Paired box protein Pax-5 - Mus musculus (Mouse)

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Q02650 (PAX5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Paired box protein Pax-5

Alternative name(s):
B-cell-specific transcription factor
Short name=BSAP

Gene names

Name:	Pax5
Synonyms:	Pax-5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.
Subunit structure	Interacts with ETS1, altering its DNA-binding properties By similarity. Interacts with DAXX and TLE4. Binds DNA as a monomer. Ref.3
Subcellular location	Nucleus.
Developmental stage	Expressed at early B-cell differentiation, in the developing CNS and in adult testis.
Post-translational modification	O-glycosylated Probable.
Sequence similarities	Contains 1 paired domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Spermatogenesis Transcription Transcription regulation
Cellular component	Nucleus
Domain	Paired box
Ligand	DNA-binding
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of histone H3-K9 methylation Inferred from mutant phenotype PubMed 15258579. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15258579. Source: MGI nervous system development Inferred from electronic annotation. Source: UniProtKB-KW organ morphogenesis Traceable author statement PubMed 10197584. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 15094381. Source: MGI skeletal muscle cell differentiation Inferred from mutant phenotype PubMed 22147266. Source: MGI spermatogenesis Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Traceable author statement PubMed 10197584. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 14594818. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 14594818. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DAXX	Q9UER7	4	EBI-296260,EBI-77321	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 391

391

Paired box protein Pax-5

PRO_0000050184

Regions

Domain

16 – 142

127

Paired

Sequences

Sequence

Length

Mass (Da)

Tools

Q02650 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: D703E94808DE8EC8
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FASTA

391

42,231

        10         20         30         40         50         60 
MDLEKNYPTP RTIRTGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV 

        70         80         90        100        110        120 
SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVEKIA EYKRQNPTMF AWEIRDRLLA 

       130        140        150        160        170        180 
ERVCDNDTVP SVSSINRIIR TKVQQPPNQP VPASSHSIVS TGSVTQVSSV STDSAGSSYS 

       190        200        210        220        230        240 
ISGILGITSP SADTNKRKRD EGIQESPVPN GHSLPGRDFL RKQMRGDLFT QQQLEVLDRV 

       250        260        270        280        290        300 
FERQHYSDIF TTTEPIKPEQ TTEYSAMASL AGGLDDMKAN LTSPTPADIG SSVPGPQSYP 

       310        320        330        340        350        360 
IVTGRDLAST TLPGYPPHVP PAGQGSYSAP TLTGMVPGSE FSGSPYSHPQ YSSYNDSWRF 

       370        380        390 
PNPGLLGSPY YYSPAARGAA PPAAATAYDR H

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References

[1]	"Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis." Adams B., Doerfler P., Aguzzi A., Kozmik Z., Urbanek P., Maurer-Fogy I., Busslinger M. Genes Dev. 6:1589-1607(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	"Pax: a murine multigene family of paired box-containing genes." Walther C., Guenet J.-L., Simon D., Deutsch U., Jostes B., Goulding M.D., Plachov D., Balling R., Gruss P. Genomics 11:424-434(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-136.
[3]	"The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells." Emelyanov A.V., Kovac C.R., Sepulveda M.A., Birshtein B.K. J. Biol. Chem. 277:11156-11164(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DAXX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M97013 mRNA. Translation: AAA37325.1.
IPI	IPI00130388.
PIR	B41061.
RefSeq	NP_032808.1. NM_008782.2.
UniGene	Mm.439659.
3D structure databases
ProteinModelPortal	Q02650.
SMR	Q02650. Positions 19-142, 223-281.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q02650. 3 interactions.
MINT	MINT-246854.
STRING	10090.ENSMUSP00000014174.
PTM databases
PhosphoSite	Q02650.
Proteomic databases
PRIDE	Q02650.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000014174; ENSMUSP00000014174; ENSMUSG00000014030.
GeneID	18507.
KEGG	mmu:18507.
Organism-specific databases
CTD	5079.
MGI	MGI:97489. Pax5.
Phylogenomic databases
eggNOG	NOG326044.
GeneTree	ENSGT00680000099910.
HOGENOM	HOG000230938.
HOVERGEN	HBG009115.
InParanoid	Q02650.
KO	K09383.
OMA	IXIQESP.
OrthoDB	EOG4DZ1VJ.
Gene expression databases
ArrayExpress	Q02650.
Bgee	Q02650.
CleanEx	MM_PAX5.
Genevestigator	Q02650.
GermOnline	ENSMUSG00000014030. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 2 hits.
InterPro	IPR009057. Homeodomain-like. IPR001523. Paired_dom. IPR022130. Pax2_C. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00292. PAX. 1 hit. PF12403. Pax2_C. 1 hit. [Graphical view]
PRINTS	PR00027. PAIREDBOX.
SMART	SM00351. PAX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00034. PAIRED_1. 1 hit. PS51057. PAIRED_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294232.
SOURCE	Search...

Entry information

Entry name

PAX5_MOUSE

Accession

Primary (citable) accession number: Q02650

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents