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Q02650

- PAX5_MOUSE

UniProt

Q02650 - PAX5_MOUSE

Protein

Paired box protein Pax-5

Gene

Pax5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: UniProtKB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. negative regulation of histone H3-K9 methylation Source: MGI
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    4. nervous system development Source: UniProtKB-KW
    5. organ morphogenesis Source: MGI
    6. positive regulation of transcription, DNA-templated Source: UniProtKB
    7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    8. regulation of transcription, DNA-templated Source: MGI
    9. skeletal muscle cell differentiation Source: MGI
    10. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired box protein Pax-5
    Alternative name(s):
    B-cell-specific transcription factor
    Short name:
    BSAP
    Gene namesi
    Name:Pax5
    Synonyms:Pax-5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:97489. Pax5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Paired box protein Pax-5PRO_0000050184Add
    BLAST

    Post-translational modificationi

    O-glycosylated.Curated

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ02650.

    PTM databases

    PhosphoSiteiQ02650.

    Expressioni

    Developmental stagei

    Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

    Gene expression databases

    ArrayExpressiQ02650.
    BgeeiQ02650.
    CleanExiMM_PAX5.
    GenevestigatoriQ02650.

    Interactioni

    Subunit structurei

    Interacts with ETS1, altering its DNA-binding properties By similarity. Interacts with DAXX and TLE4. Binds DNA as a monomer.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DAXXQ9UER74EBI-296260,EBI-77321From a different organism.
    Paxip1Q6NZQ43EBI-296260,EBI-1395317

    Protein-protein interaction databases

    BioGridi202032. 4 interactions.
    IntActiQ02650. 9 interactions.
    MINTiMINT-246854.
    STRINGi10090.ENSMUSP00000014174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02650.
    SMRiQ02650. Positions 19-142, 222-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 142127PairedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 paired domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Paired box

    Phylogenomic databases

    eggNOGiNOG326044.
    GeneTreeiENSGT00680000099910.
    HOGENOMiHOG000230938.
    HOVERGENiHBG009115.
    InParanoidiQ02650.
    KOiK09383.
    OMAiIXIQESP.
    PhylomeDBiQ02650.
    TreeFamiTF315397.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022130. Pax2_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    PF12403. Pax2_C. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q02650-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLEKNYPTP RTIRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR    50
    PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA 100
    EYKRQNPTMF AWEIRDRLLA ERVCDNDTVP SVSSINRIIR TKVQQPPNQP 150
    VPASSHSIVS TGSVTQVSSV STDSAGSSYS ISGILGITSP SADTNKRKRD 200
    EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV FERQHYSDIF 250
    TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP 300
    IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ 350
    YSSYNDSWRF PNPGLLGSPY YYSPAARGAA PPAAATAYDR H 391
    Length:391
    Mass (Da):42,231
    Last modified:July 1, 1993 - v1
    Checksum:iD703E94808DE8EC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97013 mRNA. Translation: AAA37325.1.
    CCDSiCCDS18125.1.
    PIRiB41061.
    RefSeqiNP_032808.1. NM_008782.2.
    UniGeneiMm.439659.

    Genome annotation databases

    EnsembliENSMUST00000014174; ENSMUSP00000014174; ENSMUSG00000014030.
    GeneIDi18507.
    KEGGimmu:18507.
    UCSCiuc008srx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M97013 mRNA. Translation: AAA37325.1 .
    CCDSi CCDS18125.1.
    PIRi B41061.
    RefSeqi NP_032808.1. NM_008782.2.
    UniGenei Mm.439659.

    3D structure databases

    ProteinModelPortali Q02650.
    SMRi Q02650. Positions 19-142, 222-282.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202032. 4 interactions.
    IntActi Q02650. 9 interactions.
    MINTi MINT-246854.
    STRINGi 10090.ENSMUSP00000014174.

    PTM databases

    PhosphoSitei Q02650.

    Proteomic databases

    PRIDEi Q02650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014174 ; ENSMUSP00000014174 ; ENSMUSG00000014030 .
    GeneIDi 18507.
    KEGGi mmu:18507.
    UCSCi uc008srx.1. mouse.

    Organism-specific databases

    CTDi 5079.
    MGIi MGI:97489. Pax5.

    Phylogenomic databases

    eggNOGi NOG326044.
    GeneTreei ENSGT00680000099910.
    HOGENOMi HOG000230938.
    HOVERGENi HBG009115.
    InParanoidi Q02650.
    KOi K09383.
    OMAi IXIQESP.
    PhylomeDBi Q02650.
    TreeFami TF315397.

    Miscellaneous databases

    NextBioi 294232.
    PROi Q02650.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02650.
    Bgeei Q02650.
    CleanExi MM_PAX5.
    Genevestigatori Q02650.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR022130. Pax2_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    PF12403. Pax2_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis."
      Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
      Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "Pax: a murine multigene family of paired box-containing genes."
      Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P.
      Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-136.
    3. "The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells."
      Emelyanov A.V., Kovac C.R., Sepulveda M.A., Birshtein B.K.
      J. Biol. Chem. 277:11156-11164(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAXX.

    Entry informationi

    Entry nameiPAX5_MOUSE
    AccessioniPrimary (citable) accession number: Q02650
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3