Q02765 (CATS_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin S
EC=3.4.22.27

Gene names

Name:

Ctss

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N By similarity. May be involved in thyroid hormone biosynthesis.
Catalytic activity	Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
Subunit structure	Monomer.
Subcellular location	Lysosome.
Tissue specificity	Highest levels occur in the ileum followed by spleen, brain, thyroid, ovary and uterus. Low levels are found in the liver, kidney, jejunum and lung with lowest levels in the heart.
Induction	By thyroid-stimulating hormone.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Propeptide	18 – 112	95	Activation peptide		PRO_0000026317
	Chain	113 – 330	218	Cathepsin S		PRO_0000026318
Sites
	Active site	137	1	By similarity
	Active site	277	1	By similarity
	Active site	297	1	By similarity
Amino acid modifications
	Glycosylation	100	1	N-linked (GlcNAc...) Potential
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 222		By similarity
	Disulfide bond	134 ↔ 179		By similarity
	Disulfide bond	168 ↔ 211		By similarity
	Disulfide bond	271 ↔ 319		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02765 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: 670E3F08D7749EFE	FASTA	330	36,833
	10 20 30 40 50 60 MAVLGAPGVL CDNGATAERP TLDHHWDLWK KTRMRRNTDQ NEEDVRRLIW EKNLKFIMLH 70 80 90 100 110 120 NLEHSMGMHS YSVGMNHMGD MTPEEVIGYM GSLRIPRPWN RSGTLKSSSN QTLPDSVDWR 130 140 150 160 170 180 EKGCVTNVKY QGSCGSCWAF SAEGALEGQL KLKTGKLVSL SAQNLVDCST EEKYGNKGCG 190 200 210 220 230 240 GGFMTEAFQY IIDTSIDSEA SYPYKAMDEK CLYDPKNRAA TCSRYIELPF GDEEALKEAV 250 260 270 280 290 300 ATKGPVSVGI DDASHSSFFL YQSGVYDDPS CTENMNHGVL VVGYGTLDGK DYWLVKNSWG 310 320 330 LHFGDQGYIR MARNNKNHCG IASYCSYPEI

References

[1]	"Sequence analysis, tissue distribution, and expression of rat cathepsin S." Petanceska S., Devi L. J. Biol. Chem. 267:26038-26043(1992) [PubMed: 1281481] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L03201 mRNA. Translation: AAA40994.1.
IPI	IPI00210228.
PIR	A45087.
RefSeq	NP_059016.1. NM_017320.1.
UniGene	Rn.11347.
3D structure databases
ProteinModelPortal	Q02765.
ModBase	Search...
Protein family/group databases
MEROPS	C01.034.
Proteomic databases
PRIDE	Q02765.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	50654.
KEGG	rno:50654.
Organism-specific databases
CTD	1520.
RGD	621513. Ctss.
Phylogenomic databases
eggNOG	maNOG06336.
HOVERGEN	HBG011513.
Enzyme and pathway databases
BRENDA	3.4.22.27. 5301.
Gene expression databases
Genevestigator	Q02765.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
KO	K01368.
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	610462.

Entry information

Entry name

CATS_RAT

Accession

Primary (citable) accession number: Q02765

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	November 16, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program