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Q02773

- RPM2_YEAST

UniProt

Q02773 - RPM2_YEAST

Protein

Ribonuclease P protein component, mitochondrial

Gene

RPM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Ribonuclease P generates mature tRNA molecules by cleaving their 5'-ends.

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. mitochondrion organization Source: SGD
    3. mRNA processing Source: SGD
    4. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    5. RNA phosphodiester bond hydrolysis Source: GOC
    6. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
    7. RNA processing Source: SGD
    8. tRNA 5'-leader removal Source: SGD

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:YML091C-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein component, mitochondrial (EC:3.1.26.5)
    Short name:
    RNase P
    Gene namesi
    Name:RPM2
    Ordered Locus Names:YML091C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYML091c.
    SGDiS000004556. RPM2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: SGD
    2. mitochondrial ribonuclease P complex Source: SGD
    3. nucleus Source: SGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 122122Mitochondrion1 PublicationAdd
    BLAST
    Chaini123 – 12021080Ribonuclease P protein component, mitochondrialPRO_0000022247Add
    BLAST

    Proteomic databases

    MaxQBiQ02773.
    PaxDbiQ02773.
    PeptideAtlasiQ02773.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02773.

    Interactioni

    Subunit structurei

    Consists of an RNA moiety (RPM1) and the protein component (RPM2). Both are necessary for full enzymatic activity.

    Protein-protein interaction databases

    BioGridi35052. 39 interactions.
    DIPiDIP-6320N.
    IntActiQ02773. 14 interactions.
    MINTiMINT-663444.
    STRINGi4932.YML091C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02773.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG44485.
    HOGENOMiHOG000141909.
    KOiK14533.
    OMAiPEFSYEF.
    OrthoDBiEOG7K3TVM.

    Family and domain databases

    InterProiIPR013888. RNase_P_Rpm2_mt.
    [Graphical view]
    PfamiPF08579. RPM2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02773-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFKSFIYSK GYHRSAAQKK TATSFFDSSY QYLRQNQGLV NSDPVLHASH     50
    LHPHPVVVAN VNYNNVDDIL HPHDLDSSIN NTNNPLTHEE LLYNQNVSLR 100
    SLKQQQSTNY VNNNNNNQHR YYSTGPTLPT NQYDPLNFSN RNFQDLSLKT 150
    SQPSVQQPQN EYSLLKDENA PVWKEDTEPC LNKSTYLQTH IDEINRCYEQ 200
    KNYNKINSLY QSLKRNDIVP PLEIFTKVLD SLCKRPLDNN DLDNKMYELL 250
    TCYQDMINNR LKPPDEIYNI VLLSLFKGSI LAYQFENPNG SDFYKIAIEL 300
    FNTTTNDPKQ KSVVKFRNFS KDVLDYNLLA MNIYPGHITL SKAQQVIKSS 350
    PAFIKDSFYF IACFSYAKLT NDKFAIKELY EDFRLSLSSG SPDQGLFDDQ 400
    FEIYSVILSS FIETGEVELA TNLLDDLVSK IQSSNGLASN ISLLLSSFLI 450
    SMSKVDPSKA YEIWFKFHNL NWIPEFSYEF YLVFMANSFQ DWNLTKKIYD 500
    YIFPMERNLS PLKKQKLSDY LLHPIGVDSI TTSLLDYSLQ LKDNEVIMKI 550
    LEESIVKNFS FDIGIYPFVF NYLREIQCGE DYLMRFIESH AEFIKKSNSI 600
    NKFQFLNMIV DNFQSQSLLN KISHAKFFKN FVEDFNLENC ELVSYNGLIS 650
    CINNFIKIPK TIKDFPYILE IHAILVTKLF DFDTYPILQN GNNEVLLKFR 700
    DQIEHQFKML AQNFCRLNLD PNLLAGVVSQ AMKMVNLDDT ANGQDLLNFF 750
    NHPGDWDKSY PLSLGSFIRN SPRGGIREFT KLSKEGYCFD YDTYKELIIK 800
    RAINKQIIDK CLEVCPDSIE LKNIVNLMIS KIPGRNLTQL IINNPKFSKV 850
    FVPNLRNDSM LKLIENCESL SNFIRICDFP EKFKSIAIQA ENKNAIELIY 900
    ERLFDGGKYA DILRYNNIVP VLNLELLLKS CIRSGEFKKY ESLSKKFNDK 950
    ISESSKIDIQ LEYLINKNDL KGAFTLFEKT PRELRTPHKT MDLYTFALFL 1000
    DSFNRNITYY ESPENTLQFA NILSSQTSFI NLLSTYNLIA HSDHLMNFNV 1050
    GGMAAKVKKE ILNQMLNNLY DSIRLLSPSI ENDKSMKEKL REKVKNYCRF 1100
    KAYLKSPELD MDELKTLVSV ESFLNPFTPS MLFNNLIETI YINEHASSLV 1150
    LQNGLIYSLQ QKGLNKILSY LEESFITSGN DANIEKVREF RSLLRKSKPL 1200
    QA 1202
    Length:1,202
    Mass (Da):139,348
    Last modified:October 1, 1993 - v1
    Checksum:iB9DA65450E8F056A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06209 Unassigned DNA. Translation: AAA03168.1.
    Z46660 Genomic DNA. Translation: CAA86647.1.
    BK006946 Genomic DNA. Translation: DAA09808.1.
    PIRiA48773.
    RefSeqiNP_013619.1. NM_001182450.1.

    Genome annotation databases

    EnsemblFungiiYML091C; YML091C; YML091C.
    GeneIDi854883.
    KEGGisce:YML091C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L06209 Unassigned DNA. Translation: AAA03168.1 .
    Z46660 Genomic DNA. Translation: CAA86647.1 .
    BK006946 Genomic DNA. Translation: DAA09808.1 .
    PIRi A48773.
    RefSeqi NP_013619.1. NM_001182450.1.

    3D structure databases

    ProteinModelPortali Q02773.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35052. 39 interactions.
    DIPi DIP-6320N.
    IntActi Q02773. 14 interactions.
    MINTi MINT-663444.
    STRINGi 4932.YML091C.

    Proteomic databases

    MaxQBi Q02773.
    PaxDbi Q02773.
    PeptideAtlasi Q02773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YML091C ; YML091C ; YML091C .
    GeneIDi 854883.
    KEGGi sce:YML091C.

    Organism-specific databases

    CYGDi YML091c.
    SGDi S000004556. RPM2.

    Phylogenomic databases

    eggNOGi NOG44485.
    HOGENOMi HOG000141909.
    KOi K14533.
    OMAi PEFSYEF.
    OrthoDBi EOG7K3TVM.

    Enzyme and pathway databases

    BioCyci YEAST:YML091C-MONOMER.

    Miscellaneous databases

    NextBioi 977834.

    Gene expression databases

    Genevestigatori Q02773.

    Family and domain databases

    InterProi IPR013888. RNase_P_Rpm2_mt.
    [Graphical view ]
    Pfami PF08579. RPM2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A 105-kDa protein is required for yeast mitochondrial RNase P activity."
      Morales M.J., Dang Y.L., Lou Y.C., Sulo P., Martin N.C.
      Proc. Natl. Acad. Sci. U.S.A. 89:9875-9879(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 123-142.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRPM2_YEAST
    AccessioniPrimary (citable) accession number: Q02773
    Secondary accession number(s): D6W0J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1160 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3