ID   CXB5_MOUSE              Reviewed;         271 AA.
AC   Q02739;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   24-JAN-2024, entry version 152.
DE   RecName: Full=Gap junction beta-5 protein;
DE   AltName: Full=Connexin-31.1;
DE            Short=Cx31.1;
GN   Name=Gjb5; Synonyms=Cxn-31.1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=1512260; DOI=10.1016/s0021-9258(18)41916-3;
RA   Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S.,
RA   Nicholson B.J., Willecke K.;
RT   "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on
RT   mouse chromosome 4 and preferentially expressed in skin.";
RL   J. Biol. Chem. 267:17225-17233(1992).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Expressed in skin, much lower in testis.
CC   -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M91236; AAA37426.1; -; mRNA.
DR   EMBL; M91442; AAA37427.1; -; Genomic_DNA.
DR   CCDS; CCDS18670.1; -.
DR   PIR; B43433; B43433.
DR   RefSeq; NP_034421.1; NM_010291.3.
DR   AlphaFoldDB; Q02739; -.
DR   SMR; Q02739; -.
DR   STRING; 10090.ENSMUSP00000045325; -.
DR   iPTMnet; Q02739; -.
DR   PhosphoSitePlus; Q02739; -.
DR   PaxDb; 10090-ENSMUSP00000045325; -.
DR   ProteomicsDB; 279218; -.
DR   Antibodypedia; 31495; 181 antibodies from 25 providers.
DR   DNASU; 14622; -.
DR   Ensembl; ENSMUST00000046498.3; ENSMUSP00000045325.3; ENSMUSG00000042357.3.
DR   GeneID; 14622; -.
DR   KEGG; mmu:14622; -.
DR   UCSC; uc008uuv.1; mouse.
DR   AGR; MGI:95723; -.
DR   CTD; 2709; -.
DR   MGI; MGI:95723; Gjb5.
DR   VEuPathDB; HostDB:ENSMUSG00000042357; -.
DR   eggNOG; ENOG502R3YE; Eukaryota.
DR   GeneTree; ENSGT01030000234513; -.
DR   HOGENOM; CLU_037388_4_1_1; -.
DR   InParanoid; Q02739; -.
DR   OMA; HSFYPKY; -.
DR   OrthoDB; 5301774at2759; -.
DR   PhylomeDB; Q02739; -.
DR   TreeFam; TF329606; -.
DR   Reactome; R-MMU-190861; Gap junction assembly.
DR   BioGRID-ORCS; 14622; 1 hit in 80 CRISPR screens.
DR   PRO; PR:Q02739; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q02739; Protein.
DR   Bgee; ENSMUSG00000042357; Expressed in ectoplacental cone and 54 other cell types or tissues.
DR   ExpressionAtlas; Q02739; baseline and differential.
DR   GO; GO:0005922; C:connexin complex; IBA:GO_Central.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   GO; GO:1905867; P:epididymis development; IEA:Ensembl.
DR   GO; GO:0060713; P:labyrinthine layer morphogenesis; IMP:MGI.
DR   GO; GO:0060708; P:spongiotrophoblast differentiation; IMP:MGI.
DR   GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
DR   Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002271; Connexin311.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; CONNEXIN; 1.
DR   PANTHER; PTHR11984:SF29; GAP JUNCTION BETA-5 PROTEIN; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01141; CONNEXINB4.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
DR   Genevisible; Q02739; MM.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..271
FT                   /note="Gap junction beta-5 protein"
FT                   /id="PRO_0000057869"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..75
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  31195 MW;  F8732F5A8F5CD51A CRC64;
     MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD FDCNTRQPGC
     TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA REKKYQEKIG EGYLYPNPGK
     KRGGLWWTYV FSLSFKATID IIFLYLFHAF YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE
     KNIFIVFMVV TAVICILLNL VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD
     FLSCDLIFLG SDAHPPLLPD RPRAHVKKTI L
//