Reviewed, UniProtKB/Swiss-Prot Q02751 (MALT_CANAL)

Names and origin

Protein names

Recommended name:
    Alpha-glucosidase
    EC=3.2.1.20
Alternative name(s):
    Maltase

Gene names

Name:	MAL2
Synonyms:	MAL1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Induction	By maltose and sucrose. Repressed by glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
Biological process	Maltose metabolism
Molecular function	Glycosidase Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	maltose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alpha-glucosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 570	569	Alpha-glucosidase		PRO_0000054327
Sites
	Active site	206	1	Nucleophile By similarity
	Active site	263	1	Proton donor By similarity
	Active site	338	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q02751-1 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: F688281082968887	FASTA	570	66,210
	10 20 30 40 50 60 MSEHKWWKEA VVYQIWPASY KDSNGDGVGD IPGIISTLDY IASLGVTTVW LSPMYDSPQD 70 80 90 100 110 120 DMGYDVSDYE NVYSKYGTLQ DMDRLIAGCH DRGLKLILDL VINHTSVEHK WFKESRSSKD 130 140 150 160 170 180 NPKRDWYIWK PPRIDSNGNK HPPNNWGSYF SGSAWKYDEL TGEYYLHLFA ESQPDLNWEN 190 200 210 220 230 240 KECREAIYNS AIKFWLDKGV DGFRIDTAGM YSKYQHFKDA PVAFPDTEFQ PCEIYHKNGP 250 260 270 280 290 300 RIHEFHKEMA KVMEPYDTMT VGEVGHSTRE QALKYVSAAE KEMNMMFLFD VVELGSDPRD 310 320 330 340 350 360 RFRYNGFDLV DLKKAIKSQG EFAEGTDAWS TVFIENHDQA RAISRFGNDS PEFRVLSGKA 370 380 390 400 410 420 IAMLQCCLTG TLFIYQGQEI GMTNVPRSWP IEEYKDINTI NYYRAFKEKY GKDADYKQKE 430 440 450 460 470 480 EKLVDVINRL ARDNARTPVQ WSHQQYAGFS EVEPWMRVND NYKEINVEDQ DGDDHSLLNF 490 500 510 520 530 540 YRKLLKLRGE YKDLFVYGEM KFLDFDDKKL FTFAKEAPGS PVAYIVINFS GEDVKFEPLI 550 560 570 KGNYKLVLTN VDKDSKDALS PYEARMYVVD

References

[1]

"Cloning and characterization of a Candida albicans maltase gene involved in sucrose utilization." Geber A., Williamson P.R., Rex J.H., Sweeney E.C., Bennett J.E. J. Bacteriol. 174:6992-6996(1992) [PubMed: 1400249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-27. Strain: ATCC 32354 / B311.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M94674 mRNA. Translation: AAA34350.2.
PIR	A45249.
3D structure databases
SMR	Q02751. Positions 3-569.
ModBase	Search...
Protein family/group databases
CAZy	GH13. Glycoside Hydrolase Family 13.
Phylogenomic databases
OMA	EKEMNMM.
Enzyme and pathway databases
BRENDA	3.2.1.20. 1124.
Family and domain databases
InterPro	IPR013780. Glyco_hydro_13_b. IPR006047. Glyco_hydro_13_cat_dom. IPR006589. Glyco_hydro_13_sub_cat_dom. IPR017853. Glyco_hydro_catalytic_core. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:2.60.40.1180. Glyco_hydro_13_b. 1 hit. G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00128. Alpha-amylase. 1 hit. [Graphical view]
SMART	SM00642. Aamy. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MALT_CANAL

Accession

Primary (citable) accession number: Q02751

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 57 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)