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Protein

Gap junction beta-5 protein

Gene

Gjb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • epididymis development Source: Ensembl
  • labyrinthine layer morphogenesis Source: MGI
  • spongiotrophoblast differentiation Source: MGI
  • trophoblast giant cell differentiation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name:
Cx31.1
Gene namesi
Name:Gjb5
Synonyms:Cxn-31.1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95723 Gjb5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 124CytoplasmicSequence analysisAdd BLAST26
Transmembranei125 – 147HelicalSequence analysisAdd BLAST23
Topological domaini148 – 183ExtracellularSequence analysisAdd BLAST36
Transmembranei184 – 206HelicalSequence analysisAdd BLAST23
Topological domaini207 – 271CytoplasmicSequence analysisAdd BLAST65

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578691 – 271Gap junction beta-5 proteinAdd BLAST271

Proteomic databases

PaxDbiQ02739
PRIDEiQ02739

PTM databases

iPTMnetiQ02739
PhosphoSitePlusiQ02739

Expressioni

Tissue specificityi

Expressed in skin, much lower in testis.

Gene expression databases

BgeeiENSMUSG00000042357
CleanExiMM_GJB5
ExpressionAtlasiQ02739 baseline and differential
GenevisibleiQ02739 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045325

Structurei

3D structure databases

ProteinModelPortaliQ02739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ02739
KOiK07624
OMAiWSDDHKD
OrthoDBiEOG091G0FKH
PhylomeDBiQ02739
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.801 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002271 Connexin303
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01141 CONNEXINB4
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q02739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA
110 120 130 140 150
REKKYQEKIG EGYLYPNPGK KRGGLWWTYV FSLSFKATID IIFLYLFHAF
160 170 180 190 200
YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE KNIFIVFMVV TAVICILLNL
210 220 230 240 250
VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD FLSCDLIFLG
260 270
SDAHPPLLPD RPRAHVKKTI L
Length:271
Mass (Da):31,195
Last modified:February 1, 1994 - v1
Checksum:iF8732F5A8F5CD51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91236 mRNA Translation: AAA37426.1
M91442 Genomic DNA Translation: AAA37427.1
CCDSiCCDS18670.1
PIRiB43433
RefSeqiNP_034421.1, NM_010291.3
UniGeneiMm.26859

Genome annotation databases

EnsembliENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357
GeneIDi14622
KEGGimmu:14622
UCSCiuc008uuv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCXB5_MOUSE
AccessioniPrimary (citable) accession number: Q02739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome