Q02641 (CACB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent L-type calcium channel subunit beta-1
Short name=CAB1

Alternative name(s):
Calcium channel voltage-dependent subunit beta 1

Gene names

Name:	CACNB1
Synonyms:	CACNLB1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	598 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subunit structure	The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with JSRP1. Interacts with RYR1 By similarity.
Subcellular location	Cell membrane › sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Tissue specificity	Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. Ref.10
Sequence similarities	Belongs to the calcium channel beta subunit family. Contains 1 SH3 domain.
Sequence caution	The sequence CAA79825.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	SH3 domain
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome protein targeting to membrane Inferred from electronic annotation. Source: Compara
Cellular_component	T-tubule Inferred from electronic annotation. Source: Compara sarcoplasmic reticulum Inferred from electronic annotation. Source: Compara voltage-gated calcium channel complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	high voltage-gated calcium channel activity Inferred from electronic annotation. Source: Compara voltage-gated calcium channel activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q02641-1)

Also known as: Beta-1b2; BetaA; Beta-1B; Beta1-2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q02641-2)

Also known as: Beta-1M; BetaC; Beta-1a;

The sequence of this isoform differs from the canonical sequence as follows:
     210-216: AKQKQKS → GNEMTNLAFELDPLELEEEEAELGEQSGSAKTSVSSVTTPPPHGKRIPFFKK
     445-478: GPYLASGDQPLERATGEHASMHEYPGELGQPPGL → VQVLTSLRRNLGFWGGLESSQRGSVVPQEQEHAM
     479-598: Missing.

Isoform 3 (identifier: Q02641-3)

Also known as: Beta-1b1; BetaB; Beta-1c; Beta1-3;

