Q02710 (ECM23_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ECM23

Alternative name(s):
Extracellular mutant protein 23
SRD1 homolog 2

Gene names

Name:	ECM23
Synonyms:	SRD2
Ordered Locus Names:	YPL021W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	187 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in morphogenesis. May be involved in cell wall organization and biogenesis. Ref.5
Induction	Expression is regulated by the KAR4 transcription factor and reduced after pheromone induction. Ref.6
Sequence similarities	Contains 1 GATA-type zinc finger.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pseudohyphal growth Inferred from mutant phenotype Ref.5. Source: SGD
Molecular_function	sequence-specific DNA binding Inferred from direct assay PubMed 19111667. Source: SGD sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 187	187	Protein ECM23		PRO_0000083483
Regions
	Zinc finger	126 – 180	55	GATA-type

Sequences

	Sequence		Length	Mass (Da)
	Q02710 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8682AFC484011926	FASTA	187	20,614
	10 20 30 40 50 60 MLYNKEQGTS GASSSGRRTK FHFDRFVQMV LFIAANPNYC CSVASIPKSG VTPDLKRADI 70 80 90 100 110 120 LEQKIKSLNS ALSPKLKEES RLGGPLHNPS ILPAPSFSSL PISSNGKKSL AGYRPKSRKK 130 140 150 160 170 180 QTILPNGQPK ECATCGDTWT SQWRSGPNGN VELCSRCGIA YRKKMEKKIR SQQSSDDGTK NFIFKNK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	Marsischky G., Rolfs A., Richardson A., Kane M., Baqui M., Taycher E., Hu Y., Vannberg F., Weger J., Kramer J., Moreira D., Kelley F., Zuo D., Raphael J., Hogle C., Jepson D., Williamson J., Camargo A. , Gonzaga L., Vasconcelos A.T., Simpson A.J.G., Kolodner R., Harlow E., LaBaer J. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae." Lussier M., White A.-M., Sheraton J., di Paolo T., Treadwell J., Southard S.B., Horenstein C.I., Chen-Weiner J., Ram A.F.J., Kapteyn J.C., Roemer T.W., Vo D.H., Bondoc D.C., Hall J., Zhong W.-W., Sdicu A.-M., Davies J., Klis F.M., Robbins P.W., Bussey H. Genetics 147:435-450(1997) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"The SRD2 gene is involved in Saccharomyces cerevisiae morphogenesis." Canizares J.V., Pallotti C., Sainz-Pardo I., Iranzo M., Mormeneo S. Arch. Microbiol. 177:352-357(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway." Lahav R., Gammie A., Tavazoie S., Rose M.D. Mol. Cell. Biol. 27:818-829(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36624 Genomic DNA. Translation: AAB68166.1. AY558439 Genomic DNA. Translation: AAS56765.1. BK006949 Genomic DNA. Translation: DAA11407.1.
PIR	S63461.
RefSeq	NP_015304.1. NM_001183835.1.
3D structure databases
ProteinModelPortal	Q02710.
SMR	Q02710. Positions 128-164.
ModBase	Search...
Protein-protein interaction databases
STRING	4932.YPL021W.
Proteomic databases
PaxDb	Q02710.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPL021W; YPL021W; YPL021W.
GeneID	856086.
KEGG	sce:YPL021W.
Organism-specific databases
CYGD	YPL021w.
SGD	S000005942. ECM23.
Phylogenomic databases
eggNOG	NOG311416.
GeneTree	ENSGT00530000068273.
OrthoDB	EOG42JS2R.
Gene expression databases
Genevestigator	Q02710.
GermOnline	YPL021W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	3.30.50.10. 1 hit.
InterPro	IPR000679. Znf_GATA. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00320. GATA. 1 hit. [Graphical view]
SMART	SM00401. ZnF_GATA. 1 hit. [Graphical view]
PROSITE	PS00344. GATA_ZN_FINGER_1. 1 hit. PS50114. GATA_ZN_FINGER_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981104.

Entry information

Entry name

ECM23_YEAST

Accession

Primary (citable) accession number: Q02710
Secondary accession number(s): D6W3Z1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program