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Protein

Cytochrome b

Gene

petB

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Iron 1 (heme b562 axial ligand)
Metal bindingi111 – 1111Iron 2 (heme b566 axial ligand)
Metal bindingi198 – 1981Iron 1 (heme b562 axial ligand)
Metal bindingi212 – 2121Iron 2 (heme b566 axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

TCDBi3.E.2.1.1. the photosynthetic reaction center (prc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Gene namesi
Name:petB
Synonyms:fbcB
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 4948Cytoplasmic1 PublicationAdd
BLAST
Transmembranei50 – 6718HelicalCuratedAdd
BLAST
Topological domaini68 – 9427Periplasmic1 PublicationAdd
BLAST
Transmembranei95 – 11319HelicalCuratedAdd
BLAST
Topological domaini114 – 12916Cytoplasmic1 PublicationAdd
BLAST
Transmembranei130 – 14920HelicalCuratedAdd
BLAST
Topological domaini150 – 19344Periplasmic1 PublicationAdd
BLAST
Transmembranei194 – 21623HelicalCuratedAdd
BLAST
Topological domaini217 – 25236Cytoplasmic1 PublicationAdd
BLAST
Transmembranei253 – 27018HelicalCuratedAdd
BLAST
Topological domaini271 – 32959Periplasmic1 PublicationAdd
BLAST
Transmembranei330 – 34617HelicalCuratedAdd
BLAST
Topological domaini347 – 36418Cytoplasmic1 PublicationAdd
BLAST
Transmembranei365 – 38218HelicalCuratedAdd
BLAST
Topological domaini383 – 3886Periplasmic1 Publication
Transmembranei389 – 40820HelicalCuratedAdd
BLAST
Topological domaini409 – 44537Cytoplasmic1 PublicationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 445444Cytochrome bPRO_0000061774Add
BLAST

Interactioni

Subunit structurei

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.By similarity

Protein-protein interaction databases

DIPiDIP-61256N.
STRINGi272943.RSP_1395.

Structurei

Secondary structure

1
445
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 207Combined sources
Helixi25 – 339Combined sources
Beta strandi36 – 383Combined sources
Helixi43 – 453Combined sources
Helixi47 – 6620Combined sources
Turni73 – 753Combined sources
Helixi76 – 8510Combined sources
Helixi90 – 11829Combined sources
Turni119 – 1213Combined sources
Turni123 – 1253Combined sources
Helixi126 – 14823Combined sources
Helixi153 – 16715Combined sources
Turni170 – 1723Combined sources
Helixi173 – 1819Combined sources
Beta strandi183 – 1864Combined sources
Helixi188 – 21932Combined sources
Helixi234 – 2407Combined sources
Beta strandi241 – 2433Combined sources
Helixi244 – 26926Combined sources
Turni271 – 2744Combined sources
Helixi277 – 2804Combined sources
Helixi296 – 2983Combined sources
Helixi299 – 3079Combined sources
Helixi313 – 3219Combined sources
Turni322 – 3243Combined sources
Helixi328 – 34417Combined sources
Helixi346 – 3494Combined sources
Helixi357 – 3593Combined sources
Helixi361 – 38121Combined sources
Helixi389 – 40517Combined sources
Helixi407 – 4148Combined sources
Helixi424 – 4296Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FYNX-ray3.20A/D/G/J/M/P1-445[»]
2QJKX-ray3.10A/D/G/J/M/P3-430[»]
2QJPX-ray2.60A/D/G/J3-430[»]
2QJYX-ray2.40A/D/G/J/M/P1-445[»]
ProteinModelPortaliQ02761.
SMRiQ02761. Positions 3-430.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02761.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DJ5. Bacteria.
COG1290. LUCA.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIPHDHYE PRTGIEKWLH SRLPIVALAY DTIMIPTPRN LNWMWIWGVV
60 70 80 90 100
LAFCLVLQIV TGIVLAMHYT PHVDLAFASV EHIMRNVNGG FMLRYLHANG
110 120 130 140 150
ASLFFIAVYL HIFRGLYYGS YKAPREVTWI VGMLIYLAMM ATAFMGYVLP
160 170 180 190 200
WGQMSFWGAT VITGLFGAIP GIGHSIQTWL LGGPAVDNAT LNRFFSLHYL
210 220 230 240 250
LPFVIAALVA IHIWAFHSTG NNNPTGVEVR RTSKAEAQKD TVPFWPYFII
260 270 280 290 300
KDVFALAVVL LVFFAIVGFM PNYLGHPDNY IEANPLSTPA HIVPEWYFLP
310 320 330 340 350
FYAILRAFTA DVWVVQIANF ISFGIIDAKF FGVLAMFGAI LVMALVPWLD
360 370 380 390 400
TSPVRSGRYR PMFKIYFWLL AADFVILTWV GAQQTTFPYD WISLIASAYW
410 420 430 440
FAYFLVILPI LGAIEKPVAP PATIEEDFNA HYSPATGGTK TVVAE
Length:445
Mass (Da):50,050
Last modified:January 23, 2007 - v2
Checksum:i3DE9FB13523CDBD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56157 Genomic DNA. Translation: CAA39624.1.
PIRiS13869.
RefSeqiWP_002722007.1. NZ_CP012960.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56157 Genomic DNA. Translation: CAA39624.1.
PIRiS13869.
RefSeqiWP_002722007.1. NZ_CP012960.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FYNX-ray3.20A/D/G/J/M/P1-445[»]
2QJKX-ray3.10A/D/G/J/M/P3-430[»]
2QJPX-ray2.60A/D/G/J3-430[»]
2QJYX-ray2.40A/D/G/J/M/P1-445[»]
ProteinModelPortaliQ02761.
SMRiQ02761. Positions 3-430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61256N.
STRINGi272943.RSP_1395.

Protein family/group databases

TCDBi3.E.2.1.1. the photosynthetic reaction center (prc) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DJ5. Bacteria.
COG1290. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ02761.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYB_RHOSH
AccessioniPrimary (citable) accession number: Q02761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.