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Q02816

- IGF2_ONCMY

UniProt

Q02816 - IGF2_ONCMY

Protein

Insulin-like growth factor II

Gene

igf2

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor II
    Short name:
    IGF-II
    Alternative name(s):
    Erythrotropin
    Gene namesi
    Name:igf2
    OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
    Taxonomic identifieri8022 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 47By similarityPRO_0000015724
    Signal peptidei1 – ?
    Chaini48 – 11770Insulin-like growth factor IIPRO_0000015725Add
    BLAST
    Propeptidei118 – 21497E peptidePRO_0000015726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 97By similarity
    Disulfide bondi68 ↔ 110By similarity
    Disulfide bondi96 ↔ 101By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ02816.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02816.
    SMRiQ02816. Positions 52-117.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni48 – 7932BAdd
    BLAST
    Regioni80 – 9011CAdd
    BLAST
    Regioni91 – 11121AAdd
    BLAST
    Regioni112 – 1176D

    Sequence similaritiesi

    Belongs to the insulin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006137.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomiPD005188. IGF2_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02816-1 [UniParc]FASTAAdd to Basket

    « Hide

    METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA    50
    SAETLCGGEL VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS 100
    CDLNLLEQYC AKPAKSERDV SATSLQIIPM VPTIKQDVPR KHVTVKYSKY 150
    EAWQRKAAQR LRRGVPAILR ARKFRRQAVK IKAQEQAMFH RPLITLPSKL 200
    PPVLPPTDNY VSHN 214
    Length:214
    Mass (Da):24,637
    Last modified:February 1, 1995 - v1
    Checksum:iFF8CCB173314C8FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95184 mRNA. Translation: AAA49411.1.
    PIRiB46244.
    RefSeqiNP_001118169.1. NM_001124697.1.
    UniGeneiOmy.11849.

    Genome annotation databases

    GeneIDi100136742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M95184 mRNA. Translation: AAA49411.1 .
    PIRi B46244.
    RefSeqi NP_001118169.1. NM_001124697.1.
    UniGenei Omy.11849.

    3D structure databases

    ProteinModelPortali Q02816.
    SMRi Q02816. Positions 52-117.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q02816.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100136742.

    Organism-specific databases

    CTDi 3481.

    Phylogenomic databases

    HOVERGENi HBG006137.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR022334. IGF2.
    IPR013576. IGF2_C.
    IPR016179. Insulin-like.
    IPR022350. Insulin-like_growth_factor.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF08365. IGF2_C. 1 hit.
    PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR02002. INSLNLIKEGF.
    PR02006. INSLNLIKEGF2.
    PR00276. INSULINFAMLY.
    ProDomi PD005188. IGF2_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a second insulin-like growth factor in a fish species."
      Shamblott M.J., Chen T.T.
      Proc. Natl. Acad. Sci. U.S.A. 89:8913-8917(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiIGF2_ONCMY
    AccessioniPrimary (citable) accession number: Q02816
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3