Q02817 (MUC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mucin-2
Short name=MUC-2

Alternative name(s):
Intestinal mucin-2

Gene names

Name:	MUC2
Synonyms:	SMUC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. Ref.11
Subunit structure	Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked. Ref.7 Ref.10 Ref.11
Subcellular location	Secreted. Note: In the intestine, secreted into the inner and outer mucus layers By similarity.
Tissue specificity	Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Post-translational modification	O-glycosylated. Ref.6 May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria By similarity. At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
Polymorphism	The number of repeats is highly polymorphic and varies among different alleles.
Sequence similarities	Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 TIL (trypsin inhibitory-like) domain. Contains 2 VWFC domains. Contains 4 VWFD domains.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Repeat Signal
PTM	Autocatalytic cleavage Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	O-glycan processing Traceable author statement. Source: Reactome post-translational protein modification Traceable author statement. Source: Reactome
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome inner mucus layer Inferred from sequence or structural similarity. Source: UniProtKB outer mucus layer Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 5179	5159	Mucin-2		PRO_0000019281
Regions
	Domain	36 – 240	205	VWFD 1
	Domain	295 – 351	57	TIL
	Domain	390 – 604	215	VWFD 2
	Domain	859 – 1065	207	VWFD 3
	Repeat	1401 – 1416	16	1
	Repeat	1417 – 1432	16	2
	Repeat	1433 – 1448	16	3
	Repeat	1449 – 1464	16	4
	Repeat	1465 – 1471	7	5
	Repeat	1472 – 1478	7	6
	Repeat	1479 – 1494	16	7A
	Repeat	1495 – 1517	23	7B
	Repeat	1518 – 1533	16	8A
	Repeat	1534 – 1556	23	8B
	Repeat	1557 – 1572	16	9A
	Repeat	1573 – 1596	24	9B
	Repeat	1597 – 1612	16	10A
	Repeat	1613 – 1635	23	10B
	Repeat	1636 – 1651	16	11A
	Repeat	1652 – 1675	24	11B
	Repeat	1676 – 1683	8	12
	Repeat	1684 – 1699	16	13
	Repeat	1700 – 1715	16	14
	Repeat	1716 – 1731	16	15
	Repeat	1732 – 1747	16	16
	Domain	4480 – 4690	211	VWFD 4
	Domain	4815 – 4886	72	VWFC 1
	Domain	4924 – 4991	68	VWFC 2
	Domain	5075 – 5160	86	CTCK
	Region	1401 – 1747	347	Approximate repeats
Sites
	Site	4486 – 4487	2	Cleavage; by autolysis; in vitro
Amino acid modifications
	Modified residue	16	1	Phosphoserine Ref.9
	Modified residue	21	1	Phosphoserine Ref.9
	Glycosylation	163	1	N-linked (GlcNAc...) Potential
	Glycosylation	423	1	N-linked (GlcNAc...) Potential
	Glycosylation	670	1	N-linked (GlcNAc...) Potential
	Glycosylation	770	1	N-linked (GlcNAc...) Potential
	Glycosylation	894	1	N-linked (GlcNAc...) Potential
	Glycosylation	1139	1	N-linked (GlcNAc...) Potential
	Glycosylation	1154	1	N-linked (GlcNAc...) Potential
	Glycosylation	1215	1	N-linked (GlcNAc...) Potential
	Glycosylation	1230	1	N-linked (GlcNAc...) Potential
	Glycosylation	1246	1	N-linked (GlcNAc...) Potential
	Glycosylation	1787	1	N-linked (GlcNAc...) Potential
	Glycosylation	1820	1	N-linked (GlcNAc...) Potential
	Glycosylation	4339	1	N-linked (GlcNAc...) Potential
	Glycosylation	4351	1	N-linked (GlcNAc...) Potential
	Glycosylation	4362	1	N-linked (GlcNAc...) Potential
	Glycosylation	4373	1	N-linked (GlcNAc...) Potential
	Glycosylation	4422	1	N-linked (GlcNAc...) Potential
	Glycosylation	4438	1	N-linked (GlcNAc...) Potential
	Glycosylation	4502	1	N-linked (GlcNAc...) Potential
	Glycosylation	4616	1	N-linked (GlcNAc...) Potential
	Glycosylation	4627	1	N-linked (GlcNAc...) Potential
	Glycosylation	4752	1	N-linked (GlcNAc...) Potential
	Glycosylation	4787	1	N-linked (GlcNAc...) Potential
	Glycosylation	4881	1	N-linked (GlcNAc...) Potential
	Glycosylation	4888	1	N-linked (GlcNAc...) Potential
	Glycosylation	4955	1	N-linked (GlcNAc...) Potential
	Glycosylation	4970	1	N-linked (GlcNAc...) Potential
	Glycosylation	5019	1	N-linked (GlcNAc...) Potential
	Glycosylation	5038	1	N-linked (GlcNAc...) Potential
	Glycosylation	5069	1	N-linked (GlcNAc...) Potential
	Disulfide bond	59 ↔ 67		By similarity
	Disulfide bond	5075 ↔ 5122		By similarity
	Disulfide bond	5089 ↔ 5136		By similarity
	Disulfide bond	5098 ↔ 5152		By similarity
	Disulfide bond	5102 ↔ 5154		By similarity
	Disulfide bond	? ↔ 5159		By similarity
Natural variations
	Natural variant	58	1	L → P. Corresponds to variant rs2856111 [ dbSNP | Ensembl ].		VAR_056582
	Natural variant	116	1	V → M. Corresponds to variant rs11825977 [ dbSNP | Ensembl ].		VAR_056583
	Natural variant	832	1	G → S. Corresponds to variant rs11245936 [ dbSNP | Ensembl ].		VAR_056584
	Natural variant	1619	1	S → R. Corresponds to variant rs11245947 [ dbSNP | Ensembl ].		VAR_059531
	Natural variant	1689	1	P → L. Corresponds to variant rs11245949 [ dbSNP | Ensembl ].		VAR_059532
	Natural variant	1768	1	P → H. Corresponds to variant rs34493663 [ dbSNP | Ensembl ].		VAR_061487
	Natural variant	2154	1	I → T. Corresponds to variant rs6421972 [ dbSNP | Ensembl ].		VAR_059533
	Natural variant	2524	1	T → P. Corresponds to variant rs7480563 [ dbSNP | Ensembl ].		VAR_059534
	Natural variant	2524	1	T → S. Corresponds to variant rs7480563 [ dbSNP | Ensembl ].		VAR_059535
	Natural variant	2653	1	Q → L. Corresponds to variant rs7126405 [ dbSNP | Ensembl ].		VAR_059536
	Natural variant	2653	1	Q → P. Corresponds to variant rs7126405 [ dbSNP | Ensembl ].		VAR_059537
Experimental info
	Sequence conflict	1351	1	H → L in AAA59875. Ref.3
	Sequence conflict	1412	1	T → S in AAA59875. Ref.3
	Sequence conflict	1449	1	L → P in AAA59875. Ref.3
	Sequence conflict	1504	1	M → T in AAA59875. Ref.3
	Sequence conflict	4076 – 4083	8	TGTQTPTT → NGLQAPTP Ref.4
	Sequence conflict	4087	1	T → S Ref.4
	Sequence conflict	4130 – 4131	2	TP → VL Ref.4
	Sequence conflict	4138	1	V → M Ref.4
	Sequence conflict	4146 – 4152	7	GTQTPTT → STKSTTV Ref.4
	Sequence conflict	4163	1	P → A Ref.4
	Sequence conflict	4175 – 4176	2	TT → MI Ref.4
	Sequence conflict	4179	1	T → S Ref.4
	Sequence conflict	4192 – 4194	3	GTQ → TGS Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q02817 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 85CD7571FB9A5663	FASTA	5,179	540,300
	10 20 30 40 50 60 MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG DVFRFPGLCD 70 80 90 100 110 120 YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP 130 140 150 160 170 180 HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE 190 200 210 220 230 240 FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL 250 260 270 280 290 300 VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV 310 320 330 340 350 360 YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY 370 380 390 400 410 420 TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG 430 440 450 460 470 480 DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA 490 500 510 520 530 540 SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK 550 560 570 580 590 600 TASGLVEATG AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR 610 620 630 640 650 660 CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS 670 680 690 700 710 720 CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC 730 740 750 760 770 780 YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR 790 800 810 820 830 840 ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN 850 860 870 880 890 900 TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF 910 920 930 940 950 960 SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV 970 980 990 1000 1010 1020 ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS 1030 1040 1050 1060 1070 1080 WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC 1090 1100 1110 1120 1130 1140 SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR 1150 1160 1170 1180 1190 1200 SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA 1210 1220 1230 1240 1250 1260 SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT 1270 1280 1290 1300 1310 1320 RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD 1330 1340 1350 1360 1370 1380 GDREPFDGVC GAPEDIECRS VKDPHLSLEQ HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY 1390 1400 1410 1420 1430 1440 DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP 1450 1460 1470 1480 1490 1500 PITTTTTPLP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP 1510 1520 1530 1540 1550 1560 SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP TSTTTLPPTT 1570 1580 1590 1600 1610 1620 TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT TPSPPTTTTT TPPPTTTPSP 1630 1640 1650 1660 1670 1680 PTTTPITPPT STTTLPPTTT PSPPPTTTTT PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT 1690 1700 1710 1720 1730 1740 PSSPITTTPS PPTTTMTTPS PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP 1750 1760 1770 1780 1790 1800 TTTMTTLPPT TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH 1810 1820 1830 1840 1850 1860 KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC KNEDQKPGGV 1870 1880 1890 1900 1910 1920 IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP ITTTTTVTPT PTPTGTQTPT 1930 1940 1950 1960 1970 1980 TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP 1990 2000 2010 2020 2030 2040 TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT 2050 2060 2070 2080 2090 2100 TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 2110 2120 2130 2140 2150 2160 QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 2170 2180 2190 2200 2210 2220 TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 2230 2240 2250 2260 2270 2280 TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT 2290 2300 2310 2320 2330 2340 PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT 2350 2360 2370 2380 2390 2400 TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ 2410 2420 2430 2440 2450 2460 TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT 2470 2480 2490 2500 2510 2520 PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 2530 2540 2550 2560 2570 2580 PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 2590 2600 2610 2620 2630 2640 TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT 2650 2660 2670 2680 2690 2700 TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT 2710 2720 2730 2740 2750 2760 PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 2770 2780 2790 2800 2810 2820 TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP 2830 2840 2850 2860 2870 2880 ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT 2890 2900 2910 2920 2930 2940 GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT 2950 2960 2970 2980 2990 3000 TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP 3010 3020 3030 3040 3050 3060 TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT 3070 3080 3090 3100 3110 3120 PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI 3130 3140 3150 3160 3170 3180 TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG 3190 3200 3210 3220 3230 3240 TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT 3250 3260 3270 3280 3290 3300 VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT 3310 3320 3330 3340 3350 3360 TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP 3370 3380 3390 3400 3410 3420 TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT 3430 3440 3450 3460 3470 3480 TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT 3490 3500 3510 3520 3530 3540 QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV 3550 3560 3570 3580 3590 3600 TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT 3610 3620 3630 3640 3650 3660 TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT 3670 3680 3690 3700 3710 3720 PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT 3730 3740 3750 3760 3770 3780 TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ 3790 3800 3810 3820 3830 3840 TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT 3850 3860 3870 3880 3890 3900 PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT 3910 3920 3930 3940 3950 3960 PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP 3970 3980 3990 4000 4010 4020 TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT 4030 4040 4050 4060 4070 4080 TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT 4090 4100 4110 4120 4130 4140 PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP 4150 4160 4170 4180 4190 4200 TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH 4210 4220 4230 4240 4250 4260 TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST APPSTPTAPT 4270 4280 4290 4300 4310 4320 TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ TTTTSAWTPT PTPLSTPSII 4330 4340 4350 4360 4370 4380 RTTGLRPYPS SVLICCVLND TYYAPGEEVY NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP 4390 4400 4410 4420 4430 4440 SPTPTPSKST PTPSKPSSTP SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT 4450 4460 4470 4480 4490 4500 VEIVKVECEP PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ 4510 4520 4530 4540 4550 4560 GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI KTVHMMPMQV 4570 4580 4590 4600 4610 4620 QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY NGLSFSVRLP YHRFGNNTKG 4630 4640 4650 4660 4670 4680 QCGTCTNTTS DDCILPSGEI VSNCEAAADQ WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK 4690 4700 4710 4720 4730 4740 TTPHKDCTPS PLCQLIKDSL FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL 4750 4760 4770 4780 4790 4800 CAQQNICLDW RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG 4810 4820 4830 4840 4850 4860 TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ PKRCSQKPVT 4870 4880 4890 4900 4910 4920 HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP LGFEVKSKMV PGRCCPFYWC 4930 4940 4950 4960 4970 4980 ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT DKVDNNTLLN VIACTHVPCN TSCSPGFELM 4990 5000 5010 5020 5030 5040 EAPGECCKKC EQTHCIIKRP DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT 5050 5060 5070 5080 5090 5100 CPNFDASICI PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG 5110 5120 5130 5140 5150 5160 SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE SCQCQDTVCG 5170 LPTGTSRRAR RSPRHLGSG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor." Gum J.R. Jr., Hicks J.W., Toribara N.W., Siddiki B., Kim Y.S. J. Biol. Chem. 269:2440-2446(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Intestine.
[2]	"The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region." Gum J.R. Jr., Hicks J.W., Toribara N.W., Rothe E.-M., Lagace R.E., Kim Y.S. J. Biol. Chem. 267:21375-21383(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 626-1895 AND 4196-5179. Tissue: Colon.
[3]	"MUC-2 human small intestinal mucin gene structure. Repeated arrays and polymorphism." Toribara N.W., Gum J.R. Jr., Culhane P.J., Lagace R.E., Hicks J.W., Petersen G.M., Kim Y.S. J. Clin. Invest. 88:1005-1013(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1343-1895 AND 4176-4195.
[4]	"Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism." Gum J.R. Jr., Byrd J.C., Hicks J.W., Toribara N.W., Lamport D.T.A., Kim Y.S. J. Biol. Chem. 264:6480-6487(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4075-4352.
[5]	"Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5." Xu G., Huan L., Khatri I., Sajjan U.S., McCool D., Wang D., Jones C., Forstner G., Forstner J. Biochem. Biophys. Res. Commun. 183:821-828(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4487-4627.
[6]	"In vivo glycosylation of mucin tandem repeats." Silverman H.S., Parry S., Sutton-Smith M., Burdick M.D., McDermott K., Reid C.J., Batra S.K., Morris H.R., Hollingsworth M.A., Dell A., Harris A. Glycobiology 11:459-471(2001) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE OF O-LINKED CARBOHYDRATES.
[7]	"The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment." Godl K., Johansson M.E.V., Lidell M.E., Moergelin M., Karlsson H., Olson F.J., Gum J.R. Jr., Kim Y.S., Hansson G.C. J. Biol. Chem. 277:47248-47256(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[8]	"An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway." Lidell M.E., Johansson M.E.V., Hansson G.C. J. Biol. Chem. 278:13944-13951(2003) [PubMed] [Europe PMC] [Abstract] Cited for: AUTOCATALYTIC CLEAVAGE.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16 AND SER-21, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"The protein disulfide isomerase AGR2 is essential for production of intestinal mucus." Park S.-W., Zhen G., Verhaeghe C., Nakagami Y., Nguyenvu L.T., Barczak A.J., Killeen N., Erle D.J. Proc. Natl. Acad. Sci. U.S.A. 106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AGR2.
[11]	"Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein." Johansson M.E.V., Thomsson K.A., Hansson G.C. J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH FCGBP.
+	Additional computationally mapped references.

Web resources

Mucin database

Cross-references

Sequence databases
EMBL GenBank DDBJ	L21998 mRNA. Translation: AAB95295.1. M74027 Genomic DNA. Translation: AAA59875.1. M94131 mRNA. Translation: AAA59163.1. M94132 mRNA. Translation: AAA59164.1.
IPI	IPI00027201.
PIR	A43932. A49963.
RefSeq	NP_002448.2. NM_002457.2.
UniGene	Hs.315.
3D structure databases
ProteinModelPortal	Q02817.
SMR	Q02817. Positions 292-362, 4759-4814.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48824N.
IntAct	Q02817. 2 interactions.
STRING	9606.ENSP00000415183.
PTM databases
GlycoSuiteDB	Q02817.
PhosphoSite	Q02817.
Polymorphism databases
DMDM	2506877.
Proteomic databases
PaxDb	Q02817.
PRIDE	Q02817.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359061; ENSP00000351956; ENSG00000198788.
GeneID	4583.
KEGG	hsa:4583.
UCSC	uc001lsx.1. human.
Organism-specific databases
CTD	4583.
GeneCards	GC11P001064.
HGNC	HGNC:7512. MUC2.
HPA	CAB005317. CAB016275. HPA006197.
MIM	158370. gene.
neXtProt	NX_Q02817.
PharmGKB	PA31316.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000168234.
HOVERGEN	HBG004380.
InParanoid	Q02817.
KO	K10955.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q02817.
Bgee	Q02817.
CleanEx	HS_MUC2.
Genevestigator	Q02817.
GermOnline	ENSG00000198788. Homo sapiens.
Family and domain databases
InterPro	IPR006207. Cys_knot_C. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR006552. VWC_out. IPR001007. VWF_C. IPR001846. VWF_type-D. IPR025155. WxxW_domain. [Graphical view]
Pfam	PF08742. C8. 4 hits. PF13330. Mucin2_WxxW. 2 hits. PF01826. TIL. 1 hit. PF00094. VWD. 4 hits. [Graphical view]
SMART	SM00832. C8. 4 hits. SM00041. CT. 1 hit. SM00214. VWC. 2 hits. SM00215. VWC_out. 1 hit. SM00216. VWD. 4 hits. [Graphical view]
SUPFAM	SSF57567. Cysrich_TIL. 5 hits.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS01208. VWFC_1. 2 hits. PS50184. VWFC_2. 2 hits. PS51233. VWFD. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MUC2. human.
DrugBank	DB01411. Pranlukast.
GenomeRNAi	4583.
NextBio	17613.
SOURCE	Search...

Entry information

Entry name

MUC2_HUMAN

Accession

Primary (citable) accession number: Q02817
Secondary accession number(s): Q14878

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.