Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction beta-5 protein

Gene

Gjb5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • labyrinthine layer morphogenesis Source: MGI
  • spongiotrophoblast differentiation Source: MGI
  • trophoblast giant cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-5 protein
Alternative name(s):
Connexin-31.1
Short name:
Cx31.1
Gene namesi
Name:Gjb5
Synonyms:Cxn-31.1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95723. Gjb5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 12426CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei125 – 14723HelicalSequence AnalysisAdd
BLAST
Topological domaini148 – 18336ExtracellularSequence AnalysisAdd
BLAST
Transmembranei184 – 20623HelicalSequence AnalysisAdd
BLAST
Topological domaini207 – 27165CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Gap junction beta-5 proteinPRO_0000057869Add
BLAST

Proteomic databases

PRIDEiQ02739.

PTM databases

PhosphoSiteiQ02739.

Expressioni

Tissue specificityi

Expressed in skin, much lower in testis.

Gene expression databases

BgeeiQ02739.
CleanExiMM_GJB5.
ExpressionAtlasiQ02739. baseline and differential.
GenevisibleiQ02739. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045325.

Structurei

3D structure databases

ProteinModelPortaliQ02739.
SMRiQ02739. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39157.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02739.
KOiK07624.
OMAiVWSDDHK.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ02739.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF28. PTHR11984:SF28. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA
110 120 130 140 150
REKKYQEKIG EGYLYPNPGK KRGGLWWTYV FSLSFKATID IIFLYLFHAF
160 170 180 190 200
YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE KNIFIVFMVV TAVICILLNL
210 220 230 240 250
VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD FLSCDLIFLG
260 270
SDAHPPLLPD RPRAHVKKTI L
Length:271
Mass (Da):31,195
Last modified:February 1, 1994 - v1
Checksum:iF8732F5A8F5CD51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91236 mRNA. Translation: AAA37426.1.
M91442 Genomic DNA. Translation: AAA37427.1.
CCDSiCCDS18670.1.
PIRiB43433.
RefSeqiNP_034421.1. NM_010291.3.
UniGeneiMm.26859.

Genome annotation databases

EnsembliENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
GeneIDi14622.
KEGGimmu:14622.
UCSCiuc008uuv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91236 mRNA. Translation: AAA37426.1.
M91442 Genomic DNA. Translation: AAA37427.1.
CCDSiCCDS18670.1.
PIRiB43433.
RefSeqiNP_034421.1. NM_010291.3.
UniGeneiMm.26859.

3D structure databases

ProteinModelPortaliQ02739.
SMRiQ02739. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045325.

PTM databases

PhosphoSiteiQ02739.

Proteomic databases

PRIDEiQ02739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
GeneIDi14622.
KEGGimmu:14622.
UCSCiuc008uuv.1. mouse.

Organism-specific databases

CTDi2709.
MGIiMGI:95723. Gjb5.

Phylogenomic databases

eggNOGiNOG39157.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02739.
KOiK07624.
OMAiVWSDDHK.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ02739.
TreeFamiTF329606.

Miscellaneous databases

NextBioi286452.
PROiQ02739.
SOURCEiSearch...

Gene expression databases

BgeeiQ02739.
CleanExiMM_GJB5.
ExpressionAtlasiQ02739. baseline and differential.
GenevisibleiQ02739. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002270. Connexin311.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF28. PTHR11984:SF28. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01141. CONNEXINB4.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
    Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
    J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiCXB5_MOUSE
AccessioniPrimary (citable) accession number: Q02739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 24, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.