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Q02753

- RL21A_YEAST

UniProt

Q02753 - RL21A_YEAST

Protein

60S ribosomal protein L21-A

Gene

RPL21A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29133-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L21-A
    Gene namesi
    Name:RPL21A
    Synonyms:URP1
    Ordered Locus Names:YBR191W
    ORF Names:YBR1401
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR191w.
    SGDiS000000395. RPL21A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 16015960S ribosomal protein L21-APRO_0000149682Add
    BLAST

    Proteomic databases

    MaxQBiQ02753.
    PeptideAtlasiQ02753.
    PRIDEiQ02753.

    Expressioni

    Gene expression databases

    GenevestigatoriQ02753.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi32888. 69 interactions.
    IntActiQ02753. 4 interactions.
    MINTiMINT-1324156.
    STRINGi4932.YBR191W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-Q4-100[»]
    1S1Ielectron microscopy11.70Q1-100[»]
    1VW8electron microscopy6.10U1-160[»]
    1VWUelectron microscopy6.10U1-160[»]
    3IZSelectron microscopy-U1-160[»]
    3J65electron microscopy8.70T1-160[»]
    3O58X-ray4.00T1-160[»]
    3O5HX-ray4.00T1-160[»]
    3U5EX-ray3.00T1-160[»]
    3U5IX-ray3.00T1-160[»]
    4B6Aelectron microscopy8.10T1-160[»]
    4BYNelectron microscopy4.30T2-160[»]
    4BYUelectron microscopy6.60T2-160[»]
    4CUWelectron microscopy3.70T1-160[»]
    ProteinModelPortaliQ02753.
    SMRiQ02753. Positions 2-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ02753.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L21e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000001293.
    HOGENOMiHOG000194513.
    KOiK02889.
    OMAiHITVSIC.
    OrthoDBiEOG7GBG8K.

    Family and domain databases

    Gene3Di2.30.30.70. 1 hit.
    InterProiIPR001147. Ribosomal_L21e.
    IPR018259. Ribosomal_L21e_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR20981. PTHR20981. 1 hit.
    PfamiPF01157. Ribosomal_L21e. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02753-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKSHGYRSR TRYMFQRDFR KHGAVHLSTY LKVYKVGDIV DIKANGSIQK    50
    GMPHKFYQGK TGVVYNVTKS SVGVIINKMV GNRYLEKRLN LRVEHIKHSK 100
    CRQEFLERVK ANAAKRAEAK AQGVAVQLKR QPAQPRESRI VSTEGNVPQT 150
    LAPVPYETFI 160
    Length:160
    Mass (Da):18,242
    Last modified:July 1, 1993 - v1
    Checksum:i45286521C8473A72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86408 Genomic DNA. Translation: AAA35202.1.
    Z36059 Genomic DNA. Translation: CAA85153.1.
    Z21487 Genomic DNA. Translation: CAA79677.1.
    U02073 Genomic DNA. Translation: AAB60284.1.
    BK006936 Genomic DNA. Translation: DAA07305.1.
    PIRiS28921.
    RefSeqiNP_009750.1. NM_001178539.1.

    Genome annotation databases

    EnsemblFungiiYBR191W; YBR191W; YBR191W.
    GeneIDi852489.
    KEGGisce:YBR191W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M86408 Genomic DNA. Translation: AAA35202.1 .
    Z36059 Genomic DNA. Translation: CAA85153.1 .
    Z21487 Genomic DNA. Translation: CAA79677.1 .
    U02073 Genomic DNA. Translation: AAB60284.1 .
    BK006936 Genomic DNA. Translation: DAA07305.1 .
    PIRi S28921.
    RefSeqi NP_009750.1. NM_001178539.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - Q 4-100 [» ]
    1S1I electron microscopy 11.70 Q 1-100 [» ]
    1VW8 electron microscopy 6.10 U 1-160 [» ]
    1VWU electron microscopy 6.10 U 1-160 [» ]
    3IZS electron microscopy - U 1-160 [» ]
    3J65 electron microscopy 8.70 T 1-160 [» ]
    3O58 X-ray 4.00 T 1-160 [» ]
    3O5H X-ray 4.00 T 1-160 [» ]
    3U5E X-ray 3.00 T 1-160 [» ]
    3U5I X-ray 3.00 T 1-160 [» ]
    4B6A electron microscopy 8.10 T 1-160 [» ]
    4BYN electron microscopy 4.30 T 2-160 [» ]
    4BYU electron microscopy 6.60 T 2-160 [» ]
    4CUW electron microscopy 3.70 T 1-160 [» ]
    ProteinModelPortali Q02753.
    SMRi Q02753. Positions 2-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32888. 69 interactions.
    IntActi Q02753. 4 interactions.
    MINTi MINT-1324156.
    STRINGi 4932.YBR191W.

    Proteomic databases

    MaxQBi Q02753.
    PeptideAtlasi Q02753.
    PRIDEi Q02753.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR191W ; YBR191W ; YBR191W .
    GeneIDi 852489.
    KEGGi sce:YBR191W.

    Organism-specific databases

    CYGDi YBR191w.
    SGDi S000000395. RPL21A.

    Phylogenomic databases

    GeneTreei ENSGT00390000001293.
    HOGENOMi HOG000194513.
    KOi K02889.
    OMAi HITVSIC.
    OrthoDBi EOG7GBG8K.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29133-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei Q02753.
    NextBioi 971474.

    Gene expression databases

    Genevestigatori Q02753.

    Family and domain databases

    Gene3Di 2.30.30.70. 1 hit.
    InterProi IPR001147. Ribosomal_L21e.
    IPR018259. Ribosomal_L21e_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR20981. PTHR20981. 1 hit.
    Pfami PF01157. Ribosomal_L21e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    PROSITEi PS01171. RIBOSOMAL_L21E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast single copy gene URP1 is a homolog of rat ribosomal protein gene L21."
      Jank B., Waldherr M., Schweyen R.J.
      Curr. Genet. 23:15-18(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "A 12.5 kb fragment of the yeast chromosome II contains two adjacent genes encoding ribosomal proteins and six putative new genes, one of which encodes a putative transcriptional factor."
      Demolis N., Jacquet M., Mallet L.
      Yeast 10:1511-1525(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
      Strain: ATCC 204508 / S288c.
    5. "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif."
      Demolis N., Mallet L., Bussereau F., Jacquet M.
      Yeast 9:645-659(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-160.
      Strain: ATCC 204508 / S288c.
    6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 4-100, ELECTRON MICROSCOPY.
    10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 2-100, ELECTRON MICROSCOPY.
    11. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL21A_YEAST
    AccessioniPrimary (citable) accession number: Q02753
    Secondary accession number(s): D6VQI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are 2 genes for L21 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3