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Protein

60S ribosomal protein L21-A

Gene

RPL21A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-29133-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L21-A
Gene namesi
Name:RPL21A
Synonyms:URP1
Ordered Locus Names:YBR191W
ORF Names:YBR1401
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR191W.
SGDiS000000395. RPL21A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 16015960S ribosomal protein L21-APRO_0000149682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki32 – 32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ02753.
PRIDEiQ02753.

PTM databases

iPTMnetiQ02753.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi32888. 33 interactions.
IntActiQ02753. 7 interactions.
MINTiMINT-1324156.

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni7 – 104Combined sources
Turni12 – 143Combined sources
Helixi28 – 314Combined sources
Beta strandi39 – 424Combined sources
Helixi55 – 573Combined sources
Beta strandi61 – 677Combined sources
Beta strandi69 – 8012Combined sources
Beta strandi83 – 9210Combined sources
Helixi93 – 953Combined sources
Beta strandi96 – 983Combined sources
Helixi100 – 1023Combined sources
Helixi103 – 12018Combined sources
Turni121 – 1233Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Q4-100[»]
3J6Xelectron microscopy6.10611-160[»]
3J6Yelectron microscopy6.10611-160[»]
3J77electron microscopy6.20711-160[»]
3J78electron microscopy6.30711-160[»]
3JCTelectron microscopy3.08T1-160[»]
4U3MX-ray3.00N1/n12-160[»]
4U3NX-ray3.20N1/n12-160[»]
4U3UX-ray2.90N1/n12-160[»]
4U4NX-ray3.10N1/n12-160[»]
4U4OX-ray3.60N1/n12-160[»]
4U4QX-ray3.00N1/n12-160[»]
4U4RX-ray2.80N1/n12-160[»]
4U4UX-ray3.00N1/n12-160[»]
4U4YX-ray3.20N1/n12-160[»]
4U4ZX-ray3.10N1/n12-160[»]
4U50X-ray3.20N1/n12-160[»]
4U51X-ray3.20N1/n12-160[»]
4U52X-ray3.00N1/n12-160[»]
4U53X-ray3.30N1/n12-160[»]
4U55X-ray3.20N1/n12-160[»]
4U56X-ray3.45N1/n12-160[»]
4U6FX-ray3.10N1/n12-160[»]
4V4Belectron microscopy11.70BQ1-100[»]
4V6Ielectron microscopy8.80BU1-160[»]
4V7Felectron microscopy8.70T1-160[»]
4V7RX-ray4.00BT/DT1-160[»]
4V88X-ray3.00BT/DT1-160[»]
4V8Telectron microscopy8.10T1-160[»]
4V8Yelectron microscopy4.30BT2-160[»]
4V8Zelectron microscopy6.60BT2-160[»]
4V91electron microscopy3.70T1-160[»]
5APNelectron microscopy3.91T1-160[»]
5APOelectron microscopy3.41T1-160[»]
5DC3X-ray3.25N1/n12-160[»]
5FCIX-ray3.40N1/n12-160[»]
5FCJX-ray3.10N1/n12-160[»]
5FL8electron microscopy9.50T1-160[»]
5GAKelectron microscopy3.88V1-160[»]
5I4LX-ray3.10N1/n12-160[»]
ProteinModelPortaliQ02753.
SMRiQ02753. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02753.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L21e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001293.
HOGENOMiHOG000194513.
InParanoidiQ02753.
KOiK02889.
OMAiEHVKHSA.
OrthoDBiEOG092C537Y.

Family and domain databases

Gene3Di2.30.30.70. 1 hit.
InterProiIPR001147. Ribosomal_L21e.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR20981. PTHR20981. 1 hit.
PfamiPF01157. Ribosomal_L21e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSHGYRSR TRYMFQRDFR KHGAVHLSTY LKVYKVGDIV DIKANGSIQK
60 70 80 90 100
GMPHKFYQGK TGVVYNVTKS SVGVIINKMV GNRYLEKRLN LRVEHIKHSK
110 120 130 140 150
CRQEFLERVK ANAAKRAEAK AQGVAVQLKR QPAQPRESRI VSTEGNVPQT
160
LAPVPYETFI
Length:160
Mass (Da):18,242
Last modified:July 1, 1993 - v1
Checksum:i45286521C8473A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86408 Genomic DNA. Translation: AAA35202.1.
Z36059 Genomic DNA. Translation: CAA85153.1.
Z21487 Genomic DNA. Translation: CAA79677.1.
U02073 Genomic DNA. Translation: AAB60284.1.
BK006936 Genomic DNA. Translation: DAA07305.1.
PIRiS28921.
RefSeqiNP_009750.1. NM_001178539.1.

Genome annotation databases

EnsemblFungiiYBR191W; YBR191W; YBR191W.
GeneIDi852489.
KEGGisce:YBR191W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86408 Genomic DNA. Translation: AAA35202.1.
Z36059 Genomic DNA. Translation: CAA85153.1.
Z21487 Genomic DNA. Translation: CAA79677.1.
U02073 Genomic DNA. Translation: AAB60284.1.
BK006936 Genomic DNA. Translation: DAA07305.1.
PIRiS28921.
RefSeqiNP_009750.1. NM_001178539.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Q4-100[»]
3J6Xelectron microscopy6.10611-160[»]
3J6Yelectron microscopy6.10611-160[»]
3J77electron microscopy6.20711-160[»]
3J78electron microscopy6.30711-160[»]
3JCTelectron microscopy3.08T1-160[»]
4U3MX-ray3.00N1/n12-160[»]
4U3NX-ray3.20N1/n12-160[»]
4U3UX-ray2.90N1/n12-160[»]
4U4NX-ray3.10N1/n12-160[»]
4U4OX-ray3.60N1/n12-160[»]
4U4QX-ray3.00N1/n12-160[»]
4U4RX-ray2.80N1/n12-160[»]
4U4UX-ray3.00N1/n12-160[»]
4U4YX-ray3.20N1/n12-160[»]
4U4ZX-ray3.10N1/n12-160[»]
4U50X-ray3.20N1/n12-160[»]
4U51X-ray3.20N1/n12-160[»]
4U52X-ray3.00N1/n12-160[»]
4U53X-ray3.30N1/n12-160[»]
4U55X-ray3.20N1/n12-160[»]
4U56X-ray3.45N1/n12-160[»]
4U6FX-ray3.10N1/n12-160[»]
4V4Belectron microscopy11.70BQ1-100[»]
4V6Ielectron microscopy8.80BU1-160[»]
4V7Felectron microscopy8.70T1-160[»]
4V7RX-ray4.00BT/DT1-160[»]
4V88X-ray3.00BT/DT1-160[»]
4V8Telectron microscopy8.10T1-160[»]
4V8Yelectron microscopy4.30BT2-160[»]
4V8Zelectron microscopy6.60BT2-160[»]
4V91electron microscopy3.70T1-160[»]
5APNelectron microscopy3.91T1-160[»]
5APOelectron microscopy3.41T1-160[»]
5DC3X-ray3.25N1/n12-160[»]
5FCIX-ray3.40N1/n12-160[»]
5FCJX-ray3.10N1/n12-160[»]
5FL8electron microscopy9.50T1-160[»]
5GAKelectron microscopy3.88V1-160[»]
5I4LX-ray3.10N1/n12-160[»]
ProteinModelPortaliQ02753.
SMRiQ02753. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32888. 33 interactions.
IntActiQ02753. 7 interactions.
MINTiMINT-1324156.

PTM databases

iPTMnetiQ02753.

Proteomic databases

MaxQBiQ02753.
PRIDEiQ02753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR191W; YBR191W; YBR191W.
GeneIDi852489.
KEGGisce:YBR191W.

Organism-specific databases

EuPathDBiFungiDB:YBR191W.
SGDiS000000395. RPL21A.

Phylogenomic databases

GeneTreeiENSGT00390000001293.
HOGENOMiHOG000194513.
InParanoidiQ02753.
KOiK02889.
OMAiEHVKHSA.
OrthoDBiEOG092C537Y.

Enzyme and pathway databases

BioCyciYEAST:G3O-29133-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiQ02753.
PROiQ02753.

Family and domain databases

Gene3Di2.30.30.70. 1 hit.
InterProiIPR001147. Ribosomal_L21e.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR20981. PTHR20981. 1 hit.
PfamiPF01157. Ribosomal_L21e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL21A_YEAST
AccessioniPrimary (citable) accession number: Q02753
Secondary accession number(s): D6VQI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L21 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.