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Q02751

- MALT_CANAX

UniProt

Q02751 - MALT_CANAX

Protein

Alpha-glucosidase

Gene

MAL2

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei206 – 2061NucleophileBy similarity
    Active sitei263 – 2631Proton donorBy similarity
    Sitei338 – 3381Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. maltose metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Maltose metabolism

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.
    mycoCLAPiAGL13B_CANAL.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-glucosidase (EC:3.2.1.20)
    Alternative name(s):
    Maltase
    Gene namesi
    Name:MAL2
    Synonyms:MAL1
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 570569Alpha-glucosidasePRO_0000054327Add
    BLAST

    Expressioni

    Inductioni

    By maltose and sucrose. Repressed by glucose.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Phylogenomic databases

    eggNOGiCOG0366.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02751-1 [UniParc]FASTAAdd to Basket

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    MSEHKWWKEA VVYQIWPASY KDSNGDGVGD IPGIISTLDY IASLGVTTVW    50
    LSPMYDSPQD DMGYDVSDYE NVYSKYGTLQ DMDRLIAGCH DRGLKLILDL 100
    VINHTSVEHK WFKESRSSKD NPKRDWYIWK PPRIDSNGNK HPPNNWGSYF 150
    SGSAWKYDEL TGEYYLHLFA ESQPDLNWEN KECREAIYNS AIKFWLDKGV 200
    DGFRIDTAGM YSKYQHFKDA PVAFPDTEFQ PCEIYHKNGP RIHEFHKEMA 250
    KVMEPYDTMT VGEVGHSTRE QALKYVSAAE KEMNMMFLFD VVELGSDPRD 300
    RFRYNGFDLV DLKKAIKSQG EFAEGTDAWS TVFIENHDQA RAISRFGNDS 350
    PEFRVLSGKA IAMLQCCLTG TLFIYQGQEI GMTNVPRSWP IEEYKDINTI 400
    NYYRAFKEKY GKDADYKQKE EKLVDVINRL ARDNARTPVQ WSHQQYAGFS 450
    EVEPWMRVND NYKEINVEDQ DGDDHSLLNF YRKLLKLRGE YKDLFVYGEM 500
    KFLDFDDKKL FTFAKEAPGS PVAYIVINFS GEDVKFEPLI KGNYKLVLTN 550
    VDKDSKDALS PYEARMYVVD 570
    Length:570
    Mass (Da):66,210
    Last modified:January 23, 2007 - v4
    Checksum:iF688281082968887
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94674 mRNA. Translation: AAA34350.2.
    PIRiA45249.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94674 mRNA. Translation: AAA34350.2 .
    PIRi A45249.

    3D structure databases

    ProteinModelPortali Q02751.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH13. Glycoside Hydrolase Family 13.
    mycoCLAPi AGL13B_CANAL.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0366.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a Candida albicans maltase gene involved in sucrose utilization."
      Geber A., Williamson P.R., Rex J.H., Sweeney E.C., Bennett J.E.
      J. Bacteriol. 174:6992-6996(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-27.
      Strain: ATCC 32354 / B311.

    Entry informationi

    Entry nameiMALT_CANAX
    AccessioniPrimary (citable) accession number: Q02751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3