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Q02773

- RPM2_YEAST

UniProt

Q02773 - RPM2_YEAST

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Protein

Ribonuclease P protein component, mitochondrial

Gene
RPM2, YML091C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ribonuclease P generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. mitochondrion organization Source: SGD
  3. mRNA processing Source: SGD
  4. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  5. RNA phosphodiester bond hydrolysis Source: GOC
  6. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
  7. RNA processing Source: SGD
  8. tRNA 5'-leader removal Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciYEAST:YML091C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component, mitochondrial (EC:3.1.26.5)
Short name:
RNase P
Gene namesi
Name:RPM2
Ordered Locus Names:YML091C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYML091c.
SGDiS000004556. RPM2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: SGD
  2. mitochondrial ribonuclease P complex Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 122122Mitochondrion1 PublicationAdd
BLAST
Chaini123 – 12021080Ribonuclease P protein component, mitochondrialPRO_0000022247Add
BLAST

Proteomic databases

MaxQBiQ02773.
PaxDbiQ02773.
PeptideAtlasiQ02773.

Expressioni

Gene expression databases

GenevestigatoriQ02773.

Interactioni

Subunit structurei

Consists of an RNA moiety (RPM1) and the protein component (RPM2). Both are necessary for full enzymatic activity.

Protein-protein interaction databases

BioGridi35052. 39 interactions.
DIPiDIP-6320N.
IntActiQ02773. 14 interactions.
MINTiMINT-663444.
STRINGi4932.YML091C.

Structurei

3D structure databases

ProteinModelPortaliQ02773.

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG44485.
HOGENOMiHOG000141909.
KOiK14533.
OMAiPEFSYEF.
OrthoDBiEOG7K3TVM.

Family and domain databases

InterProiIPR013888. RNase_P_Rpm2_mt.
[Graphical view]
PfamiPF08579. RPM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02773-1 [UniParc]FASTAAdd to Basket

« Hide

MAFKSFIYSK GYHRSAAQKK TATSFFDSSY QYLRQNQGLV NSDPVLHASH     50
LHPHPVVVAN VNYNNVDDIL HPHDLDSSIN NTNNPLTHEE LLYNQNVSLR 100
SLKQQQSTNY VNNNNNNQHR YYSTGPTLPT NQYDPLNFSN RNFQDLSLKT 150
SQPSVQQPQN EYSLLKDENA PVWKEDTEPC LNKSTYLQTH IDEINRCYEQ 200
KNYNKINSLY QSLKRNDIVP PLEIFTKVLD SLCKRPLDNN DLDNKMYELL 250
TCYQDMINNR LKPPDEIYNI VLLSLFKGSI LAYQFENPNG SDFYKIAIEL 300
FNTTTNDPKQ KSVVKFRNFS KDVLDYNLLA MNIYPGHITL SKAQQVIKSS 350
PAFIKDSFYF IACFSYAKLT NDKFAIKELY EDFRLSLSSG SPDQGLFDDQ 400
FEIYSVILSS FIETGEVELA TNLLDDLVSK IQSSNGLASN ISLLLSSFLI 450
SMSKVDPSKA YEIWFKFHNL NWIPEFSYEF YLVFMANSFQ DWNLTKKIYD 500
YIFPMERNLS PLKKQKLSDY LLHPIGVDSI TTSLLDYSLQ LKDNEVIMKI 550
LEESIVKNFS FDIGIYPFVF NYLREIQCGE DYLMRFIESH AEFIKKSNSI 600
NKFQFLNMIV DNFQSQSLLN KISHAKFFKN FVEDFNLENC ELVSYNGLIS 650
CINNFIKIPK TIKDFPYILE IHAILVTKLF DFDTYPILQN GNNEVLLKFR 700
DQIEHQFKML AQNFCRLNLD PNLLAGVVSQ AMKMVNLDDT ANGQDLLNFF 750
NHPGDWDKSY PLSLGSFIRN SPRGGIREFT KLSKEGYCFD YDTYKELIIK 800
RAINKQIIDK CLEVCPDSIE LKNIVNLMIS KIPGRNLTQL IINNPKFSKV 850
FVPNLRNDSM LKLIENCESL SNFIRICDFP EKFKSIAIQA ENKNAIELIY 900
ERLFDGGKYA DILRYNNIVP VLNLELLLKS CIRSGEFKKY ESLSKKFNDK 950
ISESSKIDIQ LEYLINKNDL KGAFTLFEKT PRELRTPHKT MDLYTFALFL 1000
DSFNRNITYY ESPENTLQFA NILSSQTSFI NLLSTYNLIA HSDHLMNFNV 1050
GGMAAKVKKE ILNQMLNNLY DSIRLLSPSI ENDKSMKEKL REKVKNYCRF 1100
KAYLKSPELD MDELKTLVSV ESFLNPFTPS MLFNNLIETI YINEHASSLV 1150
LQNGLIYSLQ QKGLNKILSY LEESFITSGN DANIEKVREF RSLLRKSKPL 1200
QA 1202
Length:1,202
Mass (Da):139,348
Last modified:October 1, 1993 - v1
Checksum:iB9DA65450E8F056A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06209 Unassigned DNA. Translation: AAA03168.1.
Z46660 Genomic DNA. Translation: CAA86647.1.
BK006946 Genomic DNA. Translation: DAA09808.1.
PIRiA48773.
RefSeqiNP_013619.1. NM_001182450.1.

Genome annotation databases

EnsemblFungiiYML091C; YML091C; YML091C.
GeneIDi854883.
KEGGisce:YML091C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06209 Unassigned DNA. Translation: AAA03168.1 .
Z46660 Genomic DNA. Translation: CAA86647.1 .
BK006946 Genomic DNA. Translation: DAA09808.1 .
PIRi A48773.
RefSeqi NP_013619.1. NM_001182450.1.

3D structure databases

ProteinModelPortali Q02773.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35052. 39 interactions.
DIPi DIP-6320N.
IntActi Q02773. 14 interactions.
MINTi MINT-663444.
STRINGi 4932.YML091C.

Proteomic databases

MaxQBi Q02773.
PaxDbi Q02773.
PeptideAtlasi Q02773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YML091C ; YML091C ; YML091C .
GeneIDi 854883.
KEGGi sce:YML091C.

Organism-specific databases

CYGDi YML091c.
SGDi S000004556. RPM2.

Phylogenomic databases

eggNOGi NOG44485.
HOGENOMi HOG000141909.
KOi K14533.
OMAi PEFSYEF.
OrthoDBi EOG7K3TVM.

Enzyme and pathway databases

BioCyci YEAST:YML091C-MONOMER.

Miscellaneous databases

NextBioi 977834.

Gene expression databases

Genevestigatori Q02773.

Family and domain databases

InterProi IPR013888. RNase_P_Rpm2_mt.
[Graphical view ]
Pfami PF08579. RPM2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 105-kDa protein is required for yeast mitochondrial RNase P activity."
    Morales M.J., Dang Y.L., Lou Y.C., Sulo P., Martin N.C.
    Proc. Natl. Acad. Sci. U.S.A. 89:9875-9879(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 123-142.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRPM2_YEAST
AccessioniPrimary (citable) accession number: Q02773
Secondary accession number(s): D6W0J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1160 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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