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Protein

SAP30-binding protein

Gene

Sap30bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival (By similarity). May be involved in the regulation of beta-2-microglobulin genes.By similarity

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processApoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SAP30-binding protein
Alternative name(s):
Transcriptional regulator protein HCNGP
Gene namesi
Name:Sap30bp
Synonyms:Hcngp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927479. Sap30bp.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000839241 – 308SAP30-binding proteinAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei52PhosphoserineBy similarity1
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei113PhosphoserineCombined sources1
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02614.
MaxQBiQ02614.
PaxDbiQ02614.
PeptideAtlasiQ02614.
PRIDEiQ02614.

PTM databases

iPTMnetiQ02614.
PhosphoSitePlusiQ02614.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020755.
CleanExiMM_SAP30BP.
GenevisibleiQ02614. MM.

Interactioni

Subunit structurei

Interacts with SAP30.By similarity

Protein-protein interaction databases

BioGridi208215. 1 interactor.
IntActiQ02614. 2 interactors.
MINTiMINT-4119830.
STRINGi10090.ENSMUSP00000114844.

Structurei

3D structure databases

ProteinModelPortaliQ02614.
SMRiQ02614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi225 – 294Thr-richAdd BLAST70

Sequence similaritiesi

Belongs to the HCNGP family.Curated

Phylogenomic databases

eggNOGiKOG2959. Eukaryota.
ENOG4111K05. LUCA.
GeneTreeiENSGT00390000007870.
HOGENOMiHOG000007692.
HOVERGENiHBG051891.
InParanoidiQ02614.
OMAiVSEAYGE.
OrthoDBiEOG091G0RRE.
PhylomeDBiQ02614.
TreeFamiTF323387.

Family and domain databases

InterProiView protein in InterPro
IPR012479. SAP30BP.
PANTHERiPTHR13464. PTHR13464. 1 hit.
PfamiView protein in Pfam
PF07818. HCNGP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q02614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKKNVLSS LAIYAEYSDP ESDGETGVDA VGGATEEKGG LVSDAYGEDD
60 70 80 90 100
FSRPGGDEDG YEEEEDENSK QSEDDDSETE KPEADDPKDN TEAEKRDPQE
110 120 130 140 150
LVASFSERVR NMSPDEIKIP PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN
160 170 180 190 200
YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN YPKDMFDPHG WSEDSYYEAL
210 220 230 240 250
AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATATST STASTAVADA
260 270 280 290 300
QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG

TIVKKAKQ
Length:308
Mass (Da):33,832
Last modified:July 11, 2006 - v2
Checksum:i4E36A6A4B58098FB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → R in CAA48198 (PubMed:1459361).Curated1
Sequence conflicti298A → T in CAA48198 (PubMed:1459361).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68061 mRNA. Translation: CAA48198.1.
AK147869 mRNA. Translation: BAE28192.1.
BC021757 mRNA. Translation: AAH21757.1.
CCDSiCCDS25651.1.
PIRiS26660.
RefSeqiNP_065229.2. NM_020483.3.
UniGeneiMm.267810.

Genome annotation databases

EnsembliENSMUST00000140991; ENSMUSP00000114844; ENSMUSG00000020755.
GeneIDi57230.
KEGGimmu:57230.
UCSCiuc007mjd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiS30BP_MOUSE
AccessioniPrimary (citable) accession number: Q02614
Secondary accession number(s): Q8VDJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2006
Last modified: August 30, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families