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Q02816

- IGF2_ONCMY

UniProt

Q02816 - IGF2_ONCMY

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Protein
Insulin-like growth factor II
Gene
igf2
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Alternative name(s):
Erythrotropin
Gene namesi
Name:igf2
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 47 By similarityPRO_0000015724
Signal peptidei1 – ?
Chaini48 – 11770Insulin-like growth factor II
PRO_0000015725Add
BLAST
Propeptidei118 – 21497E peptide
PRO_0000015726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 97 By similarity
Disulfide bondi68 ↔ 110 By similarity
Disulfide bondi96 ↔ 101 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ02816.

Structurei

3D structure databases

ProteinModelPortaliQ02816.
SMRiQ02816. Positions 52-117.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 7932B
Add
BLAST
Regioni80 – 9011C
Add
BLAST
Regioni91 – 11121A
Add
BLAST
Regioni112 – 1176D

Sequence similaritiesi

Belongs to the insulin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02816-1 [UniParc]FASTAAdd to Basket

« Hide

METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA    50
SAETLCGGEL VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS 100
CDLNLLEQYC AKPAKSERDV SATSLQIIPM VPTIKQDVPR KHVTVKYSKY 150
EAWQRKAAQR LRRGVPAILR ARKFRRQAVK IKAQEQAMFH RPLITLPSKL 200
PPVLPPTDNY VSHN 214
Length:214
Mass (Da):24,637
Last modified:February 1, 1995 - v1
Checksum:iFF8CCB173314C8FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95184 mRNA. Translation: AAA49411.1.
PIRiB46244.
RefSeqiNP_001118169.1. NM_001124697.1.
UniGeneiOmy.11849.

Genome annotation databases

GeneIDi100136742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M95184 mRNA. Translation: AAA49411.1 .
PIRi B46244.
RefSeqi NP_001118169.1. NM_001124697.1.
UniGenei Omy.11849.

3D structure databases

ProteinModelPortali Q02816.
SMRi Q02816. Positions 52-117.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q02816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136742.

Organism-specific databases

CTDi 3481.

Phylogenomic databases

HOVERGENi HBG006137.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a second insulin-like growth factor in a fish species."
    Shamblott M.J., Chen T.T.
    Proc. Natl. Acad. Sci. U.S.A. 89:8913-8917(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiIGF2_ONCMY
AccessioniPrimary (citable) accession number: Q02816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi