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Q02738 (CXB4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction beta-4 protein
Alternative name(s):
Connexin-30.3
Short name=Cx30.3
Gene names
Name:Gjb4
Synonyms:Cxn-30.3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Tissue specificity

Expressed in skin.

Sequence similarities

Belongs to the connexin family. Beta-type (group I) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Gap junction beta-4 protein
PRO_0000057866

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4020Helical; Potential
Topological domain41 – 7535Extracellular Potential
Transmembrane76 – 9823Helical; Potential
Topological domain99 – 12628Cytoplasmic Potential
Transmembrane127 – 14923Helical; Potential
Topological domain150 – 18738Extracellular Potential
Transmembrane188 – 21023Helical; Potential
Topological domain211 – 26656Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q02738 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 0772D708C004EFC1

FASTA26630,389
        10         20         30         40         50         60 
MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD FICNTKQPGC 

        70         80         90        100        110        120 
PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE RERKHRLKHG PNAPALYSNL 

       130        140        150        160        170        180 
SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH CIYKDYDMPR VVACSVTPCP HTVDCYIARP 

       190        200        210        220        230        240 
TEKKVFTYFM VVTAAICILL NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS 

       250        260 
KGGHPQDESV ILTKAGMATV DAGVYP 

« Hide

References

« Hide 'large scale' references
[1]"Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin."
Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K.
J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91443 Genomic DNA. Translation: AAA37428.1.
BC064060 mRNA. Translation: AAH64060.1.
PIRA43433.
RefSeqNP_032153.1. NM_008127.4.
UniGeneMm.56906.

3D structure databases

ProteinModelPortalQ02738.
SMRQ02738. Positions 2-209.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ02738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623.
ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623.
GeneID14621.
KEGGmmu:14621.
UCSCuc008uuu.1. mouse.

Organism-specific databases

CTD127534.
MGIMGI:95722. Gjb4.

Phylogenomic databases

eggNOGNOG39157.
GeneTreeENSGT00750000117571.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidQ02738.
KOK07623.
OMAWDDEQKD.
OrthoDBEOG7P2XSS.
PhylomeDBQ02738.
TreeFamTF329606.

Gene expression databases

BgeeQ02738.
CleanExMM_GJB4.
GenevestigatorQ02738.

Family and domain databases

InterProIPR000500. Connexin.
IPR002271. Connexin303.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF30. PTHR11984:SF30. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01142. CONNEXINB5.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286448.
PROQ02738.
SOURCESearch...

Entry information

Entry nameCXB4_MOUSE
AccessionPrimary (citable) accession number: Q02738
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot