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Q02816 (IGF2_ONCMY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor II

Short name=IGF-II
Alternative name(s):
Erythrotropin
Gene names
Name:igf2
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the insulin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ?
Propeptide? – 47 By similarityPRO_0000015724
Chain48 – 11770Insulin-like growth factor II
PRO_0000015725
Propeptide118 – 21497E peptide
PRO_0000015726

Regions

Region48 – 7932B
Region80 – 9011C
Region91 – 11121A
Region112 – 1176D

Amino acid modifications

Disulfide bond56 ↔ 97 By similarity
Disulfide bond68 ↔ 110 By similarity
Disulfide bond96 ↔ 101 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02816 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: FF8CCB173314C8FA

FASTA21424,637
        10         20         30         40         50         60 
METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA SAETLCGGEL 

        70         80         90        100        110        120 
VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS CDLNLLEQYC AKPAKSERDV 

       130        140        150        160        170        180 
SATSLQIIPM VPTIKQDVPR KHVTVKYSKY EAWQRKAAQR LRRGVPAILR ARKFRRQAVK 

       190        200        210 
IKAQEQAMFH RPLITLPSKL PPVLPPTDNY VSHN 

« Hide

References

[1]"Identification of a second insulin-like growth factor in a fish species."
Shamblott M.J., Chen T.T.
Proc. Natl. Acad. Sci. U.S.A. 89:8913-8917(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M95184 mRNA. Translation: AAA49411.1.
PIRB46244.
RefSeqNP_001118169.1. NM_001124697.1.
UniGeneOmy.11849.

3D structure databases

ProteinModelPortalQ02816.
SMRQ02816. Positions 52-117.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ02816.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100136742.

Organism-specific databases

CTD3481.

Phylogenomic databases

HOVERGENHBG006137.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIGF2_ONCMY
AccessionPrimary (citable) accession number: Q02816
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families