKCITTPS
1410 1420 1430 1440 1450
PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP PITTTTTPLP
1460 1470 1480 1490 1500
TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
1510 1520 1530 1540 1550
SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP
1560 1570 1580 1590 1600
TSTTTLPPTT TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT
1610 1620 1630 1640 1650
TPSPPTTTTT TPPPTTTPSP PTTTPITPPT STTTLPPTTT PSPPPTTTTT
1660 1670 1680 1690 1700
PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT PSSPITTTPS PPTTTMTTPS
1710 1720 1730 1740 1750
PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP TTTMTTLPPT
1760 1770 1780 1790 1800
TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH
1810 1820 1830 1840 1850
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC
1860 1870 1880 1890 1900
KNEDQKPGGV IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP
1910 1920 1930 1940 1950
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
1960 1970 1980 1990 2000
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
2010 2020 2030 2040 2050
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
2060 2070 2080 2090 2100
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
2110 2120 2130 2140 2150
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
2160 2170 2180 2190 2200
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
2210 2220 2230 2240 2250
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
2260 2270 2280 2290 2300
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
2310 2320 2330 2340 2350
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
2360 2370 2380 2390 2400
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
2410 2420 2430 2440 2450
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
2460 2470 2480 2490 2500
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
2510 2520 2530 2540 2550
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
2560 2570 2580 2590 2600
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
2610 2620 2630 2640 2650
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
2660 2670 2680 2690 2700
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
2710 2720 2730 2740 2750
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
2760 2770 2780 2790 2800
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
2810 2820 2830 2840 2850
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
2860 2870 2880 2890 2900
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
2910 2920 2930 2940 2950
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
2960 2970 2980 2990 3000
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
3010 3020 3030 3040 3050
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP
3060 3070 3080 3090 3100
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
3110 3120 3130 3140 3150
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
3160 3170 3180 3190 3200
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
3210 3220 3230 3240 3250
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
3260 3270 3280 3290 3300
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
3310 3320 3330 3340 3350
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
3360 3370 3380 3390 3400
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
3410 3420 3430 3440 3450
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
3460 3470 3480 3490 3500
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
3510 3520 3530 3540 3550
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
3560 3570 3580 3590 3600
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
3610 3620 3630 3640 3650
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
3660 3670 3680 3690 3700
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
3710 3720 3730 3740 3750
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
3760 3770 3780 3790 3800
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
3810 3820 3830 3840 3850
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
3860 3870 3880 3890 3900
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
3910 3920 3930 3940 3950
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
3960 3970 3980 3990 4000
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
4010 4020 4030 4040 4050
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
4060 4070 4080 4090 4100
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
4110 4120 4130 4140 4150
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
4160 4170 4180 4190 4200
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH
4210 4220 4230 4240 4250
TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST
4260 4270 4280 4290 4300
APPSTPTAPT TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ
4310 4320 4330 4340 4350
TTTTSAWTPT PTPLSTPSII RTTGLRPYPS SVLICCVLND TYYAPGEEVY
4360 4370 4380 4390 4400
NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST PTPSKPSSTP
4410 4420 4430 4440 4450
SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP
4460 4470 4480 4490 4500
PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ
4510 4520 4530 4540 4550
GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI
4560 4570 4580 4590 4600
KTVHMMPMQV QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY
4610 4620 4630 4640 4650
NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS DDCILPSGEI VSNCEAAADQ
4660 4670 4680 4690 4700
WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS PLCQLIKDSL
4710 4720 4730 4740 4750
FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW
4760 4770 4780 4790 4800
RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG
4810 4820 4830 4840 4850
TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ
4860 4870 4880 4890 4900
PKRCSQKPVT HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP
4910 4920 4930 4940 4950
LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT
4960 4970 4980 4990 5000
DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC EQTHCIIKRP
5010 5020 5030 5040 5050
DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI
5060 5070 5080 5090 5100
PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG
5110 5120 5130 5140 5150
SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE
5160 5170
SCQCQDTVCG LPTGTSRRAR RSPRHLGSG
Length:5,179
Mass (Da):540,300
Last modified:November 1, 1997 - v2
Checksum:i85CD7571FB9A5663
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1351 – 13511H → L in AAA59875. (PubMed:1885763)Curated
Sequence conflicti1412 – 14121T → S in AAA59875. (PubMed:1885763)Curated
Sequence conflicti1449 – 14491L → P in AAA59875. (PubMed:1885763)Curated
Sequence conflicti1504 – 15041M → T in AAA59875. (PubMed:1885763)Curated
Sequence conflicti4076 – 40838TGTQTPTT → NGLQAPTP(PubMed:2703501)Curated
Sequence conflicti4087 – 40871T → S(PubMed:2703501)Curated
Sequence conflicti4130 – 41312TP → VL(PubMed:2703501)Curated
Sequence conflicti4138 – 41381V → M(PubMed:2703501)Curated
Sequence conflicti4146 – 41527GTQTPTT → STKSTTV(PubMed:2703501)Curated
Sequence conflicti4163 – 41631P → A(PubMed:2703501)Curated
Sequence conflicti4175 – 41762TT → MI(PubMed:2703501)Curated
Sequence conflicti4179 – 41791T → S(PubMed:2703501)Curated
Sequence conflicti4192 – 41943GTQ → TGS(PubMed:2703501)Curated

Polymorphismi

The number of repeats is highly polymorphic and varies among different alleles.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581L → P.
Corresponds to variant rs2856111 [ dbSNP | Ensembl ].
VAR_056582
Natural varianti116 – 1161V → M.
Corresponds to variant rs11825977 [ dbSNP | Ensembl ].
VAR_056583
Natural varianti832 – 8321G → S.
Corresponds to variant rs11245936 [ dbSNP | Ensembl ].
VAR_056584
Natural varianti1619 – 16191S → R.
Corresponds to variant rs11245947 [ dbSNP | Ensembl ].
VAR_059531
Natural varianti1689 – 16891P → L.
Corresponds to variant rs11245949 [ dbSNP | Ensembl ].
VAR_059532
Natural varianti1768 – 17681P → H.
Corresponds to variant rs34493663 [ dbSNP | Ensembl ].
VAR_061487
Natural varianti2154 – 21541I → T.
Corresponds to variant rs6421972 [ dbSNP | Ensembl ].
VAR_059533
Natural varianti2524 – 25241T → P.
Corresponds to variant rs7480563 [ dbSNP | Ensembl ].
VAR_059534
Natural varianti2524 – 25241T → S.
Corresponds to variant rs7480563 [ dbSNP | Ensembl ].
VAR_059535
Natural varianti2653 – 26531Q → L.
Corresponds to variant rs7126405 [ dbSNP | Ensembl ].
VAR_059536
Natural varianti2653 – 26531Q → P.
Corresponds to variant rs7126405 [ dbSNP | Ensembl ].
VAR_059537

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21998 mRNA. Translation: AAB95295.1.
M74027 Genomic DNA. Translation: AAA59875.1.
M94131 mRNA. Translation: AAA59163.1.
M94132 mRNA. Translation: AAA59164.1.
PIRiA49963. A43932.
RefSeqiNP_002448.3. NM_002457.3.
UniGeneiHs.315.

Genome annotation databases

EnsembliENST00000359061; ENSP00000351956; ENSG00000198788.
GeneIDi4583.
KEGGihsa:4583.
UCSCiuc001lsx.1. human.

Polymorphism databases

DMDMi2506877.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21998 mRNA. Translation: AAB95295.1 .
M74027 Genomic DNA. Translation: AAA59875.1 .
M94131 mRNA. Translation: AAA59163.1 .
M94132 mRNA. Translation: AAA59164.1 .
PIRi A49963. A43932.
RefSeqi NP_002448.3. NM_002457.3.
UniGenei Hs.315.

3D structure databases

ProteinModelPortali Q02817.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110670. 3 interactions.
DIPi DIP-48824N.
IntActi Q02817. 2 interactions.
STRINGi 9606.ENSP00000415183.

Chemistry

DrugBanki DB01411. Pranlukast.

Protein family/group databases

MEROPSi I08.954.

PTM databases

PhosphoSitei Q02817.
UniCarbKBi Q02817.

Polymorphism databases

DMDMi 2506877.

Proteomic databases

PaxDbi Q02817.
PRIDEi Q02817.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359061 ; ENSP00000351956 ; ENSG00000198788 .
GeneIDi 4583.
KEGGi hsa:4583.
UCSCi uc001lsx.1. human.

Organism-specific databases

CTDi 4583.
GeneCardsi GC11P001074.
HGNCi HGNC:7512. MUC2.
HPAi CAB005317.
CAB016275.
HPA006197.
MIMi 158370. gene.
neXtProti NX_Q02817.
PharmGKBi PA31316.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000168234.
HOVERGENi HBG004380.
InParanoidi Q02817.
KOi K10955.

Enzyme and pathway databases

Reactomei REACT_115606. O-linked glycosylation of mucins.
REACT_115835. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSi MUC2. human.
GeneWikii MUC2.
GenomeRNAii 4583.
NextBioi 17613.
PROi Q02817.
SOURCEi Search...

Gene expression databases

Bgeei Q02817.
CleanExi HS_MUC2.
Genevestigatori Q02817.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR006552. VWC_out.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view ]
PANTHERi PTHR11339:SF261. PTHR11339:SF261. 1 hit.
Pfami PF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 2 hits.
PF01826. TIL. 1 hit.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 2 hits.
SM00215. VWC_out. 1 hit.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 4 hits.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor."
    Gum J.R. Jr., Hicks J.W., Toribara N.W., Siddiki B., Kim Y.S.
    J. Biol. Chem. 269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region."
    Gum J.R. Jr., Hicks J.W., Toribara N.W., Rothe E.-M., Lagace R.E., Kim Y.S.
    J. Biol. Chem. 267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 626-1895 AND 4196-5179.
    Tissue: Colon.
  3. "MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism."
    Toribara N.W., Gum J.R. Jr., Culhane P.J., Lagace R.E., Hicks J.W., Petersen G.M., Kim Y.S.
    J. Clin. Invest. 88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1343-1895 AND 4176-4195.
  4. "Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism."
    Gum J.R. Jr., Byrd J.C., Hicks J.W., Toribara N.W., Lamport D.T.A., Kim Y.S.
    J. Biol. Chem. 264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4075-4352.
  5. "Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5."
    Xu G., Huan L., Khatri I., Sajjan U.S., McCool D., Wang D., Jones C., Forstner G., Forstner J.
    Biochem. Biophys. Res. Commun. 183:821-828(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4487-4627.
  6. Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES.
  7. "The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment."
    Godl K., Johansson M.E.V., Lidell M.E., Moergelin M., Karlsson H., Olson F.J., Gum J.R. Jr., Kim Y.S., Hansson G.C.
    J. Biol. Chem. 277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  8. "An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway."
    Lidell M.E., Johansson M.E.V., Hansson G.C.
    J. Biol. Chem. 278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: AUTOCATALYTIC CLEAVAGE.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."
    Park S.-W., Zhen G., Verhaeghe C., Nakagami Y., Nguyenvu L.T., Barczak A.J., Killeen N., Erle D.J.
    Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AGR2.
  11. "Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
    Johansson M.E.V., Thomsson K.A., Hansson G.C.
    J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH FCGBP.

Entry informationi

Entry nameiMUC2_HUMAN
AccessioniPrimary (citable) accession number: Q02817
Secondary accession number(s): Q14878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3