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Q02650

- PAX5_MOUSE

UniProt

Q02650 - PAX5_MOUSE

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Protein

Paired box protein Pax-5

Gene

Pax5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. negative regulation of histone H3-K9 methylation Source: MGI
  2. negative regulation of transcription, DNA-templated Source: UniProtKB
  3. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  4. nervous system development Source: UniProtKB-KW
  5. organ morphogenesis Source: MGI
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  8. regulation of transcription, DNA-templated Source: MGI
  9. skeletal muscle cell differentiation Source: MGI
  10. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Spermatogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-5
Alternative name(s):
B-cell-specific transcription factor
Short name:
BSAP
Gene namesi
Name:Pax5
Synonyms:Pax-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:97489. Pax5.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Paired box protein Pax-5PRO_0000050184Add
BLAST

Post-translational modificationi

O-glycosylated.Curated

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ02650.
PRIDEiQ02650.

PTM databases

PhosphoSiteiQ02650.

Expressioni

Developmental stagei

Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

Gene expression databases

BgeeiQ02650.
CleanExiMM_PAX5.
ExpressionAtlasiQ02650. baseline and differential.
GenevestigatoriQ02650.

Interactioni

Subunit structurei

Interacts with ETS1, altering its DNA-binding properties (By similarity). Interacts with DAXX and TLE4. Binds DNA as a monomer.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DAXXQ9UER74EBI-296260,EBI-77321From a different organism.
Paxip1Q6NZQ43EBI-296260,EBI-1395317

Protein-protein interaction databases

BioGridi202032. 4 interactions.
IntActiQ02650. 9 interactions.
MINTiMINT-246854.
STRINGi10090.ENSMUSP00000014174.

Structurei

3D structure databases

ProteinModelPortaliQ02650.
SMRiQ02650. Positions 19-142, 222-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 142127PairedPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 paired domain.PROSITE-ProRule annotation

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiNOG326044.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiQ02650.
KOiK09383.
OMAiIXIQESP.
PhylomeDBiQ02650.
TreeFamiTF315397.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02650-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLEKNYPTP RTIRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR
60 70 80 90 100
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA
110 120 130 140 150
EYKRQNPTMF AWEIRDRLLA ERVCDNDTVP SVSSINRIIR TKVQQPPNQP
160 170 180 190 200
VPASSHSIVS TGSVTQVSSV STDSAGSSYS ISGILGITSP SADTNKRKRD
210 220 230 240 250
EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV FERQHYSDIF
260 270 280 290 300
TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP
310 320 330 340 350
IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ
360 370 380 390
YSSYNDSWRF PNPGLLGSPY YYSPAARGAA PPAAATAYDR H
Length:391
Mass (Da):42,231
Last modified:July 1, 1993 - v1
Checksum:iD703E94808DE8EC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97013 mRNA. Translation: AAA37325.1.
CCDSiCCDS18125.1.
PIRiB41061.
RefSeqiNP_032808.1. NM_008782.2.
UniGeneiMm.439659.

Genome annotation databases

EnsembliENSMUST00000014174; ENSMUSP00000014174; ENSMUSG00000014030.
GeneIDi18507.
KEGGimmu:18507.
UCSCiuc008srx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M97013 mRNA. Translation: AAA37325.1 .
CCDSi CCDS18125.1.
PIRi B41061.
RefSeqi NP_032808.1. NM_008782.2.
UniGenei Mm.439659.

3D structure databases

ProteinModelPortali Q02650.
SMRi Q02650. Positions 19-142, 222-282.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202032. 4 interactions.
IntActi Q02650. 9 interactions.
MINTi MINT-246854.
STRINGi 10090.ENSMUSP00000014174.

PTM databases

PhosphoSitei Q02650.

Proteomic databases

MaxQBi Q02650.
PRIDEi Q02650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014174 ; ENSMUSP00000014174 ; ENSMUSG00000014030 .
GeneIDi 18507.
KEGGi mmu:18507.
UCSCi uc008srx.1. mouse.

Organism-specific databases

CTDi 5079.
MGIi MGI:97489. Pax5.

Phylogenomic databases

eggNOGi NOG326044.
GeneTreei ENSGT00680000099553.
HOGENOMi HOG000230938.
HOVERGENi HBG009115.
InParanoidi Q02650.
KOi K09383.
OMAi IXIQESP.
PhylomeDBi Q02650.
TreeFami TF315397.

Miscellaneous databases

NextBioi 294232.
PROi Q02650.
SOURCEi Search...

Gene expression databases

Bgeei Q02650.
CleanExi MM_PAX5.
ExpressionAtlasi Q02650. baseline and differential.
Genevestigatori Q02650.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis."
    Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M.
    Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "Pax: a murine multigene family of paired box-containing genes."
    Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P.
    Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-136.
  3. "The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells."
    Emelyanov A.V., Kovac C.R., Sepulveda M.A., Birshtein B.K.
    J. Biol. Chem. 277:11156-11164(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAXX.

Entry informationi

Entry nameiPAX5_MOUSE
AccessioniPrimary (citable) accession number: Q02650
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3