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Protein

Cathepsin S

Gene

Ctss

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity). May be involved in thyroid hormone biosynthesis.By similarity

Catalytic activityi

Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137By similarity1
Active sitei277By similarity1
Active sitei297By similarity1

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • basement membrane disassembly Source: GO_Central
  • bone resorption Source: RGD
  • immune response Source: GO_Central
  • metanephros development Source: UniProtKB
  • proteolysis involved in cellular protein catabolic process Source: GO_Central
  • regulation of sensory perception of pain Source: RGD

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.27 5301

Protein family/group databases

MEROPSiI29.004

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin S (EC:3.4.22.27)
Gene namesi
Name:Ctss
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621513 Ctss

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075217

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000002631718 – 112Activation peptideAdd BLAST95
ChainiPRO_0000026318113 – 330Cathepsin SAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 222By similarity
Disulfide bondi134 ↔ 179By similarity
Disulfide bondi168 ↔ 211By similarity
Disulfide bondi271 ↔ 319By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiQ02765

PTM databases

PhosphoSitePlusiQ02765

Expressioni

Tissue specificityi

Highest levels occur in the ileum followed by spleen, brain, thyroid, ovary and uterus. Low levels are found in the liver, kidney, jejunum and lung with lowest levels in the heart.

Inductioni

By thyroid-stimulating hormone.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ02765
SMRiQ02765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG011513
InParanoidiQ02765
KOiK01368
PhylomeDBiQ02765

Family and domain databases

InterProiView protein in InterPro
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLGAPGVL CDNGATAERP TLDHHWDLWK KTRMRRNTDQ NEEDVRRLIW
60 70 80 90 100
EKNLKFIMLH NLEHSMGMHS YSVGMNHMGD MTPEEVIGYM GSLRIPRPWN
110 120 130 140 150
RSGTLKSSSN QTLPDSVDWR EKGCVTNVKY QGSCGSCWAF SAEGALEGQL
160 170 180 190 200
KLKTGKLVSL SAQNLVDCST EEKYGNKGCG GGFMTEAFQY IIDTSIDSEA
210 220 230 240 250
SYPYKAMDEK CLYDPKNRAA TCSRYIELPF GDEEALKEAV ATKGPVSVGI
260 270 280 290 300
DDASHSSFFL YQSGVYDDPS CTENMNHGVL VVGYGTLDGK DYWLVKNSWG
310 320 330
LHFGDQGYIR MARNNKNHCG IASYCSYPEI
Length:330
Mass (Da):36,833
Last modified:July 1, 1993 - v1
Checksum:i670E3F08D7749EFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03201 mRNA Translation: AAA40994.1
PIRiA45087
RefSeqiNP_059016.1, NM_017320.1
UniGeneiRn.11347

Genome annotation databases

GeneIDi50654
KEGGirno:50654
UCSCiRGD:621513 rat

Similar proteinsi

Entry informationi

Entry nameiCATS_RAT
AccessioniPrimary (citable) accession number: Q02765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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