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Protein

Cytochrome b

Gene

petB

Organism
Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.By similarity

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Iron 1 (heme b562 axial ligand)1
Metal bindingi111Iron 2 (heme b566 axial ligand)1
Metal bindingi198Iron 1 (heme b562 axial ligand)1
Metal bindingi212Iron 2 (heme b566 axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

TCDBi3.E.2.1.1. the photosynthetic reaction center (prc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b
Gene namesi
Name:petB
Synonyms:fbcB
OrganismiRhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
Taxonomic identifieri1063 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 49Cytoplasmic1 PublicationAdd BLAST48
Transmembranei50 – 67HelicalCuratedAdd BLAST18
Topological domaini68 – 94Periplasmic1 PublicationAdd BLAST27
Transmembranei95 – 113HelicalCuratedAdd BLAST19
Topological domaini114 – 129Cytoplasmic1 PublicationAdd BLAST16
Transmembranei130 – 149HelicalCuratedAdd BLAST20
Topological domaini150 – 193Periplasmic1 PublicationAdd BLAST44
Transmembranei194 – 216HelicalCuratedAdd BLAST23
Topological domaini217 – 252Cytoplasmic1 PublicationAdd BLAST36
Transmembranei253 – 270HelicalCuratedAdd BLAST18
Topological domaini271 – 329Periplasmic1 PublicationAdd BLAST59
Transmembranei330 – 346HelicalCuratedAdd BLAST17
Topological domaini347 – 364Cytoplasmic1 PublicationAdd BLAST18
Transmembranei365 – 382HelicalCuratedAdd BLAST18
Topological domaini383 – 388Periplasmic1 Publication6
Transmembranei389 – 408HelicalCuratedAdd BLAST20
Topological domaini409 – 445Cytoplasmic1 PublicationAdd BLAST37

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000617742 – 445Cytochrome bAdd BLAST444

Interactioni

Subunit structurei

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.By similarity

Protein-protein interaction databases

DIPiDIP-61256N.
STRINGi272943.RSP_1395.

Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 20Combined sources7
Helixi25 – 33Combined sources9
Beta strandi36 – 38Combined sources3
Helixi43 – 45Combined sources3
Helixi47 – 66Combined sources20
Turni73 – 75Combined sources3
Helixi76 – 85Combined sources10
Helixi90 – 118Combined sources29
Turni119 – 121Combined sources3
Turni123 – 125Combined sources3
Helixi126 – 148Combined sources23
Helixi153 – 167Combined sources15
Turni170 – 172Combined sources3
Helixi173 – 181Combined sources9
Beta strandi183 – 186Combined sources4
Helixi188 – 219Combined sources32
Helixi234 – 240Combined sources7
Beta strandi241 – 243Combined sources3
Helixi244 – 269Combined sources26
Turni271 – 274Combined sources4
Helixi277 – 280Combined sources4
Helixi296 – 298Combined sources3
Helixi299 – 307Combined sources9
Helixi313 – 321Combined sources9
Turni322 – 324Combined sources3
Helixi328 – 344Combined sources17
Helixi346 – 349Combined sources4
Helixi357 – 359Combined sources3
Helixi361 – 381Combined sources21
Helixi389 – 405Combined sources17
Helixi407 – 414Combined sources8
Helixi424 – 429Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FYNX-ray3.20A/D/G/J/M/P1-445[»]
2QJKX-ray3.10A/D/G/J/M/P3-430[»]
2QJPX-ray2.60A/D/G/J3-430[»]
2QJYX-ray2.40A/D/G/J/M/P1-445[»]
5KKZX-ray2.97A/E/K/O1-445[»]
5KLIX-ray3.00A/E/K/O1-445[»]
ProteinModelPortaliQ02761.
SMRiQ02761.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02761.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DJ5. Bacteria.
COG1290. LUCA.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIPHDHYE PRTGIEKWLH SRLPIVALAY DTIMIPTPRN LNWMWIWGVV
60 70 80 90 100
LAFCLVLQIV TGIVLAMHYT PHVDLAFASV EHIMRNVNGG FMLRYLHANG
110 120 130 140 150
ASLFFIAVYL HIFRGLYYGS YKAPREVTWI VGMLIYLAMM ATAFMGYVLP
160 170 180 190 200
WGQMSFWGAT VITGLFGAIP GIGHSIQTWL LGGPAVDNAT LNRFFSLHYL
210 220 230 240 250
LPFVIAALVA IHIWAFHSTG NNNPTGVEVR RTSKAEAQKD TVPFWPYFII
260 270 280 290 300
KDVFALAVVL LVFFAIVGFM PNYLGHPDNY IEANPLSTPA HIVPEWYFLP
310 320 330 340 350
FYAILRAFTA DVWVVQIANF ISFGIIDAKF FGVLAMFGAI LVMALVPWLD
360 370 380 390 400
TSPVRSGRYR PMFKIYFWLL AADFVILTWV GAQQTTFPYD WISLIASAYW
410 420 430 440
FAYFLVILPI LGAIEKPVAP PATIEEDFNA HYSPATGGTK TVVAE
Length:445
Mass (Da):50,050
Last modified:January 23, 2007 - v2
Checksum:i3DE9FB13523CDBD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56157 Genomic DNA. Translation: CAA39624.1.
PIRiS13869.
RefSeqiWP_002722007.1. NZ_CP015210.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56157 Genomic DNA. Translation: CAA39624.1.
PIRiS13869.
RefSeqiWP_002722007.1. NZ_CP015210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FYNX-ray3.20A/D/G/J/M/P1-445[»]
2QJKX-ray3.10A/D/G/J/M/P3-430[»]
2QJPX-ray2.60A/D/G/J3-430[»]
2QJYX-ray2.40A/D/G/J/M/P1-445[»]
5KKZX-ray2.97A/E/K/O1-445[»]
5KLIX-ray3.00A/E/K/O1-445[»]
ProteinModelPortaliQ02761.
SMRiQ02761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61256N.
STRINGi272943.RSP_1395.

Protein family/group databases

TCDBi3.E.2.1.1. the photosynthetic reaction center (prc) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105DJ5. Bacteria.
COG1290. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ02761.

Family and domain databases

CDDicd00284. Cytochrome_b_N. 1 hit.
Gene3Di1.20.810.10. 1 hit.
InterProiIPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR030689. Cytochrome_b.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PfamiPF00032. Cytochrom_B_C. 1 hit.
PF00033. Cytochrome_B. 1 hit.
[Graphical view]
PIRSFiPIRSF038885. COB. 1 hit.
SUPFAMiSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEiPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYB_RHOSH
AccessioniPrimary (citable) accession number: Q02761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.By similarity

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.