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Q02643

- GHRHR_HUMAN

UniProt

Q02643 - GHRHR_HUMAN

Protein

Growth hormone-releasing hormone receptor

Gene

GHRHR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: BHF-UCL
    2. growth factor binding Source: BHF-UCL
    3. growth hormone-releasing hormone receptor activity Source: BHF-UCL
    4. peptide hormone binding Source: BHF-UCL
    5. protein binding Source: BHF-UCL

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: Ensembl
    2. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    3. cAMP-mediated signaling Source: BHF-UCL
    4. cell maturation Source: Ensembl
    5. cellular response to insulin stimulus Source: Ensembl
    6. determination of adult lifespan Source: Ensembl
    7. growth hormone secretion Source: Ensembl
    8. hormone metabolic process Source: Ensembl
    9. lactation Source: Ensembl
    10. multicellular organismal reproductive process Source: BHF-UCL
    11. positive regulation of cAMP biosynthetic process Source: BHF-UCL
    12. positive regulation of cell proliferation Source: BHF-UCL
    13. positive regulation of growth hormone secretion Source: BHF-UCL
    14. positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
    15. positive regulation of multicellular organism growth Source: BHF-UCL
    16. regulation of intracellular steroid hormone receptor signaling pathway Source: Ensembl
    17. regulation of protein metabolic process Source: Ensembl
    18. response to estrogen Source: BHF-UCL
    19. response to glucocorticoid Source: BHF-UCL
    20. response to insulin Source: BHF-UCL
    21. somatotropin secreting cell development Source: Ensembl
    22. water homeostasis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Protein family/group databases

    TCDBi9.A.14.4.7. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth hormone-releasing hormone receptor
    Short name:
    GHRH receptor
    Alternative name(s):
    Growth hormone-releasing factor receptor
    Short name:
    GRF receptor
    Short name:
    GRFR
    Gene namesi
    Name:GHRHR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:4266. GHRHR.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: BHF-UCL
    2. cytoplasm Source: BHF-UCL
    3. integral component of membrane Source: BHF-UCL
    4. nuclear inner membrane Source: BHF-UCL
    5. nuclear matrix Source: BHF-UCL
    6. nuclear outer membrane Source: BHF-UCL
    7. plasma membrane Source: BHF-UCL
    8. secretory granule Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Growth hormone deficiency, isolated, 1B (IGHD1B) [MIM:612781]: An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti144 – 1441L → H in IGHD1B. 1 Publication
    Corresponds to variant rs121918118 [ dbSNP | Ensembl ].
    VAR_015796
    Natural varianti176 – 1761A → V in IGHD1B; reduced cAMP response to GHRH. 1 Publication
    VAR_015797
    Natural varianti222 – 2221A → E in IGHD1B. 1 Publication
    VAR_015798
    Natural varianti242 – 2421F → C in IGHD1B. 1 Publication
    VAR_015799
    Natural varianti329 – 3291K → E in IGHD1B. 1 Publication
    VAR_015800

    Keywords - Diseasei

    Disease mutation, Dwarfism

    Organism-specific databases

    MIMi612781. phenotype.
    Orphaneti231671. Isolated growth hormone deficiency type IB.
    PharmGKBiPA28676.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 423401Growth hormone-releasing hormone receptorPRO_0000012828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 641 Publication
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 961 Publication
    Disulfide bondi78 ↔ 1121 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ02643.
    PRIDEiQ02643.

    Expressioni

    Tissue specificityi

    Pituitary gland.

    Gene expression databases

    ArrayExpressiQ02643.
    BgeeiQ02643.
    CleanExiHS_GHRHR.
    GenevestigatoriQ02643.

    Interactioni

    Protein-protein interaction databases

    BioGridi108959. 1 interaction.
    STRINGi9606.ENSP00000320180.

    Structurei

    Secondary structure

    1
    423
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 4512
    Beta strandi53 – 553
    Beta strandi72 – 765
    Helixi80 – 845
    Beta strandi92 – 976
    Helixi108 – 1114
    Helixi116 – 1194

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XDGX-ray1.95A/B34-123[»]
    ProteinModelPortaliQ02643.
    SMRiQ02643. Positions 34-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ02643.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 132110ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 16210CytoplasmicSequence Analysis
    Topological domaini182 – 20423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 32925CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini349 – 36113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 42342CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei133 – 15220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18119Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22723Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30424Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei330 – 34819Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249002.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiQ02643.
    KOiK04584.
    OMAiIHYIIFN.
    OrthoDBiEOG7TF78W.
    PhylomeDBiQ02643.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003288. GPCR_2_GHRH_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01352. GHRHRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q02643-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRRMWGAHV FCVLSPLPTV LGHMHPECDF ITQLREDESA CLQAAEEMPN    50
    TTLGCPATWD GLLCWPTAGS GEWVTLPCPD FFSHFSSESG AVKRDCTITG 100
    WSEPFPPYPV ACPVPLELLA EEESYFSTVK IIYTVGHSIS IVALFVAITI 150
    LVALRRLHCP RNYVHTQLFT TFILKAGAVF LKDAALFHSD DTDHCSFSTV 200
    LCKVSVAASH FATMTNFSWL LAEAVYLNCL LASTSPSSRR AFWWLVLAGW 250
    GLPVLFTGTW VSCKLAFEDI ACWDLDDTSP YWWIIKGPIV LSVGVNFGLF 300
    LNIIRILVRK LEPAQGSLHT QSQYWRLSKS TLFLIPLFGI HYIIFNFLPD 350
    NAGLGIRLPL ELGLGSFQGF IVAILYCFLN QEVRTEISRK WHGHDPELLP 400
    AWRTRAKWTT PSRSAAKVLT SMC 423
    Length:423
    Mass (Da):47,402
    Last modified:July 15, 1998 - v2
    Checksum:iC9C5E2E7D6649E06
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781A → R in AAA35890. (PubMed:1333056)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036223
    Natural varianti57 – 571A → T.
    Corresponds to variant rs4988496 [ dbSNP | Ensembl ].
    VAR_033962
    Natural varianti121 – 1211E → D.
    Corresponds to variant rs4988498 [ dbSNP | Ensembl ].
    VAR_033963
    Natural varianti144 – 1441L → H in IGHD1B. 1 Publication
    Corresponds to variant rs121918118 [ dbSNP | Ensembl ].
    VAR_015796
    Natural varianti176 – 1761A → V in IGHD1B; reduced cAMP response to GHRH. 1 Publication
    VAR_015797
    Natural varianti222 – 2221A → E in IGHD1B. 1 Publication
    VAR_015798
    Natural varianti225 – 2251V → I.
    Corresponds to variant rs28371560 [ dbSNP | Ensembl ].
    VAR_033964
    Natural varianti242 – 2421F → C in IGHD1B. 1 Publication
    VAR_015799
    Natural varianti329 – 3291K → E in IGHD1B. 1 Publication
    VAR_015800
    Natural varianti422 – 4221M → T.
    Corresponds to variant rs2228078 [ dbSNP | Ensembl ].
    VAR_033965

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01406 mRNA. Translation: AAA35890.1.
    L09237 mRNA. Translation: AAA58619.1.
    AB065701 Genomic DNA. Translation: BAC05924.1.
    AY557192 mRNA. Translation: AAS59864.1.
    AC005155 Genomic DNA. Translation: AAC23789.1.
    U42225
    , U42222, U42223, U42224 Genomic DNA. Translation: AAB37758.1.
    CCDSiCCDS5432.1.
    PIRiA45363.
    RefSeqiNP_000814.2. NM_000823.3.
    UniGeneiHs.733003.
    Hs.767.

    Genome annotation databases

    EnsembliENST00000326139; ENSP00000320180; ENSG00000106128.
    GeneIDi2692.
    KEGGihsa:2692.
    UCSCiuc003tbx.3. human.

    Polymorphism databases

    DMDMi3041685.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01406 mRNA. Translation: AAA35890.1 .
    L09237 mRNA. Translation: AAA58619.1 .
    AB065701 Genomic DNA. Translation: BAC05924.1 .
    AY557192 mRNA. Translation: AAS59864.1 .
    AC005155 Genomic DNA. Translation: AAC23789.1 .
    U42225
    , U42222 , U42223 , U42224 Genomic DNA. Translation: AAB37758.1 .
    CCDSi CCDS5432.1.
    PIRi A45363.
    RefSeqi NP_000814.2. NM_000823.3.
    UniGenei Hs.733003.
    Hs.767.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XDG X-ray 1.95 A/B 34-123 [» ]
    ProteinModelPortali Q02643.
    SMRi Q02643. Positions 34-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108959. 1 interaction.
    STRINGi 9606.ENSP00000320180.

    Chemistry

    ChEMBLi CHEMBL2032.
    DrugBanki DB00010. Sermorelin.
    GuidetoPHARMACOLOGYi 247.

    Protein family/group databases

    TCDBi 9.A.14.4.7. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    Polymorphism databases

    DMDMi 3041685.

    Proteomic databases

    PaxDbi Q02643.
    PRIDEi Q02643.

    Protocols and materials databases

    DNASUi 2692.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326139 ; ENSP00000320180 ; ENSG00000106128 .
    GeneIDi 2692.
    KEGGi hsa:2692.
    UCSCi uc003tbx.3. human.

    Organism-specific databases

    CTDi 2692.
    GeneCardsi GC07P030978.
    HGNCi HGNC:4266. GHRHR.
    MIMi 139191. gene.
    612781. phenotype.
    neXtProti NX_Q02643.
    Orphaneti 231671. Isolated growth hormone deficiency type IB.
    PharmGKBi PA28676.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249002.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi Q02643.
    KOi K04584.
    OMAi IHYIIFN.
    OrthoDBi EOG7TF78W.
    PhylomeDBi Q02643.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    EvolutionaryTracei Q02643.
    GeneWikii Growth-hormone-releasing_hormone_receptor.
    Growth_hormone-releasing_hormone_receptor.
    GenomeRNAii 2692.
    NextBioi 10644.
    PROi Q02643.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q02643.
    Bgeei Q02643.
    CleanExi HS_GHRHR.
    Genevestigatori Q02643.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003288. GPCR_2_GHRH_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01352. GHRHRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone."
      Mayo K.E.
      Mol. Endocrinol. 6:1734-1744(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    2. "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone."
      Gaylinn B.D., Harrison J.K., Zysk J.R., Lyons C.E. Jr., Lynch K.R., Thorner M.O.
      Mol. Endocrinol. 7:77-84(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary.
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The structure of the gene coding for human growth hormone releasing hormone."
      Tang J., Collu R.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-271.
    7. "Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor."
      Structural genomics consortium (SGC)
      Submitted (JUN-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 34-123, DISULFIDE BONDS.
    8. "Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB."
      Salvatori R., Fan X., Phillips J.A. III, Espigares-Martin R., Martin De Lara I., Freeman K.L., Plotnick L., Al-Ashwal A., Levine M.A.
      J. Clin. Endocrinol. Metab. 86:273-279(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS IGHD1B HIS-144; GLU-222 AND CYS-242.
    9. Cited for: VARIANT IGHD1B GLU-329.
    10. "A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency."
      Carakushansky M., Whatmore A.J., Clayton P.E., Shalet S.M., Gleeson H.K., Price D.A., Levine M.A., Salvatori R.
      Eur. J. Endocrinol. 148:25-30(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT IGHD1B VAL-176.
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-45.

    Entry informationi

    Entry nameiGHRHR_HUMAN
    AccessioniPrimary (citable) accession number: Q02643
    Secondary accession number(s): Q99863
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3