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Q02738

- CXB4_MOUSE

UniProt

Q02738 - CXB4_MOUSE

Protein

Gap junction beta-4 protein

Gene

Gjb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Biological processi

    1. cell communication Source: InterPro
    2. olfactory behavior Source: MGI
    3. sensory perception of smell Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction beta-4 protein
    Alternative name(s):
    Connexin-30.3
    Short name:
    Cx30.3
    Gene namesi
    Name:Gjb4
    Synonyms:Cxn-30.3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:95722. Gjb4.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Gap junction beta-4 proteinPRO_0000057866Add
    BLAST

    Proteomic databases

    PRIDEiQ02738.

    Expressioni

    Tissue specificityi

    Expressed in skin.

    Gene expression databases

    BgeeiQ02738.
    CleanExiMM_GJB4.
    GenevestigatoriQ02738.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02738.
    SMRiQ02738. Positions 2-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7535ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 12628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 18738ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini211 – 26656CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 21023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39157.
    GeneTreeiENSGT00750000117571.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiQ02738.
    KOiK07623.
    OMAiVISKGGH.
    OrthoDBiEOG7P2XSS.
    PhylomeDBiQ02738.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002271. Connexin303.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF30. PTHR11984:SF30. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01142. CONNEXINB5.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02738-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD    50
    FICNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE 100
    RERKHRLKHG PNAPALYSNL SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH 150
    CIYKDYDMPR VVACSVTPCP HTVDCYIARP TEKKVFTYFM VVTAAICILL 200
    NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS KGGHPQDESV 250
    ILTKAGMATV DAGVYP 266
    Length:266
    Mass (Da):30,389
    Last modified:February 1, 1994 - v1
    Checksum:i0772D708C004EFC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91443 Genomic DNA. Translation: AAA37428.1.
    BC064060 mRNA. Translation: AAH64060.1.
    CCDSiCCDS18669.1.
    PIRiA43433.
    RefSeqiNP_032153.1. NM_008127.4.
    UniGeneiMm.56906.

    Genome annotation databases

    EnsembliENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623.
    ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623.
    GeneIDi14621.
    KEGGimmu:14621.
    UCSCiuc008uuu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M91443 Genomic DNA. Translation: AAA37428.1 .
    BC064060 mRNA. Translation: AAH64060.1 .
    CCDSi CCDS18669.1.
    PIRi A43433.
    RefSeqi NP_032153.1. NM_008127.4.
    UniGenei Mm.56906.

    3D structure databases

    ProteinModelPortali Q02738.
    SMRi Q02738. Positions 2-209.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q02738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060419 ; ENSMUSP00000053307 ; ENSMUSG00000046623 .
    ENSMUST00000106090 ; ENSMUSP00000101696 ; ENSMUSG00000046623 .
    GeneIDi 14621.
    KEGGi mmu:14621.
    UCSCi uc008uuu.1. mouse.

    Organism-specific databases

    CTDi 127534.
    MGIi MGI:95722. Gjb4.

    Phylogenomic databases

    eggNOGi NOG39157.
    GeneTreei ENSGT00750000117571.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi Q02738.
    KOi K07623.
    OMAi VISKGGH.
    OrthoDBi EOG7P2XSS.
    PhylomeDBi Q02738.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 286448.
    PROi Q02738.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q02738.
    CleanExi MM_GJB4.
    Genevestigatori Q02738.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002271. Connexin303.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    PTHR11984:SF30. PTHR11984:SF30. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01142. CONNEXINB5.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
      Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
      J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.

    Entry informationi

    Entry nameiCXB4_MOUSE
    AccessioniPrimary (citable) accession number: Q02738
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3