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Q02738

- CXB4_MOUSE

UniProt

Q02738 - CXB4_MOUSE

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Protein

Gap junction beta-4 protein

Gene

Gjb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  1. cell communication Source: InterPro
  2. olfactory behavior Source: MGI
  3. sensory perception of smell Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-4 protein
Alternative name(s):
Connexin-30.3
Short name:
Cx30.3
Gene namesi
Name:Gjb4
Synonyms:Cxn-30.3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:95722. Gjb4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 12628CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei127 – 14923HelicalSequence AnalysisAdd
BLAST
Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 21023HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 26656CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Gap junction beta-4 proteinPRO_0000057866Add
BLAST

Proteomic databases

PRIDEiQ02738.

Expressioni

Tissue specificityi

Expressed in skin.

Gene expression databases

BgeeiQ02738.
CleanExiMM_GJB4.
GenevestigatoriQ02738.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

ProteinModelPortaliQ02738.
SMRiQ02738. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39157.
GeneTreeiENSGT00760000118780.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02738.
KOiK07623.
OMAiVISKGGH.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ02738.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD
60 70 80 90 100
FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE
110 120 130 140 150
RERKHRLKHG PNAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH
160 170 180 190 200
CIYKDYDMPR VVACSVTPCP HTVDCYIARP TEKKVFTYFM VVTAAICILL
210 220 230 240 250
NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS KGGHPQDESV
260
ILTKAGMATV DAGVYP
Length:266
Mass (Da):30,389
Last modified:February 1, 1994 - v1
Checksum:i0772D708C004EFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91443 Genomic DNA. Translation: AAA37428.1.
BC064060 mRNA. Translation: AAH64060.1.
CCDSiCCDS18669.1.
PIRiA43433.
RefSeqiNP_032153.1. NM_008127.4.
UniGeneiMm.56906.

Genome annotation databases

EnsembliENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623.
ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623.
GeneIDi14621.
KEGGimmu:14621.
UCSCiuc008uuu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91443 Genomic DNA. Translation: AAA37428.1 .
BC064060 mRNA. Translation: AAH64060.1 .
CCDSi CCDS18669.1.
PIRi A43433.
RefSeqi NP_032153.1. NM_008127.4.
UniGenei Mm.56906.

3D structure databases

ProteinModelPortali Q02738.
SMRi Q02738. Positions 2-209.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q02738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060419 ; ENSMUSP00000053307 ; ENSMUSG00000046623 .
ENSMUST00000106090 ; ENSMUSP00000101696 ; ENSMUSG00000046623 .
GeneIDi 14621.
KEGGi mmu:14621.
UCSCi uc008uuu.1. mouse.

Organism-specific databases

CTDi 127534.
MGIi MGI:95722. Gjb4.

Phylogenomic databases

eggNOGi NOG39157.
GeneTreei ENSGT00760000118780.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi Q02738.
KOi K07623.
OMAi VISKGGH.
OrthoDBi EOG7P2XSS.
PhylomeDBi Q02738.
TreeFami TF329606.

Miscellaneous databases

NextBioi 286448.
PROi Q02738.
SOURCEi Search...

Gene expression databases

Bgeei Q02738.
CleanExi MM_GJB4.
Genevestigatori Q02738.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
    Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
    J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiCXB4_MOUSE
AccessioniPrimary (citable) accession number: Q02738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3