FK506-binding protein 4 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q02790 (FKBP4_HUMAN)

Last modified November 25, 2008. Version 102. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    FK506-binding protein 4
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase
    HSP-binding immunophilin
      Short name=HBI
    FKBP52 protein
    52 kDa FK506-binding protein
    FKBP59
    p59 protein

Gene names

Name:

FKBP4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. May have a rotamase activity. May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit structure	Interacts with NR3C1 and dynein By similarity. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH).
Subcellular location	Cytoplasm. Nucleus.
Tissue specificity	Widely expressed.
Post-translational modification	Phosphorylation by CK2 results in loss of HSP90 binding activity By similarity. Phosphorylated upon DNA damage, probably by ATM or ATR.
Sequence similarities	Contains 2 PPIase FKBP-type domains. Contains 3 TPR repeats.
Sequence caution	The sequence AAH02887.2 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

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Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat TPR repeat
Molecular function	Isomerase Rotamase
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	protein folding Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Ref.4 Traceable author statement. Source: ProtInc nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FK506 binding Ref.3 Traceable author statement. Source: UniProtKB peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding, bridging Ref.4 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
LOXHD1	Q8IVV2	1	EBI-1047444,EBI-1044376
SAE1	Q9UBE0	1	EBI-1047444,EBI-743154

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed

Chain

2 – 459

458

FK506-binding protein 4

PRO_0000075318

Regions

Domain

50 – 138

PPIase FKBP-type 1

Domain

167 – 253

PPIase FKBP-type 2

Repeat

270 – 303

TPR 1

Repeat

319 – 352

TPR 2

Repeat

353 – 386

TPR 3

Amino acid modifications

Modified residue

143

Phosphothreonine; by CK2 By similarity

Modified residue

274

N6-acetyllysine

Modified residue

451

Phosphoserine

Modified residue

453

Phosphoserine

Secondary structure

459

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q02790-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6A498105418D9435
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FASTA

459

51,805

        10         20         30         40         50         60 
MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW 

        70         80         90        100        110        120 
LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP 

       130        140        150        160        170        180 
KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD 

       190        200        210        220        230        240 
KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN 

       250        260        270        280        290        300 
AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKYKQAL LQYKKIVSWL 

       310        320        330        340        350        360 
EYESSFSNEE AQKAQALRLA SHLNLAMCHL KLQAFSAAIE SCNKALELDS NNEKGLFRRG 

       370        380        390        400        410        420 
EAHLAVNDFE LARADFQKVL QLYPNNKAAK TQLAVCQQRI RRQLAREKKL YANMFERLAE 

       430        440        450 
EENKAKAEAS SGDHPTDTEM KEEQKSNTAG SQSQVETEA

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes." Peattie D.A., Harding M.W., Fleming M.A., Decenzo M.T., Lippke J.A., Livingston D.J., Benasutti M. Proc. Natl. Acad. Sci. U.S.A. 89:10974-10978(1992) [PubMed: 1279700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung, Lymph and Uterus.
[3]	"Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex." Tai P.-K.K., Albers M.W., Chang H., Faber L.E., Schreiber S.L. Science 256:1315-1318(1992) [PubMed: 1376003] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-25, SUBUNIT, FUNCTION. Tissue: Thymus.
[4]	"The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins." Sanchez E.R., Faber L.E., Henzel W.J., Pratt W.B. Biochemistry 29:5145-5152(1990) [PubMed: 2378870] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION. Tissue: Lymphocyte.
[5]	"The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13." Yem A.W., Tomasselli A.G., Heinrikson R.L., Zurcher-Neely H., Ruff V.A., Johnson R.A., Deibel M.R. Jr. J. Biol. Chem. 267:2868-2871(1992) [PubMed: 1371107] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-18. Tissue: T-cell.
[6]	"Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex." Wiederrecht G., Hung S., Chan H.K., Marcy A., Martin M., Calaycay J., Boulton D., Sigal N., Kincaid R.L., Siekierka J.J. J. Biol. Chem. 267:21753-21760(1992) [PubMed: 1383226] [Abstract] Cited for: PROTEIN SEQUENCE OF 16-32.
[7]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-274, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-451 AND SER-453, MASS SPECTROMETRY.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453, MASS SPECTROMETRY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

M88279 mRNA. Translation: AAA36111.1.
BC001786 mRNA. Translation: AAH01786.1.
BC002887 mRNA. Translation: AAH02887.2. Sequence problems.
BC007924 mRNA. Translation: AAH07924.1.

PIR

A46372.

RefSeq

NP_002005.1.

UniGene

Hs.524183

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1N1A	X-ray	2.40	A/B	1-140	[»]
1P5Q	X-ray	2.80	A/B/C	145-459	[»]
1Q1C	X-ray	1.90	A	1-260	[»]
1QZ2	X-ray	3.00	A/B/C	145-459	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q02790.

PTM databases

PhosphoSite

Q02790.

2-D gel databases

REPRODUCTION-2DPAGE

IPI00219005.

Proteomic databases

PeptideAtlas

Q02790.

Genome annotation databases

Ensembl

ENSG00000004478. Homo sapiens. [Contig view]

GeneID

2288.

KEGG

hsa:2288.

Organism-specific databases

H-InvDB

HIX0010330.

HGNC

HGNC:3720. FKBP4.

HPA

CAB017441.
HPA006148.

MIM

600611. gene.

PharmGKB

PA28161.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q02790.

HOVERGEN

Q02790.

Gene expression databases

ArrayExpress

Q02790.

CleanEx

HS_FKBP4.

GermOnline

ENSG00000004478. Homo sapiens.

Family and domain databases

InterPro

IPR001179. PPIase_FKBP.
IPR001440. TPR-1.
IPR011990. TPR-like_helical.
IPR013026. TPR_region.
[Graphical view]

Gene3D

G3DSA:1.25.40.10. TPR-like_helical. 1 hit.

PANTHER

PTHR10516. PPIase_FKBP. 1 hit.

Pfam

PF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 3 hits.
[Graphical view]

SMART

SM00028. TPR. 3 hits.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB01093. Dimethyl sulfoxide.

NextBio

9299.

SOURCE

Search...

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Entry information

Entry name

FKBP4_HUMAN

Accession

Primary (citable) accession number: Q02790
Secondary accession number(s): Q9UCP1, Q9UCV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2-D gel databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents