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Protein

Mucin-2

Gene

MUC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.1 Publication

GO - Biological processi

  • maintenance of gastrointestinal epithelium Source: UniProtKB
  • O-glycan processing Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31908-MONOMER.
ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Protein family/group databases

MEROPSiI08.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-2
Short name:
MUC-2
Alternative name(s):
Intestinal mucin-2
Gene namesi
Name:MUC2
Synonyms:SMUC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:7512. MUC2.

Subcellular locationi

  • Secreted

  • Note: In the intestine, secreted into the inner and outer mucus layers.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4583.
PharmGKBiPA31316.

Chemistry databases

DrugBankiDB01411. Pranlukast.

Polymorphism and mutation databases

BioMutaiMUC2.
DMDMi2506877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001928121 – 5179Mucin-2Add BLAST5159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi? ↔ 5159By similarity
Modified residuei21PhosphoserineCombined sources1
Disulfide bondi59 ↔ 67By similarity
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi423N-linked (GlcNAc...)Sequence analysis1
Glycosylationi670N-linked (GlcNAc...)Sequence analysis1
Glycosylationi770N-linked (GlcNAc...)Sequence analysis1
Glycosylationi894N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1139N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1154N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1230N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1246N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1787N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1820N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4339N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4351N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4422N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4502N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4616N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4627N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4752N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4787N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4881N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4888N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4955N-linked (GlcNAc...)Sequence analysis1
Glycosylationi4970N-linked (GlcNAc...)Sequence analysis1
Glycosylationi5019N-linked (GlcNAc...)Sequence analysis1
Glycosylationi5038N-linked (GlcNAc...)Sequence analysis1
Glycosylationi5069N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi5075 ↔ 5122By similarity
Disulfide bondi5089 ↔ 5136By similarity
Disulfide bondi5098 ↔ 5152By similarity
Disulfide bondi5102 ↔ 5154By similarity

Post-translational modificationi

O-glycosylated.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.By similarity
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4486 – 4487Cleavage; by autolysis; in vitro2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ02817.
PeptideAtlasiQ02817.
PRIDEiQ02817.

PTM databases

iPTMnetiQ02817.
PhosphoSitePlusiQ02817.
UniCarbKBiQ02817.

Expressioni

Tissue specificityi

Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.

Gene expression databases

BgeeiENSG00000198788.
CleanExiHS_MUC2.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.3 Publications

Protein-protein interaction databases

BioGridi110670. 2 interactors.
DIPiDIP-48824N.
IntActiQ02817. 2 interactors.
STRINGi9606.ENSP00000415183.

Structurei

3D structure databases

ProteinModelPortaliQ02817.
SMRiQ02817.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 240VWFD 1PROSITE-ProRule annotationAdd BLAST205
Domaini295 – 351TILAdd BLAST57
Domaini390 – 604VWFD 2PROSITE-ProRule annotationAdd BLAST215
Domaini859 – 1065VWFD 3PROSITE-ProRule annotationAdd BLAST207
Repeati1401 – 14161Add BLAST16
Repeati1417 – 14322Add BLAST16
Repeati1433 – 14483Add BLAST16
Repeati1449 – 14644Add BLAST16
Repeati1465 – 147157
Repeati1472 – 147867
Repeati1479 – 14947AAdd BLAST16
Repeati1495 – 15177BAdd BLAST23
Repeati1518 – 15338AAdd BLAST16
Repeati1534 – 15568BAdd BLAST23
Repeati1557 – 15729AAdd BLAST16
Repeati1573 – 15969BAdd BLAST24
Repeati1597 – 161210AAdd BLAST16
Repeati1613 – 163510BAdd BLAST23
Repeati1636 – 165111AAdd BLAST16
Repeati1652 – 167511BAdd BLAST24
Repeati1676 – 1683128
Repeati1684 – 169913Add BLAST16
Repeati1700 – 171514Add BLAST16
Repeati1716 – 173115Add BLAST16
Repeati1732 – 174716Add BLAST16
Domaini4480 – 4690VWFD 4PROSITE-ProRule annotationAdd BLAST211
Domaini4815 – 4886VWFC 1PROSITE-ProRule annotationAdd BLAST72
Domaini4924 – 4991VWFC 2PROSITE-ProRule annotationAdd BLAST68
Domaini5075 – 5160CTCKPROSITE-ProRule annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1401 – 1747Approximate repeatsAdd BLAST347

