Q02637 (CEBP_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CCAAT/enhancer-binding protein
Short name=C/EBP

Alternative name(s):
Slow border cell protein

Gene names

Name:	slbo
ORF Names:	CG4354

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for the expression of gene products mediating border cell migration. Among the DNA sequences that this protein binds with high affinity is a conserved site within the promoter of its gene.
Subunit structure	Binds DNA as a dimer and can form stable heterodimers.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the bZIP family. C/EBP subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	border follicle cell migration Inferred from mutant phenotype. Source: FlyBase cell fate specification Traceable author statement. Source: FlyBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	CCAAT/enhancer-binding protein		PRO_0000076631
Regions
	Domain	391 – 427	37	Leucine-zipper By similarity
	DNA binding	369 – 385	17	Basic motif
	Compositional bias	45 – 72	28	Poly-Gln
Experimental info
	Sequence conflict	45 – 48	4	Missing in AAA28415. Ref.1
	Sequence conflict	167 – 175	9	PPSGMVSAA → RRANGLGG in AAA28415. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q02637 [UniParc]. Last modified June 21, 2005. Version 3. Checksum: 6E56D7246C83C34C	FASTA	449	49,420
	10 20 30 40 50 60 MLNMESPQMY ADAVQTLAQL DLKKEPPLQQ ATIGQITLTA MSTAQQQQQQ QQQQQQQQQQ 70 80 90 100 110 120 QQQQQQQQPQ QQTTDANNNT SQDAALLVKQ HAMHQMQQVA ALGSNNNLLQ KQMLQQYSTQ 130 140 150 160 170 180 TDLDELTTQE ITLDLQHLID DQFRDTETLG IFSDMVTSPG GLSATLPPSG MVSAAAKVLQ 190 200 210 220 230 240 QQTLRNQHGY GGRGGGGGAG GALAYMPQPV HATYNNSSDE NSSVGSDSST IKEEPIDPEY 250 260 270 280 290 300 RRHLQEAASQ QAAFMGNGAG LYNGYGSGAN GLTGGGNPLN GGNTTPSSNG SNGSTGSSNG 310 320 330 340 350 360 SQFTNLTTAN VLAHHNLPHL AAAAGAHNLL KQHSKLHAQQ QHQQHQQQQQ HRKHSNKHVD 370 380 390 400 410 420 KGTDEYRRRR ERNNIAVRKS REKAKVRSRE VEERVKSLLK EKDALIRQLG EMTNELQLHK 430 440 QIYMQLMNHA NPEVSRVCRS FLNTNEHSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila C/EBP." Montell D.J., Rorth P., Spradling A.C. Cell 71:51-62(1992) [PubMed: 1394432] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Canton-S.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[5]	"Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development." Rorth P., Montell D.J. Genes Dev. 6:2299-2311(1992) [PubMed: 1459454] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L00632 Genomic DNA. Translation: AAA28415.1. AE013599 Genomic DNA. Translation: AAF47194.1. BT009992 mRNA. Translation: AAQ22461.1.
PIR	A43481.
RefSeq	NP_523843.1. NM_079119.2.
UniGene	Dm.2680.
3D structure databases
ProteinModelPortal	Q02637.
SMR	Q02637. Positions 358-428.
ModBase	Search...
Protein-protein interaction databases
STRING	Q02637.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0072272; FBpp0072179; FBgn0005638.
GeneID	37889.
KEGG	dme:Dmel_CG4354.
NMPDR	fig|7227.3.peg.7293.
Organism-specific databases
CTD	37889.
FlyBase	FBgn0005638. slbo.
Phylogenomic databases
eggNOG	inNOG09669.
GeneTree	EMGT00050000002155.
InParanoid	Q02637.
OMA	IDDQFRD.
OrthoDB	EOG4THT92.
PhylomeDB	Q02637.
Gene expression databases
ArrayExpress	Q02637.
Bgee	Q02637.
GermOnline	CG4354. Drosophila melanogaster.
Family and domain databases
InterPro	IPR004827. bZIP. IPR011700. bZIP_2. [Graphical view]
KO	K10052.
Pfam	PF07716. bZIP_2. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	805882.

Entry information

Entry name

CEBP_DROME

Accession

Primary (citable) accession number: Q02637
Secondary accession number(s): Q9W183

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project