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Q02739 (CXB5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name=Cx31.1
Gene names
Name:Gjb5
Synonyms:Cxn-31.1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Expressed in skin, much lower in testis.

Sequence similarities

Belongs to the connexin family. Beta-type (group I) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Gap junction beta-5 protein
PRO_0000057869

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4020Helical; Potential
Topological domain41 – 7535Extracellular Potential
Transmembrane76 – 9823Helical; Potential
Topological domain99 – 12426Cytoplasmic Potential
Transmembrane125 – 14723Helical; Potential
Topological domain148 – 18336Extracellular Potential
Transmembrane184 – 20623Helical; Potential
Topological domain207 – 27165Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q02739 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: F8732F5A8F5CD51A

FASTA27131,195
        10         20         30         40         50         60 
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD FDCNTRQPGC 

        70         80         90        100        110        120 
TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA REKKYQEKIG EGYLYPNPGK 

       130        140        150        160        170        180 
KRGGLWWTYV FSLSFKATID IIFLYLFHAF YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE 

       190        200        210        220        230        240 
KNIFIVFMVV TAVICILLNL VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD 

       250        260        270 
FLSCDLIFLG SDAHPPLLPD RPRAHVKKTI L 

« Hide

References

[1]"Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91236 mRNA. Translation: AAA37426.1.
M91442 Genomic DNA. Translation: AAA37427.1.
PIRB43433.
RefSeqNP_034421.1. NM_010291.3.
UniGeneMm.26859.

3D structure databases

ProteinModelPortalQ02739.
SMRQ02739. Positions 2-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000045325.

PTM databases

PhosphoSiteQ02739.

Proteomic databases

PRIDEQ02739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
GeneID14622.
KEGGmmu:14622.
UCSCuc008uuv.1. mouse.

Organism-specific databases

CTD2709.
MGIMGI:95723. Gjb5.

Phylogenomic databases

eggNOGNOG39157.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidQ02739.
KOK07624.
OMAVWSDDHK.
OrthoDBEOG7P2XSS.
TreeFamTF329606.

Gene expression databases

ArrayExpressQ02739.
BgeeQ02739.
CleanExMM_GJB5.
GenevestigatorQ02739.

Family and domain databases

InterProIPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF28. PTHR11984:SF28. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286452.
PROQ02739.
SOURCESearch...

Entry information

Entry nameCXB5_MOUSE
AccessionPrimary (citable) accession number: Q02739
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot