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Q02788 (CO6A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-2(VI) chain
Gene names
Name:Col6a2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1034 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Collagen VI acts as a cell-binding protein.

Subunit structure

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI). Interacts with CSPG4 By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity. Membrane; Peripheral membrane protein By similarity. Note: Recruited on membranes by CSPG4 By similarity.

Tissue specificity

Highly expressed in adipose tissue, lung, adrenal glands and ovary. Lower levels in testis, tongue, skin, kidney, heart, intestine and spleen. No expression in skeletal muscle or liver.

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Sequence similarities

Belongs to the type VI collagen family.

Contains 3 VWFA domains.

Sequence caution

The sequence BAC31374.2 differs from that shown. Reason: Erroneous initiation.

The sequence CAA46541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA46541.1 differs from that shown. Reason: Frameshift at position 4.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 10341009Collagen alpha-2(VI) chain
PRO_0000005833

Regions

Domain61 – 249189VWFA 1
Domain630 – 820191VWFA 2
Domain848 – 1029182VWFA 3
Region26 – 270245Nonhelical region
Region271 – 605335Triple-helical region
Region606 – 1034429Nonhelical region
Motif381 – 3833Cell attachment site Potential
Motif441 – 4433Cell attachment site Potential
Motif504 – 5063Cell attachment site Potential
Motif513 – 5153Cell attachment site Potential
Motif554 – 5563Cell attachment site Potential

Amino acid modifications

Modified residue7161Phosphothreonine By similarity
Modified residue7181Phosphothreonine By similarity
Modified residue7201Phosphoserine By similarity
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation6451N-linked (GlcNAc...) Potential
Glycosylation8001N-linked (GlcNAc...) Potential
Glycosylation9121N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict121S → P in CAA46541. Ref.1
Sequence conflict2051V → L in CAA46541. Ref.1
Sequence conflict2731H → S in AAA37441. Ref.5
Sequence conflict8091A → S in CAA79153. Ref.6
Sequence conflict8531L → Q in CAA46541. Ref.1
Sequence conflict8531L → Q in CAA44206. Ref.4
Sequence conflict967 – 9715TGNDS → GNDSL in CAA46541. Ref.1
Sequence conflict967 – 9715TGNDS → GNDSL in CAA44206. Ref.4
Sequence conflict981 – 9822KQ → TR in CAA46541. Ref.1
Sequence conflict981 – 9822KQ → TR in CAA44206. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q02788 [UniParc].

Last modified February 6, 2007. Version 3.
Checksum: DC56F4CC552E9997

FASTA1,034110,334
        10         20         30         40         50         60 
MTTIKMLQGP LSVLLIGGLL GVLHAQQQEA ISPQEQEAVS PDISTTERNN NCPEKADCPV 

        70         80         90        100        110        120 
NVYFVLDTSE SVAMQSPTDS LLYHMQQFVP QFISQLQNEF YLDQVALSWR YGGLHFSDQV 

       130        140        150        160        170        180 
EVFSPPGSDR ASFTKSLQGI RSFRRGTFTD CALANMTQQI RQHVGKGVVN FAVVITDGHV 

       190        200        210        220        230        240 
TGSPCGGIKM QAERAREEGI RLFAVAPNRN LNEQGLRDIA NSPHELYRNN YATMRPDSTE 

       250        260        270        280        290        300 
IDQDTINRII KVMKHEAYGE CYKVSCLEIP GPHGPKGYRG QKGAKGNMGE PGEPGQKGRQ 

       310        320        330        340        350        360 
GDPGIEGPIG FPGPKGVPGF KGEKGEFGSD GRKGAPGLAG KNGTDGQKGK LGRIGPPGCK 

       370        380        390        400        410        420 
GDPGSRGPDG YPGEAGSPGE RGDQGAKGDS GRPGRRGPPG DPGDKGSKGY QGNNGAPGSP 

       430        440        450        460        470        480 
GVKGGKGGPG PRGPKGEPGR RGDPGTKGGP GSDGPKGEKG DPGPEGPRGL AGEVGSKGAK 

       490        500        510        520        530        540 
GDRGLPGPRG PQGALGEPGK QGSRGDPGDA GPRGDSGQPG PKGDPGRPGF SYPGPRGTPG 

       550        560        570        580        590        600 
EKGEPGPPGP EGGRGDFGLK GTPGRKGDKG EPADPGPPGE PGPRGPRGIP GPEGEPGPPG 

