Q02738 (CXB4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Gap junction beta-4 protein

Alternative name(s):
Connexin-30.3
Short name=Cx30.3

Gene names

Name:	Gjb4
Synonyms:	Cxn-30.3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subunit structure	A connexon is composed of a hexamer of connexins.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › gap junction.
Tissue specificity	Expressed in skin.
Sequence similarities	Belongs to the connexin family. Beta-type (group I) subfamily.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro olfactory behavior Inferred from mutant phenotype PubMed 17728008. Source: MGI sensory perception of smell Inferred from mutant phenotype PubMed 17728008. Source: MGI
Cellular_component	connexon complex Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Gap junction beta-4 protein		PRO_0000057866
Regions
	Topological domain	1 – 20	20	Cytoplasmic Potential
	Transmembrane	21 – 40	20	Helical; Potential
	Topological domain	41 – 75	35	Extracellular Potential
	Transmembrane	76 – 98	23	Helical; Potential
	Topological domain	99 – 126	28	Cytoplasmic Potential
	Transmembrane	127 – 149	23	Helical; Potential
	Topological domain	150 – 187	38	Extracellular Potential
	Transmembrane	188 – 210	23	Helical; Potential
	Topological domain	211 – 266	56	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q02738 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 0772D708C004EFC1	FASTA	266	30,389
	10 20 30 40 50 60 MNWGFLQGIL SGVNKYSTAL GRIWLSVVFI FRVLVYVVAA EEVWDDDQKD FICNTKQPGC 70 80 90 100 110 120 PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE RERKHRLKHG PNAPALYSNL 130 140 150 160 170 180 SKKRGGLWWT YLLSLIFKAA VDSGFLYIFH CIYKDYDMPR VVACSVTPCP HTVDCYIARP 190 200 210 220 230 240 TEKKVFTYFM VVTAAICILL NLSEVVYLVG KRCMEVFRPR RRKASRRHQL PDTCPPYVIS 250 260 KGGHPQDESV ILTKAGMATV DAGVYP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin." Hennemann H., Dahl E., White J.B., Schwarz H.J., Lalley P.A., Chang S., Nicholson B.J., Willecke K. J. Biol. Chem. 267:17225-17233(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Skin.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M91443 Genomic DNA. Translation: AAA37428.1. BC064060 mRNA. Translation: AAH64060.1.
IPI	IPI00131280.
PIR	A43433.
RefSeq	NP_032153.1. NM_008127.4.
UniGene	Mm.56906.
3D structure databases
ProteinModelPortal	Q02738.
SMR	Q02738. Positions 2-209.
ModBase	Search...
Proteomic databases
PRIDE	Q02738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000060419; ENSMUSP00000053307; ENSMUSG00000046623. ENSMUST00000106090; ENSMUSP00000101696; ENSMUSG00000046623.
GeneID	14621.
KEGG	mmu:14621.
Organism-specific databases
CTD	127534.
MGI	MGI:95722. Gjb4.
Phylogenomic databases
eggNOG	NOG39157.
GeneTree	ENSGT00700000104405.
HOGENOM	HOG000231127.
HOVERGEN	HBG009576.
InParanoid	Q02738.
KO	K07623.
OMA	YDMPRVV.
OrthoDB	EOG4S7JR0.
Gene expression databases
ArrayExpress	Q02738.
Bgee	Q02738.
CleanEx	MM_GJB4.
Genevestigator	Q02738.
GermOnline	ENSMUSG00000046623. Mus musculus.
Family and domain databases
InterPro	IPR000500. Connexin. IPR002271. Connexin303. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. [Graphical view]
PANTHER	PTHR11984. PTHR11984. 1 hit. PTHR11984:SF30. PTHR11984:SF30. 1 hit.
Pfam	PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view]
PRINTS	PR00206. CONNEXIN. PR01142. CONNEXINB5.
SMART	SM00037. CNX. 1 hit. SM01089. Connexin_CCC. 1 hit. [Graphical view]
PROSITE	PS00407. CONNEXINS_1. 1 hit. PS00408. CONNEXINS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286448.
SOURCE	Search...

Entry information

Entry name

CXB4_MOUSE

Accession

Primary (citable) accession number: Q02738

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program