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Protein

Growth hormone-releasing hormone receptor

Gene

Ghrhr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

GO - Molecular functioni

  • growth hormone-releasing hormone receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-releasing hormone receptor
Short name:
GHRH receptor
Alternative name(s):
Growth hormone-releasing factor receptor
Short name:
GRF receptor
Short name:
GRFR
Gene namesi
Name:Ghrhr
Synonyms:Grfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2688. Ghrhr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 132ExtracellularSequence analysisAdd BLAST110
Transmembranei133 – 152Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini153 – 162CytoplasmicSequence analysis10
Transmembranei163 – 181Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini182 – 204ExtracellularSequence analysisAdd BLAST23
Transmembranei205 – 227Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 262Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 304Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini305 – 370CytoplasmicSequence analysisAdd BLAST66
Transmembranei371 – 389Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini390 – 402ExtracellularSequence analysisAdd BLAST13
Transmembranei403 – 422Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini423 – 464CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • cell surface Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • nuclear inner membrane Source: Ensembl
  • nuclear matrix Source: Ensembl
  • nuclear outer membrane Source: Ensembl
  • plasma membrane Source: RGD
  • sarcolemma Source: RGD
  • secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3709.
GuidetoPHARMACOLOGYi247.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001283123 – 464Growth hormone-releasing hormone receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 64By similarity
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 96By similarity
Disulfide bondi78 ↔ 112By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ02644.
PRIDEiQ02644.

PTM databases

PhosphoSitePlusiQ02644.

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSRNOG00000011808.
ExpressionAtlasiQ02644. baseline and differential.
GenevisibleiQ02644. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016087.

Chemistry databases

BindingDBiQ02644.

Structurei

3D structure databases

ProteinModelPortaliQ02644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ02644.
KOiK04584.
OMAiIHYIIFN.
OrthoDBiEOG091G0NF8.
PhylomeDBiQ02644.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003288. GPCR_2_GHRH_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01352. GHRHRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q02644-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLLWATWV LCLLNLWGVA LGHLHLECDF ITQLRDDELA CLQAAEGTNN
60 70 80 90 100
SSMGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDPG AVKRDCTITG
110 120 130 140 150
WSDPFPPYPV ACPVPLELLT EEKSYFSTVK IIYTTGHSIS IVALCVAIAI
160 170 180 190 200
LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAVFQGD STDHCSMSTI
210 220 230 240 250
LCKVSVAVSH FATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW
260 270 280 290 300
GLPVLCTGTW VGCKLAFEDT ACWDLDDSSP YWWIIKGPIV LSVGVNFGLF
310 320 330 340 350
LNIICILLRK LGPAQGGLHT RAQYCNYLLP WSCPLPQVPR ERTDLGPSSH
360 370 380 390 400
EITVQESGTR NCQLPWRLSK STLLLIPLFG IHYIIFNFLP DSAGLGIRLP
410 420 430 440 450
LELGLGSFQG FVVAVLYCFL NQEVRTEISR KWYGHDPELL PARRTCTEWT
460
TPPRSRVKVL TSEC
Length:464
Mass (Da):51,522
Last modified:June 1, 1994 - v2
Checksum:i5FFF49A7D79A4114
GO
Isoform Short (identifier: Q02644-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-365: Missing.

Show »
Length:423
Mass (Da):46,917
Checksum:i79F335DB3E92A912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233S → W in L07380 (PubMed:1334535).Curated1
Sequence conflicti305C → S in L07380 (PubMed:1334535).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002003325 – 365Missing in isoform Short. CuratedAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01407 mRNA. Translation: AAA41221.1.
L07380 mRNA. No translation available.
PIRiS29754.
RefSeqiNP_036982.1. NM_012850.1. [Q02644-2]
UniGeneiRn.10936.

Genome annotation databases

EnsembliENSRNOT00000016087; ENSRNOP00000016087; ENSRNOG00000011808. [Q02644-1]
ENSRNOT00000044578; ENSRNOP00000043884; ENSRNOG00000011808. [Q02644-2]
GeneIDi25321.
KEGGirno:25321.
UCSCiRGD:2688. rat. [Q02644-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01407 mRNA. Translation: AAA41221.1.
L07380 mRNA. No translation available.
PIRiS29754.
RefSeqiNP_036982.1. NM_012850.1. [Q02644-2]
UniGeneiRn.10936.

3D structure databases

ProteinModelPortaliQ02644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016087.

Chemistry databases

BindingDBiQ02644.
ChEMBLiCHEMBL3709.
GuidetoPHARMACOLOGYi247.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ02644.

Proteomic databases

PaxDbiQ02644.
PRIDEiQ02644.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016087; ENSRNOP00000016087; ENSRNOG00000011808. [Q02644-1]
ENSRNOT00000044578; ENSRNOP00000043884; ENSRNOG00000011808. [Q02644-2]
GeneIDi25321.
KEGGirno:25321.
UCSCiRGD:2688. rat. [Q02644-1]

Organism-specific databases

CTDi2692.
RGDi2688. Ghrhr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiQ02644.
KOiK04584.
OMAiIHYIIFN.
OrthoDBiEOG091G0NF8.
PhylomeDBiQ02644.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiQ02644.

Gene expression databases

BgeeiENSRNOG00000011808.
ExpressionAtlasiQ02644. baseline and differential.
GenevisibleiQ02644. RN.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003288. GPCR_2_GHRH_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01352. GHRHRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHRHR_RAT
AccessioniPrimary (citable) accession number: Q02644
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.