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Q02753

- RL21A_YEAST

UniProt

Q02753 - RL21A_YEAST

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Protein

60S ribosomal protein L21-A

Gene

RPL21A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29133-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L21-A
Gene namesi
Name:RPL21A
Synonyms:URP1
Ordered Locus Names:YBR191W
ORF Names:YBR1401
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR191w.
SGDiS000000395. RPL21A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 16015960S ribosomal protein L21-APRO_0000149682Add
BLAST

Proteomic databases

MaxQBiQ02753.
PeptideAtlasiQ02753.
PRIDEiQ02753.

Expressioni

Gene expression databases

GenevestigatoriQ02753.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi32888. 70 interactions.
IntActiQ02753. 4 interactions.
MINTiMINT-1324156.
STRINGi4932.YBR191W.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Q4-100[»]
1S1Ielectron microscopy11.70Q1-100[»]
1VW8electron microscopy6.10U1-160[»]
1VWUelectron microscopy6.10U1-160[»]
1VXVelectron microscopy6.20U1-160[»]
1VXYelectron microscopy6.30U1-160[»]
3IZSelectron microscopy-U1-160[»]
3J65electron microscopy8.70T1-160[»]
3O58X-ray4.00T1-160[»]
3O5HX-ray4.00T1-160[»]
3U5EX-ray3.00T1-160[»]
3U5IX-ray3.00T1-160[»]
4B6Aelectron microscopy8.10T1-160[»]
4BYNelectron microscopy4.30T2-160[»]
4BYUelectron microscopy6.60T2-160[»]
4CUWelectron microscopy3.70T1-160[»]
ProteinModelPortaliQ02753.
SMRiQ02753. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02753.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L21e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001293.
HOGENOMiHOG000194513.
InParanoidiQ02753.
KOiK02889.
OMAiHITVSIC.
OrthoDBiEOG7GBG8K.

Family and domain databases

Gene3Di2.30.30.70. 1 hit.
InterProiIPR001147. Ribosomal_L21e.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR20981. PTHR20981. 1 hit.
PfamiPF01157. Ribosomal_L21e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02753-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKSHGYRSR TRYMFQRDFR KHGAVHLSTY LKVYKVGDIV DIKANGSIQK
60 70 80 90 100
GMPHKFYQGK TGVVYNVTKS SVGVIINKMV GNRYLEKRLN LRVEHIKHSK
110 120 130 140 150
CRQEFLERVK ANAAKRAEAK AQGVAVQLKR QPAQPRESRI VSTEGNVPQT
160
LAPVPYETFI
Length:160
Mass (Da):18,242
Last modified:July 1, 1993 - v1
Checksum:i45286521C8473A72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86408 Genomic DNA. Translation: AAA35202.1.
Z36059 Genomic DNA. Translation: CAA85153.1.
Z21487 Genomic DNA. Translation: CAA79677.1.
U02073 Genomic DNA. Translation: AAB60284.1.
BK006936 Genomic DNA. Translation: DAA07305.1.
PIRiS28921.
RefSeqiNP_009750.1. NM_001178539.1.

Genome annotation databases

EnsemblFungiiYBR191W; YBR191W; YBR191W.
GeneIDi852489.
KEGGisce:YBR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M86408 Genomic DNA. Translation: AAA35202.1 .
Z36059 Genomic DNA. Translation: CAA85153.1 .
Z21487 Genomic DNA. Translation: CAA79677.1 .
U02073 Genomic DNA. Translation: AAB60284.1 .
BK006936 Genomic DNA. Translation: DAA07305.1 .
PIRi S28921.
RefSeqi NP_009750.1. NM_001178539.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - Q 4-100 [» ]
1S1I electron microscopy 11.70 Q 1-100 [» ]
1VW8 electron microscopy 6.10 U 1-160 [» ]
1VWU electron microscopy 6.10 U 1-160 [» ]
1VXV electron microscopy 6.20 U 1-160 [» ]
1VXY electron microscopy 6.30 U 1-160 [» ]
3IZS electron microscopy - U 1-160 [» ]
3J65 electron microscopy 8.70 T 1-160 [» ]
3O58 X-ray 4.00 T 1-160 [» ]
3O5H X-ray 4.00 T 1-160 [» ]
3U5E X-ray 3.00 T 1-160 [» ]
3U5I X-ray 3.00 T 1-160 [» ]
4B6A electron microscopy 8.10 T 1-160 [» ]
4BYN electron microscopy 4.30 T 2-160 [» ]
4BYU electron microscopy 6.60 T 2-160 [» ]
4CUW electron microscopy 3.70 T 1-160 [» ]
ProteinModelPortali Q02753.
SMRi Q02753. Positions 2-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32888. 70 interactions.
IntActi Q02753. 4 interactions.
MINTi MINT-1324156.
STRINGi 4932.YBR191W.

Proteomic databases

MaxQBi Q02753.
PeptideAtlasi Q02753.
PRIDEi Q02753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR191W ; YBR191W ; YBR191W .
GeneIDi 852489.
KEGGi sce:YBR191W.

Organism-specific databases

CYGDi YBR191w.
SGDi S000000395. RPL21A.

Phylogenomic databases

GeneTreei ENSGT00390000001293.
HOGENOMi HOG000194513.
InParanoidi Q02753.
KOi K02889.
OMAi HITVSIC.
OrthoDBi EOG7GBG8K.

Enzyme and pathway databases

BioCyci YEAST:G3O-29133-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

EvolutionaryTracei Q02753.
NextBioi 971474.

Gene expression databases

Genevestigatori Q02753.

Family and domain databases

Gene3Di 2.30.30.70. 1 hit.
InterProi IPR001147. Ribosomal_L21e.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR20981. PTHR20981. 1 hit.
Pfami PF01157. Ribosomal_L21e. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
PROSITEi PS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast single copy gene URP1 is a homolog of rat ribosomal protein gene L21."
    Jank B., Waldherr M., Schweyen R.J.
    Curr. Genet. 23:15-18(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A 12.5 kb fragment of the yeast chromosome II contains two adjacent genes encoding ribosomal proteins and six putative new genes, one of which encodes a putative transcriptional factor."
    Demolis N., Jacquet M., Mallet L.
    Yeast 10:1511-1525(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
    Strain: ATCC 204508 / S288c.
  5. "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif."
    Demolis N., Mallet L., Bussereau F., Jacquet M.
    Yeast 9:645-659(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-160.
    Strain: ATCC 204508 / S288c.
  6. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  7. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 4-100, ELECTRON MICROSCOPY.
  10. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 2-100, ELECTRON MICROSCOPY.
  11. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL21A_YEAST
AccessioniPrimary (citable) accession number: Q02753
Secondary accession number(s): D6VQI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L21 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3