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Q02739

- CXB5_MOUSE

UniProt

Q02739 - CXB5_MOUSE

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Protein

Gap junction beta-5 protein

Gene

Gjb5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. cell communication Source: InterPro
  2. labyrinthine layer morphogenesis Source: MGI
  3. spongiotrophoblast differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name:
Cx31.1
Gene namesi
Name:Gjb5
Synonyms:Cxn-31.1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95723. Gjb5.

Subcellular locationi

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Gap junction beta-5 proteinPRO_0000057869Add
BLAST

Proteomic databases

PRIDEiQ02739.

PTM databases

PhosphoSiteiQ02739.

Expressioni

Tissue specificityi

Expressed in skin, much lower in testis.

Gene expression databases

BgeeiQ02739.
CleanExiMM_GJB5.
ExpressionAtlasiQ02739. differential.
GenevestigatoriQ02739.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045325.

Structurei

3D structure databases

ProteinModelPortaliQ02739.
SMRiQ02739. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
BLAST
Topological domaini99 – 12426CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini148 – 18336ExtracellularSequence AnalysisAdd
BLAST
Topological domaini207 – 27165CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14723HelicalSequence AnalysisAdd
BLAST
Transmembranei184 – 20623HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39157.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02739.
KOiK07624.
OMAiCSLVFKA.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ02739.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF28. PTHR11984:SF28. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02739-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA
110 120 130 140 150
REKKYQEKIG EGYLYPNPGK KRGGLWWTYV FSLSFKATID IIFLYLFHAF
160 170 180 190 200
YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE KNIFIVFMVV TAVICILLNL
210 220 230 240 250
VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD FLSCDLIFLG
260 270
SDAHPPLLPD RPRAHVKKTI L
Length:271
Mass (Da):31,195
Last modified:February 1, 1994 - v1
Checksum:iF8732F5A8F5CD51A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91236 mRNA. Translation: AAA37426.1.
M91442 Genomic DNA. Translation: AAA37427.1.
CCDSiCCDS18670.1.
PIRiB43433.
RefSeqiNP_034421.1. NM_010291.3.
UniGeneiMm.26859.

Genome annotation databases

EnsembliENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
GeneIDi14622.
KEGGimmu:14622.
UCSCiuc008uuv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M91236 mRNA. Translation: AAA37426.1 .
M91442 Genomic DNA. Translation: AAA37427.1 .
CCDSi CCDS18670.1.
PIRi B43433.
RefSeqi NP_034421.1. NM_010291.3.
UniGenei Mm.26859.

3D structure databases

ProteinModelPortali Q02739.
SMRi Q02739. Positions 2-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000045325.

PTM databases

PhosphoSitei Q02739.

Proteomic databases

PRIDEi Q02739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046498 ; ENSMUSP00000045325 ; ENSMUSG00000042357 .
GeneIDi 14622.
KEGGi mmu:14622.
UCSCi uc008uuv.1. mouse.

Organism-specific databases

CTDi 2709.
MGIi MGI:95723. Gjb5.

Phylogenomic databases

eggNOGi NOG39157.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi Q02739.
KOi K07624.
OMAi CSLVFKA.
OrthoDBi EOG7P2XSS.
PhylomeDBi Q02739.
TreeFami TF329606.

Miscellaneous databases

NextBioi 286452.
PROi Q02739.
SOURCEi Search...

Gene expression databases

Bgeei Q02739.
CleanExi MM_GJB5.
ExpressionAtlasi Q02739. differential.
Genevestigatori Q02739.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
PTHR11984:SF28. PTHR11984:SF28. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
    Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
    J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiCXB5_MOUSE
AccessioniPrimary (citable) accession number: Q02739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3