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Q02773 (RPM2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein component, mitochondrial

Short name=RNase P
EC=3.1.26.5
Gene names
Name:RPM2
Ordered Locus Names:YML091C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ribonuclease P generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subunit structure

Consists of an RNA moiety (RPM1) and the protein component (RPM2). Both are necessary for full enzymatic activity.

Subcellular location

Mitochondrion.

Miscellaneous

Present with 1160 molecules/cell in log phase SD medium.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 122122Mitochondrion Ref.1
Chain123 – 12021080Ribonuclease P protein component, mitochondrial
PRO_0000022247

Sequences

Sequence LengthMass (Da)Tools
Q02773 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: B9DA65450E8F056A

FASTA1,202139,348
        10         20         30         40         50         60 
MAFKSFIYSK GYHRSAAQKK TATSFFDSSY QYLRQNQGLV NSDPVLHASH LHPHPVVVAN 

        70         80         90        100        110        120 
VNYNNVDDIL HPHDLDSSIN NTNNPLTHEE LLYNQNVSLR SLKQQQSTNY VNNNNNNQHR 

       130        140        150        160        170        180 
YYSTGPTLPT NQYDPLNFSN RNFQDLSLKT SQPSVQQPQN EYSLLKDENA PVWKEDTEPC 

       190        200        210        220        230        240 
LNKSTYLQTH IDEINRCYEQ KNYNKINSLY QSLKRNDIVP PLEIFTKVLD SLCKRPLDNN 

       250        260        270        280        290        300 
DLDNKMYELL TCYQDMINNR LKPPDEIYNI VLLSLFKGSI LAYQFENPNG SDFYKIAIEL 

       310        320        330        340        350        360 
FNTTTNDPKQ KSVVKFRNFS KDVLDYNLLA MNIYPGHITL SKAQQVIKSS PAFIKDSFYF 

       370        380        390        400        410        420 
IACFSYAKLT NDKFAIKELY EDFRLSLSSG SPDQGLFDDQ FEIYSVILSS FIETGEVELA 

       430        440        450        460        470        480 
TNLLDDLVSK IQSSNGLASN ISLLLSSFLI SMSKVDPSKA YEIWFKFHNL NWIPEFSYEF 

       490        500        510        520        530        540 
YLVFMANSFQ DWNLTKKIYD YIFPMERNLS PLKKQKLSDY LLHPIGVDSI TTSLLDYSLQ 

       550        560        570        580        590        600 
LKDNEVIMKI LEESIVKNFS FDIGIYPFVF NYLREIQCGE DYLMRFIESH AEFIKKSNSI 

       610        620        630        640        650        660 
NKFQFLNMIV DNFQSQSLLN KISHAKFFKN FVEDFNLENC ELVSYNGLIS CINNFIKIPK 

       670        680        690        700        710        720 
TIKDFPYILE IHAILVTKLF DFDTYPILQN GNNEVLLKFR DQIEHQFKML AQNFCRLNLD 

       730        740        750        760        770        780 
PNLLAGVVSQ AMKMVNLDDT ANGQDLLNFF NHPGDWDKSY PLSLGSFIRN SPRGGIREFT 

       790        800        810        820        830        840 
KLSKEGYCFD YDTYKELIIK RAINKQIIDK CLEVCPDSIE LKNIVNLMIS KIPGRNLTQL 

       850        860        870        880        890        900 
IINNPKFSKV FVPNLRNDSM LKLIENCESL SNFIRICDFP EKFKSIAIQA ENKNAIELIY 

       910        920        930        940        950        960 
ERLFDGGKYA DILRYNNIVP VLNLELLLKS CIRSGEFKKY ESLSKKFNDK ISESSKIDIQ 

       970        980        990       1000       1010       1020 
LEYLINKNDL KGAFTLFEKT PRELRTPHKT MDLYTFALFL DSFNRNITYY ESPENTLQFA 

      1030       1040       1050       1060       1070       1080 
NILSSQTSFI NLLSTYNLIA HSDHLMNFNV GGMAAKVKKE ILNQMLNNLY DSIRLLSPSI 

      1090       1100       1110       1120       1130       1140 
ENDKSMKEKL REKVKNYCRF KAYLKSPELD MDELKTLVSV ESFLNPFTPS MLFNNLIETI 

      1150       1160       1170       1180       1190       1200 
YINEHASSLV LQNGLIYSLQ QKGLNKILSY LEESFITSGN DANIEKVREF RSLLRKSKPL 


QA 

« Hide

References

« Hide 'large scale' references
[1]"A 105-kDa protein is required for yeast mitochondrial RNase P activity."
Morales M.J., Dang Y.L., Lou Y.C., Sulo P., Martin N.C.
Proc. Natl. Acad. Sci. U.S.A. 89:9875-9879(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 123-142.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L06209 Unassigned DNA. Translation: AAA03168.1.
Z46660 Genomic DNA. Translation: CAA86647.1.
BK006946 Genomic DNA. Translation: DAA09808.1.
PIRA48773.
RefSeqNP_013619.1. NM_001182450.1.

3D structure databases

ProteinModelPortalQ02773.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35052. 39 interactions.
DIPDIP-6320N.
IntActQ02773. 14 interactions.
MINTMINT-663444.
STRING4932.YML091C.

Proteomic databases

MaxQBQ02773.
PaxDbQ02773.
PeptideAtlasQ02773.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYML091C; YML091C; YML091C.
GeneID854883.
KEGGsce:YML091C.

Organism-specific databases

CYGDYML091c.
SGDS000004556. RPM2.

Phylogenomic databases

eggNOGNOG44485.
HOGENOMHOG000141909.
KOK14533.
OMAPEFSYEF.
OrthoDBEOG7K3TVM.

Enzyme and pathway databases

BioCycYEAST:YML091C-MONOMER.

Gene expression databases

GenevestigatorQ02773.

Family and domain databases

InterProIPR013888. RNase_P_Rpm2_mt.
[Graphical view]
PfamPF08579. RPM2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio977834.

Entry information

Entry nameRPM2_YEAST
AccessionPrimary (citable) accession number: Q02773
Secondary accession number(s): D6W0J4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 14, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD