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Q02650 (PAX5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired box protein Pax-5
Alternative name(s):
B-cell-specific transcription factor
Short name=BSAP
Gene names
Name:Pax5
Synonyms:Pax-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

Subunit structure

Interacts with ETS1, altering its DNA-binding properties By similarity. Interacts with DAXX and TLE4. Binds DNA as a monomer. Ref.3

Subcellular location

Nucleus.

Developmental stage

Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

Post-translational modification

O-glycosylated Probable.

Sequence similarities

Contains 1 paired domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Spermatogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainPaired box
   LigandDNA-binding
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of histone H3-K9 methylation

Inferred from mutant phenotype PubMed 15258579. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15258579. Source: MGI

negative regulation of transcription, DNA-templated

Traceable author statement Ref.3. Source: UniProtKB

nervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

organ morphogenesis

Traceable author statement PubMed 10197584. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 15094381. Source: MGI

positive regulation of transcription, DNA-templated

Traceable author statement Ref.3. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 14594818. Source: MGI

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 14594818. Source: MGI

transcription factor complex

Traceable author statement PubMed 10197584. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14594818. Source: MGI

protein binding

Inferred from physical interaction Ref.3. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 14594818. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DAXXQ9UER74EBI-296260,EBI-77321From a different organism.
Paxip1Q6NZQ43EBI-296260,EBI-1395317

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Paired box protein Pax-5
PRO_0000050184

Regions

Domain16 – 142127Paired

Sequences

Sequence LengthMass (Da)Tools
Q02650 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: D703E94808DE8EC8

FASTA39142,231
        10         20         30         40         50         60 
MDLEKNYPTP RTIRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV 

        70         80         90        100        110        120 
SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA EYKRQNPTMF AWEIRDRLLA 

       130        140        150        160        170        180 
ERVCDNDTVP SVSSINRIIR TKVQQPPNQP VPASSHSIVS TGSVTQVSSV STDSAGSSYS 

       190        200        210        220        230        240 
ISGILGITSP SADTNKRKRD EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV 

       250        260        270        280        290        300 
FERQHYSDIF TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP 

       310        320        330        340        350        360 
IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ YSSYNDSWRF 

       370        380        390 
PNPGLLGSPY YYSPAARGAA PPAAATAYDR H 

« Hide

References

[1]"Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis."
Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Pax: a murine multigene family of paired box-containing genes."
Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P.
Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-136.
[3]"The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells."
Emelyanov A.V., Kovac C.R., Sepulveda M.A., Birshtein B.K.
J. Biol. Chem. 277:11156-11164(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH DAXX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M97013 mRNA. Translation: AAA37325.1.
CCDSCCDS18125.1.
PIRB41061.
RefSeqNP_032808.1. NM_008782.2.
UniGeneMm.439659.

3D structure databases

ProteinModelPortalQ02650.
SMRQ02650. Positions 19-142, 222-282.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202032. 4 interactions.
IntActQ02650. 9 interactions.
MINTMINT-246854.
STRING10090.ENSMUSP00000014174.

PTM databases

PhosphoSiteQ02650.

Proteomic databases

PRIDEQ02650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000014174; ENSMUSP00000014174; ENSMUSG00000014030.
GeneID18507.
KEGGmmu:18507.
UCSCuc008srx.1. mouse.

Organism-specific databases

CTD5079.
MGIMGI:97489. Pax5.

Phylogenomic databases

eggNOGNOG326044.
GeneTreeENSGT00680000099910.
HOGENOMHOG000230938.
HOVERGENHBG009115.
InParanoidQ02650.
KOK09383.
OMAIXIQESP.
PhylomeDBQ02650.
TreeFamTF315397.

Gene expression databases

ArrayExpressQ02650.
BgeeQ02650.
CleanExMM_PAX5.
GenevestigatorQ02650.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
InterProIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio294232.
PROQ02650.
SOURCESearch...

Entry information

Entry namePAX5_MOUSE
AccessionPrimary (citable) accession number: Q02650
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot