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Protein

Gap junction beta-5 protein

Gene

Gjb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • epididymis development Source: Ensembl
  • labyrinthine layer morphogenesis Source: MGI
  • spongiotrophoblast differentiation Source: MGI
  • trophoblast giant cell differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name:
Cx31.1
Gene namesi
Name:Gjb5
Synonyms:Cxn-31.1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95723. Gjb5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 124CytoplasmicSequence analysisAdd BLAST26
Transmembranei125 – 147HelicalSequence analysisAdd BLAST23
Topological domaini148 – 183ExtracellularSequence analysisAdd BLAST36
Transmembranei184 – 206HelicalSequence analysisAdd BLAST23
Topological domaini207 – 271CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578691 – 271Gap junction beta-5 proteinAdd BLAST271

Proteomic databases

PaxDbiQ02739.
PRIDEiQ02739.

PTM databases

iPTMnetiQ02739.
PhosphoSitePlusiQ02739.

Expressioni

Tissue specificityi

Expressed in skin, much lower in testis.

Gene expression databases

BgeeiENSMUSG00000042357.
CleanExiMM_GJB5.
ExpressionAtlasiQ02739. baseline and differential.
GenevisibleiQ02739. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045325.

Structurei

3D structure databases

ProteinModelPortaliQ02739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00900000140773.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02739.
KOiK07624.
OMAiWSDDHKD.
OrthoDBiEOG091G0FKH.
PhylomeDBiQ02739.
TreeFamiTF329606.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA
110 120 130 140 150
REKKYQEKIG EGYLYPNPGK KRGGLWWTYV FSLSFKATID IIFLYLFHAF
160 170 180 190 200
YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE KNIFIVFMVV TAVICILLNL
210 220 230 240 250
VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD FLSCDLIFLG
260 270
SDAHPPLLPD RPRAHVKKTI L
Length:271
Mass (Da):31,195
Last modified:February 1, 1994 - v1
Checksum:iF8732F5A8F5CD51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91236 mRNA. Translation: AAA37426.1.
M91442 Genomic DNA. Translation: AAA37427.1.
CCDSiCCDS18670.1.
PIRiB43433.
RefSeqiNP_034421.1. NM_010291.3.
UniGeneiMm.26859.

Genome annotation databases

EnsembliENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
GeneIDi14622.
KEGGimmu:14622.
UCSCiuc008uuv.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCXB5_MOUSE
AccessioniPrimary (citable) accession number: Q02739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 25, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families