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Protein

Guanylin

Gene

GUCA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.

GO - Molecular functioni

  • guanylate cyclase activator activity Source: UniProtKB
  • hormone activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SIGNORiQ02747.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylin
Alternative name(s):
Guanylate cyclase activator 2A
Guanylate cyclase-activating protein 1
Guanylate cyclase-activating protein I
Short name:
GCAP-I
Cleaved into the following 2 chains:
Gene namesi
Name:GUCA2A
Synonyms:GUCA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4682. GUCA2A.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29065.

Polymorphism and mutation databases

BioMutaiGUCA2A.
DMDMi290457645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 11594HMW-guanylinPRO_0000013135Add
BLAST
Peptidei101 – 11515GuanylinPRO_0000013136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 821 Publication
Disulfide bondi104 ↔ 1121 Publication
Disulfide bondi107 ↔ 1151 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ02747.
PeptideAtlasiQ02747.
PRIDEiQ02747.

Expressioni

Tissue specificityi

Highly expressed in ileum and colon. Found in plasma.

Gene expression databases

BgeeiENSG00000197273.
CleanExiHS_GUCA2A.
GenevisibleiQ02747. HS.

Organism-specific databases

HPAiHPA018215.

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Protein-protein interaction databases

BioGridi109235. 1 interaction.
STRINGi9606.ENSP00000349493.

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 319Combined sources
Helixi34 – 374Combined sources
Turni38 – 414Combined sources
Helixi76 – 783Combined sources
Helixi79 – 824Combined sources
Helixi87 – 9812Combined sources
Turni104 – 1074Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GNANMR-A103-115[»]
1GNBNMR-A103-115[»]
1O8RNMR-A22-115[»]
ProteinModelPortaliQ02747.
SMRiQ02747. Positions 22-115.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ02747.

Family & Domainsi

Sequence similaritiesi

Belongs to the guanylin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiQ02747.
OMAiSCEICAF.
OrthoDBiEOG091G0WKF.
PhylomeDBiQ02747.
TreeFamiTF330731.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q02747-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV
60 70 80 90 100
GKLRNFAPIP GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED
110
PGTCEICAYA ACTGC
Length:115
Mass (Da):12,388
Last modified:March 2, 2010 - v2
Checksum:iC644DA910EED26FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71S → F.3 Publications
Corresponds to variant rs2071499 [ dbSNP | Ensembl ].
VAR_062678

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97496 mRNA. Translation: AAA35915.1.
M95174 mRNA. Translation: AAA58625.1.
X74322 Genomic DNA. Translation: CAC22258.1.
AC114492 Genomic DNA. No translation available.
CCDSiCCDS465.1.
PIRiA46279.
RefSeqiNP_291031.2. NM_033553.2.
UniGeneiHs.778.

Genome annotation databases

EnsembliENST00000357001; ENSP00000349493; ENSG00000197273.
GeneIDi2980.
KEGGihsa:2980.
UCSCiuc001chd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97496 mRNA. Translation: AAA35915.1.
M95174 mRNA. Translation: AAA58625.1.
X74322 Genomic DNA. Translation: CAC22258.1.
AC114492 Genomic DNA. No translation available.
CCDSiCCDS465.1.
PIRiA46279.
RefSeqiNP_291031.2. NM_033553.2.
UniGeneiHs.778.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GNANMR-A103-115[»]
1GNBNMR-A103-115[»]
1O8RNMR-A22-115[»]
ProteinModelPortaliQ02747.
SMRiQ02747. Positions 22-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109235. 1 interaction.
STRINGi9606.ENSP00000349493.

Polymorphism and mutation databases

BioMutaiGUCA2A.
DMDMi290457645.

Proteomic databases

PaxDbiQ02747.
PeptideAtlasiQ02747.
PRIDEiQ02747.

Protocols and materials databases

DNASUi2980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357001; ENSP00000349493; ENSG00000197273.
GeneIDi2980.
KEGGihsa:2980.
UCSCiuc001chd.2. human.

Organism-specific databases

CTDi2980.
GeneCardsiGUCA2A.
H-InvDBHIX0028941.
HGNCiHGNC:4682. GUCA2A.
HPAiHPA018215.
MIMi139392. gene.
neXtProtiNX_Q02747.
PharmGKBiPA29065.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J44S. Eukaryota.
ENOG410Z6NA. LUCA.
GeneTreeiENSGT00730000111358.
HOGENOMiHOG000231183.
HOVERGENiHBG051861.
InParanoidiQ02747.
OMAiSCEICAF.
OrthoDBiEOG091G0WKF.
PhylomeDBiQ02747.
TreeFamiTF330731.

Enzyme and pathway databases

SIGNORiQ02747.

Miscellaneous databases

EvolutionaryTraceiQ02747.
GenomeRNAii2980.
PROiQ02747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197273.
CleanExiHS_GUCA2A.
GenevisibleiQ02747. HS.

Family and domain databases

Gene3Di3.90.1450.10. 1 hit.
InterProiIPR000879. Guanylin.
[Graphical view]
PANTHERiPTHR11318. PTHR11318. 1 hit.
PfamiPF02058. Guanylin. 1 hit.
[Graphical view]
PIRSFiPIRSF001849. Guanylin. 1 hit.
PRINTSiPR00774. GUANYLIN.
ProDomiPD005588. Guanylin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF89890. SSF89890. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGUC2A_HUMAN
AccessioniPrimary (citable) accession number: Q02747
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 2, 2010
Last modified: September 7, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.