Reviewed, UniProtKB/Swiss-Prot Q02794 (STD1_YEAST)

Names and origin

Protein names

Recommended name:
    Protein STD1
Alternative name(s):
    Glucose repression modulator MSN3
    Suppressor of fluoride sensitivity 3

Gene names

Name:	STD1
Synonyms:	MSN3, SFS3
Ordered Locus Names:	YOR047C

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Potential transcriptional activator. Suppressor of TATA-binding protein (TBP) with a deletion of the nonconserved N-terminus which disrupts normal transcriptional regulation in the cell. Physically interacts with the SNF1 kinase.
Miscellaneous	Present with 238 molecules/cell in log phase SD medium. Ref.4
Sequence similarities	To yeast MTH1.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from mutant phenotype. Source: SGD regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype. Source: SGD response to salt stress Inferred from mutant phenotype. Source: SGD signal transduction Inferred from mutant phenotype. Source: SGD transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: SGD plasma membrane Inferred from direct assay. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: IntAct protein kinase activator activity Inferred from genetic interaction. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	P32862	1	EBI-18344,EBI-26647
CAT8	P39113	1	EBI-18344,EBI-4052
DID4	P36108	1	EBI-18344,EBI-26574
HAP2	P06774	1	EBI-18344,EBI-8152
HAP5	Q02516	1	EBI-18344,EBI-8165
PRE2	P30656	1	EBI-18344,EBI-14001
SOH1	P38633	1	EBI-18344,EBI-17658
VMA6	P32366	1	EBI-18344,EBI-20201
YMR31	P19955	1	EBI-18344,EBI-16295
YOR302W	P08521	1	EBI-18344,EBI-10197

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Protein STD1		PRO_0000072260
Experimental info
	Sequence conflict	139	1	E → D in AAA18535. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q02794-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 888D2D78A72A6507	FASTA	444	50,261
	10 20 30 40 50 60 MFVSPPPATA RNQVLGKRKS KRHDENPKNV QPNADTEMTN SVPSIGFNSN LPHNNQEINT 70 80 90 100 110 120 PNHYNLSSNS GNVRSNNNFV TTPPEYADRA RIEIIKRLLP TAGTKPMEVN SNTAENANIQ 130 140 150 160 170 180 HINTPDSQSF VSDHSSSYES SIFSQPSTAL TDITTGSSLI DTKTPKFVTE VTLEDALPKT 190 200 210 220 230 240 FYDMYSPEVL MSDPANILYN GRPKFTKREL LDWDLNDIRS LLIVEQLRPE WGSQLPTVVT 250 260 270 280 290 300 SGINLPQFRL QLLPLSSSDE FIIATLVNSD LYIEANLDRN FKLTSAKYTV ASARKRHEEM 310 320 330 340 350 360 TGSKEPIMRL SKPEWRNIIE NYLLNVAVEA QCRYDFKQKR SEYKRWKLLN SNLKRPDMPP 370 380 390 400 410 420 PSLIPHGFKI HDCTNSGSLL KKALMKNLQL KNYKNDAKTL GAGTQKNVVN KVSLTSEERA 430 440 AIWFQCQTQV YQRLGLDWKP DGMS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein." Ganster R.W., Shen W., Schmidt M.C. Mol. Cell. Biol. 13:3650-3659(1993) [PubMed: 8497275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BJ1991.
[2]	"Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae." Hubbard E.J.A., Jiang R., Carlson M. Mol. Cell. Biol. 14:1972-1978(1994) [PubMed: 8114728] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 204508 / S288c.
[3]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L06011 Unassigned DNA. Translation: AAA16951.1. L21932 Unassigned DNA. Translation: AAA18535.1. Z74955 Genomic DNA. Translation: CAA99238.1.
PIR	B48129.
RefSeq	NP_014690.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1300N.
IntAct	Q02794. 32 interactions.
STRING	Q02794.
Genome annotation databases
Ensembl	YOR047C; YOR047C; YOR047C; Saccharomyces cerevisiae. [Genome view]
GeneID	854212.
KEGG	sce:YOR047C.
NMPDR	fig|4932.3.peg.5790.
Organism-specific databases
CYGD	YOR047c.
SGD	S000005573. STD1.
Phylogenomic databases
HOGENOM	HBG756486.
OrthoDB	EOG973R7S.
Gene expression databases
ArrayExpress	Q02794.
Genevestigator	Q02794.
GermOnline	YOR047C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	976068.

Entry information

Entry name

STD1_YEAST

Accession

Primary (citable) accession number: Q02794

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	December 15, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)