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Protein

Increased recombination centers protein 15

Gene

IRC15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 6400 molecules/cell in log phase SD medium.1 Publication

Caution

Although strongly related to the LPD1 dihydrolipoyl dehydrogenase, it lacks the redox-active disulfide bond suggesting that it has no dehydrogenase activity.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 56FADBy similarity10

GO - Molecular functioni

  • electron transfer activity Source: InterPro
  • flavin adenine dinucleotide binding Source: InterPro
  • microtubule binding Source: SGD
  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  • attachment of mitotic spindle microtubules to kinetochore Source: SGD
  • cell redox homeostasis Source: InterPro
  • meiotic sister chromatid segregation Source: SGD
  • microtubule anchoring Source: SGD
  • microtubule nucleation Source: SGD
  • mitotic recombination Source: SGD
  • positive regulation of mitotic cell cycle Source: SGD

Keywordsi

LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciYEAST:G3O-33936-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Increased recombination centers protein 15
Gene namesi
Name:IRC15
Ordered Locus Names:YPL017C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL017C
SGDiS000005938 IRC15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002681791 – 499Increased recombination centers protein 15Add BLAST499

Proteomic databases

MaxQBiQ02733
PaxDbiQ02733
PRIDEiQ02733

Interactioni

GO - Molecular functioni

  • microtubule binding Source: SGD

Protein-protein interaction databases

BioGridi36160, 131 interactors
IntActiQ02733, 3 interactors
STRINGi4932.YPL017C

Structurei

3D structure databases

ProteinModelPortaliQ02733
SMRiQ02733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000276708
InParanoidiQ02733
KOiK00382
OrthoDBiEOG092C1XBY

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55424 SSF55424, 1 hit

Sequencei

Sequence statusi: Complete.

Q02733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEDEILST MEDFAAVYDV LVIGCGPGGF TAAMQASQAG LLTACVDQRA
60 70 80 90 100
SLGGAYLVDG AVPSKTLLYE SYLYRLLQQQ ELIEQRGTRL FPAKFDMQAA
110 120 130 140 150
QSALKHNIEE LGNVYKRELS KNNVTVYKGT AAFKDPHHVE IAQRGMKPFI
160 170 180 190 200
VEAKYIVVAT GSAVIQCPGV AIDNDKIISS DKALSLDYIP SRFTIMGGGT
210 220 230 240 250
IGLEIACIFN NLGSRVTIVE SQSEICQNMD NELASATKTL LQCQGIAFLL
260 270 280 290 300
DTRVQLAEAD AAGQLNITLL NKVSKKTYVH HCDVLMVSIG RRPLLKGLDI
310 320 330 340 350
SSIGLDERDF VENVDVQTQS LLKYPHIKPI GDVTLGPMLA LKAEEQAIRA
360 370 380 390 400
IQSIGCTGSD GTSNCGFPPN VLYCQPQIGW VGYTEEGLAK ARIPYQKGRV
410 420 430 440 450
LFSQNVRYNT LLPREENTTV SPFIKVLIDS RDMKILGVHM INDDANELLS
460 470 480 490
QASMAVSLGL TAHDVCKVPF PHPSLSESFK QAVQLAMANG TSPGVHVRE
Length:499
Mass (Da):54,156
Last modified:November 1, 1996 - v1
Checksum:i1EF2A29D4327031B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36624 Genomic DNA Translation: AAB68170.1
BK006949 Genomic DNA Translation: DAA11411.1
PIRiS63465
RefSeqiNP_015308.1, NM_001183831.1

Genome annotation databases

EnsemblFungiiYPL017C; YPL017C; YPL017C
GeneIDi856090
KEGGisce:YPL017C

Similar proteinsi

Entry informationi

Entry nameiIRC15_YEAST
AccessioniPrimary (citable) accession number: Q02733
Secondary accession number(s): D6W3Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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