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Q02751

- MALT_CANAX

UniProt

Q02751 - MALT_CANAX

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Protein

Alpha-glucosidase

Gene
MAL2, MAL1
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061Nucleophile By similarity
Active sitei263 – 2631Proton donor By similarity
Sitei338 – 3381Transition state stabilizer By similarity

GO - Molecular functioni

  1. cation binding Source: InterPro
  2. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. maltose metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Maltose metabolism

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.
mycoCLAPiAGL13B_CANAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-glucosidase (EC:3.2.1.20)
Alternative name(s):
Maltase
Gene namesi
Name:MAL2
Synonyms:MAL1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 570569Alpha-glucosidasePRO_0000054327Add
BLAST

Expressioni

Inductioni

By maltose and sucrose. Repressed by glucose.

Structurei

3D structure databases

ProteinModelPortaliQ02751.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0366.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02751-1 [UniParc]FASTAAdd to Basket

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MSEHKWWKEA VVYQIWPASY KDSNGDGVGD IPGIISTLDY IASLGVTTVW    50
LSPMYDSPQD DMGYDVSDYE NVYSKYGTLQ DMDRLIAGCH DRGLKLILDL 100
VINHTSVEHK WFKESRSSKD NPKRDWYIWK PPRIDSNGNK HPPNNWGSYF 150
SGSAWKYDEL TGEYYLHLFA ESQPDLNWEN KECREAIYNS AIKFWLDKGV 200
DGFRIDTAGM YSKYQHFKDA PVAFPDTEFQ PCEIYHKNGP RIHEFHKEMA 250
KVMEPYDTMT VGEVGHSTRE QALKYVSAAE KEMNMMFLFD VVELGSDPRD 300
RFRYNGFDLV DLKKAIKSQG EFAEGTDAWS TVFIENHDQA RAISRFGNDS 350
PEFRVLSGKA IAMLQCCLTG TLFIYQGQEI GMTNVPRSWP IEEYKDINTI 400
NYYRAFKEKY GKDADYKQKE EKLVDVINRL ARDNARTPVQ WSHQQYAGFS 450
EVEPWMRVND NYKEINVEDQ DGDDHSLLNF YRKLLKLRGE YKDLFVYGEM 500
KFLDFDDKKL FTFAKEAPGS PVAYIVINFS GEDVKFEPLI KGNYKLVLTN 550
VDKDSKDALS PYEARMYVVD 570
Length:570
Mass (Da):66,210
Last modified:January 23, 2007 - v4
Checksum:iF688281082968887
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94674 mRNA. Translation: AAA34350.2.
PIRiA45249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94674 mRNA. Translation: AAA34350.2 .
PIRi A45249.

3D structure databases

ProteinModelPortali Q02751.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH13. Glycoside Hydrolase Family 13.
mycoCLAPi AGL13B_CANAL.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0366.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a Candida albicans maltase gene involved in sucrose utilization."
    Geber A., Williamson P.R., Rex J.H., Sweeney E.C., Bennett J.E.
    J. Bacteriol. 174:6992-6996(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-27.
    Strain: ATCC 32354 / B311.

Entry informationi

Entry nameiMALT_CANAX
AccessioniPrimary (citable) accession number: Q02751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 78 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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