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Q02644

- GHRHR_RAT

UniProt

Q02644 - GHRHR_RAT

Protein

Growth hormone-releasing hormone receptor

Gene

Ghrhr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

    GO - Molecular functioni

    1. growth hormone-releasing hormone receptor activity Source: RGD
    2. peptide hormone binding Source: RGD

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: RGD
    2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
    3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
    4. cAMP-mediated signaling Source: Ensembl
    5. cell maturation Source: Ensembl
    6. cellular response to insulin stimulus Source: Ensembl
    7. determination of adult lifespan Source: Ensembl
    8. growth hormone secretion Source: Ensembl
    9. hormone metabolic process Source: Ensembl
    10. lactation Source: Ensembl
    11. positive regulation of cAMP metabolic process Source: RGD
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of growth hormone secretion Source: Ensembl
    14. positive regulation of multicellular organism growth Source: Ensembl
    15. regulation of growth Source: RGD
    16. regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
    17. regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
    18. regulation of protein metabolic process Source: Ensembl
    19. response to estrogen Source: Ensembl
    20. response to glucocorticoid Source: Ensembl
    21. signal transduction Source: RGD
    22. somatotropin secreting cell development Source: Ensembl
    23. water homeostasis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth hormone-releasing hormone receptor
    Short name:
    GHRH receptor
    Alternative name(s):
    Growth hormone-releasing factor receptor
    Short name:
    GRF receptor
    Short name:
    GRFR
    Gene namesi
    Name:Ghrhr
    Synonyms:Grfr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi2688. Ghrhr.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. nuclear inner membrane Source: Ensembl
    4. nuclear matrix Source: Ensembl
    5. nuclear outer membrane Source: Ensembl
    6. plasma membrane Source: RGD
    7. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 464442Growth hormone-releasing hormone receptorPRO_0000012831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 64By similarity
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 96By similarity
    Disulfide bondi78 ↔ 112By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ02644.

    Expressioni

    Tissue specificityi

    Pituitary gland.

    Gene expression databases

    GenevestigatoriQ02644.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ02644.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 132110ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 16210CytoplasmicSequence Analysis
    Topological domaini182 – 20423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 37066CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini390 – 40213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini423 – 46442CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei133 – 15220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18119Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22723Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30424Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei371 – 38919Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei403 – 42220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249002.
    GeneTreeiENSGT00740000115231.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiQ02644.
    KOiK04584.
    OMAiIHYIIFN.
    OrthoDBiEOG7TF78W.
    PhylomeDBiQ02644.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003288. GPCR_2_GHRH_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01352. GHRHRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q02644-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSLLWATWV LCLLNLWGVA LGHLHLECDF ITQLRDDELA CLQAAEGTNN    50
    SSMGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDPG AVKRDCTITG 100
    WSDPFPPYPV ACPVPLELLT EEKSYFSTVK IIYTTGHSIS IVALCVAIAI 150
    LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAVFQGD STDHCSMSTI 200
    LCKVSVAVSH FATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW 250
    GLPVLCTGTW VGCKLAFEDT ACWDLDDSSP YWWIIKGPIV LSVGVNFGLF 300
    LNIICILLRK LGPAQGGLHT RAQYCNYLLP WSCPLPQVPR ERTDLGPSSH 350
    EITVQESGTR NCQLPWRLSK STLLLIPLFG IHYIIFNFLP DSAGLGIRLP 400
    LELGLGSFQG FVVAVLYCFL NQEVRTEISR KWYGHDPELL PARRTCTEWT 450
    TPPRSRVKVL TSEC 464
    Length:464
    Mass (Da):51,522
    Last modified:June 1, 1994 - v2
    Checksum:i5FFF49A7D79A4114
    GO
    Isoform Short (identifier: Q02644-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         325-365: Missing.

    Show »
    Length:423
    Mass (Da):46,917
    Checksum:i79F335DB3E92A912
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti233 – 2331S → W in L07380. (PubMed:1334535)Curated
    Sequence conflicti305 – 3051C → S in L07380. (PubMed:1334535)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei325 – 36541Missing in isoform Short. CuratedVSP_002003Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01407 mRNA. Translation: AAA41221.1.
    L07380 mRNA. No translation available.
    PIRiS29754.
    RefSeqiNP_036982.1. NM_012850.1. [Q02644-2]
    UniGeneiRn.10936.

    Genome annotation databases

    EnsembliENSRNOT00000016087; ENSRNOP00000016087; ENSRNOG00000011808. [Q02644-1]
    ENSRNOT00000044578; ENSRNOP00000043884; ENSRNOG00000011808. [Q02644-2]
    GeneIDi25321.
    KEGGirno:25321.
    UCSCiRGD:2688. rat. [Q02644-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01407 mRNA. Translation: AAA41221.1 .
    L07380 mRNA. No translation available.
    PIRi S29754.
    RefSeqi NP_036982.1. NM_012850.1. [Q02644-2 ]
    UniGenei Rn.10936.

    3D structure databases

    ProteinModelPortali Q02644.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016087.

    Chemistry

    BindingDBi Q02644.
    ChEMBLi CHEMBL3709.
    GuidetoPHARMACOLOGYi 247.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi Q02644.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000016087 ; ENSRNOP00000016087 ; ENSRNOG00000011808 . [Q02644-1 ]
    ENSRNOT00000044578 ; ENSRNOP00000043884 ; ENSRNOG00000011808 . [Q02644-2 ]
    GeneIDi 25321.
    KEGGi rno:25321.
    UCSCi RGD:2688. rat. [Q02644-1 ]

    Organism-specific databases

    CTDi 2692.
    RGDi 2688. Ghrhr.

    Phylogenomic databases

    eggNOGi NOG249002.
    GeneTreei ENSGT00740000115231.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi Q02644.
    KOi K04584.
    OMAi IHYIIFN.
    OrthoDBi EOG7TF78W.
    PhylomeDBi Q02644.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 606165.
    PROi Q02644.

    Gene expression databases

    Genevestigatori Q02644.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003288. GPCR_2_GHRH_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01352. GHRHRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone."
      Mayo K.E.
      Mol. Endocrinol. 6:1734-1744(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth."
      Lin C.R., Lin S.-C., Chang C.P., Rosenfeld M.G.
      Nature 360:765-768(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGHRHR_RAT
    AccessioniPrimary (citable) accession number: Q02644
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3