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Protein

ATP-dependent permease PDR12

Gene

PDR12

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plasma membrane transporter which mediates resistance to water-soluble, monocarboxylic acids with chain lengths of from C1 to C7 by active extrusion of the preservative anions from the cytosol. Also involved in the export of aromatic and branched-chain organic acids produced in amino acid catabolism.7 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi878 – 8858ATP 1PROSITE-ProRule annotation
Nucleotide bindingi972 – 9798ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to drug Source: GO_Central
  • organic acid transport Source: SGD
  • sterol import Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33969-MONOMER.

Protein family/group databases

TCDBi3.A.1.205.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent permease PDR12
Gene namesi
Name:PDR12
Ordered Locus Names:YPL058C
ORF Names:LPE14C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL058C.
SGDiS000005979. PDR12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 508507CytoplasmicSequence analysisAdd
BLAST
Transmembranei509 – 52921HelicalSequence analysisAdd
BLAST
Topological domaini530 – 54819ExtracellularSequence analysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST
Topological domaini570 – 59728CytoplasmicSequence analysisAdd
BLAST
Transmembranei598 – 61821HelicalSequence analysisAdd
BLAST
Topological domaini619 – 6224ExtracellularSequence analysis
Transmembranei623 – 64321HelicalSequence analysisAdd
BLAST
Topological domaini644 – 65714CytoplasmicSequence analysisAdd
BLAST
Transmembranei658 – 67821HelicalSequence analysisAdd
BLAST
Topological domaini679 – 76587ExtracellularSequence analysisAdd
BLAST
Transmembranei766 – 78621HelicalSequence analysisAdd
BLAST
Topological domaini787 – 1182396CytoplasmicSequence analysisAdd
BLAST
Transmembranei1183 – 120321HelicalSequence analysisAdd
BLAST
Topological domaini1204 – 12041ExtracellularSequence analysis
Transmembranei1205 – 122521HelicalSequence analysisAdd
BLAST
Topological domaini1226 – 125429CytoplasmicSequence analysisAdd
BLAST
Transmembranei1255 – 127521HelicalSequence analysisAdd
BLAST
Topological domaini1276 – 129116ExtracellularSequence analysisAdd
BLAST
Transmembranei1292 – 131221HelicalSequence analysisAdd
BLAST
Topological domaini1313 – 13186CytoplasmicSequence analysis
Transmembranei1319 – 133921HelicalSequence analysisAdd
BLAST
Topological domaini1340 – 1444105ExtracellularSequence analysisAdd
BLAST
Transmembranei1445 – 146521HelicalSequence analysisAdd
BLAST
Topological domaini1466 – 151146CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 15111510ATP-dependent permease PDR12PRO_0000093445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei32 – 321PhosphoserineCombined sources
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei56 – 561PhosphoserineCombined sources
Cross-linki426 – 426Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Glycosylationi1405 – 14051N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ02785.

PTM databases

iPTMnetiQ02785.

Expressioni

Inductioni

By weak acids like sorbate through the WAR1 transcription activator.7 Publications

Interactioni

Protein-protein interaction databases

BioGridi36122. 82 interactions.
IntActiQ02785. 66 interactions.
MINTiMINT-4504565.

