Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q02788

- CO6A2_MOUSE

UniProt

Q02788 - CO6A2_MOUSE

Protein

Collagen alpha-2(VI) chain

Gene

Col6a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (06 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Collagen VI acts as a cell-binding protein.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. protein heterotrimerization Source: MGI
    3. response to glucose Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_196606. ECM proteoglycans.
    REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-2(VI) chain
    Gene namesi
    Name:Col6a2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:88460. Col6a2.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix By similarity. Membrane By similarity; Peripheral membrane protein By similarity
    Note: Recruited on membranes by CSPG4.By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular matrix Source: MGI
    3. extracellular region Source: MGI
    4. extracellular space Source: Ensembl
    5. proteinaceous extracellular matrix Source: UniProtKB-SubCell
    6. protein complex Source: MGI
    7. sarcolemma Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 10341009Collagen alpha-2(VI) chainPRO_0000005833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi645 – 6451N-linked (GlcNAc...)Sequence Analysis
    Modified residuei716 – 7161PhosphothreonineBy similarity
    Modified residuei718 – 7181PhosphothreonineBy similarity
    Modified residuei720 – 7201PhosphoserineBy similarity
    Glycosylationi800 – 8001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi912 – 9121N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

    Keywords - PTMi

    Glycoprotein, Hydroxylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ02788.
    PaxDbiQ02788.
    PRIDEiQ02788.

    2D gel databases

    REPRODUCTION-2DPAGEQ02788.

    PTM databases

    PhosphoSiteiQ02788.

    Expressioni

    Tissue specificityi

    Highly expressed in adipose tissue, lung, adrenal glands and ovary. Lower levels in testis, tongue, skin, kidney, heart, intestine and spleen. No expression in skeletal muscle or liver.

    Gene expression databases

    ArrayExpressiQ02788.
    BgeeiQ02788.
    CleanExiMM_COL6A2.
    GenevestigatoriQ02788.

    Interactioni

    Subunit structurei

    Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI). Interacts with CSPG4 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ02788. 2 interactions.
    MINTiMINT-4381294.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02788.
    SMRiQ02788. Positions 627-823, 842-1034.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 249189VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini630 – 820191VWFA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini848 – 1029182VWFA 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 270245Nonhelical regionAdd
    BLAST
    Regioni271 – 605335Triple-helical regionAdd
    BLAST
    Regioni606 – 1034429Nonhelical regionAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi381 – 3833Cell attachment siteSequence Analysis
    Motifi441 – 4433Cell attachment siteSequence Analysis
    Motifi504 – 5063Cell attachment siteSequence Analysis
    Motifi513 – 5153Cell attachment siteSequence Analysis
    Motifi554 – 5563Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the type VI collagen family.Curated
    Contains 3 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG256042.
    GeneTreeiENSGT00750000117694.
    HOGENOMiHOG000111863.
    HOVERGENiHBG051051.
    InParanoidiQ02788.
    KOiK06238.
    OrthoDBiEOG72G16P.
    PhylomeDBiQ02788.
    TreeFamiTF331207.

    Family and domain databases

    Gene3Di3.40.50.410. 3 hits.
    InterProiIPR008160. Collagen.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01391. Collagen. 5 hits.
    PF00092. VWA. 3 hits.
    [Graphical view]
    SMARTiSM00327. VWA. 3 hits.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 3 hits.
    PROSITEiPS50234. VWFA. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02788-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTIKMLQGP LSVLLIGGLL GVLHAQQQEA ISPQEQEAVS PDISTTERNN     50
    NCPEKADCPV NVYFVLDTSE SVAMQSPTDS LLYHMQQFVP QFISQLQNEF 100
    YLDQVALSWR YGGLHFSDQV EVFSPPGSDR ASFTKSLQGI RSFRRGTFTD 150
    CALANMTQQI RQHVGKGVVN FAVVITDGHV TGSPCGGIKM QAERAREEGI 200
    RLFAVAPNRN LNEQGLRDIA NSPHELYRNN YATMRPDSTE IDQDTINRII 250
    KVMKHEAYGE CYKVSCLEIP GPHGPKGYRG QKGAKGNMGE PGEPGQKGRQ 300
    GDPGIEGPIG FPGPKGVPGF KGEKGEFGSD GRKGAPGLAG KNGTDGQKGK 350
    LGRIGPPGCK GDPGSRGPDG YPGEAGSPGE RGDQGAKGDS GRPGRRGPPG 400
    DPGDKGSKGY QGNNGAPGSP GVKGGKGGPG PRGPKGEPGR RGDPGTKGGP 450
    GSDGPKGEKG DPGPEGPRGL AGEVGSKGAK GDRGLPGPRG PQGALGEPGK 500
    QGSRGDPGDA GPRGDSGQPG PKGDPGRPGF SYPGPRGTPG EKGEPGPPGP 550
    EGGRGDFGLK GTPGRKGDKG EPADPGPPGE PGPRGPRGIP GPEGEPGPPG 600
    DPGLTECDVM TYVRETCGCC DCEKRCGALD VVFVIDSSES IGYTNFTLEK 650
    NFVINVVNRL GAIAKDPKSE TGTRVGVVQY SHEGTFEAIR LDDERVNSLS 700
    SFKEAVKNLE WIAGGTWTPS ALKFAYNQLI KESRRQKTRV FAVVITDGRH 750
    DPRDDDLNLR ALCDRDVTVT AIGIGDMFHE THESENLYSI ACDKPQQVRN 800
    MTLFSDLVAE KFIDDMEDVL CPDPQIVCPE LPCQTELYVA QCTQRPVDIV 850
    FLLDGSERLG EQNFHKVRRF VEDVSRRLTL ARRDDDPLNA RMALLQYGSQ 900
    NQQQVAFPLT YNVTTIHEAL ERATYLNSFS HVGTGIVHAI NNVVRGARGG 950
    ARRHAELSFV FLTDGVTGND SLEESVHSMR KQNVVPTVVA VGGDVDMDVL 1000
    TKISLGDRAA IFREKDFDSL AQPSFFDRFI RWIC 1034
    Length:1,034
    Mass (Da):110,334
    Last modified:February 6, 2007 - v3
    Checksum:iDC56F4CC552E9997
    GO

    Sequence cautioni

    The sequence CAA46541.1 differs from that shown. Reason: Frameshift at position 4.
    The sequence BAC31374.2 differs from that shown. Reason: Erroneous initiation.
    The sequence CAA46541.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121S → P in CAA46541. 1 PublicationCurated
    Sequence conflicti205 – 2051V → L in CAA46541. 1 PublicationCurated
    Sequence conflicti273 – 2731H → S in AAA37441. (PubMed:1709252)Curated
    Sequence conflicti809 – 8091A → S in CAA79153. (PubMed:8489506)Curated
    Sequence conflicti853 – 8531L → Q in CAA46541. 1 PublicationCurated
    Sequence conflicti853 – 8531L → Q in CAA44206. (PubMed:8380980)Curated
    Sequence conflicti967 – 9715TGNDS → GNDSL in CAA46541. 1 PublicationCurated
    Sequence conflicti967 – 9715TGNDS → GNDSL in CAA44206. (PubMed:8380980)Curated
    Sequence conflicti981 – 9822KQ → TR in CAA46541. 1 PublicationCurated
    Sequence conflicti981 – 9822KQ → TR in CAA44206. (PubMed:8380980)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65582 mRNA. Translation: CAA46541.1. Sequence problems.
    BC034414 mRNA. Translation: AAH34414.1.
    AK042826 mRNA. Translation: BAC31374.2. Different initiation.
    X62332 mRNA. Translation: CAA44206.1.
    L06343 mRNA. Translation: AAA37441.1.
    Z18272 mRNA. Translation: CAA79153.1.
    CCDSiCCDS23951.1.
    PIRiS21369.
    S32604.
    RefSeqiNP_666119.1. NM_146007.2.
    UniGeneiMm.1949.