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 2 VWFC domains.PROSITE-ProRule annotation
Contains 4 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
ENOG410YA0C. LUCA.
HOGENOMiHOG000168234.
HOVERGENiHBG004380.
InParanoidiQ02817.
KOiK10955.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PANTHERiPTHR11339:SF261. PTHR11339:SF261. 2 hits.
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 2 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02817-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPLARLAA VCLALSLAGG SELQTEGRTR YHGRNVCSTW GNFHYKTFDG
60 70 80 90 100
DVFRFPGLCD YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD
110 120 130 140 150
DTIYLTRHLA VLNGAVVSTP HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE
160 170 180 190 200
DALMLELDTK FRNHTCGLCG DYNGLQSYSE FLSDGVLFSP LEFGNMQKIN
210 220 230 240 250
QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL VPLEPYLRAC
260 270 280 290 300
QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
310 320 330 340 350
YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ
360 370 380 390 400
CHCRLHGHLY TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT
410 420 430 440 450
TFDGKTYTFH GDCYYVLAKG DHNDSYALLG ELAPCGSTDK QTCLKTVVLL
460 470 480 490 500
ADKKKNAVVF KSDGSVLLNQ LQVNLPHVTA SFSVFRPSSY HIMVSMAIGV
510 520 530 540 550
RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK TASGLVEATG
560 570 580 590 600
AGFANTWKAQ STCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
610 620 630 640 650
CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR
660 670 680 690 700
EHVCNKDVGS CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC
710 720 730 740 750
PDHTFLDEKG RCVPLAKCSC YHRGLYLEAG DVVVRQEERC VCRDGRLHCR
760 770 780 790 800
QIRLIGQSCT APKIHMDCSN LTALATSKPR ALSCQTLAAG YYHTECVSGC
810 820 830 840 850
VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN TCTCKRGRWV
860 870 880 890 900
CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
910 920 930 940 950
SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT
960 970 980 990 1000
TREVGQYLVV ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN
1010 1020 1030 1040 1050
NDFTTRDHMV VSSELDFGNS WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ
1060 1070 1080 1090 1100
CSILKSSVFS ICHSKVDPKP FYEACVHDSC SCDTGGDCEC FCSAVASYAQ
1110 1120 1130 1140 1150
ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR SFETCRTING
1160 1170 1180 1190 1200
IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
1210 1220 1230 1240 1250
SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE
1260 1270 1280 1290 1300
KHFNICSITT RPSTLTTFTT ITLPTTPTSF TTTTTTTTPT SSTVLSTTPK
1310 1320 1330 1340 1350
LCCLWSDWIN EDHPSSGSDD GDREPFDGVC GAPEDIECRS VKDPHLSLEQ
1360 1370 1380 1390 1400
HGQKVQCDVS VGFICKNEDQ FGNGPFGLCY DYKIRVNCCW PMDKCITTPS
1410 1420 1430 1440 1450
PPTTTPSPPP TTTTTLPPTT TPSPPTTTTT TPPPTTTPSP PITTTTTPLP
1460 1470 1480 1490 1500
TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
1510 1520 1530 1540 1550
SPPMTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPS PPTTTPITPP
1560 1570 1580 1590 1600
TSTTTLPPTT TPSPPPTTTT TPPPTTTPSP PTTTTPSPPT ITTTTPPPTT
1610 1620 1630 1640 1650
TPSPPTTTTT TPPPTTTPSP PTTTPITPPT STTTLPPTTT PSPPPTTTTT
1660 1670 1680 1690 1700
PPPTTTPSPP TTTTPSPPIT TTTTPPPTTT PSSPITTTPS PPTTTMTTPS