       610        620        630        640        650        660 
DPGLTECDVM TYVRETCGCC DCEKRCGALD VVFVIDSSES IGYTNFTLEK NFVINVVNRL 

       670        680        690        700        710        720 
GAIAKDPKSE TGTRVGVVQY SHEGTFEAIR LDDERVNSLS SFKEAVKNLE WIAGGTWTPS 

       730        740        750        760        770        780 
ALKFAYNQLI KESRRQKTRV FAVVITDGRH DPRDDDLNLR ALCDRDVTVT AIGIGDMFHE 

       790        800        810        820        830        840 
THESENLYSI ACDKPQQVRN MTLFSDLVAE KFIDDMEDVL CPDPQIVCPE LPCQTELYVA 

       850        860        870        880        890        900 
QCTQRPVDIV FLLDGSERLG EQNFHKVRRF VEDVSRRLTL ARRDDDPLNA RMALLQYGSQ 

       910        920        930        940        950        960 
NQQQVAFPLT YNVTTIHEAL ERATYLNSFS HVGTGIVHAI NNVVRGARGG ARRHAELSFV 

       970        980        990       1000       1010       1020 
FLTDGVTGND SLEESVHSMR KQNVVPTVVA VGGDVDMDVL TKISLGDRAA IFREKDFDSL 

      1030 
AQPSFFDRFI RWIC 

« Hide

References

« Hide 'large scale' references
[1]Ibrahimi A., Bardon S., Dani C.
Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-343.
Strain: C57BL/6J.
Tissue: Cerebellum.
[4]"Cloning of alpha 2 chain of type VI collagen and expression during mouse development."
Ibrahimi A., Bertrand B., Bardon S., Amri E.-Z., Grimaldi P., Ailhaud G., Dani C.
Biochem. J. 289:141-147(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-1034.
[5]"Structure of cDNAs encoding the triple-helical domain of murine alpha 2 (VI) collagen chain and comparison to human and chick homologues. Use of polymerase chain reaction and partially degenerate oligonucleotide for generation of novel cDNA clones."
Constantinou C.D., Jimenez S.A.
Matrix 11:1-9(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-605.
Strain: C57BL/6.
Tissue: Fibroblast.
[6]"Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI."
Zhang R.Z., Pan T.C., Timpl R., Chu M.-L.
Biochem. J. 291:787-792(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 664-1034.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65582 mRNA. Translation: CAA46541.1. Sequence problems.
BC034414 mRNA. Translation: AAH34414.1.
AK042826 mRNA. Translation: BAC31374.2. Different initiation.
X62332 mRNA. Translation: CAA44206.1.
L06343 mRNA. Translation: AAA37441.1.
Z18272 mRNA. Translation: CAA79153.1.
CCDSCCDS23951.1.
PIRS21369.
S32604.
RefSeqNP_666119.1. NM_146007.2.
UniGeneMm.1949.

3D structure databases

ProteinModelPortalQ02788.
SMRQ02788. Positions 627-823, 842-1034.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ02788. 2 interactions.
MINTMINT-4381294.

PTM databases

PhosphoSiteQ02788.

2D gel databases

REPRODUCTION-2DPAGEQ02788.

Proteomic databases

MaxQBQ02788.
PaxDbQ02788.
PRIDEQ02788.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001181; ENSMUSP00000001181; ENSMUSG00000020241.
GeneID12834.
KEGGmmu:12834.
UCSCuc007fuu.2. mouse.

Organism-specific databases

CTD1292.
MGIMGI:88460. Col6a2.

Phylogenomic databases

eggNOGNOG256042.
GeneTreeENSGT00750000117694.
HOGENOMHOG000111863.
HOVERGENHBG051051.
InParanoidQ02788.
KOK06238.
OrthoDBEOG72G16P.
PhylomeDBQ02788.
TreeFamTF331207.

Gene expression databases

ArrayExpressQ02788.
BgeeQ02788.
CleanExMM_COL6A2.
GenevestigatorQ02788.

Family and domain databases

Gene3D3.40.50.410. 3 hits.
InterProIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamPF01391. Collagen. 5 hits.
PF00092. VWA. 3 hits.
[Graphical view]
SMARTSM00327. VWA. 3 hits.
[Graphical view]
SUPFAMSSF53300. SSF53300. 3 hits.
PROSITEPS50234. VWFA. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCOL6A2. mouse.
NextBio282346.
PROQ02788.
SOURCESearch...

Entry information

Entry nameCO6A2_MOUSE
AccessionPrimary (citable) accession number: Q02788
Secondary accession number(s): Q05505, Q8C972, Q8K229
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot