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Protein

Increased recombination centers protein 15

Gene

IRC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 5610FADBy similarity

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • microtubule binding Source: SGD
  • oxidoreductase activity Source: InterPro
  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: SGD
  • cell redox homeostasis Source: InterPro
  • meiotic sister chromatid segregation Source: SGD
  • methylation Source: GOC
  • microtubule anchoring Source: SGD
  • microtubule nucleation Source: SGD
  • mitotic recombination Source: SGD
  • positive regulation of mitotic cell cycle Source: SGD
Complete GO annotation...

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciYEAST:G3O-33936-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Increased recombination centers protein 15
Gene namesi
Name:IRC15
Ordered Locus Names:YPL017C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL017C.
SGDiS000005938. IRC15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • microtubule Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Increased recombination centers protein 15PRO_0000268179Add
BLAST

Proteomic databases

MaxQBiQ02733.
PeptideAtlasiQ02733.

Interactioni

GO - Molecular functioni

  • microtubule binding Source: SGD

Protein-protein interaction databases

BioGridi36160. 62 interactions.
IntActiQ02733. 3 interactions.
MINTiMINT-4504371.

Structurei

3D structure databases

ProteinModelPortaliQ02733.
SMRiQ02733. Positions 18-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000276708.
InParanoidiQ02733.
KOiK00382.
OMAiMINDDAN.
OrthoDBiEOG7K0ZNC.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEDEILST MEDFAAVYDV LVIGCGPGGF TAAMQASQAG LLTACVDQRA
60 70 80 90 100
SLGGAYLVDG AVPSKTLLYE SYLYRLLQQQ ELIEQRGTRL FPAKFDMQAA
110 120 130 140 150
QSALKHNIEE LGNVYKRELS KNNVTVYKGT AAFKDPHHVE IAQRGMKPFI
160 170 180 190 200
VEAKYIVVAT GSAVIQCPGV AIDNDKIISS DKALSLDYIP SRFTIMGGGT
210 220 230 240 250
IGLEIACIFN NLGSRVTIVE SQSEICQNMD NELASATKTL LQCQGIAFLL
260 270 280 290 300
DTRVQLAEAD AAGQLNITLL NKVSKKTYVH HCDVLMVSIG RRPLLKGLDI
310 320 330 340 350
SSIGLDERDF VENVDVQTQS LLKYPHIKPI GDVTLGPMLA LKAEEQAIRA
360 370 380 390 400
IQSIGCTGSD GTSNCGFPPN VLYCQPQIGW VGYTEEGLAK ARIPYQKGRV
410 420 430 440 450
LFSQNVRYNT LLPREENTTV SPFIKVLIDS RDMKILGVHM INDDANELLS
460 470 480 490
QASMAVSLGL TAHDVCKVPF PHPSLSESFK QAVQLAMANG TSPGVHVRE
Length:499
Mass (Da):54,156
Last modified:November 1, 1996 - v1
Checksum:i1EF2A29D4327031B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36624 Genomic DNA. Translation: AAB68170.1.
BK006949 Genomic DNA. Translation: DAA11411.1.
PIRiS63465.
RefSeqiNP_015308.1. NM_001183831.1.

Genome annotation databases

EnsemblFungiiYPL017C; YPL017C; YPL017C.
GeneIDi856090.
KEGGisce:YPL017C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36624 Genomic DNA. Translation: AAB68170.1.
BK006949 Genomic DNA. Translation: DAA11411.1.
PIRiS63465.
RefSeqiNP_015308.1. NM_001183831.1.

3D structure databases

ProteinModelPortaliQ02733.
SMRiQ02733. Positions 18-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36160. 62 interactions.
IntActiQ02733. 3 interactions.
MINTiMINT-4504371.

Proteomic databases

MaxQBiQ02733.
PeptideAtlasiQ02733.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL017C; YPL017C; YPL017C.
GeneIDi856090.
KEGGisce:YPL017C.

Organism-specific databases

EuPathDBiFungiDB:YPL017C.
SGDiS000005938. IRC15.

Phylogenomic databases

HOGENOMiHOG000276708.
InParanoidiQ02733.
KOiK00382.
OMAiMINDDAN.
OrthoDBiEOG7K0ZNC.

Enzyme and pathway databases

BioCyciYEAST:G3O-33936-MONOMER.

Miscellaneous databases

PROiQ02733.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
SSF55424. SSF55424. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIRC15_YEAST
AccessioniPrimary (citable) accession number: Q02733
Secondary accession number(s): D6W3Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 6400 molecules/cell in log phase SD medium.1 Publication

Caution

Although strongly related to the LPD1 dihydrolipoyl dehydrogenase, it lacks the redox-active disulfide bond suggesting that it has no dehydrogenase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.