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Protein

SAP30-binding protein

Gene

Sap30bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival (By similarity). May be involved in the regulation of beta-2-microglobulin genes.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SAP30-binding protein
Alternative name(s):
Transcriptional regulator protein HCNGP
Gene namesi
Name:Sap30bp
Synonyms:Hcngp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1927479. Sap30bp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308SAP30-binding proteinPRO_0000083924Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei52 – 521PhosphoserineBy similarity
Modified residuei113 – 1131PhosphoserineCombined sources
Cross-linki220 – 220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki304 – 304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ02614.
MaxQBiQ02614.
PaxDbiQ02614.
PeptideAtlasiQ02614.
PRIDEiQ02614.

PTM databases

iPTMnetiQ02614.
PhosphoSiteiQ02614.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020755.
CleanExiMM_SAP30BP.
GenevisibleiQ02614. MM.

Interactioni

Subunit structurei

Interacts with SAP30.By similarity

Protein-protein interaction databases

BioGridi208215. 1 interaction.
IntActiQ02614. 2 interactions.
MINTiMINT-4119830.
STRINGi10090.ENSMUSP00000114844.

Structurei

3D structure databases

ProteinModelPortaliQ02614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 29470Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the HCNGP family.Curated

Phylogenomic databases

eggNOGiKOG2959. Eukaryota.
ENOG4111K05. LUCA.
GeneTreeiENSGT00390000007870.
HOGENOMiHOG000007692.
HOVERGENiHBG051891.
InParanoidiQ02614.
OMAiENSKQSX.
OrthoDBiEOG091G0RRE.
PhylomeDBiQ02614.
TreeFamiTF323387.

Family and domain databases

InterProiIPR012479. SAP30BP.
[Graphical view]
PANTHERiPTHR13464. PTHR13464. 1 hit.
PfamiPF07818. HCNGP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q02614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKKNVLSS LAIYAEYSDP ESDGETGVDA VGGATEEKGG LVSDAYGEDD
60 70 80 90 100
FSRPGGDEDG YEEEEDENSK QSEDDDSETE KPEADDPKDN TEAEKRDPQE
110 120 130 140 150
LVASFSERVR NMSPDEIKIP PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN
160 170 180 190 200
YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN YPKDMFDPHG WSEDSYYEAL
210 220 230 240 250
AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATATST STASTAVADA
260 270 280 290 300
QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG

TIVKKAKQ
Length:308
Mass (Da):33,832
Last modified:July 11, 2006 - v2
Checksum:i4E36A6A4B58098FB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → R in CAA48198 (PubMed:1459361).Curated
Sequence conflicti298 – 2981A → T in CAA48198 (PubMed:1459361).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68061 mRNA. Translation: CAA48198.1.
AK147869 mRNA. Translation: BAE28192.1.
BC021757 mRNA. Translation: AAH21757.1.
CCDSiCCDS25651.1.
PIRiS26660.
RefSeqiNP_065229.2. NM_020483.3.
UniGeneiMm.267810.

Genome annotation databases

EnsembliENSMUST00000140991; ENSMUSP00000114844; ENSMUSG00000020755.
GeneIDi57230.
KEGGimmu:57230.
UCSCiuc007mjd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68061 mRNA. Translation: CAA48198.1.
AK147869 mRNA. Translation: BAE28192.1.
BC021757 mRNA. Translation: AAH21757.1.
CCDSiCCDS25651.1.
PIRiS26660.
RefSeqiNP_065229.2. NM_020483.3.
UniGeneiMm.267810.

3D structure databases

ProteinModelPortaliQ02614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208215. 1 interaction.
IntActiQ02614. 2 interactions.
MINTiMINT-4119830.
STRINGi10090.ENSMUSP00000114844.

PTM databases

iPTMnetiQ02614.
PhosphoSiteiQ02614.

Proteomic databases

EPDiQ02614.
MaxQBiQ02614.
PaxDbiQ02614.
PeptideAtlasiQ02614.
PRIDEiQ02614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000140991; ENSMUSP00000114844; ENSMUSG00000020755.
GeneIDi57230.
KEGGimmu:57230.
UCSCiuc007mjd.1. mouse.

Organism-specific databases

CTDi29115.
MGIiMGI:1927479. Sap30bp.

Phylogenomic databases

eggNOGiKOG2959. Eukaryota.
ENOG4111K05. LUCA.
GeneTreeiENSGT00390000007870.
HOGENOMiHOG000007692.
HOVERGENiHBG051891.
InParanoidiQ02614.
OMAiENSKQSX.
OrthoDBiEOG091G0RRE.
PhylomeDBiQ02614.
TreeFamiTF323387.

Miscellaneous databases

PROiQ02614.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020755.
CleanExiMM_SAP30BP.
GenevisibleiQ02614. MM.

Family and domain databases

InterProiIPR012479. SAP30BP.
[Graphical view]
PANTHERiPTHR13464. PTHR13464. 1 hit.
PfamiPF07818. HCNGP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS30BP_MOUSE
AccessioniPrimary (citable) accession number: Q02614
Secondary accession number(s): Q8VDJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2006
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.