Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ROD1

Gene

ROD1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates resistance to o-dinitrobenzene, calcium and zinc.2 Publications

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
  • cellular response to glucose stimulus Source: SGD
  • positive regulation of receptor internalization Source: SGD
  • response to drug Source: SGD
  • ubiquitin-dependent endocytosis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33566-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ROD1
Alternative name(s):
Resistance to o-dinitrobenzene protein 1
Gene namesi
Name:ROD1
Ordered Locus Names:YOR018W
ORF Names:OR26.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR018W.
SGDiS000005544. ROD1.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi487 – 4882PP → QA: Reduced binding to RSP5. 1 Publication
Mutagenesisi656 – 6572PP → QA: Reduced binding to RSP5. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837Protein ROD1PRO_0000097396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei138 – 1381PhosphoserineCombined sources
Modified residuei141 – 1411PhosphoserineCombined sources
Cross-linki401 – 401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei436 – 4361PhosphoserineCombined sources
Modified residuei536 – 5361PhosphoserineCombined sources
Modified residuei720 – 7201PhosphoserineCombined sources
Modified residuei725 – 7251PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ02805.

PTM databases

iPTMnetiQ02805.

Interactioni

Subunit structurei

Interacts with RSP5 via its 2 PY-motifs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399403EBI-15679,EBI-16219

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

Protein-protein interaction databases

BioGridi34422. 47 interactions.
DIPiDIP-4189N.
IntActiQ02805. 5 interactions.
MINTiMINT-523247.

Structurei

3D structure databases

ProteinModelPortaliQ02805.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi487 – 4904PY-motif
Motifi656 – 6594PY-motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 64Poly-Ser
Compositional biasi524 – 60178Asn-richAdd
BLAST
Compositional biasi684 – 815132Ser-richAdd
BLAST

Domaini

The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase and important for resistance to o-dinitrobenzene.1 Publication

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000112717.
HOGENOMiHOG000248143.
InParanoidiQ02805.
KOiK20062.
OMAiKHIRVVR.
OrthoDBiEOG092C0NX0.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSSSRPSK EPLLFDIRLR NLDNDVLLIK GPPDEASSVL LSGTIVLSIT
60 70 80 90 100
EPIQIKSLAL RLFGRLRLNI PTVLQTVHGP HKRYSKFERN IYSHFWDDFN
110 120 130 140 150
IKSYFQNLYD NHNNGKITIS SKSSTNLAAL PKRKRALSTA SLISSNGQTS
160 170 180 190 200
ASKNYHTLVK GNYEFPFSAI IPGSLVESVE GLPNAAVTYA LEATIERPKQ
210 220 230 240 250
PDLICKKHLR VIRTLAIDAV ELSETVSVDN SWPEKVDYTI SIPTKAIAIG
260 270 280 290 300
SSTMINILIV PILKGLKLGP VRISLVENSQ YCGSYGGVIN QERMVAKLKL
310 320 330 340 350
KDPLKHVAQI KKKRSLNEAA DEGVDTDTGE FQDKWEVRAL LNIPASLTKC
360 370 380 390 400
SQDCRILSNI KVRHKIKFTI SLLNPDGHIS ELRAALPVQL FISPFVPVNV
410 420 430 440 450
KTSDVIERTL KTFGPSYQVT SQHDNSFSSK NFVDDSEEDV IFQRSASALQ
460 470 480 490 500
LSSMPTIVSG STLNINSTDA EATAVADTTM VTSLMVPPNY GNHVYDRVYG
510 520 530 540 550
EVTNEDETSA SASSSAVESQ AIHNIQNLYI SDSNNSNNPI LAPNPQIKIE
560 570 580 590 600
DDSLNNCDSR GDSVNNSNLN LVNSNLTISE NWNNNSPSAN RYNNIINAGL
610 620 630 640 650
NSPSLTPSFA HLSRRNSYSR QTSSTSLKND LELTDLSRVP SYDKAMKSDM
660 670 680 690 700
IGEDLPPAYP EEELGVQENK KIELERPQIL HHKSTSSLLP LPGSSKSSNN
710 720 730 740 750
LKRSSSRTHL SHSPLPRNNS GSSVSLQQLA RNNTDSSFNL NLSFTSAKSS
760 770 780 790 800
TGSRHFPFNM TTSFTSNSSS KNNSHFDKTD STSDANKPRE EENYTSATHN
810 820 830
RRSRSSSVRS NNSNSPLRQG TGSFANLMEM FTKRDRS
Length:837
Mass (Da):92,349
Last modified:November 1, 1997 - v1
Checksum:iFD9A64174B1DC443
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti618 – 6181Y → D in AAB03678 (PubMed:8621680).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40561 Genomic DNA. Translation: AAB03678.1.
X87331 Genomic DNA. Translation: CAA60767.1.
Z74926 Genomic DNA. Translation: CAA99208.1.
BK006948 Genomic DNA. Translation: DAA10800.1.
PIRiS54624.
RefSeqiNP_014661.1. NM_001183437.1.

Genome annotation databases

EnsemblFungiiYOR018W; YOR018W; YOR018W.
GeneIDi854183.
KEGGisce:YOR018W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40561 Genomic DNA. Translation: AAB03678.1.
X87331 Genomic DNA. Translation: CAA60767.1.
Z74926 Genomic DNA. Translation: CAA99208.1.
BK006948 Genomic DNA. Translation: DAA10800.1.
PIRiS54624.
RefSeqiNP_014661.1. NM_001183437.1.

3D structure databases

ProteinModelPortaliQ02805.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34422. 47 interactions.
DIPiDIP-4189N.
IntActiQ02805. 5 interactions.
MINTiMINT-523247.

PTM databases

iPTMnetiQ02805.

Proteomic databases

MaxQBiQ02805.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR018W; YOR018W; YOR018W.
GeneIDi854183.
KEGGisce:YOR018W.

Organism-specific databases

EuPathDBiFungiDB:YOR018W.
SGDiS000005544. ROD1.

Phylogenomic databases

GeneTreeiENSGT00730000112717.
HOGENOMiHOG000248143.
InParanoidiQ02805.
KOiK20062.
OMAiKHIRVVR.
OrthoDBiEOG092C0NX0.

Enzyme and pathway databases

BioCyciYEAST:G3O-33566-MONOMER.

Miscellaneous databases

PROiQ02805.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiROD1_YEAST
AccessioniPrimary (citable) accession number: Q02805
Secondary accession number(s): D6W284, Q12475
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 386 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.