Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q02816

- IGF2_ONCMY

UniProt

Q02816 - IGF2_ONCMY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Insulin-like growth factor II

Gene

igf2

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Alternative name(s):
Erythrotropin
Gene namesi
Name:igf2
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 47By similarityPRO_0000015724
Signal peptidei1 – ?
Chaini48 – 11770Insulin-like growth factor IIPRO_0000015725Add
BLAST
Propeptidei118 – 21497E peptidePRO_0000015726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 97By similarity
Disulfide bondi68 ↔ 110By similarity
Disulfide bondi96 ↔ 101By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ02816.

Structurei

3D structure databases

ProteinModelPortaliQ02816.
SMRiQ02816. Positions 52-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni48 – 7932BAdd
BLAST
Regioni80 – 9011CAdd
BLAST
Regioni91 – 11121AAdd
BLAST
Regioni112 – 1176D

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomiPD005188. IGF2_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02816-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA
60 70 80 90 100
SAETLCGGEL VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS
110 120 130 140 150
CDLNLLEQYC AKPAKSERDV SATSLQIIPM VPTIKQDVPR KHVTVKYSKY
160 170 180 190 200
EAWQRKAAQR LRRGVPAILR ARKFRRQAVK IKAQEQAMFH RPLITLPSKL
210
PPVLPPTDNY VSHN
Length:214
Mass (Da):24,637
Last modified:February 1, 1995 - v1
Checksum:iFF8CCB173314C8FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95184 mRNA. Translation: AAA49411.1.
PIRiB46244.
RefSeqiNP_001118169.1. NM_001124697.1.
UniGeneiOmy.11849.

Genome annotation databases

GeneIDi100136742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95184 mRNA. Translation: AAA49411.1 .
PIRi B46244.
RefSeqi NP_001118169.1. NM_001124697.1.
UniGenei Omy.11849.

3D structure databases

ProteinModelPortali Q02816.
SMRi Q02816. Positions 52-117.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q02816.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100136742.

Organism-specific databases

CTDi 3481.

Phylogenomic databases

HOVERGENi HBG006137.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR022334. IGF2.
IPR013576. IGF2_C.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF08365. IGF2_C. 1 hit.
PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR02002. INSLNLIKEGF.
PR02006. INSLNLIKEGF2.
PR00276. INSULINFAMLY.
ProDomi PD005188. IGF2_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a second insulin-like growth factor in a fish species."
    Shamblott M.J., Chen T.T.
    Proc. Natl. Acad. Sci. U.S.A. 89:8913-8917(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiIGF2_ONCMY
AccessioniPrimary (citable) accession number: Q02816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3