1710 1720 1730 1740 1750
PTTTPSSPIT TTTTPSSTTT PSPPPTTMTT PSPTTTPSPP TTTMTTLPPT
1760 1770 1780 1790 1800
TTSSPLTTTP LPPSITPPTF SPFSTTTPTT PCVPLCNWTG WLDSGKPNFH
1810 1820 1830 1840 1850
KPGGDTELIG DVCGPGWAAN ISCRATMYPD VPIGQLGQTV VCDVSVGLIC
1860 1870 1880 1890 1900
KNEDQKPGGV IPMAFCLNYE INVQCCECVT QPTTMTTTTT ENPTPPTTTP
1910 1920 1930 1940 1950
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
1960 1970 1980 1990 2000
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
2010 2020 2030 2040 2050
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
2060 2070 2080 2090 2100
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
2110 2120 2130 2140 2150
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
2160 2170 2180 2190 2200
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
2210 2220 2230 2240 2250
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
2260 2270 2280 2290 2300
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
2310 2320 2330 2340 2350
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
2360 2370 2380 2390 2400
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
2410 2420 2430 2440 2450
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
2460 2470 2480 2490 2500
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
2510 2520 2530 2540 2550
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
2560 2570 2580 2590 2600
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
2610 2620 2630 2640 2650
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
2660 2670 2680 2690 2700
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
2710 2720 2730 2740 2750
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
2760 2770 2780 2790 2800
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
2810 2820 2830 2840 2850
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
2860 2870 2880 2890 2900
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
2910 2920 2930 2940 2950
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
2960 2970 2980 2990 3000
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
3010 3020 3030 3040 3050
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP
3060 3070 3080 3090 3100
ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT
3110 3120 3130 3140 3150
TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT
3160 3170 3180 3190 3200
PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
3210 3220 3230 3240 3250
PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT
3260 3270 3280 3290 3300
QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT
3310 3320 3330 3340 3350
TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI
3360 3370 3380 3390 3400
TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT
3410 3420 3430 3440 3450
TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP
3460 3470 3480 3490 3500
TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP
3510 3520 3530 3540 3550
TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ
3560 3570 3580 3590 3600
TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT
3610 3620 3630 3640 3650
TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG TQTPTTTPIT
3660 3670 3680 3690 3700
TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP TTTPITTTTT
3710 3720 3730 3740 3750
VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT
3760 3770 3780 3790 3800
PTPTGTQTPT TTPITTTTTV TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT
3810 3820 3830 3840 3850
GTQTPTTTPI TTTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT
3860 3870 3880 3890 3900
PTTTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT
3910 3920 3930 3940 3950
PITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QTPTTTPITT
3960 3970 3980 3990 4000
TTTVTPTPTP TGTQTPTTTP ITTTTTVTPT PTPTGTQTPT TTPITTTTTV
4010 4020 4030 4040 4050
TPTPTPTGTQ TPTTTPITTT TTVTPTPTPT GTQTPTTTPI TTTTTVTPTP
4060 4070 4080 4090 4100
TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPITTTT TVTPTPTPTG
4110 4120 4130 4140 4150
TQTPTTTPIT TTTTVTPTPT PTGTQTPTTT PITTTTTVTP TPTPTGTQTP
4160 4170 4180 4190 4200
TTTPITTTTT VTPTPTPTGT QTPTTTPITT TTTVTPTPTP TGTQTGPPTH
4210 4220 4230 4240 4250
TSTAPIAELT TSNPPPESST PQTSRSTSSP LTESTTLLST LPPAIEMTST
4260 4270 4280 4290 4300
APPSTPTAPT TTSGGHTLSP PPSTTTSPPG TPTRGTTTGS SSAPTPSTVQ
4310 4320 4330 4340 4350
TTTTSAWTPT PTPLSTPSII RTTGLRPYPS SVLICCVLND TYYAPGEEVY
4360 4370 4380 4390 4400
NGTYGDTCYF VNCSLSCTLE FYNWSCPSTP SPTPTPSKST PTPSKPSSTP
4410 4420 4430 4440 4450
SKPTPGTKPP ECPDFDPPRQ ENETWWLCDC FMATCKYNNT VEIVKVECEP
4460 4470 4480 4490 4500
PPMPTCSNGL QPVRVEDPDG CCWHWECDCY CTGWGDPHYV TFDGLYYSYQ
4510 4520 4530 4540 4550
GNCTYVLVEE ISPSVDNFGV YIDNYHCDPN DKVSCPRTLI VRHETQEVLI
4560 4570 4580 4590 4600
KTVHMMPMQV QVQVNRQAVA LPYKKYGLEV YQSGINYVVD IPELGVLVSY
4610 4620 4630 4640 4650
NGLSFSVRLP YHRFGNNTKG QCGTCTNTTS DDCILPSGEI VSNCEAAADQ
4660 4670 4680 4690 4700
WLVNDPSKPH CPHSSSTTKR PAVTVPGGGK TTPHKDCTPS PLCQLIKDSL
4710 4720 4730 4740 4750
FAQCHALVPP QHYYDACVFD SCFMPGSSLE CASLQAYAAL CAQQNICLDW
4760 4770 4780 4790 4800
RNHTHGACLV ECPSHREYQA CGPAEEPTCK SSSSQQNNTV LVEGCFCPEG
4810 4820 4830 4840 4850
TMNYAPGFDV CVKTCGCVGP DNVPREFGEH FEFDCKNCVC LEGGSGIICQ
4860 4870 4880 4890 4900
PKRCSQKPVT HCVEDGTYLA TEVNPADTCC NITVCKCNTS LCKEKPSVCP
4910 4920 4930 4940 4950
LGFEVKSKMV PGRCCPFYWC ESKGVCVHGN AEYQPGSPVY SSKCQDCVCT
4960 4970 4980 4990 5000
DKVDNNTLLN VIACTHVPCN TSCSPGFELM EAPGECCKKC EQTHCIIKRP
5010 5020 5030 5040 5050
DNQHVILKPG DFKSDPKNNC TFFSCVKIHN QLISSVSNIT CPNFDASICI
5060 5070 5080 5090 5100
PGSITFMPNG CCKTCTPRNE TRVPCSTVPV TTEVSYAGCT KTVLMNHCSG
5110 5120 5130 5140 5150
SCGTFVMYSA KAQALDHSCS CCKEEKTSQR EVVLSCPNGG SLTHTYTHIE
5160 5170
SCQCQDTVCG LPTGTSRRAR RSPRHLGSG
Length:5,179
Mass (Da):540,300
Last modified:November 1, 1997 - v2
Checksum:i85CD7571FB9A5663
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1351H → L in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti1412T → S in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti1449L → P in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti1504M → T in AAA59875 (PubMed:1885763).Curated1
Sequence conflicti4076 – 4083TGTQTPTT → NGLQAPTP (PubMed:2703501).Curated8
Sequence conflicti4087T → S (PubMed:2703501).Curated1
Sequence conflicti4130 – 4131TP → VL (PubMed:2703501).Curated2
Sequence conflicti4138V → M (PubMed:2703501).Curated1
Sequence conflicti4146 – 4152GTQTPTT → STKSTTV (PubMed:2703501).Curated7
Sequence conflicti4163P → A (PubMed:2703501).Curated1
Sequence conflicti4175 – 4176TT → MI (PubMed:2703501).Curated2
Sequence conflicti4179T → S (PubMed:2703501).Curated1
Sequence conflicti4192 – 4194GTQ → TGS (PubMed:2703501).Curated3

Polymorphismi

The number of repeats is highly polymorphic and varies among different alleles.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05658258L → P.Corresponds to variant rs2856111dbSNPEnsembl.1
Natural variantiVAR_056583116V → M.Corresponds to variant rs11825977dbSNPEnsembl.1
Natural variantiVAR_056584832G → S.Corresponds to variant rs11245936dbSNPEnsembl.1
Natural variantiVAR_0595311619S → R.Corresponds to variant rs11245947dbSNPEnsembl.1
Natural variantiVAR_0595321689P → L.Corresponds to variant rs11245949dbSNPEnsembl.1
Natural variantiVAR_0614871768P → H.Corresponds to variant rs34493663dbSNPEnsembl.1
Natural variantiVAR_0595332154I → T.Corresponds to variant rs6421972dbSNPEnsembl.1
Natural variantiVAR_0595342524T → P.Corresponds to variant rs7480563dbSNPEnsembl.1
Natural variantiVAR_0595352524T → S.Corresponds to variant rs7480563dbSNPEnsembl.1
Natural variantiVAR_0595362653Q → L.Corresponds to variant rs7126405dbSNPEnsembl.1
Natural variantiVAR_0595372653Q → P.Corresponds to variant rs7126405dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21998 mRNA. Translation: AAB95295.1.
M74027 Genomic DNA. Translation: AAA59875.1.
M94131 mRNA. Translation: AAA59163.1.
M94132 mRNA. Translation: AAA59164.1.
PIRiA49963. A43932.
RefSeqiNP_002448.3. NM_002457.3.
UniGeneiHs.315.

Genome annotation databases

GeneIDi4583.
KEGGihsa:4583.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Mucin database
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21998 mRNA. Translation: AAB95295.1.
M74027 Genomic DNA. Translation: AAA59875.1.
M94131 mRNA. Translation: AAA59163.1.
M94132 mRNA. Translation: AAA59164.1.
PIRiA49963. A43932.
RefSeqiNP_002448.3. NM_002457.3.
UniGeneiHs.315.

3D structure databases

ProteinModelPortaliQ02817.
SMRiQ02817.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110670. 2 interactors.
DIPiDIP-48824N.
IntActiQ02817. 2 interactors.
STRINGi9606.ENSP00000415183.

Chemistry databases

DrugBankiDB01411. Pranlukast.

Protein family/group databases

MEROPSiI08.951.

PTM databases

iPTMnetiQ02817.
PhosphoSitePlusiQ02817.
UniCarbKBiQ02817.

Polymorphism and mutation databases

BioMutaiMUC2.
DMDMi2506877.

Proteomic databases

PaxDbiQ02817.
PeptideAtlasiQ02817.
PRIDEiQ02817.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4583.
KEGGihsa:4583.

Organism-specific databases

CTDi4583.
DisGeNETi4583.
GeneCardsiMUC2.
HGNCiHGNC:7512. MUC2.
MIMi158370. gene.
neXtProtiNX_Q02817.
PharmGKBiPA31316.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1216. Eukaryota.
ENOG410YA0C. LUCA.
HOGENOMiHOG000168234.
HOVERGENiHBG004380.
InParanoidiQ02817.
KOiK10955.

Enzyme and pathway databases

BioCyciZFISH:G66-31908-MONOMER.
ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiMUC2. human.
GeneWikiiMUC2.
GenomeRNAii4583.
PROiQ02817.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198788.
CleanExiHS_MUC2.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PANTHERiPTHR11339:SF261. PTHR11339:SF261. 2 hits.
PfamiPF08742. C8. 4 hits.
PF13330. Mucin2_WxxW. 2 hits.
PF01826. TIL. 2 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00041. CT. 1 hit.
SM00214. VWC. 3 hits.
SM00215. VWC_out. 2 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 4 hits.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
PS51233. VWFD. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC2_HUMAN
AccessioniPrimary (citable) accession number: Q02817
Secondary accession number(s): Q14878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.