Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor II

Gene

igf2

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei71Important for interaction with integrinBy similarity1
Sitei81Important for interaction with integrinBy similarity1
Sitei86Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Alternative name(s):
Erythrotropin
Gene namesi
Name:igf2
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000015724? – 47By similarity
Signal peptidei1 – ?
ChainiPRO_000001572548 – 117Insulin-like growth factor IIAdd BLAST70
PropeptideiPRO_0000015726118 – 214E peptideAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 97By similarity
Disulfide bondi68 ↔ 110By similarity
Disulfide bondi96 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ02816

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ02816
SMRiQ02816
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 79BAdd BLAST32
Regioni80 – 90CAdd BLAST11
Regioni91 – 111AAdd BLAST21
Regioni112 – 117D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 1 hit
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02816-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA
60 70 80 90 100
SAETLCGGEL VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS
110 120 130 140 150
CDLNLLEQYC AKPAKSERDV SATSLQIIPM VPTIKQDVPR KHVTVKYSKY
160 170 180 190 200
EAWQRKAAQR LRRGVPAILR ARKFRRQAVK IKAQEQAMFH RPLITLPSKL
210
PPVLPPTDNY VSHN
Length:214
Mass (Da):24,637
Last modified:February 1, 1995 - v1
Checksum:iFF8CCB173314C8FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95184 mRNA Translation: AAA49411.1
PIRiB46244
RefSeqiNP_001118169.1, NM_001124697.1
UniGeneiOmy.11849

Genome annotation databases

GeneIDi100136742

Similar proteinsi

Entry informationi

Entry nameiIGF2_ONCMY
AccessioniPrimary (citable) accession number: Q02816
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health