The sequence of this isoform differs from the canonical sequence as follows:
     445-478: GPYLASGDQPLERATGEHASMHEYPGELGQPPGL → VQVLTSLRRNLGFWGGLESSQRGSVVPQEQEHAM
     479-598: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 598	598	Voltage-dependent L-type calcium channel subunit beta-1		PRO_0000144046
Regions
	Domain	100 – 161	62	SH3
Amino acid modifications
	Modified residue	186	1	Phosphoserine By similarity
	Modified residue	499	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	210 – 216	7	AKQKQKS → GNEMTNLAFELDPLELEEEE AELGEQSGSAKTSVSSVTTP PPHGKRIPFFKK in isoform 2.		VSP_000623
	Alternative sequence	445 – 478	34	GPYLA…QPPGL → VQVLTSLRRNLGFWGGLESS QRGSVVPQEQEHAM in isoform 2 and isoform 3.		VSP_000624
	Alternative sequence	479 – 598	120	Missing in isoform 2 and isoform 3.		VSP_000625
	Natural variant	339	1	P → L in a colorectal cancer sample; somatic mutation. Ref.11		VAR_036349
Experimental info
	Sequence conflict	5 – 6	2	TS → SG in AAA36167. Ref.3
	Sequence conflict	21	1	E → G in AAA51894. Ref.2
	Sequence conflict	28	1	Missing in AAA36168. Ref.3
	Sequence conflict	28	1	Missing in AAA36169. Ref.3
	Sequence conflict	29	1	G → R in AAA36167. Ref.3
	Sequence conflict	29	1	G → R in AAA36168. Ref.3
	Sequence conflict	29	1	G → R in AAA36169. Ref.3
	Sequence conflict	135	1	H → D in AAA36167. Ref.3
	Sequence conflict	175 – 176	2	KL → TV in AAA36167. Ref.3
	Sequence conflict	182	1	G → S in AAA36167. Ref.3
	Sequence conflict	217	1	T → S in AAA36167. Ref.3
	Sequence conflict	264	1	I → T in AAH37311. Ref.8
	Sequence conflict	293 – 296	4	SNTR → LQHT in AAA36167. Ref.3
	Sequence conflict	344	1	I → L in AAA36167. Ref.3
	Sequence conflict	381	1	P → H in AAH37311. Ref.8
	Sequence conflict	428	1	M → I in AAA36167. Ref.3
	Sequence conflict	434 – 435	2	AA → RR in AAA35631. Ref.1
	Sequence conflict	434 – 435	2	AA → RR in AAA35632. Ref.1
	Sequence conflict	434 – 435	2	AA → RR in AAA35633. Ref.1
	Sequence conflict	434 – 435	2	AA → RR in AAB58779. Ref.5
	Sequence conflict	434 – 435	2	AA → RR in AAB58780. Ref.5
	Sequence conflict	434 – 435	2	AA → RR in AAB58781. Ref.5
	Sequence conflict	456	1	E → D in AAA36167. Ref.3
	Sequence conflict	465	1	M → V in AAA36167. Ref.3
	Sequence conflict	482	1	S → N in AAA36167. Ref.3
	Sequence conflict	492	1	R → W in AAA36167. Ref.3
	Sequence conflict	515	1	L → P in AAA36167. Ref.3
	Sequence conflict	532	1	L → P in AAA36167. Ref.3
	Sequence conflict	539 – 541	3	GTP → A in AAA35633. Ref.1
	Sequence conflict	539 – 541	3	GTP → A in AAB58781. Ref.5
	Sequence conflict	550	1	Missing in AAA36167. Ref.3
	Sequence conflict	559	1	L → M in AAA36167. Ref.3
	Sequence conflict	573 – 574	2	CA → WP in AAA35633. Ref.1
	Sequence conflict	573 – 574	2	CA → WP in AAB58781. Ref.5
	Sequence conflict	593	1	R → Q in AAA36167. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Beta-1b2) (BetaA) (Beta-1B) (Beta1-2) [UniParc]. Last modified May 2, 2002. Version 3. Checksum: 44FE4E3BA6F016FD	FASTA	598	65,714
	10 20 30 40 50 60 MVQKTSMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 70 80 90 100 110 120 ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 130 140 150 160 170 180 VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR 190 200 210 220 230 240 LGSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK 250 260 270 280 290 300 GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA 310 320 330 340 350 360 EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG 370 380 390 400 410 420 KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP 430 440 450 460 470 480 NPLLNRTMAT AALAASPAPV SNLQGPYLAS GDQPLERATG EHASMHEYPG ELGQPPGLYP 490 500 510 520 530 540 SSHPPGRAGT LRALSRQDTF DADTPGSRNS AYTELGDSCV DMETDPSEGP GLGDPAGGGT 550 560 570 580 590 PPARQGSWED EEEDYEEELT DNRNRGRNKA RYCAEGGGPV LGRNKNELEG WGRGVYIR
	Isoform 2 (Beta-1M) (BetaC) (Beta-1a) [UniParc]. Checksum: 9F8B7C748A65087C	FASTA	523	57,864
	10 20 30 40 50 60 MVQKTSMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 70 80 90 100 110 120 ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 130 140 150 160 170 180 VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR 190 200 210 220 230 240 LGSSKSGDNS SSSLGDVVTG TRRPTPPASG NEMTNLAFEL DPLELEEEEA ELGEQSGSAK 250 260 270 280 290 300 TSVSSVTTPP PHGKRIPFFK KTEHVPPYDV VPSMRPIILV GPSLKGYEVT DMMQKALFDF 310 320 330 340 350 360 LKHRFDGRIS ITRVTADISL AKRSVLNNPS KHIIIERSNT RSSLAEVQSE IERIFELART 370 380 390 400 410 420 LQLVALDADT INHPAQLSKT SLAPIIVYIK ITSPKVLQRL IKSRGKSQSK HLNVQIAASE 430 440 450 460 470 480 KLAQCPPEMF DIILDENQLE DACEHLAEYL EAYWKATHPP SSTPPNPLLN RTMATAALAA 490 500 510 520 SPAPVSNLQV QVLTSLRRNL GFWGGLESSQ RGSVVPQEQE HAM
	Isoform 3 (Beta-1b1) (BetaB) (Beta-1c) (Beta1-3) [UniParc]. Checksum: 1D0A53AE67443655	FASTA	478	53,006
	10 20 30 40 50 60 MVQKTSMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 70 80 90 100 110 120 ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 130 140 150 160 170 180 VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR 190 200 210 220 230 240 LGSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK 250 260 270 280 290 300 GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA 310 320 330 340 350 360 EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG 370 380 390 400 410 420 KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP 430 440 450 460 470 NPLLNRTMAT AALAASPAPV SNLQVQVLTS LRRNLGFWGG LESSQRGSVV PQEQEHAM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene." Powers P.A., Liu S., Hogan K., Gregg R.G. J. Biol. Chem. 267:22967-22972(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Hippocampus and Skeletal muscle.
[2]	"Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." Williams M.E., Feldman D.H., McCue A.F., Brenner R., Velicelebi G., Ellis S.B., Harpold M.M. Neuron 8:71-84(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart." Collin T., Wang J., Nargeot J., Schwartz A. Circ. Res. 72:1337-1344(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Heart.
[4]	"Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes." Fukuda K., Kaneko S., Yada N., Kikuwaka M., Akaike A., Satoh M. Neurosci. Lett. 217:13-16(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain cortex.
[5]	"Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels." Hogan K., Greg R.G., Powers P.A. Neurosci. Lett. 277:111-114(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Hippocampus.
[9]	"Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility." Iles D.E., Segers B., Sengers R.C.A., Monsieurs K., Heytens L., Halsall P.J., Hopkins P.M., Ellis F.R., Hall-Curran J.L., Stewart A.D., Wieringa B. Hum. Mol. Genet. 2:863-868(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-209.
[10]	"Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly." Brust P.F., Simerson S., McCue A.F., Deal C.R., Schoonmaker S., Williams M.E., Velicelebi G., Johnson E.C., Harpold M.M., Ellis S.B. Neuropharmacology 32:1089-1102(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 445-598 (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
[11]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-339.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M92303 mRNA. Translation: AAA35633.1. M92301 mRNA. Translation: AAA35631.1. M92302 mRNA. Translation: AAA35632.1. M76560 mRNA. Translation: AAA51894.1. L06110 mRNA. Translation: AAA36167.1. L06111 mRNA. Translation: AAA36168.1. L06112 mRNA. Translation: AAA36169.1. AB054985 mRNA. Translation: BAB21444.1. U86960 , U86952, U86953, U86954, U86955, U86956, U86957, U86958, U86959 Genomic DNA. Translation: AAB58779.1. U86960 , U86952, U86953, U86954, U86955, U86956, U86957, U86958, U86959 Genomic DNA. Translation: AAB58780.1. U86961 , U86952, U86953, U86954, U86955, U86956, U86957, U86958, U86959, U86960 Genomic DNA. Translation: AAB58781.1. Sequence problems. AK289729 mRNA. Translation: BAF82418.1. CH471152 Genomic DNA. Translation: EAW60562.1. BC037311 mRNA. Translation: AAH37311.2. Z21725 Genomic DNA. Translation: CAA79824.1. Z21726 Genomic DNA. Translation: CAA79825.1. Different initiation.
IPI	IPI00183965. IPI00219983. IPI00219984.
PIR	A44461. B44461. C44461. I38002. I52859. I65766. I65767. JH0566.
RefSeq	NP_000714.3. NM_000723.4. NP_954855.1. NM_199247.2. NP_954856.1. NM_199248.2.
UniGene	Hs.635.
3D structure databases
ProteinModelPortal	Q02641.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q02641. 1 interaction.
MINT	MINT-2857287.
STRING	9606.ENSP00000377840.
PTM databases
PhosphoSite	Q02641.
Polymorphism databases
DMDM	20455481.
Proteomic databases
PaxDb	Q02641.
PRIDE	Q02641.
Protocols and materials databases
DNASU	782.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344140; ENSP00000345461; ENSG00000067191. ENST00000394303; ENSP00000377840; ENSG00000067191. ENST00000394310; ENSP00000377847; ENSG00000067191.
GeneID	782.
KEGG	hsa:782.
UCSC	uc002hrl.1. human. uc002hrn.3. human. uc002hro.3. human.
Organism-specific databases
CTD	782.
GeneCards	GC17M037329.
HGNC	HGNC:1401. CACNB1.
HPA	CAB009779. HPA023343.
MIM	114207. gene.
neXtProt	NX_Q02641.
PharmGKB	PA87.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG326500.
HOVERGEN	HBG050765.
KO	K04862.
OMA	KTEHVPP.
OrthoDB	EOG4X6C83.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q02641.
CleanEx	HS_CACNB1.
Genevestigator	Q02641.
GermOnline	ENSG00000067191. Homo sapiens.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR027417. P-loop_NTPase. IPR001452. SH3_domain. IPR005443. VDCC_L_b1su. IPR000584. VDCC_L_bsu. [Graphical view]
PANTHER	PTHR11824. PTHR11824. 1 hit.
Pfam	PF00625. Guanylate_kin. 1 hit. PF12052. VGCC_beta4Aa_N. 1 hit. [Graphical view]
PRINTS	PR01626. LCACHANNELB. PR01627. LCACHANNELB1.
SMART	SM00072. GuKc. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit. SSF52540. SSF52540. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00308. Ibutilide. DB00653. Magnesium Sulfate. DB01388. Mibefradil. DB00661. Verapamil.
GenomeRNAi	782.
NextBio	3164.
SOURCE	Search...

Entry information

Entry name

CACB1_HUMAN

Accession

Primary (citable) accession number: Q02641
Secondary accession number(s): A8K114 , O15331, Q02639, Q02640, Q8N3X9, Q9C085, Q9UD79

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	May 2, 2002
Last modified:	May 29, 2013
This is version 136 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.