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Q02766 (COX1_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:MT-CO1
Synonyms:COI, COXI, MTCO1
Encoded onMitochondrion
OrganismPlasmodium falciparum
Taxonomic identifier5833 [NCBI]
Taxonomic lineageEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Cytochrome c oxidase subunit 1
PRO_0000183396

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane278 – 29821Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane345 – 36521Helical; Potential
Transmembrane379 – 39921Helical; Potential
Transmembrane415 – 43521Helical; Potential
Transmembrane455 – 47521Helical; Potential

Sites

Metal binding661Iron (heme A axial ligand) Probable
Metal binding2461Copper B Probable
Metal binding2501Copper B Probable
Metal binding2951Copper B Probable
Metal binding2961Copper B Probable
Metal binding3821Iron (heme A3 axial ligand) Probable
Metal binding3841Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link246 ↔ 2501'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q02766 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A51CEE2F28618AA9

FASTA47652,729
        10         20         30         40         50         60 
MVLNRYSLIT NCNHKTLGLY YLWFSFLFGS YGFLLSVILR TELYSSSLRI IAQENVNLYN 

        70         80         90        100        110        120 
MIFTIHGIIM IFFNIMPGLF GGFGNYFLPI LCGSPELAYP RINSISLLLQ PIAFVLVILS 

       130        140        150        160        170        180 
TAAEFGGGTG WTLYPPLSTS LMSLSPVAVD VIIFGLLVSG VASIMSSLNF ITTVMHLRAK 

       190        200        210        220        230        240 
GLTLGILSVS TWSLIITSGM LLLTLPVLTG GVLMLLSDLH FNTLFFDPTF AGDPILYQHL 

       250        260        270        280        290        300 
FWFFGHPEVY ILILPAFGVI SHVISTNYCR NLFGNQSMIL AMGCIAVLGS LVWVHHMYTT 

       310        320        330        340        350        360 
GLEVDTRAYF TSTTILISIP TGTKVFNWIC TYMSSNFGMI HSSSLLSLLF ICTFTFGGTT 

       370        380        390        400        410        420 
GVILGNAAID VALHDTYYVI AHFHFVLSIG AIIGLFTTVS AFQDNFFGKN LRENSIVILW 

       430        440        450        460        470 
SMLFFVGVIL TFLPMHFLGF NVMPRRIPDY PDALNGWNMI CSIGSTMTLF GLLIFK

« Hide

References

[1]"Homologies between the contiguous and fragmented rRNAs of the two Plasmodium falciparum extrachromosomal DNAs are limited to core sequences."
Feagin J.E., Werner E., Gardner M.J., Williamson D.H., Wilson R.J.
Nucleic Acids Res. 20:879-887(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and partial sequence of a 5.8 kilobase pair repetitive DNA from Plasmodium falciparum."
Suplick K., Akella R., Saul A.J., Vaidya A.
Mol. Biochem. Parasitol. 30:289-290(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MALAY CAMP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M76611 Genomic DNA. Translation: AAC63390.2. Sequence problems.
M99416 Genomic DNA. Translation: AAC06269.1. Sequence problems.

3D structure databases

ProteinModelPortalQ02766.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. COX1. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_PLAFA
AccessionPrimary (citable) accession number: Q02766
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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