Q02739 (CXB5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gap junction beta-5 protein

Alternative name(s):
Connexin-31.1
Short name=Cx31.1

Gene names

Name:	Gjb5
Synonyms:	Cxn-31.1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit structure	A connexon is composed of a hexamer of connexins.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
Tissue specificity	Expressed in skin, much lower in testis.
Sequence similarities	Belongs to the connexin family. Beta-type (group I) subfamily.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro labyrinthine layer morphogenesis Inferred from mutant phenotype PubMed 17961533. Source: MGI spongiotrophoblast differentiation Inferred from mutant phenotype PubMed 17961533. Source: MGI
Cellular_component	connexon complex Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Gap junction beta-5 protein		PRO_0000057869
Regions
	Topological domain	1 – 20	20	Cytoplasmic Potential
	Transmembrane	21 – 40	20	Helical; Potential
	Topological domain	41 – 75	35	Extracellular Potential
	Transmembrane	76 – 98	23	Helical; Potential
	Topological domain	99 – 124	26	Cytoplasmic Potential
	Transmembrane	125 – 147	23	Helical; Potential
	Topological domain	148 – 183	36	Extracellular Potential
	Transmembrane	184 – 206	23	Helical; Potential
	Topological domain	207 – 271	65	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q02739 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: F8732F5A8F5CD51A	FASTA	271	31,195
	10 20 30 40 50 60 MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD FDCNTRQPGC 70 80 90 100 110 120 TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA REKKYQEKIG EGYLYPNPGK 130 140 150 160 170 180 KRGGLWWTYV FSLSFKATID IIFLYLFHAF YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE 190 200 210 220 230 240 KNIFIVFMVV TAVICILLNL VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD 250 260 270 FLSCDLIFLG SDAHPPLLPD RPRAHVKKTI L

References

[1]	"Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin." Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K. J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91236 mRNA. Translation: AAA37426.1. M91442 Genomic DNA. Translation: AAA37427.1.
IPI	IPI00131281.
PIR	B43433.
RefSeq	NP_034421.1. NM_010291.3.
UniGene	Mm.26859.
3D structure databases
ProteinModelPortal	Q02739.
SMR	Q02739. Positions 2-209.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000045325.
PTM databases
PhosphoSite	Q02739.
Proteomic databases
PRIDE	Q02739.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
GeneID	14622.
KEGG	mmu:14622.
Organism-specific databases
CTD	2709.
MGI	MGI:95723. Gjb5.
Phylogenomic databases
eggNOG	NOG39157.
HOGENOM	HOG000231127.
HOVERGEN	HBG009576.
InParanoid	Q02739.
KO	K07624.
OMA	SDDHKDF.
OrthoDB	EOG4S7JR0.
Gene expression databases
ArrayExpress	Q02739.
Bgee	Q02739.
CleanEx	MM_GJB5.
Genevestigator	Q02739.
GermOnline	ENSMUSG00000042357. Mus musculus.
Family and domain databases
InterPro	IPR000500. Connexin. IPR002270. Connexin311. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. [Graphical view]
PANTHER	PTHR11984. PTHR11984. 1 hit. PTHR11984:SF28. PTHR11984:SF28. 1 hit.
Pfam	PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view]
PRINTS	PR00206. CONNEXIN. PR01141. CONNEXINB4.
SMART	SM00037. CNX. 1 hit. SM01089. Connexin_CCC. 1 hit. [Graphical view]
PROSITE	PS00407. CONNEXINS_1. 1 hit. PS00408. CONNEXINS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286452.
SOURCE	Search...

Entry information

Entry name

CXB5_MOUSE

Accession

Primary (citable) accession number: Q02739

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program