Structurei

3D structure databases

ProteinModelPortaliQ02785.
SMRiQ02785. Positions 112-403, 761-1067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 397254ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini836 – 1084249ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiQ02785.
OrthoDBiEOG092C1HKF.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTDEHIEK DISSRSNHDD DYANSVQSYA ASEGQVDNED LAATSQLSRH
60 70 80 90 100
LSNILSNEEG IERLESMARV ISHKTKKEMD SFEINDLDFD LRSLLHYLRS
110 120 130 140 150
RQLEQGIEPG DSGIAFKNLT AVGVDASAAY GPSVEEMFRN IASIPAHLIS
160 170 180 190 200
KFTKKSDVPL RNIIQNCTGV VESGEMLFVV GRPGAGCSTF LKCLSGETSE
210 220 230 240 250
LVDVQGEFSY DGLDQSEMMS KYKGYVIYCP ELDFHFPKIT VKETIDFALK
260 270 280 290 300
CKTPRVRIDK MTRKQYVDNI RDMWCTVFGL RHTYATKVGN DFVRGVSGGE
310 320 330 340 350
RKRVSLVEAQ AMNASIYSWD NATRGLDAST ALEFAQAIRT ATNMVNNSAI
360 370 380 390 400
VAIYQAGENI YELFDKTTVL YNGRQIYFGP ADKAVGYFQR MGWVKPNRMT
410 420 430 440 450
SAEFLTSVTV DFENRTLDIK PGYEDKVPKS SSEFEEYWLN SEDYQELLRT
460 470 480 490 500
YDDYQSRHPV NETRDRLDVA KKQRLQQGQR ENSQYVVNYW TQVYYCMIRG
510 520 530 540 550
FQRVKGDSTY TKVYLSSFLI KALIIGSMFH KIDDKSQSTT AGAYSRGGML
560 570 580 590 600
FYVLLFASVT SLAEIGNSFS SRPVIVKHKS YSMYHLSAES LQEIITEFPT
610 620 630 640 650
KFVAIVILCL ITYWIPFMKY EAGAFFQYIL YLLTVQQCTS FIFKFVATMS
660 670 680 690 700
KSGVDAHAVG GLWVLMLCVY AGFVLPIGEM HHWIRWLHFI NPLTYAFESL
710 720 730 740 750
VSTEFHHREM LCSALVPSGP GYEGISIANQ VCDAAGAVKG NLYVSGDSYI
760 770 780 790 800
LHQYHFAYKH AWRNWGVNIV WTFGYIVFNV ILSEYLKPVE GGGDLLLYKR
810 820 830 840 850
GHMPELGTEN ADARTASREE MMEALNGPNV DLEKVIAEKD VFTWNHLDYT
860 870 880 890 900
IPYDGATRKL LSDVFGYVKP GKMTALMGES GAGKTTLLNV LAQRINMGVI
910 920 930 940 950
TGDMLVNAKP LPASFNRSCG YVAQADNHMA ELSVRESLRF AAELRQQSSV
960 970 980 990 1000
PLEEKYEYVE KIITLLGMQN YAEALVGKTG RGLNVEQRKK LSIGVELVAK
1010 1020 1030 1040 1050
PSLLLFLDEP TSGLDSQSAW SIVQFMRALA DSGQSILCTI HQPSATLFEQ
1060 1070 1080 1090 1100
FDRLLLLKKG GKMVYFGDIG PNSETLLKYF ERQSGMKCGV SENPAEYILN
1110 1120 1130 1140 1150
CIGAGATASV NSDWHDLWLA SPECAAARAE VEELHRTLPG RAVNDDPELA
1160 1170 1180 1190 1200
TRFAASYMTQ IKCVLRRTAL QFWRSPVYIR AKFFECVACA LFVGLSYVGV
1210 1220 1230 1240 1250
NHSVGGAIEA FSSIFMLLLI ALAMINQLHV FAYDSRELYE VREAASNTFH
1260 1270 1280 1290 1300
WSVLLLCHAA VENFWSTLCQ FMCFICYYWP AQFSGRASHA GFFFFFYVLI
1310 1320 1330 1340 1350
FPLYFVTYGL WILYMSPDVP SASMINSNLF AAMLLFCGIL QPREKMPAFW
1360 1370 1380 1390 1400
RRLMYNVSPF TYVVQALVTP LVHNKKVVCN PHEYNIMDPP SGKTCGEFLS
1410 1420 1430 1440 1450
TYMDNNTGYL VNPTATENCQ YCPYTVQDQV VAKYNVKWDH RWRNFGFMWA
1460 1470 1480 1490 1500
YICFNIAAML ICYYVVRVKV WSLKSVLNFK KWFNGPRKER HEKDTNIFQT
1510
VPGDENKITK K
Length:1,511
Mass (Da):171,065
Last modified:November 1, 1996 - v1
Checksum:i4962762AAE1997FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39205 Genomic DNA. Translation: AAB68307.1.
BK006949 Genomic DNA. Translation: DAA11372.1.
PIRiS60932.
RefSeqiNP_015267.1. NM_001183872.1.

Genome annotation databases

EnsemblFungiiYPL058C; YPL058C; YPL058C.
GeneIDi856049.
KEGGisce:YPL058C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39205 Genomic DNA. Translation: AAB68307.1.
BK006949 Genomic DNA. Translation: DAA11372.1.
PIRiS60932.
RefSeqiNP_015267.1. NM_001183872.1.

3D structure databases

ProteinModelPortaliQ02785.
SMRiQ02785. Positions 112-403, 761-1067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36122. 82 interactions.
IntActiQ02785. 66 interactions.
MINTiMINT-4504565.

Protein family/group databases

TCDBi3.A.1.205.3. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ02785.

Proteomic databases

MaxQBiQ02785.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL058C; YPL058C; YPL058C.
GeneIDi856049.
KEGGisce:YPL058C.

Organism-specific databases

EuPathDBiFungiDB:YPL058C.
SGDiS000005979. PDR12.

Phylogenomic databases

GeneTreeiENSGT00550000075308.
HOGENOMiHOG000162078.
InParanoidiQ02785.
OrthoDBiEOG092C1HKF.

Enzyme and pathway databases

BioCyciYEAST:G3O-33969-MONOMER.

Miscellaneous databases

PROiQ02785.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR010929. PDR_CDR_ABC.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF06422. PDR_CDR. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDR12_YEAST
AccessioniPrimary (citable) accession number: Q02785
Secondary accession number(s): D6W3V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 752 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.