    Genome annotation databases

    EnsembliENSMUST00000001181; ENSMUSP00000001181; ENSMUSG00000020241.
    GeneIDi12834.
    KEGGimmu:12834.
    UCSCiuc007fuu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65582 mRNA. Translation: CAA46541.1 . Sequence problems.
    BC034414 mRNA. Translation: AAH34414.1 .
    AK042826 mRNA. Translation: BAC31374.2 . Different initiation.
    X62332 mRNA. Translation: CAA44206.1 .
    L06343 mRNA. Translation: AAA37441.1 .
    Z18272 mRNA. Translation: CAA79153.1 .
    CCDSi CCDS23951.1.
    PIRi S21369.
    S32604.
    RefSeqi NP_666119.1. NM_146007.2.
    UniGenei Mm.1949.

    3D structure databases

    ProteinModelPortali Q02788.
    SMRi Q02788. Positions 627-823, 842-1034.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q02788. 2 interactions.
    MINTi MINT-4381294.

    PTM databases

    PhosphoSitei Q02788.

    2D gel databases

    REPRODUCTION-2DPAGE Q02788.

    Proteomic databases

    MaxQBi Q02788.
    PaxDbi Q02788.
    PRIDEi Q02788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001181 ; ENSMUSP00000001181 ; ENSMUSG00000020241 .
    GeneIDi 12834.
    KEGGi mmu:12834.
    UCSCi uc007fuu.2. mouse.

    Organism-specific databases

    CTDi 1292.
    MGIi MGI:88460. Col6a2.

    Phylogenomic databases

    eggNOGi NOG256042.
    GeneTreei ENSGT00750000117694.
    HOGENOMi HOG000111863.
    HOVERGENi HBG051051.
    InParanoidi Q02788.
    KOi K06238.
    OrthoDBi EOG72G16P.
    PhylomeDBi Q02788.
    TreeFami TF331207.

    Enzyme and pathway databases

    Reactomei REACT_196606. ECM proteoglycans.
    REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199046. Assembly of collagen fibrils and other multimeric structures.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi COL6A2. mouse.
    NextBioi 282346.
    PROi Q02788.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02788.
    Bgeei Q02788.
    CleanExi MM_COL6A2.
    Genevestigatori Q02788.

    Family and domain databases

    Gene3Di 3.40.50.410. 3 hits.
    InterProi IPR008160. Collagen.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01391. Collagen. 5 hits.
    PF00092. VWA. 3 hits.
    [Graphical view ]
    SMARTi SM00327. VWA. 3 hits.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 3 hits.
    PROSITEi PS50234. VWFA. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Ibrahimi A., Bardon S., Dani C.
      Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-343.
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    4. "Cloning of alpha 2 chain of type VI collagen and expression during mouse development."
      Ibrahimi A., Bertrand B., Bardon S., Amri E.-Z., Grimaldi P., Ailhaud G., Dani C.
      Biochem. J. 289:141-147(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-1034.
    5. "Structure of cDNAs encoding the triple-helical domain of murine alpha 2 (VI) collagen chain and comparison to human and chick homologues. Use of polymerase chain reaction and partially degenerate oligonucleotide for generation of novel cDNA clones."
      Constantinou C.D., Jimenez S.A.
      Matrix 11:1-9(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 271-605.
      Strain: C57BL/6.
      Tissue: Fibroblast.
    6. "Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI."
      Zhang R.Z., Pan T.C., Timpl R., Chu M.-L.
      Biochem. J. 291:787-792(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 664-1034.

    Entry informationi

    Entry nameiCO6A2_MOUSE
    AccessioniPrimary (citable) accession number: Q02788
    Secondary accession number(s): Q05505, Q8C972, Q8K229
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3