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Protein

Paired box protein Pax-5

Gene

Pax5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • adult behavior Source: MGI
  • aging Source: MGI
  • animal organ morphogenesis Source: MGI
  • cerebral cortex development Source: MGI
  • dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • embryonic cranial skeleton morphogenesis Source: MGI
  • lateral ventricle development Source: MGI
  • negative regulation of histone H3-K9 methylation Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • spermatogenesis Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8939245 RUNX1 regulates transcription of genes involved in BCR signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-5
Alternative name(s):
B-cell-specific transcription factor
Short name:
BSAP
Gene namesi
Name:Pax5
Synonyms:Pax-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97489 Pax5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501841 – 391Paired box protein Pax-5Add BLAST391

Post-translational modificationi

O-glycosylated.Curated

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ02650
PaxDbiQ02650
PRIDEiQ02650

PTM databases

iPTMnetiQ02650
PhosphoSitePlusiQ02650

Expressioni

Developmental stagei

Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

Gene expression databases

BgeeiENSMUSG00000014030
CleanExiMM_PAX5
ExpressionAtlasiQ02650 baseline and differential
GenevisibleiQ02650 MM

Interactioni

Subunit structurei

Interacts with ETS1, altering its DNA-binding properties (By similarity). Interacts with DAXX and TLE4. Binds DNA as a monomer.By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi2020324 interactors.
IntActiQ02650 12 interactors.
MINTiQ02650
STRINGi10090.ENSMUSP00000014174

Structurei

3D structure databases

ProteinModelPortaliQ02650
SMRiQ02650
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 142PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230938
HOVERGENiHBG009115
InParanoidiQ02650
KOiK09383
OMAiYSTYNDS
OrthoDBiEOG091G0S4E
PhylomeDBiQ02650
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.102 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q02650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLEKNYPTP RTIRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR
60 70 80 90 100
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA
110 120 130 140 150
EYKRQNPTMF AWEIRDRLLA ERVCDNDTVP SVSSINRIIR TKVQQPPNQP
160 170 180 190 200
VPASSHSIVS TGSVTQVSSV STDSAGSSYS ISGILGITSP SADTNKRKRD
210 220 230 240 250
EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV FERQHYSDIF
260 270 280 290 300
TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP
310 320 330 340 350
IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ
360 370 380 390
YSSYNDSWRF PNPGLLGSPY YYSPAARGAA PPAAATAYDR H
Length:391
Mass (Da):42,231
Last modified:July 1, 1993 - v1
Checksum:iD703E94808DE8EC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M97013 mRNA Translation: AAA37325.1
CCDSiCCDS18125.1
PIRiB41061
RefSeqiNP_032808.1, NM_008782.2
UniGeneiMm.439659

Genome annotation databases

EnsembliENSMUST00000014174; ENSMUSP00000014174; ENSMUSG00000014030
GeneIDi18507
KEGGimmu:18507
UCSCiuc008srx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPAX5_MOUSE
AccessioniPrimary (citable) accession number: Q02650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome