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Protein

Central kinetochore subunit CTF19

Gene

CTF19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.

GO - Biological processi

  • attachment of spindle microtubules to kinetochore Source: SGD
  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: SGD
  • establishment of mitotic sister chromatid cohesion Source: SGD
  • meiotic cell cycle Source: UniProtKB-KW
  • mitotic spindle assembly checkpoint Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-33937-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Central kinetochore subunit CTF19
Alternative name(s):
Chromosome transmission fidelity protein 19
Minichromosome maintenance protein 18
Gene namesi
Name:CTF19
Synonyms:MCM18
Ordered Locus Names:YPL018W
ORF Names:LPB13W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL018W.
SGDiS000005939. CTF19.

Subcellular locationi

GO - Cellular componenti

  • COMA complex Source: SGD
  • condensed nuclear chromosome kinetochore Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Central kinetochore subunit CTF19PRO_0000079492Add
BLAST

Proteomic databases

MaxQBiQ02732.

Interactioni

Subunit structurei

Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1. The COMA subcomplex is part of a larger central kinetochore CTF19 complex, which is composed of at least AME1, CHL4, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, NKP1, NKP2 and OKP1. Interacts with the CTF3 complex subunits CTF3, MCM16 and MCM22 as well as CHL4 and IML3. Interacts with the N-terminal domain of CSE4 and with the CBF3 complex subunit A (CBF2).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTF3Q127483EBI-5199,EBI-30457
DAM1P532672EBI-5199,EBI-23268
MCM16Q122622EBI-5199,EBI-31487

Protein-protein interaction databases

BioGridi36159. 196 interactions.
DIPiDIP-3009N.
IntActiQ02732. 15 interactions.
MINTiMINT-438402.

Structurei

3D structure databases

ProteinModelPortaliQ02732.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 8737Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the CTF19 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ02732.
KOiK11554.
OMAiMRIESAN.
OrthoDBiEOG092C43R0.

Sequencei

Sequence statusi: Complete.

Q02732-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTSDTTNS HDTSNSHLSL EDAVGTHHAG EADVNIDGDE KQQLSLLDDD
60 70 80 90 100
QVRALKLQEE KDALLTRRNT LLQEIQTYQN ILMKENNSKT KNGDILQNDI
110 120 130 140 150
TQDFLNLISI SSSNPNSAIS DRKRVERING LTNLQKELVT KYDTLPLLNM
160 170 180 190 200
NLRLSYLRDH TYPHLQVSVQ SRDRVHNDGI EVLVVNYKFC RNTMNPFEIQ
210 220 230 240 250
FKMFYKFEDS TLLKWEILRI STNVRLKAKQ LLATRNFQKC LLSLYEFDKI
260 270 280 290 300
KSKKTGIFQN LINLLKRKTR CYLMNNSDSL IVERVIREGR LTTIKLQINF
310 320 330 340 350
IITMPGERGK PRNCFLPMSK ISIALWKGGE RFNQIDLDEI CYGLIKEYGV
360
KTGLKEICNV CLFPDMYAR
Length:369
Mass (Da):42,782
Last modified:November 1, 1996 - v1
Checksum:i23B4CBD6AE26E793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72265 Genomic DNA. Translation: AAB17275.1.
U36624 Genomic DNA. Translation: AAB68169.1.
BK006949 Genomic DNA. Translation: DAA11410.1.
PIRiS63464.
RefSeqiNP_015307.1. NM_001183832.1.

Genome annotation databases

EnsemblFungiiYPL018W; YPL018W; YPL018W.
GeneIDi856089.
KEGGisce:YPL018W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72265 Genomic DNA. Translation: AAB17275.1.
U36624 Genomic DNA. Translation: AAB68169.1.
BK006949 Genomic DNA. Translation: DAA11410.1.
PIRiS63464.
RefSeqiNP_015307.1. NM_001183832.1.

3D structure databases

ProteinModelPortaliQ02732.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36159. 196 interactions.
DIPiDIP-3009N.
IntActiQ02732. 15 interactions.
MINTiMINT-438402.

Proteomic databases

MaxQBiQ02732.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL018W; YPL018W; YPL018W.
GeneIDi856089.
KEGGisce:YPL018W.

Organism-specific databases

EuPathDBiFungiDB:YPL018W.
SGDiS000005939. CTF19.

Phylogenomic databases

InParanoidiQ02732.
KOiK11554.
OMAiMRIESAN.
OrthoDBiEOG092C43R0.

Enzyme and pathway databases

BioCyciYEAST:G3O-33937-MONOMER.

Miscellaneous databases

PROiQ02732.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCTF19_YEAST
AccessioniPrimary (citable) accession number: Q02732
Secondary accession number(s): D6W3Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1254 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.