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Protein

Gap junction beta-4 protein

Gene

Gjb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • olfactory behavior Source: MGI
  • sensory perception of smell Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-4 protein
Alternative name(s):
Connexin-30.3
Short name:
Cx30.3
Gene namesi
Name:Gjb4
Synonyms:Cxn-30.3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95722. Gjb4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
BLAST
Transmembranei76 – 9823HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 12628CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei127 – 14923HelicalSequence AnalysisAdd
BLAST
Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 21023HelicalSequence AnalysisAdd
BLAST
Topological domaini211 – 26656CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Gap junction beta-4 proteinPRO_0000057866Add
BLAST

Proteomic databases

PRIDEiQ02738.

Expressioni

Tissue specificityi

Expressed in skin.

Gene expression databases

BgeeiQ02738.
CleanExiMM_GJB4.
GenevisibleiQ02738. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053307.

Structurei

3D structure databases

ProteinModelPortaliQ02738.
SMRiQ02738. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39157.
GeneTreeiENSGT00800000124042.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02738.
KOiK07623.
OMAiWDDEQKD.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ02738.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD
60 70 80 90 100
FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE
110 120 130 140 150
RERKHRLKHG PNAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH
160 170 180 190 200
CIYKDYDMPR VVACSVTPCP HTVDCYIARP TEKKVFTYFM VVTAAICILL
210 220 230 240 250
NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS KGGHPQDESV
260
ILTKAGMATV DAGVYP
Length:266
Mass (Da):30,389
Last modified:February 1, 1994 - v1
Checksum:i0772D708C004EFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91443 Genomic DNA. Translation: AAA37428.1.
BC064060 mRNA. Translation: AAH64060.1.
CCDSiCCDS18669.1.
PIRiA43433.
RefSeqiNP_032153.1. NM_008127.4.
UniGeneiMm.56906.

Genome annotation databases

EnsembliENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623.
ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623.
GeneIDi14621.
KEGGimmu:14621.
UCSCiuc008uuu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91443 Genomic DNA. Translation: AAA37428.1.
BC064060 mRNA. Translation: AAH64060.1.
CCDSiCCDS18669.1.
PIRiA43433.
RefSeqiNP_032153.1. NM_008127.4.
UniGeneiMm.56906.

3D structure databases

ProteinModelPortaliQ02738.
SMRiQ02738. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053307.

Proteomic databases

PRIDEiQ02738.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623.
ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623.
GeneIDi14621.
KEGGimmu:14621.
UCSCiuc008uuu.1. mouse.

Organism-specific databases

CTDi127534.
MGIiMGI:95722. Gjb4.

Phylogenomic databases

eggNOGiNOG39157.
GeneTreeiENSGT00800000124042.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ02738.
KOiK07623.
OMAiWDDEQKD.
OrthoDBiEOG7P2XSS.
PhylomeDBiQ02738.
TreeFamiTF329606.

Miscellaneous databases

NextBioi286448.
PROiQ02738.
SOURCEiSearch...

Gene expression databases

BgeeiQ02738.
CleanExiMM_GJB4.
GenevisibleiQ02738. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
    Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
    J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiCXB4_MOUSE
AccessioniPrimary (citable) accession number: Q02738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 22, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.