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Q02644

- GHRHR_RAT

UniProt

Q02644 - GHRHR_RAT

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Protein

Growth hormone-releasing hormone receptor

Gene
Ghrhr, Grfr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

GO - Molecular functioni

  1. growth hormone-releasing hormone receptor activity Source: RGD
  2. peptide hormone binding Source: RGD

GO - Biological processi

  1. activation of adenylate cyclase activity Source: RGD
  2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  4. cAMP-mediated signaling Source: Ensembl
  5. cell maturation Source: Ensembl
  6. cellular response to insulin stimulus Source: Ensembl
  7. determination of adult lifespan Source: Ensembl
  8. growth hormone secretion Source: Ensembl
  9. hormone metabolic process Source: Ensembl
  10. lactation Source: Ensembl
  11. positive regulation of cAMP metabolic process Source: RGD
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of growth hormone secretion Source: Ensembl
  14. positive regulation of multicellular organism growth Source: Ensembl
  15. regulation of growth Source: RGD
  16. regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
  17. regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
  18. regulation of protein metabolic process Source: Ensembl
  19. response to estrogen Source: Ensembl
  20. response to glucocorticoid Source: Ensembl
  21. signal transduction Source: RGD
  22. somatotropin secreting cell development Source: Ensembl
  23. water homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-releasing hormone receptor
Short name:
GHRH receptor
Alternative name(s):
Growth hormone-releasing factor receptor
Short name:
GRF receptor
Short name:
GRFR
Gene namesi
Name:Ghrhr
Synonyms:Grfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi2688. Ghrhr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 132110Extracellular Reviewed predictionAdd
BLAST
Transmembranei133 – 15220Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini153 – 16210Cytoplasmic Reviewed prediction
Transmembranei163 – 18119Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini182 – 20423Extracellular Reviewed predictionAdd
BLAST
Transmembranei205 – 22723Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini228 – 24013Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei241 – 26222Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini263 – 28018Extracellular Reviewed predictionAdd
BLAST
Transmembranei281 – 30424Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini305 – 37066Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei371 – 38919Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini390 – 40213Extracellular Reviewed predictionAdd
BLAST
Transmembranei403 – 42220Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini423 – 46442Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. nuclear inner membrane Source: Ensembl
  4. nuclear matrix Source: Ensembl
  5. nuclear outer membrane Source: Ensembl
  6. plasma membrane Source: RGD
  7. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 464442Growth hormone-releasing hormone receptorPRO_0000012831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 64 By similarity
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi55 ↔ 96 By similarity
Disulfide bondi78 ↔ 112 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ02644.

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

GenevestigatoriQ02644.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016087.

Structurei

3D structure databases

ProteinModelPortaliQ02644.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249002.
GeneTreeiENSGT00740000115231.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ02644.
KOiK04584.
OMAiIHYIIFN.
OrthoDBiEOG7TF78W.
PhylomeDBiQ02644.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003288. GPCR_2_GHRH_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01352. GHRHRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q02644-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDSLLWATWV LCLLNLWGVA LGHLHLECDF ITQLRDDELA CLQAAEGTNN    50
SSMGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDPG AVKRDCTITG 100
WSDPFPPYPV ACPVPLELLT EEKSYFSTVK IIYTTGHSIS IVALCVAIAI 150
LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAVFQGD STDHCSMSTI 200
LCKVSVAVSH FATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW 250
GLPVLCTGTW VGCKLAFEDT ACWDLDDSSP YWWIIKGPIV LSVGVNFGLF 300
LNIICILLRK LGPAQGGLHT RAQYCNYLLP WSCPLPQVPR ERTDLGPSSH 350
EITVQESGTR NCQLPWRLSK STLLLIPLFG IHYIIFNFLP DSAGLGIRLP 400
LELGLGSFQG FVVAVLYCFL NQEVRTEISR KWYGHDPELL PARRTCTEWT 450
TPPRSRVKVL TSEC 464
Length:464
Mass (Da):51,522
Last modified:June 1, 1994 - v2
Checksum:i5FFF49A7D79A4114
GO
Isoform Short (identifier: Q02644-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-365: Missing.

Show »
Length:423
Mass (Da):46,917
Checksum:i79F335DB3E92A912
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 36541Missing in isoform Short. VSP_002003Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331S → W in L07380. 1 Publication
Sequence conflicti305 – 3051C → S in L07380. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01407 mRNA. Translation: AAA41221.1.
L07380 mRNA. No translation available.
PIRiS29754.
RefSeqiNP_036982.1. NM_012850.1. [Q02644-2]
UniGeneiRn.10936.

Genome annotation databases

EnsembliENSRNOT00000016087; ENSRNOP00000016087; ENSRNOG00000011808. [Q02644-1]
ENSRNOT00000044578; ENSRNOP00000043884; ENSRNOG00000011808. [Q02644-2]
GeneIDi25321.
KEGGirno:25321.
UCSCiRGD:2688. rat. [Q02644-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L01407 mRNA. Translation: AAA41221.1 .
L07380 mRNA. No translation available.
PIRi S29754.
RefSeqi NP_036982.1. NM_012850.1. [Q02644-2 ]
UniGenei Rn.10936.

3D structure databases

ProteinModelPortali Q02644.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016087.

Chemistry

BindingDBi Q02644.
ChEMBLi CHEMBL3709.
GuidetoPHARMACOLOGYi 247.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi Q02644.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000016087 ; ENSRNOP00000016087 ; ENSRNOG00000011808 . [Q02644-1 ]
ENSRNOT00000044578 ; ENSRNOP00000043884 ; ENSRNOG00000011808 . [Q02644-2 ]
GeneIDi 25321.
KEGGi rno:25321.
UCSCi RGD:2688. rat. [Q02644-1 ]

Organism-specific databases

CTDi 2692.
RGDi 2688. Ghrhr.

Phylogenomic databases

eggNOGi NOG249002.
GeneTreei ENSGT00740000115231.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi Q02644.
KOi K04584.
OMAi IHYIIFN.
OrthoDBi EOG7TF78W.
PhylomeDBi Q02644.
TreeFami TF315710.

Miscellaneous databases

NextBioi 606165.
PROi Q02644.

Gene expression databases

Genevestigatori Q02644.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003288. GPCR_2_GHRH_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01352. GHRHRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone."
    Mayo K.E.
    Mol. Endocrinol. 6:1734-1744(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.
  2. "Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth."
    Lin C.R., Lin S.-C., Chang C.P., Rosenfeld M.G.
    Nature 360:765-768(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGHRHR_RAT
AccessioniPrimary (citable) accession number: Q02644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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