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Q02739

- CXB5_MOUSE

UniProt

Q02739 - CXB5_MOUSE

Protein

Gap junction beta-5 protein

Gene

Gjb5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Biological processi

    1. cell communication Source: InterPro
    2. labyrinthine layer morphogenesis Source: MGI
    3. spongiotrophoblast differentiation Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction beta-5 protein
    Alternative name(s):
    Connexin-31.1
    Short name:
    Cx31.1
    Gene namesi
    Name:Gjb5
    Synonyms:Cxn-31.1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95723. Gjb5.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Gap junction beta-5 proteinPRO_0000057869Add
    BLAST

    Proteomic databases

    PRIDEiQ02739.

    PTM databases

    PhosphoSiteiQ02739.

    Expressioni

    Tissue specificityi

    Expressed in skin, much lower in testis.

    Gene expression databases

    BgeeiQ02739.
    CleanExiMM_GJB5.
    GenevestigatoriQ02739.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045325.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02739.
    SMRiQ02739. Positions 2-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 12426CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini148 – 18336ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini207 – 27165CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei184 – 20623HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39157.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiQ02739.
    KOiK07624.
    OMAiCSLVFKA.
    OrthoDBiEOG7P2XSS.
    PhylomeDBiQ02739.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002270. Connexin311.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF28. PTHR11984:SF28. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01141. CONNEXINB4.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNWSVFEGLL SGVNKYSTAF GRIWLSLVFV FRVLVYLVTA ERVWGDDQKD    50
    FDCNTRQPGC TNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYRKA 100
    REKKYQEKIG EGYLYPNPGK KRGGLWWTYV FSLSFKATID IIFLYLFHAF 150
    YPRYTLPSMV KCHAEPCPNT VDCFIAKPSE KNIFIVFMVV TAVICILLNL 200
    VELIYLVIKR CSECAQLRRP PTAHAKNDPN WANSPSKEKD FLSCDLIFLG 250
    SDAHPPLLPD RPRAHVKKTI L 271
    Length:271
    Mass (Da):31,195
    Last modified:February 1, 1994 - v1
    Checksum:iF8732F5A8F5CD51A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91236 mRNA. Translation: AAA37426.1.
    M91442 Genomic DNA. Translation: AAA37427.1.
    CCDSiCCDS18670.1.
    PIRiB43433.
    RefSeqiNP_034421.1. NM_010291.3.
    UniGeneiMm.26859.

    Genome annotation databases

    EnsembliENSMUST00000046498; ENSMUSP00000045325; ENSMUSG00000042357.
    GeneIDi14622.
    KEGGimmu:14622.
    UCSCiuc008uuv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91236 mRNA. Translation: AAA37426.1 .
    M91442 Genomic DNA. Translation: AAA37427.1 .
    CCDSi CCDS18670.1.
    PIRi B43433.
    RefSeqi NP_034421.1. NM_010291.3.
    UniGenei Mm.26859.

    3D structure databases

    ProteinModelPortali Q02739.
    SMRi Q02739. Positions 2-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045325.

    PTM databases

    PhosphoSitei Q02739.

    Proteomic databases

    PRIDEi Q02739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046498 ; ENSMUSP00000045325 ; ENSMUSG00000042357 .
    GeneIDi 14622.
    KEGGi mmu:14622.
    UCSCi uc008uuv.1. mouse.

    Organism-specific databases

    CTDi 2709.
    MGIi MGI:95723. Gjb5.

    Phylogenomic databases

    eggNOGi NOG39157.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi Q02739.
    KOi K07624.
    OMAi CSLVFKA.
    OrthoDBi EOG7P2XSS.
    PhylomeDBi Q02739.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 286452.
    PROi Q02739.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02739.
    CleanExi MM_GJB5.
    Genevestigatori Q02739.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002270. Connexin311.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF28. PTHR11984:SF28. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01141. CONNEXINB4.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
      Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
      J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiCXB5_MOUSE
    AccessioniPrimary (citable) accession number: Q02739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3